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This review provides a comprehensive overview of hydrogel film materials, including natural biopolymers, synthetic polymers, and multifunctional composites, highlighting their structural and functional diversity. We examine key fabrication techniques\u2014ranging from solvent casting and photopolymerization to advanced methods like microfluidics and 3D printing\u2014and discuss how these influence film architecture and performance. The biomedical applications of hydrogel films span wound healing, drug delivery, tissue engineering, ophthalmology, and implantable biosensors, with recent innovations enabling stimuli-responsive behavior, multi-drug loading, and integration with wearable electronics. Despite their promise, hydrogel films face persistent challenges in mechanical durability, sterilization, storage stability, regulatory approval, and scalable manufacturing. We conclude by identifying critical research gaps and outlining future directions, including AI-guided design, sustainable material development, and the establishment of standardized, regulatory-aligned, and industrially scalable fabrication strategies to accelerate clinical translation.<\/jats:p>","DOI":"10.3390\/gels11110918","type":"journal-article","created":{"date-parts":[[2025,11,19]],"date-time":"2025-11-19T12:55:31Z","timestamp":1763556931000},"page":"918","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":18,"title":["Hydrogel Films in Biomedical Applications: Fabrication, Properties and Therapeutic Potential"],"prefix":"10.3390","volume":"11","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-1933-293X","authenticated-orcid":false,"given":"Sabuj Chandra","family":"Sutradhar","sequence":"first","affiliation":[{"name":"Department of Energy Materials Science and Engineering, Konkuk University, 268 Chungwon-daero, Chungju-si 27478, Republic of Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hyoseop","family":"Shin","sequence":"additional","affiliation":[{"name":"Department of Energy Materials Science and Engineering, Konkuk University, 268 Chungwon-daero, Chungju-si 27478, Republic of Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0794-5301","authenticated-orcid":false,"given":"Whangi","family":"Kim","sequence":"additional","affiliation":[{"name":"Department of Energy Materials Science and Engineering, Konkuk University, 268 Chungwon-daero, Chungju-si 27478, Republic of Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3762-4127","authenticated-orcid":false,"given":"Hohyoun","family":"Jang","sequence":"additional","affiliation":[{"name":"Department of Energy Materials Science and Engineering, Konkuk University, 268 Chungwon-daero, Chungju-si 27478, Republic of Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2025,11,17]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"2803","DOI":"10.1002\/pen.27200","article-title":"Advances in synthetic strategies and applications of polymeric hydrogels","volume":"65","author":"Gajurel","year":"2025","journal-title":"Polym. Eng. Sci."},{"key":"ref_2","doi-asserted-by":"crossref","unstructured":"Khiabani, S.S., Aghazadeh, M., Rakhtshah, J., and Davaran, S. (2021). A review of hydrogel systems based on poly(N-isopropyl acrylamide) for use in the engineering of bone tissues. Colloids Surf. B Biointerfaces, 208.","DOI":"10.1016\/j.colsurfb.2021.112035"},{"key":"ref_3","doi-asserted-by":"crossref","unstructured":"Ubaldini, A., and Calistri, S. (2025). Advances in Hydrogel Film Fabrication and Functional Applications Across Biomedical and Environmental Fields. Appl. Sci., 15.","DOI":"10.3390\/app15179579"},{"key":"ref_4","doi-asserted-by":"crossref","first-page":"100720","DOI":"10.1016\/j.eml.2020.100720","article-title":"Thin-film hydrogels with superior stiffness, strength, and stretchability","volume":"37","author":"Le","year":"2020","journal-title":"Extrem. Mech. Lett."},{"key":"ref_5","doi-asserted-by":"crossref","unstructured":"Choi, S.M., Shin, E.J., Zo, S.M., Kummara, M.R., Kim, C.M., Kumar, A., Bae, H.J., Sood, A., and Han, S.S. (2025). Development of Scalable Elastic Gelatin Hydrogel Films Crosslinked with Waterborne Polyurethane for Enhanced Mechanical Properties and Strain Recovery. Gels, 11.","DOI":"10.3390\/gels11010049"},{"key":"ref_6","doi-asserted-by":"crossref","unstructured":"Raeisi, A., and Farjadian, F. (2024). Commercial hydrogel product for drug delivery based on route of administration. Front. Chem., 12.","DOI":"10.3389\/fchem.2024.1336717"},{"key":"ref_7","doi-asserted-by":"crossref","first-page":"4073","DOI":"10.1039\/D2BM02070J","article-title":"Hydrogels for dermal and transdermal drug delivery","volume":"11","author":"Labie","year":"2023","journal-title":"Biomater. Sci."},{"key":"ref_8","doi-asserted-by":"crossref","first-page":"111652","DOI":"10.1016\/j.eurpolymj.2022.111652","article-title":"Hydrogel-based therapeutic coatings for dental implants","volume":"181","author":"Alavi","year":"2022","journal-title":"Eur. Polym. J."},{"key":"ref_9","doi-asserted-by":"crossref","first-page":"935","DOI":"10.1038\/s41578-022-00483-4","article-title":"Hydrogel interfaces for merging humans and machines","volume":"7","author":"Yuk","year":"2022","journal-title":"Nat. Rev. Mater."},{"key":"ref_10","doi-asserted-by":"crossref","unstructured":"Periyasamy, T., Asrafali, S.P., and Lee, J. (2025). Hydrogels for Translucent Wearable Electronics: Innovations in Materials, Integration, and Applications. Gels, 11.","DOI":"10.3390\/gels11050372"},{"key":"ref_11","doi-asserted-by":"crossref","first-page":"16449","DOI":"10.1007\/s10853-024-10187-5","article-title":"smart and active hydrogels in biotechnology\u2014Synthetic techniques and applications","volume":"59","author":"Khan","year":"2024","journal-title":"J. Mater. Sci."},{"key":"ref_12","doi-asserted-by":"crossref","first-page":"2025055","DOI":"10.20517\/microstructures.2024.139","article-title":"Stimuli-responsive biomedical polymeric films for tissue regeneration","volume":"5","author":"Xu","year":"2025","journal-title":"Microstructures"},{"key":"ref_13","doi-asserted-by":"crossref","first-page":"5888","DOI":"10.1039\/C8SM01126E","article-title":"Spin-coating-assisted fabrication of ultrathin physical hydrogel films with high toughness and fast response","volume":"14","author":"Zheng","year":"2018","journal-title":"Soft Matter"},{"key":"ref_14","doi-asserted-by":"crossref","first-page":"100091","DOI":"10.1016\/j.apsadv.2021.100091","article-title":"Microfluidics meets layer-by-layer assembly for the build-up of polymeric scaffolds","volume":"5","author":"Yola","year":"2021","journal-title":"Appl. Surf. Sci. Adv."},{"key":"ref_15","doi-asserted-by":"crossref","first-page":"593","DOI":"10.1021\/acsapm.8b00165","article-title":"Photopolymerization in 3D Printing","volume":"1","author":"Bagheri","year":"2019","journal-title":"ACS Appl. Polym. Mater."},{"key":"ref_16","doi-asserted-by":"crossref","unstructured":"Uysal, B., Madduma-Bandarage, U.S.K., Jayasinghe, H.G., and Madihally, S. (2025). 3D-Printed Hydrogels from Natural Polymers for Biomedical Applications: Conventional Fabrication Methods, Current Developments, Advantages, and Challenges. Gels, 11.","DOI":"10.3390\/gels11030192"},{"key":"ref_17","doi-asserted-by":"crossref","first-page":"8","DOI":"10.1039\/D3BM01352A","article-title":"Injectable smart stimuli-responsive hydrogels: Pioneering advancements in biomedical applications","volume":"12","author":"Liu","year":"2024","journal-title":"Biomater. 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Biomater."},{"key":"ref_21","doi-asserted-by":"crossref","first-page":"2109","DOI":"10.1021\/acs.chemrev.0c00897","article-title":"Natural Biopolymer-Based Biocompatible Conductors for Stretchable Bioelectronics","volume":"121","author":"Wang","year":"2021","journal-title":"Chem. Rev."},{"key":"ref_22","doi-asserted-by":"crossref","first-page":"1595","DOI":"10.1080\/09205063.2022.2068941","article-title":"A short review on chitosan and gelatin-based hydrogel composite polymers for wound healing","volume":"33","author":"Ebhodaghe","year":"2022","journal-title":"J. Biomater. Sci. Polym. Ed."},{"key":"ref_23","doi-asserted-by":"crossref","unstructured":"Varghese, R., Dalvi, Y.B., Lochana, P., Achinthya, S., Somani, B.O., Karnaver, P., Thomas, N.G., Rupesh, S., Varghese, N., and VP, J. (2024). Physiochemical and Biomedical Properties of Hydrogels: From Fundamentals to Applications. Hydrogels and Nanogels-Applications in Medicine, IntechOpen.","DOI":"10.5772\/intechopen.1002027"},{"key":"ref_24","doi-asserted-by":"crossref","first-page":"2225426","DOI":"10.1155\/2021\/2225426","article-title":"Poly(vinyl alcohol) Hydrogels: The Old and New Functional Materials","volume":"2021","author":"Wang","year":"2021","journal-title":"Int. J. Polym. Sci."},{"key":"ref_25","doi-asserted-by":"crossref","unstructured":"Kumar, A.C., and Erothu, H. (2016). Synthetic Polymer Hydrogels. Biomedical Applications of Polymeric Materials and Composites, Wiley.","DOI":"10.1002\/9783527690916.ch6"},{"key":"ref_26","doi-asserted-by":"crossref","unstructured":"Rana, M.M., and De la Hoz Siegler, H. (2024). Evolution of Hybrid Hydrogels: Next-Generation Biomaterials for Drug Delivery and Tissue Engineering. Gels, 10.","DOI":"10.3390\/gels10040216"},{"key":"ref_27","doi-asserted-by":"crossref","first-page":"125323","DOI":"10.1016\/j.ijpharm.2025.125323","article-title":"Advances in the application of natural\/synthetic hybrid hydrogels in tissue engineering and delivery systems: A comprehensive review","volume":"672","author":"Liu","year":"2025","journal-title":"Int. J. Pharm."},{"key":"ref_28","doi-asserted-by":"crossref","unstructured":"Sevinc Ozdemir, N., and Kenar, H. (2025). Properties and Preparation Techniques of Hydrogels. Hydrogels and Bioinks in Tissue Engineering, Springer.","DOI":"10.1007\/978-3-031-90966-5_4"},{"key":"ref_29","doi-asserted-by":"crossref","unstructured":"Yammine, P., El Safadi, A., Kassab, R., El-Nakat, H., Obeid, P.J., Nasr, Z., Tannous, T., Sari-Chmayssem, N., Mansour, A., and Chmayssem, A. (2025). Types of Crosslinkers and Their Applications in Biomaterials and Biomembranes. Chemistry, 7.","DOI":"10.3390\/chemistry7020061"},{"key":"ref_30","doi-asserted-by":"crossref","first-page":"216868","DOI":"10.1016\/j.ccr.2025.216868","article-title":"Physical crosslinking of hydrogels: The potential of dynamic and reversible bonds in burn care","volume":"542","author":"Ribeiro","year":"2025","journal-title":"Coord. Chem. Rev."},{"key":"ref_31","doi-asserted-by":"crossref","first-page":"4827","DOI":"10.1021\/acs.molpharmaceut.4c00595","article-title":"Hydrogels as a Potential Biomaterial for Multimodal Therapeutic Applications","volume":"21","author":"Kaur","year":"2024","journal-title":"Mol. Pharm."},{"key":"ref_32","first-page":"197","article-title":"Structural and biological engineering of 3D hydrogels for wound healing","volume":"24","author":"Norahan","year":"2023","journal-title":"Bioact. Mater."},{"key":"ref_33","doi-asserted-by":"crossref","unstructured":"Khattak, S., Ullah, I., Yousaf, M.T., Ullah, S., Yousaf, H., Li, Y., Jin, H., Shen, J., and Xu, H.-T. (2025). Advancements in hydrogels: A comprehensive review of natural, synthetic, and hybrid innovations for wound healing. Int. J. Biol. Macromol., 327.","DOI":"10.1016\/j.ijbiomac.2025.147270"},{"key":"ref_34","doi-asserted-by":"crossref","unstructured":"Olteanu, G., Neac\u0219u, S.M., Joi\u021ba, F.A., Musuc, A.M., Lupu, E.C., Ioni\u021b\u0103-M\u00eendrican, C.B., Lupuliasa, D., and Mititelu, M. (2024). Advancements in Regenerative Hydrogels in Skin Wound Treatment: A Comprehensive Review. Int. J. Mol. Sci., 25.","DOI":"10.3390\/ijms25073849"},{"key":"ref_35","doi-asserted-by":"crossref","unstructured":"Gounden, V., and Singh, M. (2024). Hydrogels and Wound Healing: Current and Future Prospects. Gels, 10.","DOI":"10.3390\/gels10010043"},{"key":"ref_36","doi-asserted-by":"crossref","unstructured":"Cao, J., Luo, S., Huang, W., Lu, X., Kankala, R.K., Wang, S., Xu, P., and Chen, A. (2025). ECM-inspired stem cell secretome sustained releasing composite nanofibrous membranes for accelerated wound healing. Mater. Today Bio, 34.","DOI":"10.1016\/j.mtbio.2025.102141"},{"key":"ref_37","doi-asserted-by":"crossref","unstructured":"Sawadkar, P., Lali, F., Garcia-Gareta, E., Garrido, B.G., Chaudhry, A., Matharu, P., Kyriakidis, C., and Greco, K. (2025). Innovative hydrogels in cutaneous wound healing: Current status and future perspectives. Front. Bioeng. Biotechnol., 13.","DOI":"10.3389\/fbioe.2025.1454903"},{"key":"ref_38","doi-asserted-by":"crossref","first-page":"334","DOI":"10.4252\/wjsc.v16.i4.334","article-title":"Biological scaffold as potential platforms for stem cells: Current development and applications in wound healing","volume":"16","author":"Xiang","year":"2024","journal-title":"World J. Stem Cells"},{"key":"ref_39","doi-asserted-by":"crossref","first-page":"113465","DOI":"10.1016\/j.eurpolymj.2024.113465","article-title":"Silk fibroin and sericin: Multifunctional formulations for treating diabetic wound healing","volume":"220","author":"Bogadi","year":"2024","journal-title":"Eur. Polym. J."},{"key":"ref_40","doi-asserted-by":"crossref","first-page":"371","DOI":"10.1186\/s13287-024-03976-x","article-title":"Advancing wound healing by hydrogel-based dressings loaded with cell-conditioned medium: A systematic review","volume":"15","author":"Nifontova","year":"2024","journal-title":"Stem Cell Res. Ther."},{"key":"ref_41","doi-asserted-by":"crossref","first-page":"100062","DOI":"10.1016\/j.amolm.2024.100062","article-title":"Stimuli-responsive supramolecular hydrogels for paclitaxel delivery: Progress and prospects","volume":"5","author":"Qutub","year":"2025","journal-title":"Asp. Mol. Med."},{"key":"ref_42","doi-asserted-by":"crossref","first-page":"113615","DOI":"10.1016\/j.mtcomm.2025.113615","article-title":"Recent advances in hydrogel-based drug delivery systems for enhanced cancer therapy: A review","volume":"48","author":"Davodabadi","year":"2025","journal-title":"Mater. Today Commun."},{"key":"ref_43","doi-asserted-by":"crossref","unstructured":"Yaghoubi, A., Ramazani, A., Sillanpaa, M., Ghasemzadeh, H., and Mohammadi, E. (2025). Biocompatible porous PAM\/CNT nanocomposite hydrogel films for sustained drug delivery and cancer therapy. Sci. Rep., 15.","DOI":"10.1038\/s41598-025-05473-4"},{"key":"ref_44","doi-asserted-by":"crossref","first-page":"703","DOI":"10.1016\/j.jconrel.2024.03.008","article-title":"Liposome-integrated hydrogel hybrids: Promising platforms for cancer therapy and tissue regeneration","volume":"368","author":"Sanati","year":"2024","journal-title":"J. Control. Release"},{"key":"ref_45","doi-asserted-by":"crossref","unstructured":"Zhang, Y., and Wu, B.M. (2023). Current advances in stimuli-responsive hydrogels as smart drug delivery carriers. Gels, 9.","DOI":"10.3390\/gels9100838"},{"key":"ref_46","doi-asserted-by":"crossref","first-page":"6108","DOI":"10.1038\/s41467-023-41874-7","article-title":"Programmable nanocomposites of cellulose nanocrystals and zwitterionic hydrogels for soft robotics","volume":"14","author":"Nasseri","year":"2023","journal-title":"Nat. Commun."},{"key":"ref_47","doi-asserted-by":"crossref","first-page":"607","DOI":"10.1586\/erd.11.27","article-title":"Design properties of hydrogel tissue-engineering scaffolds","volume":"8","author":"Zhu","year":"2011","journal-title":"Expert Rev. Med. Devices"},{"key":"ref_48","doi-asserted-by":"crossref","first-page":"184","DOI":"10.1039\/C9PY01021A","article-title":"Hydrogel scaffolds for tissue engineering: The importance of polymer choice","volume":"11","author":"Spicer","year":"2019","journal-title":"Polym. Chem."},{"key":"ref_49","doi-asserted-by":"crossref","unstructured":"Ayala-Ham, A., L\u00f3pez-Gutierrez, J., Berm\u00fadez, M., Aguilar-Medina, M., Sarmiento-S\u00e1nchez, J.I., L\u00f3pez-Camarillo, C., Sanchez-Schmitz, G., and Ramos-Payan, R. (2021). Hydrogel-Based Scaffolds in Oral Tissue Engineering. Front. Mater., 8.","DOI":"10.3389\/fmats.2021.708945"},{"key":"ref_50","doi-asserted-by":"crossref","unstructured":"Zhang, B., Zhang, M., Jiang, C., Yan, W., Pan, Y., and Meng, F. (2026). Engineered polysaccharide scaffolds for cartilage regeneration: Mechanisms, functionalization, and clinical prospects. Colloids Surf. B Biointerfaces, 257.","DOI":"10.1016\/j.colsurfb.2025.115134"},{"key":"ref_51","doi-asserted-by":"crossref","unstructured":"Lu, J., Gao, Y., Cao, C., Wang, H., Ruan, Y., Qin, K., Liu, H., Wang, Y., Yang, P., and Liu, Y. (2025). 3D bioprinted scaffolds for osteochondral regeneration: Advancements and applications. Mater. Today Bio, 32.","DOI":"10.1016\/j.mtbio.2025.101834"},{"key":"ref_52","doi-asserted-by":"crossref","first-page":"66","DOI":"10.1038\/s41413-024-00376-y","article-title":"Engineering bone\/cartilage organoids: Strategy, progress, and application","volume":"12","author":"Bai","year":"2024","journal-title":"Bone Res."},{"key":"ref_53","doi-asserted-by":"crossref","first-page":"40","DOI":"10.1007\/s43939-024-00111-8","article-title":"Advancements in nanocomposite hydrogels: A comprehensive review of biomedical applications","volume":"4","author":"Baishya","year":"2024","journal-title":"Discov. Mater."},{"key":"ref_54","doi-asserted-by":"crossref","first-page":"062002","DOI":"10.1088\/2631-7990\/ade8b8","article-title":"Hydrogel Fabrication Techniques for Advanced Artificial Sensory Systems","volume":"7","author":"Gong","year":"2025","journal-title":"Int. J. Extrem. Manuf."},{"key":"ref_55","doi-asserted-by":"crossref","unstructured":"Gorantla, A., Hall, J.T.V.E., Troidle, A., and Janjic, J.M. (2024). Biomaterials for Protein Delivery: Opportunities and Challenges to Clinical Translation. Micromachines, 15.","DOI":"10.3390\/mi15040533"},{"key":"ref_56","doi-asserted-by":"crossref","unstructured":"Wang, Z., Wang, X., Xu, W., Li, Y., Lai, R., Qiu, X., Chen, X., Chen, Z., Mi, B., and Wu, M. (2023). Translational Challenges and Prospective Solutions in the Implementation of Biomimetic Delivery Systems. Pharmaceutics, 15.","DOI":"10.20944\/preprints202309.1912.v1"},{"key":"ref_57","doi-asserted-by":"crossref","unstructured":"Xu, F., Dawson, C., Lamb, M., Mueller, E., Stefanek, E., Akbari, M., and Hoare, T. (2022). Hydrogels for Tissue Engineering: Addressing Key Design Needs Toward Clinical Translation. Front. Bioeng. Biotechnol., 10.","DOI":"10.3389\/fbioe.2022.849831"},{"key":"ref_58","doi-asserted-by":"crossref","first-page":"18","DOI":"10.1186\/s40580-019-0188-z","article-title":"Nanocomposite hydrogel actuators hybridized with various dimensional nanomaterials for stimuli responsiveness enhancement","volume":"6","author":"Han","year":"2019","journal-title":"Nano Converg."},{"key":"ref_59","doi-asserted-by":"crossref","unstructured":"Banerjee, H., Suhail, M., and Ren, H. (2018). Hydrogel actuators and sensors for biomedical soft robots: Brief overview with impending challenges. Biomimetics, 3.","DOI":"10.3390\/biomimetics3030015"},{"key":"ref_60","doi-asserted-by":"crossref","unstructured":"Lee, H.K., Yang, Y.J., Koirala, G.R., Oh, S., and Kim, T.-i. (2024). From lab to wearables: Innovations in multifunctional hydrogel chemistry for next-generation bioelectronic devices. Biomaterials, 310.","DOI":"10.1016\/j.biomaterials.2024.122632"},{"key":"ref_61","doi-asserted-by":"crossref","unstructured":"Z\u00f6ller, K., To, D., and Bernkop-Schn\u00fcrch, A. (2025). Biomedical applications of functional hydrogels: Innovative developments, relevant clinical trials and advanced products. Biomaterials, 312.","DOI":"10.1016\/j.biomaterials.2024.122718"},{"key":"ref_62","first-page":"1","article-title":"Hydrogel-exosome system in tissue engineering: A promising therapeutic strategy","volume":"38","author":"Fan","year":"2024","journal-title":"Bioact. Mater."},{"key":"ref_63","doi-asserted-by":"crossref","first-page":"150403","DOI":"10.1016\/j.cej.2024.150403","article-title":"Engineering multifunctional dynamic hydrogel for biomedical and tissue regenerative applications","volume":"487","author":"Yin","year":"2024","journal-title":"Chem. Eng. J."},{"key":"ref_64","doi-asserted-by":"crossref","unstructured":"Sharma, R., Malviya, R., Singh, S., and Prajapati, B. (2023). A Critical Review on Classified Excipient Sodium-Alginate-Based Hydrogels: Modification, Characterization, and Application in Soft Tissue Engineering. Gels, 9.","DOI":"10.3390\/gels9050430"},{"key":"ref_65","doi-asserted-by":"crossref","first-page":"4246","DOI":"10.1021\/acsomega.3c08619","article-title":"A Review on Hydrophobically Associated Alginates: Approaches and Applications","volume":"9","author":"Akshaya","year":"2024","journal-title":"ACS Omega"},{"key":"ref_66","doi-asserted-by":"crossref","first-page":"1849","DOI":"10.1039\/D1MA00959A","article-title":"Iron(iii)-cross-linked alginate hydrogels: A critical review","volume":"3","author":"Othman","year":"2022","journal-title":"Mater. Adv."},{"key":"ref_67","doi-asserted-by":"crossref","unstructured":"Xie, Y., Gao, P., He, F., and Zhang, C. (2022). Application of Alginate-Based Hydrogels in Hemostasis. Gels, 8.","DOI":"10.3390\/gels8020109"},{"key":"ref_68","doi-asserted-by":"crossref","first-page":"221","DOI":"10.1016\/j.ijbiomac.2012.09.031","article-title":"Development of novel alginate based hydrogel films for wound healing applications","volume":"52","author":"Pereira","year":"2013","journal-title":"Int. J. Biol. Macromol."},{"key":"ref_69","doi-asserted-by":"crossref","unstructured":"Abasalizadeh, F., Moghaddam, S.V., Alizadeh, E., Akbari, E., Kashani, E., Fazljou, S.M.B., Torbati, M., and Akbarzadeh, A. (2020). Alginate-based hydrogels as drug delivery vehicles in cancer treatment and their applications in wound dressing and 3D bioprinting. J. Biol. Eng., 14.","DOI":"10.1186\/s13036-020-0227-7"},{"key":"ref_70","doi-asserted-by":"crossref","first-page":"101095","DOI":"10.1016\/j.fochx.2023.101095","article-title":"Chitosan-based hydrogels: From preparation to applications, a review","volume":"21","author":"Hong","year":"2024","journal-title":"Food Chem. 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Macromol."},{"key":"ref_74","doi-asserted-by":"crossref","first-page":"2628","DOI":"10.1007\/s10924-021-02058-w","article-title":"The Encapsulation of Green Tea Extract in Cyclodextrin and Loading into Chitosan-Based Composites: Controlled-Release Behavior and Antioxidant Properties","volume":"29","author":"Chuysinuan","year":"2021","journal-title":"J. Polym. Environ."},{"key":"ref_75","doi-asserted-by":"crossref","first-page":"889","DOI":"10.1016\/j.ijbiomac.2018.10.109","article-title":"Current advancements in chitosan-based film production for food technology; A review","volume":"121","author":"Mujtaba","year":"2019","journal-title":"Int. J. Biol. Macromol."},{"key":"ref_76","doi-asserted-by":"crossref","first-page":"115","DOI":"10.1016\/B978-0-12-385520-6.00004-2","article-title":"Chapter 4-Polysaccharides of the red algae","volume":"Volume 65","author":"Horton","year":"2011","journal-title":"Advances in Carbohydrate Chemistry and Biochemistry"},{"key":"ref_77","doi-asserted-by":"crossref","first-page":"9002","DOI":"10.1021\/acsami.7b18343","article-title":"Ultrathin \u03ba-Carrageenan\/Chitosan Hydrogel Films with High Toughness and Antiadhesion Property","volume":"10","author":"Yu","year":"2018","journal-title":"ACS Appl. Mater. Interfaces"},{"key":"ref_78","doi-asserted-by":"crossref","unstructured":"Neamtu, B., Barbu, A., Negrea, M.O., Berghea-Neam\u021bu, C.\u0218., Popescu, D., Z\u0103han, M., and Mire\u0219an, V. (2022). Carrageenan-Based Compounds as Wound Healing Materials. Int. J. Mol. Sci., 23.","DOI":"10.3390\/ijms23169117"},{"key":"ref_79","doi-asserted-by":"crossref","first-page":"108118","DOI":"10.1016\/j.porgcoat.2023.108118","article-title":"New insights into biomaterials for wound dressings and care: Challenges and trends","volume":"187","author":"Moreira","year":"2024","journal-title":"Prog. Org. Coat."},{"key":"ref_80","doi-asserted-by":"crossref","first-page":"1238","DOI":"10.1039\/D0TB02099K","article-title":"Functional silk fibroin hydrogels: Preparation, properties and applications","volume":"9","author":"Zheng","year":"2021","journal-title":"J. Mater. Chem. B"},{"key":"ref_81","doi-asserted-by":"crossref","unstructured":"Valachov\u00e1, K., Hassan, M.E., and \u0160olt\u00e9s, L. (2024). Hyaluronan: Sources, Structure, Features and Applications. Molecules, 29.","DOI":"10.3390\/molecules29030739"},{"key":"ref_82","doi-asserted-by":"crossref","unstructured":"Zhao, X., Dai, W., Liu, C., An, M., Li, S., Guo, L., Fan, Y., and Zhang, X. (2025). Gelatin\/hyaluronic acid-based in-situ forming hydrogel promotes wound regeneration by the synergy of ROS-scavenging and pro-healing activity. Regen. Biomater., 12.","DOI":"10.1093\/rb\/rbaf052"},{"key":"ref_83","doi-asserted-by":"crossref","first-page":"929","DOI":"10.1146\/annurev.biochem.77.032207.120833","article-title":"Collagen Structure and Stability","volume":"78","author":"Shoulders","year":"2009","journal-title":"Annu. Rev. Biochem."},{"key":"ref_84","doi-asserted-by":"crossref","unstructured":"Gahlawat, S., Nanda, V., and Shreiber, D.I. (2024). Designing collagens to shed light on the multi-scale structure\u2013function mapping of matrix disorders. Matrix Biol. Plus, 21.","DOI":"10.1016\/j.mbplus.2023.100139"},{"key":"ref_85","doi-asserted-by":"crossref","unstructured":"Li, Y., Dong, X., Yao, L., Wang, Y., Wang, L., Jiang, Z., and Qiu, D. (2023). Preparation and Characterization of Nanocomposite Hydrogels Based on Self-Assembling Collagen and Cellulose Nanocrystals. Polymers, 15.","DOI":"10.3390\/polym15051308"},{"key":"ref_86","first-page":"54","article-title":"Recent advances in the synthesis and applications of collagen based hydrogels: A review","volume":"3","year":"2019","journal-title":"Mediterr. J. Basic Appl. Sci."},{"key":"ref_87","doi-asserted-by":"crossref","unstructured":"Hu, T., and Lo, A.C.Y. (2021). Collagen\u2013Alginate Composite Hydrogel: Application in Tissue Engineering and Biomedical Sciences. Polymers, 13.","DOI":"10.3390\/polym13111852"},{"key":"ref_88","doi-asserted-by":"crossref","first-page":"5543","DOI":"10.1007\/s00210-024-03554-1","article-title":"Collagen and chitosan-based biogenic sprayable gel of silver nanoparticle for advanced wound care","volume":"398","author":"Markandeywar","year":"2025","journal-title":"Naunyn-Schmiedeb. Arch. Pharmacol."},{"key":"ref_89","unstructured":"Mahmood Zia, K., Jabeen, F., Anjum, M.N., and Ikram, S. (2020). Chapter 3-Natural polymers as constituents of bionanocomposites. Bionanocomposites, Elsevier."},{"key":"ref_90","doi-asserted-by":"crossref","unstructured":"Li, M., You, J., Qin, Q., Liu, M., Yang, Y., Jia, K., Zhang, Y., and Zhou, Y. (2023). A Comprehensive Review on Silk Fibroin as a Persuasive Biomaterial for Bone Tissue Engineering. Int. J. Mol. Sci., 24.","DOI":"10.3390\/ijms24032660"},{"key":"ref_91","unstructured":"Atala, A., and Yoo, J.J. (2015). Chapter 13-Polymers for Bioprinting. Essentials of 3D Biofabrication and Translation, Academic Press."},{"key":"ref_92","doi-asserted-by":"crossref","first-page":"e2295","DOI":"10.1002\/hsr2.2295","article-title":"Preparation of silk fibroin-derived hydrogels and applications in skin regeneration","volume":"7","author":"Li","year":"2024","journal-title":"Health Sci. Rep."},{"key":"ref_93","doi-asserted-by":"crossref","first-page":"784","DOI":"10.1039\/D3TB02363J","article-title":"A sustainable and self-healable silk fibroin nanocomposite with antibacterial and drug eluting properties for 3D printed wound dressings","volume":"12","author":"Sheybanikashani","year":"2024","journal-title":"J. Mater. Chem. B"},{"key":"ref_94","doi-asserted-by":"crossref","first-page":"126063","DOI":"10.1016\/j.foodchem.2019.126063","article-title":"Casein-based hydrogels: A mini-review","volume":"314","author":"Nascimento","year":"2020","journal-title":"Food Chem."},{"key":"ref_95","doi-asserted-by":"crossref","first-page":"105136","DOI":"10.1016\/j.idairyj.2021.105136","article-title":"Heat-induced changes in caseins and casein micelles, including interactions with denatured whey proteins","volume":"122","author":"Anema","year":"2021","journal-title":"Int. Dairy J."},{"key":"ref_96","doi-asserted-by":"crossref","unstructured":"Garcia, L.V., Silva, D., Costa, M.M., Arm\u00e9s, H., Salema-Oom, M., Saramago, B., and Serro, A.P. (2023). Antiseptic-Loaded Casein Hydrogels for Wound Dressings. Pharmaceutics, 15.","DOI":"10.3390\/pharmaceutics15020334"},{"key":"ref_97","doi-asserted-by":"crossref","unstructured":"Zou, P., Yao, J., Cui, Y.-N., Zhao, T., Che, J., Yang, M., Li, Z., and Gao, C. (2022). Advances in Cellulose-Based Hydrogels for Biomedical Engineering: A Review Summary. Gels, 8.","DOI":"10.3390\/gels8060364"},{"key":"ref_98","first-page":"23","article-title":"The Synthesis of Superabsorbent Polymers from a Carboxymethylcellulose\/acrylic Acid Blend Using Gamma Radiation and its Application in Agriculture","volume":"26","author":"Mizanur","year":"2015","journal-title":"J. Phys. Sci."},{"key":"ref_99","doi-asserted-by":"crossref","unstructured":"Verma, A., Aljohani, K., Aljohani, B.S., Lal, B., Jadeja, Y., Ballal, S., Chahar, M., and Suman, R. (2025). Innovations in cellulose-based hydrogels for enhanced wastewater treatment through adsorption. Int. J. Biol. Macromol., 303.","DOI":"10.1016\/j.ijbiomac.2025.140660"},{"key":"ref_100","doi-asserted-by":"crossref","unstructured":"Tang, Y., Fang, Z., and Lee, H.-J. (2024). Exploring Applications and Preparation Techniques for Cellulose Hydrogels: A Comprehensive Review. Gels, 10.","DOI":"10.3390\/gels10060365"},{"key":"ref_101","doi-asserted-by":"crossref","unstructured":"Alven, S., and Aderibigbe, B.A. (2020). Chitosan and Cellulose-Based Hydrogels for Wound Management. Int. J. Mol. Sci., 21.","DOI":"10.3390\/ijms21249656"},{"key":"ref_102","doi-asserted-by":"crossref","unstructured":"Karth\u00e4user, J., Biziks, V., Mai, C., and Militz, H. (2021). Lignin and Lignin-Derived Compounds for Wood Applications\u2014A Review. Molecules, 26.","DOI":"10.3390\/molecules26092533"},{"key":"ref_103","doi-asserted-by":"crossref","first-page":"1094","DOI":"10.1007\/s42452-019-1126-8","article-title":"Structure, chemistry and physicochemistry of lignin for material functionalization","volume":"1","author":"Narayanan","year":"2019","journal-title":"SN Appl. Sci."},{"key":"ref_104","doi-asserted-by":"crossref","unstructured":"Rico-Garc\u00eda, D., Ruiz-Rubio, L., P\u00e9rez-Alvarez, L., Hern\u00e1ndez-Olmos, S.L., Guerrero-Ram\u00edrez, G.L., and Vilas-Vilela, J.L. (2020). Lignin-Based Hydrogels: Synthesis and Applications. Polymers, 12.","DOI":"10.3390\/polym12010081"},{"key":"ref_105","doi-asserted-by":"crossref","first-page":"9037","DOI":"10.1021\/acssuschemeng.8b01371","article-title":"Synthesis and Characterization of Lignin Hydrogels for Potential Applications as Drug Eluting Antimicrobial Coatings for Medical Materials","volume":"6","author":"Toh","year":"2018","journal-title":"ACS Sustain. Chem. Eng."},{"key":"ref_106","doi-asserted-by":"crossref","first-page":"9445","DOI":"10.1039\/D4MA00680A","article-title":"A lignin-based biocomposite hydrogel for antimicrobial and wound healing applications","volume":"5","author":"Preet","year":"2024","journal-title":"Mater. Adv."},{"key":"ref_107","doi-asserted-by":"crossref","unstructured":"Ahmed, M.S., Yun, S., Kim, H.-Y., Ko, S., Islam, M., and Nam, K.-W. (2025). Hydrogels and Microgels: Driving Revolutionary Innovations in Targeted Drug Delivery, Strengthening Infection Management, and Advancing Tissue Repair and Regeneration. Gels, 11.","DOI":"10.3390\/gels11030179"},{"key":"ref_108","doi-asserted-by":"crossref","first-page":"18","DOI":"10.1016\/j.addr.2012.09.010","article-title":"Synthetic Hydrogels for Biomedical Applications","volume":"64","author":"Hoffman","year":"2012","journal-title":"Adv. Drug Deliv. Rev."},{"key":"ref_109","doi-asserted-by":"crossref","unstructured":"Rahman Khan, M.M., and Rumon, M.M.H. (2025). Synthesis of PVA-Based Hydrogels for Biomedical Applications: Recent Trends and Advances. Gels, 11.","DOI":"10.3390\/gels11020088"},{"key":"ref_110","doi-asserted-by":"crossref","first-page":"653","DOI":"10.13005\/bpj\/2647","article-title":"The discovery of drug delivery from development film forming hydrogel for wound dressing applications: A systematic review","volume":"16","author":"Annisa","year":"2023","journal-title":"Biomed. Pharmacol. J."},{"key":"ref_111","doi-asserted-by":"crossref","unstructured":"Oliveira, R.N., Meleiro, L.A.d.C., Quilty, B., and McGuinness, G.B. (2024). Release of natural extracts from PVA and PVA-CMC hydrogel wound dressings: A power law swelling\/delivery. Front. Bioeng. Biotechnol., 12.","DOI":"10.3389\/fbioe.2024.1406336"},{"key":"ref_112","doi-asserted-by":"crossref","first-page":"631","DOI":"10.1007\/s11095-008-9801-2","article-title":"PEG Hydrogels for the Controlled Release of Biomolecules in Regenerative Medicine","volume":"26","author":"Lin","year":"2009","journal-title":"Pharm. Res."},{"key":"ref_113","doi-asserted-by":"crossref","first-page":"S1201","DOI":"10.4103\/jpbs.jpbs_540_23","article-title":"Polyethylene Glycol Cross-Linked Hydrogel for Drug Absorption Properties","volume":"16","author":"Durairaj","year":"2024","journal-title":"J. Pharm. Bioallied Sci."},{"key":"ref_114","doi-asserted-by":"crossref","first-page":"e2300105","DOI":"10.1002\/adhm.202300105","article-title":"Poly Ethylene Glycol (PEG)-Based Hydrogels for Drug Delivery in Cancer Therapy: A Comprehensive Review","volume":"12","author":"Wang","year":"2023","journal-title":"Adv. Healthc. Mater."},{"key":"ref_115","doi-asserted-by":"crossref","unstructured":"Afrin, S., Shahruzzaman, M., Haque, P., Islam, M.S., Hossain, S., Rashid, T.U., Ahmed, T., Takafuji, M., and Rahman, M.M. (2022). Advanced CNC\/PEG\/PDMAA Semi-IPN Hydrogel for Drug Delivery Management in Wound Healing. Gels, 8.","DOI":"10.3390\/gels8060340"},{"key":"ref_116","doi-asserted-by":"crossref","unstructured":"Zare, M., Bigham, A., Zare, M., Luo, H., Rezvani Ghomi, E., and Ramakrishna, S. (2021). pHEMA: An Overview for Biomedical Applications. Int. J. Mol. Sci., 22.","DOI":"10.3390\/ijms22126376"},{"key":"ref_117","unstructured":"Madan, J., Baldi, A., Chaudhary, M., and Chopra, N. (2023). Chapter 6-Polymer\u2013drug linking through amide bonds: The chemistry and applications in drug delivery. Polymer-Drug Conjugates, Academic Press."},{"key":"ref_118","doi-asserted-by":"crossref","unstructured":"Arkaban, H., Barani, M., Akbarizadeh, M.R., Pal Singh Chauhan, N., Jadoun, S., Dehghani Soltani, M., and Zarrintaj, P. (2022). Polyacrylic Acid Nanoplatforms: Antimicrobial, Tissue Engineering, and Cancer Theranostic Applications. Polymers, 14.","DOI":"10.3390\/polym14061259"},{"key":"ref_119","doi-asserted-by":"crossref","first-page":"890","DOI":"10.3390\/polym6030890","article-title":"Preparation of Poly(acrylic acid) Hydrogel by Radiation Crosslinking and Its Application for Mucoadhesives","volume":"6","author":"Nho","year":"2014","journal-title":"Polymers"},{"key":"ref_120","doi-asserted-by":"crossref","unstructured":"Ito, T., Yamaguchi, S., Soga, D., Yoshimoto, T., and Koyama, Y. (2022). Preparation of a Bioadhesive Poly(Acrylic Acid)\/Polyvinylpyrrolidone Complex Gel and Its Clinical Effect on Dental Hemostasis. Gels, 8.","DOI":"10.3390\/gels8080462"},{"key":"ref_121","doi-asserted-by":"crossref","first-page":"185","DOI":"10.1016\/j.snb.2014.05.006","article-title":"Poly(vinyl alcohol) hydrogel based fiber interferometer sensor for heavy metal cations","volume":"202","author":"Tou","year":"2014","journal-title":"Sens. Actuators B Chem."},{"key":"ref_122","doi-asserted-by":"crossref","first-page":"6617","DOI":"10.1039\/D4TB00425F","article-title":"Multifunctional protocatechuic acid\u2013polyacrylic acid hydrogel adhesives for wound dressings","volume":"12","author":"Dong","year":"2024","journal-title":"J. Mater. Chem. B"},{"key":"ref_123","doi-asserted-by":"crossref","unstructured":"Oouchi, A., Ito, T., Katahira, Y., Hasegawa, H., Nakamura, K., Mizoguchi, I., Yoshimoto, T., and Koyama, Y. (2025). Wound Healing Enhancement and Physical Characterization of Bioadhesive Poly(acrylic acid)\/Polyvinylpyrrolidone Complex Gels. Gels, 11.","DOI":"10.3390\/gels11040300"},{"key":"ref_124","unstructured":"Oliveira, J.M., Silva-Correia, J., and Reis, R.L. (2024). Chapter 21-Hydrogels as filler materials. Hydrogels for Tissue Engineering and Regenerative Medicine, Academic Press."},{"key":"ref_125","doi-asserted-by":"crossref","first-page":"18599","DOI":"10.1007\/s10853-024-10267-6","article-title":"Platelet-rich plasma polyacrylamide (PAM-PRP)-based hydrogel for wound healing via low-intensity ultrasound","volume":"59","author":"Li","year":"2024","journal-title":"J. Mater. Sci."},{"key":"ref_126","doi-asserted-by":"crossref","unstructured":"Kim, Y., Kim, J., Yu, D., Kim, T., Park, J., Lee, J., Yu, S., Seo, D., Kim, B., and Yuk, S.A. (2025). Engineering a Polyacrylamide\/Polydopamine Adhesive Hydrogel Patch for Sustained Transdermal Vitamin E Delivery. Cosmetics, 12.","DOI":"10.3390\/cosmetics12040138"},{"key":"ref_127","doi-asserted-by":"crossref","first-page":"4934","DOI":"10.1039\/D3TB00099K","article-title":"Flexible and temperature-responsive hydrogel dressing for real-time and remote wound healing monitoring","volume":"11","author":"Jiang","year":"2023","journal-title":"J. Mater. Chem. B"},{"key":"ref_128","doi-asserted-by":"crossref","unstructured":"Narayana, S., Gowda, B.J., Hani, U., Ahmed, M.G., Asiri, Z.A., and Paul, K. (2025). Smart poly (N-isopropylacrylamide)-based hydrogels: A tour D\u2019horizon of biomedical applications. Gels, 11.","DOI":"10.3390\/gels11030207"},{"key":"ref_129","doi-asserted-by":"crossref","first-page":"1377","DOI":"10.3390\/polym3031377","article-title":"Poly Lactic-co-Glycolic Acid (PLGA) as Biodegradable Controlled Drug Delivery Carrier","volume":"3","author":"Makadia","year":"2011","journal-title":"Polymers"},{"key":"ref_130","doi-asserted-by":"crossref","unstructured":"Visan, A.I., and Negut, I. (2024). Development and Applications of PLGA Hydrogels for Sustained Delivery of Therapeutic Agents. Gels, 10.","DOI":"10.3390\/gels10080497"},{"key":"ref_131","doi-asserted-by":"crossref","first-page":"2940","DOI":"10.2174\/0113816128275385231027054743","article-title":"Poly(lactic-co-glycolic) Acid (PLGA) Nanoparticles and Transdermal Drug Delivery: An Overview","volume":"29","author":"Kumar","year":"2023","journal-title":"Curr. Pharm. Des."},{"key":"ref_132","doi-asserted-by":"crossref","unstructured":"Zhang, J., and Wang, Z. (2022). Nanoparticle\u2013Hydrogel Based Sensors: Synthesis and Applications. Catalysts, 12.","DOI":"10.3390\/catal12101096"},{"key":"ref_133","doi-asserted-by":"crossref","first-page":"3871","DOI":"10.1021\/acs.chemmater.5c00498","article-title":"Mechanically Reinforced Nanocomposite Hydrogels and Advanced Applications in Biosensing and Bioelectronics","volume":"37","author":"Lu","year":"2025","journal-title":"Chem. Mater."},{"key":"ref_134","doi-asserted-by":"crossref","unstructured":"Calistri, S., Ciantelli, C., Cataldo, S., Cuzzola, V., Guzzinati, R., Busi, S., and Ubaldini, A. (2025). Simple Spin-Coating Preparation of Hydrogel and Nanoparticle-Loaded Hydrogel Thin Films. Coatings, 15.","DOI":"10.3390\/coatings15070859"},{"key":"ref_135","doi-asserted-by":"crossref","first-page":"760","DOI":"10.1016\/j.carbpol.2013.03.041","article-title":"Hydrogel, aerogel and film of cellulose nanofibrils functionalized with silver nanoparticles","volume":"95","author":"Dong","year":"2013","journal-title":"Carbohydr. Polym."},{"key":"ref_136","doi-asserted-by":"crossref","unstructured":"Sheikh-Oleslami, S., Tao, B., D\u2019Souza, J., Butt, F., Suntharalingam, H., Rempel, L., and Amiri, N. (2023). A Review of Metal Nanoparticles Embedded in Hydrogel Scaffolds for Wound Healing In Vivo. Gels, 9.","DOI":"10.3390\/gels9070591"},{"key":"ref_137","doi-asserted-by":"crossref","unstructured":"Yu, Y.-C., Hu, M.-H., Zhuang, H.-Z., Phan, T.H.M., Jiang, Y.-S., and Jan, J.-S. (2023). Antibacterial Gelatin Composite Hydrogels Comprised of In Situ Formed Zinc Oxide Nanoparticles. Polymers, 15.","DOI":"10.3390\/polym15193978"},{"key":"ref_138","doi-asserted-by":"crossref","first-page":"924","DOI":"10.1007\/s13346-022-01279-3","article-title":"Nanoclays for wound management applications","volume":"13","author":"Peixoto","year":"2023","journal-title":"Drug Deliv. Transl. Res."},{"key":"ref_139","doi-asserted-by":"crossref","first-page":"9833","DOI":"10.1021\/nn503719n","article-title":"Shear-thinning nanocomposite hydrogels for the treatment of hemorrhage","volume":"8","author":"Gaharwar","year":"2014","journal-title":"ACS Nano"},{"key":"ref_140","doi-asserted-by":"crossref","first-page":"101782","DOI":"10.1016\/j.jics.2025.101782","article-title":"A comprehensive exploration of graphene and graphene oxide based hydrogels-Methods, characteristics, and applications","volume":"102","author":"Sharma","year":"2025","journal-title":"J. Indian Chem. Soc."},{"key":"ref_141","doi-asserted-by":"crossref","first-page":"387","DOI":"10.1007\/s00604-021-04945-4","article-title":"TiO2\/MXene-PVA\/GO hydrogel-based electrochemical sensor for neurological disorder screening via urinary norepinephrine detection","volume":"188","author":"Boobphahom","year":"2021","journal-title":"Microchim. Acta"},{"key":"ref_142","doi-asserted-by":"crossref","first-page":"107380","DOI":"10.1016\/j.jddst.2025.107380","article-title":"Liposomes-in-hydrogel for topical drug delivery: Mechanical, kinetic, and biological insights","volume":"113","author":"Braido","year":"2025","journal-title":"J. Drug Deliv. Sci. Technol."},{"key":"ref_143","doi-asserted-by":"crossref","unstructured":"Binaymotlagh, R., Hajareh Haghighi, F., Chronopoulou, L., and Palocci, C. (2024). Liposome\u2013Hydrogel Composites for Controlled Drug Delivery Applications. Gels, 10.","DOI":"10.3390\/gels10040284"},{"key":"ref_144","doi-asserted-by":"crossref","unstructured":"Ternullo, S., Schulte Werning, L.V., Hols\u00e6ter, A.M., and \u0160kalko-Basnet, N. (2020). Curcumin-In-Deformable Liposomes-In-Chitosan-Hydrogel as a Novel Wound Dressing. Pharmaceutics, 12.","DOI":"10.3390\/pharmaceutics12010008"},{"key":"ref_145","doi-asserted-by":"crossref","first-page":"216330","DOI":"10.1016\/j.ccr.2024.216330","article-title":"Metal-organic framework-hydrogel composites as emerging platforms for enhanced wound healing applications: Material design, therapeutic strategies, and future prospects","volume":"524","author":"Afruzi","year":"2025","journal-title":"Coord. Chem. Rev."},{"key":"ref_146","doi-asserted-by":"crossref","first-page":"37","DOI":"10.20517\/ss.2024.32","article-title":"Recent advances in multifaceted applications of MOF-based hydrogels","volume":"4","author":"He","year":"2024","journal-title":"Soft Sci."},{"key":"ref_147","doi-asserted-by":"crossref","unstructured":"Behjat, E., Koohikar, A., Rahmati, S., Fathollah Maghsoudi, M.A., Gholami, R., Kadkhodaie Kashani, G., Tajabadi, M., Naghib, S.M., and Rezaie, H.R. (2025). Antibacterial, self-healing, and pH-responsive PVA\/ZIF-8@ tannic acid nanocomposite hydrogel for sustained delivery of garlic extract. Sci. Rep., 15.","DOI":"10.1038\/s41598-025-07752-6"},{"key":"ref_148","doi-asserted-by":"crossref","first-page":"2399","DOI":"10.1007\/s10570-021-04348-x","article-title":"Development of chitosan, graphene oxide, and cerium oxide composite blended films: Structural, physical, and functional properties","volume":"29","author":"Panda","year":"2022","journal-title":"Cellulose"},{"key":"ref_149","doi-asserted-by":"crossref","unstructured":"Wathoni, N., Yuniarsih, N., Cahyanto, A., and Muhctaridi, M. (2019). \u03b1-Mangostin Hydrogel Film Based Chitosan\u2013Alginate for Recurrent Aphthous Stomatitis. Appl. Sci., 9.","DOI":"10.3390\/app9235235"},{"key":"ref_150","doi-asserted-by":"crossref","unstructured":"Stubbe, B., Mignon, A., Declercq, H., Van Vlierberghe, S., and Dubruel, P. (2019). Development of gelatin-alginate hydrogels for burn wound treatment. Macromol. Biosci., 19.","DOI":"10.1002\/mabi.201900123"},{"key":"ref_151","doi-asserted-by":"crossref","first-page":"54","DOI":"10.1016\/j.jpowsour.2016.10.110","article-title":"Enhanced Electrochemical Performance of Carbon Quantum Dots-Polyaniline Hybrid","volume":"337","author":"Zhao","year":"2017","journal-title":"J. Power Sources"},{"key":"ref_152","doi-asserted-by":"crossref","unstructured":"Bercea, M. (2024). Recent Advances in Poly(vinyl alcohol)-Based Hydrogels. Polymers, 16.","DOI":"10.3390\/polym16142021"},{"key":"ref_153","doi-asserted-by":"crossref","unstructured":"Ghauri, Z.H., Islam, A., Qadir, M.A., Gull, N., Haider, B., Khan, R.U., and Riaz, T. (2021). Development and evaluation of pH-sensitive biodegradable ternary blended hydrogel films (chitosan\/guar gum\/PVP) for drug delivery application. Sci. Rep., 11.","DOI":"10.1038\/s41598-021-00452-x"},{"key":"ref_154","doi-asserted-by":"crossref","unstructured":"Wong, R.S.H., and Dodou, K. (2017). Effect of drug loading method and drug physicochemical properties on the material and drug release properties of poly (ethylene oxide) hydrogels for transdermal delivery. Polymers, 9.","DOI":"10.3390\/polym9070286"},{"key":"ref_155","doi-asserted-by":"crossref","unstructured":"Jantrawut, P., Bunrueangtha, J., Suerthong, J., and Kantrong, N. (2019). Fabrication and characterization of low methoxyl pectin\/gelatin\/carboxymethyl cellulose absorbent hydrogel film for wound dressing applications. Materials, 12.","DOI":"10.3390\/ma12101628"},{"key":"ref_156","doi-asserted-by":"crossref","unstructured":"Bhatia, S., Shah, Y.A., Al-Harrasi, A., Jawad, M., Khan, T.S., Koca, E., and Aydemir, L.Y. (2024). Tuning the structure and physiochemical properties of sodium alginate and chitosan composite films through sodium tripolyphosphate (STPP) crosslinking. Int. J. Biol. Macromol., 264.","DOI":"10.1016\/j.ijbiomac.2024.130463"},{"key":"ref_157","doi-asserted-by":"crossref","first-page":"547","DOI":"10.1007\/s13770-018-0155-5","article-title":"In situ cross-linkable hydrogels as a dynamic matrix for tissue regenerative medicine","volume":"15","author":"Park","year":"2018","journal-title":"Tissue Eng. Regen. Med."},{"key":"ref_158","doi-asserted-by":"crossref","unstructured":"Ahmed, M.S., Islam, M., Hasan, M.K., and Nam, K.-W. (2024). A Comprehensive review of radiation-induced hydrogels: Synthesis, properties, and multidimensional applications. Gels, 10.","DOI":"10.3390\/gels10060381"},{"key":"ref_159","doi-asserted-by":"crossref","first-page":"251","DOI":"10.1016\/j.polymer.2017.03.068","article-title":"Post-synthesis modification of hydrogels. Total and partial rupture of crosslinks: Formation of aldehyde groups and re-crosslinking of cleaved hydrogels","volume":"116","author":"Wolfel","year":"2017","journal-title":"Polymer"},{"key":"ref_160","doi-asserted-by":"crossref","first-page":"111277","DOI":"10.1016\/j.eurpolymj.2022.111277","article-title":"Adhesion mechanism and application progress of hydrogels","volume":"173","author":"Xiao","year":"2022","journal-title":"Eur. Polym. J."},{"key":"ref_161","doi-asserted-by":"crossref","first-page":"332","DOI":"10.1002\/marc.201100742","article-title":"Microwave-assisted hydrogel synthesis: A new method for crosslinking polymers in aqueous solutions","volume":"33","author":"Cook","year":"2012","journal-title":"Macromol. Rapid Commun."},{"key":"ref_162","doi-asserted-by":"crossref","first-page":"586","DOI":"10.1002\/mame.201500016","article-title":"Microwave-assisted preparation of hydrogel-forming microneedle arrays for transdermal drug delivery applications","volume":"300","author":"Larraneta","year":"2015","journal-title":"Macromol. Mater. Eng."},{"key":"ref_163","doi-asserted-by":"crossref","first-page":"25973","DOI":"10.1021\/acsomega.0c03414","article-title":"A facile synthesis of self-catalytic hydrogel films and their application as a wound dressing material coupled with natural active compounds","volume":"5","author":"Thongsuksaengcharoen","year":"2020","journal-title":"Acs Omega"},{"key":"ref_164","doi-asserted-by":"crossref","first-page":"718","DOI":"10.5530\/ijper.57.3.87","article-title":"Hydrogel films of citric acid cross-linked hydroxypropyl methylcellulose\/methylcellulose for hydrophilic drug delivery","volume":"57","author":"Pargaonkar","year":"2023","journal-title":"Indian J. Pharm. Educ. Res"},{"key":"ref_165","doi-asserted-by":"crossref","first-page":"424","DOI":"10.1016\/S0022-3093(05)80653-2","article-title":"Review of sol-gel thin film formation","volume":"147","author":"Brinker","year":"1992","journal-title":"J. Non-Cryst. Solids"},{"key":"ref_166","doi-asserted-by":"crossref","first-page":"1026","DOI":"10.1002\/pol.20220451","article-title":"Recent progress in fabrications and applications of functional hydrogel films","volume":"61","author":"Dong","year":"2023","journal-title":"J. Polym. Sci."},{"key":"ref_167","doi-asserted-by":"crossref","first-page":"2408780","DOI":"10.1002\/smll.202408780","article-title":"Tough and Functional Hydrogel Coating by Electrostatic Spraying","volume":"21","author":"Wang","year":"2025","journal-title":"Small"},{"key":"ref_168","doi-asserted-by":"crossref","first-page":"2413464","DOI":"10.1002\/adfm.202413464","article-title":"Lignin-Based Ultrathin Hydrogel Coatings with Strong Substrate Adhesion Enabled by Hydrophobic Association","volume":"35","author":"Liu","year":"2025","journal-title":"Adv. Funct. Mater."},{"key":"ref_169","doi-asserted-by":"crossref","first-page":"2001267","DOI":"10.1002\/admt.202001267","article-title":"Towards Large-Scale Fabrication of Self-Healable Functional Hydrogel Coatings for Anti-Fog\/Frost Surfaces and Flexible Sensors","volume":"6","author":"Yan","year":"2021","journal-title":"Adv. Mater. Technol."},{"key":"ref_170","doi-asserted-by":"crossref","unstructured":"Pemble, O.J., Bardosova, M., Povey, I.M., and Pemble, M.E. (2021). A Slot-Die Technique for the Preparation of Continuous, High-Area, Chitosan-Based Thin Films. Polymers, 13.","DOI":"10.3390\/polym13101566"},{"key":"ref_171","doi-asserted-by":"crossref","first-page":"94","DOI":"10.1002\/asia.201801333","article-title":"Photolithographically Patterned Hydrogels with Programmed Deformations","volume":"14","author":"Li","year":"2019","journal-title":"Chem. Asian J."},{"key":"ref_172","doi-asserted-by":"crossref","unstructured":"Zhang, Y., and Wang, C. (2022). Recent advances in 3D printing hydrogel for topical drug delivery. MedComm\u2013Biomater. Appl., 1.","DOI":"10.1002\/mba2.11"},{"key":"ref_173","doi-asserted-by":"crossref","first-page":"060605","DOI":"10.1063\/5.0278581","article-title":"High-precision 3D printing of hydrogel: Material innovations, process breakthroughs, and translational applications in regenerative medicine","volume":"13","author":"Huang","year":"2025","journal-title":"APL Mater."},{"key":"ref_174","doi-asserted-by":"crossref","first-page":"6307","DOI":"10.1007\/s10570-025-06628-2","article-title":"Advancements in hydrogel materials for next-generation energy devices: Properties, applications, and future prospects","volume":"32","author":"Priya","year":"2025","journal-title":"Cellulose"},{"key":"ref_175","doi-asserted-by":"crossref","first-page":"4566","DOI":"10.1039\/D5MA00019J","article-title":"From rheological concepts to additive manufacturing assessment of hydrogel-based materials for advanced bioprinting applications","volume":"6","author":"Calafel","year":"2025","journal-title":"Mater. Adv."},{"key":"ref_176","doi-asserted-by":"crossref","unstructured":"Priya, A.S., Premanand, R., Ragupathi, I., Rao Bhaviripudi, V., Aepuru, R., Kannan, K., and Shanmugaraj, K. (2024). Comprehensive Review of Hydrogel Synthesis, Characterization, and Emerging Applications. J. Compos. Sci., 8.","DOI":"10.3390\/jcs8110457"},{"key":"ref_177","doi-asserted-by":"crossref","first-page":"554","DOI":"10.1016\/j.jsps.2015.03.022","article-title":"Methods of synthesis of hydrogels\u2014A review","volume":"24","author":"Akhtar","year":"2016","journal-title":"Saudi Pharm. J."},{"key":"ref_178","doi-asserted-by":"crossref","first-page":"105","DOI":"10.1016\/j.jare.2013.07.006","article-title":"Hydrogel: Preparation, characterization, and applications: A review","volume":"6","author":"Ahmed","year":"2015","journal-title":"J. Adv. Res."},{"key":"ref_179","first-page":"614","article-title":"How the shape and chemistry of molecular penetrants control responsive hydrogel permeability","volume":"15","author":"Kim","year":"2020","journal-title":"ACS Nano"},{"key":"ref_180","doi-asserted-by":"crossref","unstructured":"Lavrentev, F.V., Shilovskikh, V.V., Alabusheva, V.S., Yurova, V.Y., Nikitina, A.A., Ulasevich, S.A., and Skorb, E.V. (2023). Diffusion-Limited Processes in Hydrogels with Chosen Applications from Drug Delivery to Electronic Components. Molecules, 28.","DOI":"10.3390\/molecules28155931"},{"key":"ref_181","doi-asserted-by":"crossref","first-page":"5992","DOI":"10.1021\/acsabm.4c00569","article-title":"Exosome Loaded Protein Hydrogel for Enhanced Gelation Kinetics and Wound Healing","volume":"7","author":"Britton","year":"2024","journal-title":"ACS Appl. Bio Mater."},{"key":"ref_182","doi-asserted-by":"crossref","first-page":"114092","DOI":"10.1016\/j.microc.2025.114092","article-title":"Spatial heterogeneity in Hydrogels: Nanoparticle Diffusivity as a probe for network dynamics","volume":"214","author":"Hao","year":"2025","journal-title":"Microchem. J."},{"key":"ref_183","doi-asserted-by":"crossref","first-page":"28","DOI":"10.1016\/j.tca.2015.05.018","article-title":"Thermal behavior of hydrophobically modified hydrogels using TGA\/FTIR\/MS analysis technique","volume":"613","author":"Rusu","year":"2015","journal-title":"Thermochim. Acta"},{"key":"ref_184","doi-asserted-by":"crossref","first-page":"83","DOI":"10.1007\/s00216-022-04363-2","article-title":"Critical review of polymer and hydrogel deposition methods for optical and electrochemical bioanalytical sensors correlated to the sensor\u2019s applicability in real samples","volume":"415","author":"Bauer","year":"2023","journal-title":"Anal. Bioanal. Chem."},{"key":"ref_185","doi-asserted-by":"crossref","first-page":"2583","DOI":"10.1039\/b924290b","article-title":"Why are double network hydrogels so tough?","volume":"6","author":"Gong","year":"2010","journal-title":"Soft Matter"},{"key":"ref_186","doi-asserted-by":"crossref","first-page":"1672","DOI":"10.1557\/s43580-024-01004-x","article-title":"Facile fabrication route of stretchable thin-film hydrogels with high strength","volume":"9","author":"Nguyen","year":"2024","journal-title":"MRS Adv."},{"key":"ref_187","doi-asserted-by":"crossref","first-page":"2654","DOI":"10.1002\/bit.26801","article-title":"Hierarchically aligned fibrous hydrogel films through microfluidic self-assembly of graphene and polysaccharides","volume":"115","author":"Patel","year":"2018","journal-title":"Biotechnol. Bioeng."},{"key":"ref_188","doi-asserted-by":"crossref","first-page":"15077","DOI":"10.1007\/s10853-024-10103-x","article-title":"A review of recent advances in drug loading, mathematical modeling and applications of hydrogel drug delivery systems","volume":"59","author":"Hu","year":"2024","journal-title":"J. Mater. Sci."},{"key":"ref_189","doi-asserted-by":"crossref","first-page":"3017","DOI":"10.3109\/10717544.2016.1138342","article-title":"A review on therapeutic contact lenses for ocular drug delivery","volume":"23","author":"Maulvi","year":"2016","journal-title":"Drug Deliv."},{"key":"ref_190","doi-asserted-by":"crossref","first-page":"415102","DOI":"10.1088\/1361-6528\/ab2e29","article-title":"Development of film-forming gel containing nanoparticles for transdermal drug delivery","volume":"30","author":"Ngo","year":"2019","journal-title":"Nanotechnology"},{"key":"ref_191","doi-asserted-by":"crossref","unstructured":"Sun, W., Wu, W., Dong, X., and Yu, G. (2024). Frontier and hot topics in the application of hydrogel in the biomedical field: A bibliometric analysis based on CiteSpace. J. Biol. Eng., 18.","DOI":"10.1186\/s13036-024-00435-2"},{"key":"ref_192","doi-asserted-by":"crossref","first-page":"2402890","DOI":"10.1002\/adhm.202402890","article-title":"Foreign body immune response to zwitterionic and hyaluronic acid granular hydrogels made with mechanical fragmentation","volume":"14","author":"Asadikorayem","year":"2025","journal-title":"Adv. Healthc. Mater."},{"key":"ref_193","doi-asserted-by":"crossref","unstructured":"Costa, A.L.R., Willerth, S.M., de la Torre, L.G., and Han, S.W. (2022). Trends in hydrogel-based encapsulation technologies for advanced cell therapies applied to limb ischemia. Mater. Today Bio, 13.","DOI":"10.1016\/j.mtbio.2022.100221"},{"key":"ref_194","doi-asserted-by":"crossref","unstructured":"Wei, L., and Huang, J. (2025). Recent Progress in Hydrogel Synthesis and Biomedical Applications. Gels, 11.","DOI":"10.3390\/gels11060456"},{"key":"ref_195","doi-asserted-by":"crossref","unstructured":"Vegad, U., Patel, M., Khunt, D., Zupan\u010di\u010d, O., Chauhan, S., and Paudel, A. (2023). pH stimuli-responsive hydrogels from non-cellulosic biopolymers for drug delivery. Front. Bioeng. Biotechnol., 11.","DOI":"10.3389\/fbioe.2023.1270364"},{"key":"ref_196","doi-asserted-by":"crossref","first-page":"38","DOI":"10.5339\/gcsp.2013.38","article-title":"Hydrogel scaffolds for tissue engineering: Progress and challenges","volume":"2013","author":"Yacoub","year":"2013","journal-title":"Glob. Cardiol. Sci. Pract."},{"key":"ref_197","doi-asserted-by":"crossref","first-page":"34","DOI":"10.1007\/s40820-023-01225-z","article-title":"Gelatin-based metamaterial hydrogel films with high conformality for ultra-soft tissue monitoring","volume":"16","author":"Chen","year":"2024","journal-title":"Nano-Micro Lett."},{"key":"ref_198","doi-asserted-by":"crossref","first-page":"4048","DOI":"10.1021\/acsbiomaterials.0c01677","article-title":"Engineering hydrogel adhesion for biomedical applications via chemical design of the junction","volume":"7","author":"Bovone","year":"2021","journal-title":"ACS Biomater. Sci. Eng."},{"key":"ref_199","doi-asserted-by":"crossref","first-page":"426","DOI":"10.1126\/science.1147241","article-title":"Mussel-inspired surface chemistry for multifunctional coatings","volume":"318","author":"Lee","year":"2007","journal-title":"Science"},{"key":"ref_200","doi-asserted-by":"crossref","unstructured":"Kang, M., Sun, K., Seong, M., Hwang, I., Jang, H., Park, S., Choi, G., Lee, S.-H., Kim, J., and Jeong, H.E. (2021). Applications of bioinspired reversible dry and wet adhesives: A review. Front. Mech. Eng., 7.","DOI":"10.3389\/fmech.2021.668262"},{"key":"ref_201","doi-asserted-by":"crossref","first-page":"169","DOI":"10.1038\/s41586-019-1710-5","article-title":"Dry double-sided tape for adhesion of wet tissues and devices","volume":"575","author":"Yuk","year":"2019","journal-title":"Nature"},{"key":"ref_202","doi-asserted-by":"crossref","unstructured":"Ren, P., Yang, L., Wei, D., Liang, M., Xu, L., Zhang, T., Hu, W., Zhang, Z., and Zhang, Q. (2023). Alginate\/polyacrylamide host-guest supramolecular hydrogels with enhanced adhesion. Int. J. Biol. Macromol., 242.","DOI":"10.1016\/j.ijbiomac.2023.124885"},{"key":"ref_203","doi-asserted-by":"crossref","first-page":"2507397","DOI":"10.1002\/adma.202507397","article-title":"Mechanoresponsive Hydrogels Emerging from Dynamic and Non-Covalent Interactions","volume":"37","author":"Ollier","year":"2025","journal-title":"Adv. Mater."},{"key":"ref_204","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.actbio.2021.01.034","article-title":"Realizing tissue integration with supramolecular hydrogels","volume":"124","author":"Feliciano","year":"2021","journal-title":"Acta Biomater."},{"key":"ref_205","doi-asserted-by":"crossref","first-page":"695","DOI":"10.1084\/jem.97.5.695","article-title":"Studies on the Propagation In Vitro of Poliomyelitis Viruses: IV. Viral Multiplication in a Stable Strain of Human Malignant Epithelial Cells (Strain Hela) Derived from an Epidermoid Carcinoma of the Cervix","volume":"97","author":"Scherer","year":"1953","journal-title":"J. Exp. Med."},{"key":"ref_206","first-page":"485","article-title":"Biomimetic hydrogel micro-\/nanofibers for in situ soft tissue repair and regeneration","volume":"55","author":"Yi","year":"2026","journal-title":"Bioact. Mater."},{"key":"ref_207","first-page":"198","article-title":"Advances in hydrogel-based vascularized tissues for tissue repair and drug screening","volume":"9","author":"Wang","year":"2022","journal-title":"Bioact. Mater."},{"key":"ref_208","doi-asserted-by":"crossref","first-page":"2401806","DOI":"10.1002\/adem.202401806","article-title":"Mechanical Metamaterials for Bioengineering: In\u2009Vitro, Wearable, and Implantable Applications","volume":"27","author":"Kazim","year":"2025","journal-title":"Adv. Eng. Mater."},{"key":"ref_209","doi-asserted-by":"crossref","unstructured":"Jia, B., Li, G., Cao, E., Luo, J., Zhao, X., and Huang, H. (2023). Recent progress of antibacterial hydrogels in wound dressings. Mater. Today Bio, 19.","DOI":"10.1016\/j.mtbio.2023.100582"},{"key":"ref_210","doi-asserted-by":"crossref","first-page":"516","DOI":"10.7150\/thno.117949","article-title":"Recent advances and challenges in hydrogel-based delivery of immunomodulatory strategies for diabetic wound healing","volume":"16","author":"Du","year":"2026","journal-title":"Theranostics"},{"key":"ref_211","doi-asserted-by":"crossref","first-page":"4358","DOI":"10.1039\/D5BM00781J","article-title":"Recent progress in multifunctional theranostic hydrogels: The cornerstone of next-generation wound care technologies","volume":"13","author":"Karthikeyan","year":"2025","journal-title":"Biomater. Sci."},{"key":"ref_212","doi-asserted-by":"crossref","unstructured":"Han, Y., Cao, J., Li, M., Ding, P., Yang, Y., Okoro, O.V., Sun, Y., Jiang, G., Shavandi, A., and Nie, L. (2024). Fabrication and characteristics of multifunctional hydrogel dressings using dopamine modified hyaluronic acid and phenylboronic acid modified chitosan. Front. Chem., 12.","DOI":"10.3389\/fchem.2024.1402870"},{"key":"ref_213","doi-asserted-by":"crossref","unstructured":"Delgado-Pujol, E.J., Mart\u00ednez, G., Casado-Jurado, D., V\u00e1zquez, J., Le\u00f3n-Barberena, J., Rodr\u00edguez-Lucena, D., Torres, Y., Alcudia, A., and Begines, B. (2025). Hydrogels and Nanogels: Pioneering the Future of Advanced Drug Delivery Systems. Pharmaceutics, 17.","DOI":"10.3390\/pharmaceutics17020215"},{"key":"ref_214","doi-asserted-by":"crossref","unstructured":"Naran\u0111a, J., Bra\u010di\u010d, M., Maver, U., and Trojner, T. (2025). Recent Advancements in Smart Hydrogel-Based Materials in Cartilage Tissue Engineering. Materials, 18.","DOI":"10.3390\/ma18112576"},{"key":"ref_215","doi-asserted-by":"crossref","unstructured":"S\u00e1nchez-Cid, P., Jim\u00e9nez-Rosado, M., Romero, A., and P\u00e9rez-Puyana, V. (2022). Novel Trends in Hydrogel Development for Biomedical Applications: A Review. Polymers, 14.","DOI":"10.3390\/polym14153023"},{"key":"ref_216","doi-asserted-by":"crossref","unstructured":"Ho, T.-C., Chang, C.-C., Chan, H.-P., Chung, T.-W., Shu, C.-W., Chuang, K.-P., Duh, T.-H., Yang, M.-H., and Tyan, Y.-C. (2022). Hydrogels: Properties and Applications in Biomedicine. Molecules, 27.","DOI":"10.3390\/molecules27092902"},{"key":"ref_217","doi-asserted-by":"crossref","unstructured":"Segneanu, A.E., Bejenaru, L.E., Bejenaru, C., Blendea, A., Mogosanu, G.D., Bita, A., and Boia, E.R. (2025). Advancements in Hydrogels: A Comprehensive Review of Natural and Synthetic Innovations for Biomedical Applications. Polymers, 17.","DOI":"10.3390\/polym17152026"},{"key":"ref_218","first-page":"122","article-title":"Current Status and Prospect of Biomaterials Development","volume":"21","author":"Tang","year":"2000","journal-title":"J. Jinan Univ. (Nat. Sci. Ed.)"},{"key":"ref_219","doi-asserted-by":"crossref","first-page":"803","DOI":"10.1002\/masy.19950980168","article-title":"Multifunctional bioerodible\/biodegradable polymeric materials","volume":"98","author":"Chiellini","year":"1995","journal-title":"Macromol. Symp."},{"key":"ref_220","doi-asserted-by":"crossref","unstructured":"Protsak, I.S., and Morozov, Y.M. (2025). Fundamentals and Advances in Stimuli-Responsive Hydrogels and Their Applications: A Review. Gels, 11.","DOI":"10.3390\/gels11010030"},{"key":"ref_221","doi-asserted-by":"crossref","unstructured":"Garcia-Garcia, A., Mu\u00f1ana-Gonz\u00e1lez, S., Lanceros-Mendez, S., Ruiz-Rubio, L., Alvarez, L.P., and Vilas-Vilela, J.L. (2024). Biodegradable Natural Hydrogels for Tissue Engineering, Controlled Release, and Soil Remediation. Polymers, 16.","DOI":"10.3390\/polym16182599"},{"key":"ref_222","doi-asserted-by":"crossref","unstructured":"Sobczak, M. (2022). Enzyme-Responsive Hydrogels as Potential Drug Delivery Systems\u2014State of Knowledge and Future Prospects. Int. J. Mol. Sci., 23.","DOI":"10.3390\/ijms23084421"},{"key":"ref_223","doi-asserted-by":"crossref","unstructured":"Ding, K., Liao, M., Wang, Y., and Lu, J.R. (2025). Advances in Composite Stimuli-Responsive Hydrogels for Wound Healing: Mechanisms and Applications. Gels, 11.","DOI":"10.3390\/gels11060420"},{"key":"ref_224","doi-asserted-by":"crossref","unstructured":"Zhang, X., Zu, Q., Deng, C., Gao, X., Liu, H., Jin, Y., Yang, X., and Wang, E. (2025). Biodegradable Double-Layer Hydrogels with Sequential Drug Release for Multi-Phase Collaborative Regulation in Scar-Free Wound Healing. J. Funct. Biomater., 16.","DOI":"10.3390\/jfb16050164"},{"key":"ref_225","doi-asserted-by":"crossref","unstructured":"Hu, B., Gao, J., Lu, Y., and Wang, Y. (2023). Applications of Degradable Hydrogels in Novel Approaches to Disease Treatment and New Modes of Drug Delivery. Pharmaceutics, 15.","DOI":"10.3390\/pharmaceutics15102370"},{"key":"ref_226","doi-asserted-by":"crossref","unstructured":"Santhamoorthy, M., and Kim, S.-C. (2025). A Review of the Development of Biopolymer Hydrogel-Based Scaffold Materials for Drug Delivery and Tissue Engineering Applications. Gels, 11.","DOI":"10.3390\/gels11030178"},{"key":"ref_227","first-page":"219","article-title":"Enhanced Drug Delivery and Wound Healing with Novel Hydrogel Nanocomposite","volume":"59","author":"Aljeboree","year":"2023","journal-title":"Eng. Proc."},{"key":"ref_228","doi-asserted-by":"crossref","first-page":"2090813","DOI":"10.1155\/2018\/2090813","article-title":"Interplay of Oxidative Stress, Inflammation, and Autophagy: Their Role in Tissue Injury of the Heart, Liver, and Kidney","volume":"2018","author":"Mukhopadhyay","year":"2018","journal-title":"Oxidative Med. Cell. Longev."},{"key":"ref_229","doi-asserted-by":"crossref","first-page":"1093","DOI":"10.1021\/acs.biomac.5b01711","article-title":"Properties of Poly(ethylene glycol) Hydrogels Cross-Linked via Strain-Promoted Alkyne\u2013Azide Cycloaddition (SPAAC)","volume":"17","author":"Hodgson","year":"2016","journal-title":"Biomacromolecules"},{"key":"ref_230","doi-asserted-by":"crossref","first-page":"502","DOI":"10.1016\/j.xphs.2016.10.006","article-title":"Assessment of the Blood-Brain Barrier Permeability of Potential Neuroprotective Aurones in Parallel Artificial Membrane Permeability Assay and Porcine Brain Endothelial Cell Models","volume":"106","author":"Liew","year":"2017","journal-title":"J. Pharm. Sci."},{"key":"ref_231","doi-asserted-by":"crossref","unstructured":"Stidl, R., Denne, M., Goldstine, J., Kadish, B., Korakas, K.I., and Turecek, P.L. (2018). Polyethylene Glycol Exposure with Antihemophilic Factor (Recombinant), PEGylated (rurioctocog alfa pegol) and Other Therapies Indicated for the Pediatric Population: History and Safety. Pharmaceuticals, 11.","DOI":"10.20944\/preprints201806.0415.v1"},{"key":"ref_232","doi-asserted-by":"crossref","unstructured":"Fu, S., Zhu, X., Huang, F., and Chen, X. (2025). Anti-PEG Antibodies and Their Biological Impact on PEGylated Drugs: Challenges and Strategies for Optimization. Pharmaceutics, 17.","DOI":"10.3390\/pharmaceutics17081074"},{"key":"ref_233","doi-asserted-by":"crossref","first-page":"5156","DOI":"10.3390\/md13085156","article-title":"Chitosan: An update on potential biomedical and pharmaceutical applications","volume":"13","author":"Cheung","year":"2015","journal-title":"Mar. Drugs"},{"key":"ref_234","doi-asserted-by":"crossref","unstructured":"Muktar, M.Z., Bakar, M.A.A., Amin, K.A.M., Che Rose, L., Wan Ismail, W.I., Razali, M.H., Abd Razak, S.I., and in het Panhuis, M. (2021). Gellan gum hydrogels filled edible oil microemulsion for biomedical materials: Phase diagram, mechanical behavior, and in vivo studies. Polymers, 13.","DOI":"10.3390\/polym13193281"},{"key":"ref_235","doi-asserted-by":"crossref","unstructured":"Jeong, H.I., An, D.H., Lim, J.W., Oh, T., Lee, H., Park, S.-M., Jeong, J.H., and Chung, J.W. (2021). Hydrogel surface-modified polyurethane copolymer film with water permeation resistance and biocompatibility for implantable biomedical devices. Micromachines, 12.","DOI":"10.3390\/mi12040447"},{"key":"ref_236","doi-asserted-by":"crossref","unstructured":"Tottoli, E.M., Dorati, R., Genta, I., Chiesa, E., Pisani, S., and Conti, B. (2020). Skin wound healing process and new emerging technologies for skin wound care and regeneration. Pharmaceutics, 12.","DOI":"10.3390\/pharmaceutics12080735"},{"key":"ref_237","doi-asserted-by":"crossref","first-page":"6566","DOI":"10.1038\/ncomms7566","article-title":"Soft network composite materials with deterministic and bio-inspired designs","volume":"6","author":"Jang","year":"2015","journal-title":"Nat. Commun."},{"key":"ref_238","doi-asserted-by":"crossref","unstructured":"Alberts, A., Moldoveanu, E.-T., Niculescu, A.-G., and Grumezescu, A.M. (2025). Hydrogels for Wound Dressings: Applications in Burn Treatment and Chronic Wound Care. J. Compos. Sci., 9.","DOI":"10.3390\/jcs9030133"},{"key":"ref_239","doi-asserted-by":"crossref","unstructured":"Ribeiro, M., Sim\u00f5es, M., Vitorino, C., and Mascarenhas-Melo, F. (2024). Hydrogels in Cutaneous Wound Healing: Insights into Characterization, Properties, Formulation and Therapeutic Potential. Gels, 10.","DOI":"10.3390\/gels10030188"},{"key":"ref_240","doi-asserted-by":"crossref","unstructured":"He, X., Wei, Y., and Xu, K. (2025). Hydrogel-Based Treatment of Diabetic Wounds: From Smart Responsive to Smart Monitoring. Gels, 11.","DOI":"10.3390\/gels11080647"},{"key":"ref_241","doi-asserted-by":"crossref","first-page":"107","DOI":"10.1002\/jemt.10249","article-title":"Angiogenesis in wound repair: Angiogenic growth factors and the extracellular matrix","volume":"60","author":"Li","year":"2003","journal-title":"Microsc. Res. Tech."},{"key":"ref_242","doi-asserted-by":"crossref","first-page":"e1094","DOI":"10.1002\/ctm2.1094","article-title":"Anti-inflammatory hydrogel dressings and skin wound healing","volume":"12","author":"Huang","year":"2022","journal-title":"Clin. Transl. Med."},{"key":"ref_243","doi-asserted-by":"crossref","first-page":"781","DOI":"10.1007\/s40005-023-00636-9","article-title":"Recent advancements of nitric oxide-releasing hydrogels for wound dressing applications","volume":"53","author":"Hasan","year":"2023","journal-title":"J. Pharm. Investig."},{"key":"ref_244","doi-asserted-by":"crossref","first-page":"9749","DOI":"10.1021\/acsami.3c16837","article-title":"A Multifunctional, Tough, Stretchable, and Transparent Curcumin Hydrogel with Potent Antimicrobial, Antioxidative, Anti-inflammatory, and Angiogenesis Capabilities for Diabetic Wound Healing","volume":"16","author":"Fan","year":"2024","journal-title":"ACS Appl. Mater. Interfaces"},{"key":"ref_245","doi-asserted-by":"crossref","first-page":"110672","DOI":"10.1016\/j.compositesb.2023.110672","article-title":"Hydrogel\/nanofibrous membrane composites with enhanced water retention, stretchability and self-healing capability for wound healing","volume":"257","author":"Li","year":"2023","journal-title":"Compos. Part B Eng."},{"key":"ref_246","doi-asserted-by":"crossref","first-page":"2042","DOI":"10.1039\/D3TB02683C","article-title":"A ZIF-8-encapsulated interpenetrated hydrogel\/nanofiber composite patch for chronic wound treatment","volume":"12","author":"Cheng","year":"2024","journal-title":"J. Mater. Chem. B"},{"key":"ref_247","doi-asserted-by":"crossref","unstructured":"Ruan, L., Pan, C., Ran, X., Wen, Y., Lang, R., Peng, M., Cao, J., and Yang, J. (2024). Dual-Delivery Temperature-Sensitive Hydrogel with Antimicrobial and Anti-Inflammatory Brevilin A and Nitric Oxide for Wound Healing in Bacterial Infection. Gels, 10.","DOI":"10.3390\/gels10040219"},{"key":"ref_248","doi-asserted-by":"crossref","first-page":"5830","DOI":"10.1039\/D3TB00641G","article-title":"An osteogenic, antibacterial, and anti-inflammatory nanocomposite hydrogel platform to accelerate bone reconstruction","volume":"11","author":"Ullah","year":"2023","journal-title":"J. Mater. Chem. B"},{"key":"ref_249","doi-asserted-by":"crossref","unstructured":"Pratinthong, K., Punyodom, W., Jantrawut, P., Jantanasakulwong, K., Tongdeesoontorn, W., Sriyai, M., Panyathip, R., Thanakkasaranee, S., Worajittiphon, P., and Tanadchangsaeng, N. (2024). Modification of a Carboxymethyl Cellulose\/Poly(vinyl alcohol) Hydrogel Film with Citric Acid and Glutaraldehyde Crosslink Agents to Enhance the Anti-Inflammatory Effectiveness of Triamcinolone Acetonide in Wound Healing. Polymers, 16.","DOI":"10.3390\/polym16131798"},{"key":"ref_250","doi-asserted-by":"crossref","unstructured":"Xi, Y., Hu, L., Chen, X., Zuo, L., Bai, X., Du, W., and Xu, N. (2024). Antibacterial and Anti-Inflammatory Polysaccharide from Fructus Ligustri Lucidi Incorporated in PVA\/Pectin Hydrogels Accelerate Wound Healing. Molecules, 29.","DOI":"10.3390\/molecules29071423"},{"key":"ref_251","doi-asserted-by":"crossref","unstructured":"Chuysinuan, P., Pengsuk, C., Lirdprapamongkol, K., Thanyacharoen, T., Techasakul, S., Svasti, J., and Nooeaid, P. (2023). Turmeric Herb Extract-Incorporated Biopolymer Dressings with Beneficial Antibacterial, Antioxidant and Anti-Inflammatory Properties for Wound Healing. Polymers, 15.","DOI":"10.3390\/polym15051090"},{"key":"ref_252","doi-asserted-by":"crossref","first-page":"567","DOI":"10.1016\/j.ijbiomac.2022.10.249","article-title":"Fabrication of chitosan-gelatin films incorporated with thymol-loaded alginate microparticles for controlled drug delivery, antibacterial activity and wound healing: In-vitro and in-vivo studies","volume":"223","author":"Ahmady","year":"2022","journal-title":"Int. J. Biol. Macromol."},{"key":"ref_253","doi-asserted-by":"crossref","first-page":"2423","DOI":"10.1021\/acs.biomac.3c01386","article-title":"Multifunctional Hydrogel Enhances Inflammatory Control, Antimicrobial Activity, and Oxygenation to Promote Healing in Infectious Wounds","volume":"25","author":"Tang","year":"2024","journal-title":"Biomacromolecules"},{"key":"ref_254","doi-asserted-by":"crossref","first-page":"eabg9614","DOI":"10.1126\/sciadv.abg9614","article-title":"A flexible multiplexed immunosensor for point-of-care in situ wound monitoring","volume":"7","author":"Gao","year":"2021","journal-title":"Sci. Adv."},{"key":"ref_255","doi-asserted-by":"crossref","unstructured":"Cadinoiu, A.N., Rata, D.M., Daraba, O.M., Ichim, D.L., Popescu, I., Solcan, C., and Solcan, G. (2022). Silver Nanoparticles Biocomposite Films with Antimicrobial Activity: In Vitro and In Vivo Tests. Int. J. Mol. Sci., 23.","DOI":"10.3390\/ijms231810671"},{"key":"ref_256","doi-asserted-by":"crossref","unstructured":"Hashempur, M.H., Sabili, A., Karami, F., Zomorodian, K., Shenavari, S., Vaez, A., Sahraeian, K., and Zareshahrabadi, Z. (2025). Synthesize, antioxidant and antimicrobial properties of a chitosan xerogel film with Nigella Sativa extract. Sci. Rep., 15.","DOI":"10.1038\/s41598-025-09153-1"},{"key":"ref_257","doi-asserted-by":"crossref","unstructured":"Boateng, J., Mani, J., and Kianfar, F. (2013). Improving drug loading of mucosal solvent cast films using a combination of hydrophilic polymers with amoxicillin and paracetamol as model drugs. BioMed Res. Int., 2013.","DOI":"10.1155\/2013\/198137"},{"key":"ref_258","doi-asserted-by":"crossref","first-page":"1339","DOI":"10.1007\/s42247-024-00930-8","article-title":"Stimuli-responsive hydrogels for skin wound healing and regeneration","volume":"8","author":"Xin","year":"2025","journal-title":"Emergent Mater."},{"key":"ref_259","doi-asserted-by":"crossref","first-page":"719","DOI":"10.4155\/tde-2019-0066","article-title":"Challenges and opportunities of pH in chronic wounds","volume":"10","author":"Wallace","year":"2019","journal-title":"Ther. Deliv."},{"key":"ref_260","doi-asserted-by":"crossref","first-page":"126966","DOI":"10.1016\/j.snb.2019.126966","article-title":"pH-responsive materials for optical monitoring of wound status","volume":"301","author":"Gamerith","year":"2019","journal-title":"Sens. Actuators B Chem."},{"key":"ref_261","doi-asserted-by":"crossref","unstructured":"Eskilson, O., Zattarin, E., Berglund, L., Oksman, K., Hanna, K., Rakar, J., Sivl\u00e9r, P., Skog, M., Rinklake, I., and Shamasha, R. (2023). Nanocellulose composite wound dressings for real-time pH wound monitoring. Mater. Today Bio, 19.","DOI":"10.1016\/j.mtbio.2023.100574"},{"key":"ref_262","doi-asserted-by":"crossref","first-page":"198","DOI":"10.1016\/j.snb.2018.04.004","article-title":"Laser-enabled fabrication of flexible and transparent pH sensor with near-field communication for in-situ monitoring of wound infection","volume":"267","author":"Rahimi","year":"2018","journal-title":"Sens. Actuators B Chem."},{"key":"ref_263","doi-asserted-by":"crossref","first-page":"422","DOI":"10.1039\/D2NH00574C","article-title":"pH-Responsive wound dressings: Advances and prospects","volume":"8","author":"Han","year":"2023","journal-title":"Nanoscale Horiz."},{"key":"ref_264","doi-asserted-by":"crossref","first-page":"2366","DOI":"10.1021\/acssensors.1c00552","article-title":"Advanced Wound Dressing for Real-Time pH Monitoring","volume":"6","author":"Mariani","year":"2021","journal-title":"ACS Sens."},{"key":"ref_265","doi-asserted-by":"crossref","first-page":"71","DOI":"10.1007\/s40820-024-01561-8","article-title":"A Fully-Printed Wearable Bandage-Based Electrochemical Sensor with pH Correction for Wound Infection Monitoring","volume":"17","author":"Kaewpradub","year":"2024","journal-title":"Nano-Micro Lett."},{"key":"ref_266","doi-asserted-by":"crossref","unstructured":"Du, M., Jin, J., Zhou, F., Chen, J., and Jiang, W. (2023). Dual drug-loaded hydrogels with pH-responsive and antibacterial activity for skin wound dressing. Colloids Surf. B Biointerfaces, 222.","DOI":"10.1016\/j.colsurfb.2022.113063"},{"key":"ref_267","doi-asserted-by":"crossref","first-page":"2729","DOI":"10.1016\/j.ijbiomac.2022.10.054","article-title":"Skin-adaptive film dressing with smart-release of growth factors accelerated diabetic wound healing","volume":"222","author":"Zhao","year":"2022","journal-title":"Int. J. Biol. Macromol."},{"key":"ref_268","doi-asserted-by":"crossref","first-page":"1387","DOI":"10.1007\/s13726-024-01443-1","article-title":"Stimuli-responsive polymeric film based on hydrogen-bonded organic framework designing as a smart wound dressing","volume":"34","author":"Moeinipour","year":"2025","journal-title":"Iran. Polym. J."},{"key":"ref_269","doi-asserted-by":"crossref","first-page":"1965","DOI":"10.1007\/s12013-024-01402-w","article-title":"Smart dressings and their applications in chronic wound management","volume":"82","author":"Li","year":"2024","journal-title":"Cell Biochem. Biophys."},{"key":"ref_270","doi-asserted-by":"crossref","first-page":"114160","DOI":"10.1016\/j.jconrel.2025.114160","article-title":"Hierarchically structured hydrogel exhibiting spatiotemporal release profiles: Enabling digital remote diagnosis and personalized therapeutics","volume":"386","author":"Ji","year":"2025","journal-title":"J. Control. Release"},{"key":"ref_271","doi-asserted-by":"crossref","first-page":"19590","DOI":"10.1039\/c2jm34006b","article-title":"Photocrosslinkable dextran hydrogel films as substrates for osteoblast and endothelial cell growth","volume":"22","author":"Brunsen","year":"2012","journal-title":"J. Mater. Chem."},{"key":"ref_272","doi-asserted-by":"crossref","first-page":"61185","DOI":"10.1039\/C6RA11249H","article-title":"Surface patterned hydrogel film as a flexible scaffold for 2D and 3D cell co-culture","volume":"6","author":"Zhu","year":"2016","journal-title":"RSC Adv."},{"key":"ref_273","doi-asserted-by":"crossref","first-page":"13295","DOI":"10.1073\/pnas.1609603113","article-title":"Hydrogel films and coatings by swelling-induced gelation","volume":"113","author":"Moreau","year":"2016","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"ref_274","doi-asserted-by":"crossref","first-page":"2101","DOI":"10.1021\/la403590v","article-title":"A cell culture substrate with biologically relevant size-scale topography and compliance of the basement membrane","volume":"30","author":"Garland","year":"2014","journal-title":"Langmuir"},{"key":"ref_275","doi-asserted-by":"crossref","first-page":"64","DOI":"10.1208\/s12249-024-02786-x","article-title":"A Comprehensive Review of Hydrogel-Based Drug Delivery Systems: Classification, Properties, Recent Trends, and Applications","volume":"25","author":"Hameed","year":"2024","journal-title":"AAPS PharmSciTech"},{"key":"ref_276","doi-asserted-by":"crossref","first-page":"555","DOI":"10.1007\/s40005-024-00678-7","article-title":"Injectable hydrogel systems for local cancer therapy","volume":"54","author":"Kim","year":"2024","journal-title":"J. Pharm. Investig."},{"key":"ref_277","doi-asserted-by":"crossref","first-page":"17393","DOI":"10.1007\/s00289-024-05495-4","article-title":"Investigation and kinetics of hydrogel scaffold with sustained release ciprofloxacin hydrochloride","volume":"81","author":"Taha","year":"2024","journal-title":"Polym. Bull."},{"key":"ref_278","doi-asserted-by":"crossref","first-page":"18","DOI":"10.1007\/s40820-023-01228-w","article-title":"In Situ Deposition of Drug and Gene Nanoparticles on a Patterned Supramolecular Hydrogel to Construct a Directionally Osteochondral Plug","volume":"16","author":"Kang","year":"2023","journal-title":"Nano-Micro Lett."},{"key":"ref_279","doi-asserted-by":"crossref","unstructured":"\u00d6zakar, E., Sevin\u00e7-\u00d6zakar, R., and Y\u0131lmaz, B. (2023). Preparation, characterization, and evaluation of cytotoxicity of fast dissolving hydrogel based oral thin films containing pregabalin and methylcobalamin. Gels, 9.","DOI":"10.3390\/gels9020147"},{"key":"ref_280","doi-asserted-by":"crossref","unstructured":"Kulkarni, P., Ahmed, K.A., Shirsand, S.B., Raikar, P.K., and Hiraskar, A. (2025). Transdermal Patches: Design, Evaluation, and Potential Applications in Modern Therapeutics. Biomed. Mater. Devices, 1\u201319.","DOI":"10.1007\/s44174-025-00359-5"},{"key":"ref_281","doi-asserted-by":"crossref","unstructured":"Abedini, A.A., Pircheraghi, G., Kaviani, A., and Hosseini, S. (2023). Exploration of curcumin-incorporated dual anionic alginate-quince seed gum films for transdermal drug delivery. Int. J. Biol. Macromol., 248.","DOI":"10.1016\/j.ijbiomac.2023.125798"},{"key":"ref_282","doi-asserted-by":"crossref","first-page":"93","DOI":"10.1016\/j.ijbiomac.2022.01.031","article-title":"Multilayered mucoadhesive hydrogel films based on Ocimum basilicum seed mucilage\/thiolated alginate\/dopamine-modified hyaluronic acid and PDA coating for sublingual administration of nystatin","volume":"203","author":"Hosseini","year":"2022","journal-title":"Int. J. Biol. Macromol."},{"key":"ref_283","doi-asserted-by":"crossref","unstructured":"Yoon, M.S., Lee, J.M., Jo, M.J., Kang, S.J., Yoo, M.K., Park, S.Y., Bong, S., Park, C.-S., Park, C.-W., and Kim, J.-S. (2025). Dual-Drug Delivery Systems Using Hydrogel\u2013Nanoparticle Composites: Recent Advances and Key Applications. Gels, 11.","DOI":"10.3390\/gels11070520"},{"key":"ref_284","doi-asserted-by":"crossref","first-page":"94","DOI":"10.1039\/D4PM00186A","article-title":"From burst to controlled release: Using hydrogel crosslinking chemistry to tune release of micro-crystalline active pharmaceutical ingredients","volume":"2","author":"Manghnani","year":"2025","journal-title":"RSC Pharm."},{"key":"ref_285","doi-asserted-by":"crossref","first-page":"1342","DOI":"10.3390\/ma7021342","article-title":"Gelatin-based hydrogels promote chondrogenic differentiation of human adipose tissue-derived mesenchymal stem cells in vitro","volume":"7","author":"Salamon","year":"2014","journal-title":"Materials"},{"key":"ref_286","doi-asserted-by":"crossref","unstructured":"Xu, L., Zhang, J., Luo, J., Cui, Y., Chen, J., Zeng, B., Deng, Z., and Shao, L. (2025). \u201cDouble-sided protector\u201d Janus hydrogels for skin and mucosal wound repair: Applications, mechanisms, and prospects. J. Nanobiotechnology, 23.","DOI":"10.1186\/s12951-025-03438-3"},{"key":"ref_287","doi-asserted-by":"crossref","first-page":"310","DOI":"10.1038\/s41578-019-0171-7","article-title":"Overcoming the translational barriers of tissue adhesives","volume":"5","author":"Taboada","year":"2020","journal-title":"Nat. Rev. Mater."},{"key":"ref_288","doi-asserted-by":"crossref","first-page":"eaav1281","DOI":"10.1126\/sciadv.aav1281","article-title":"Sutureless repair of corneal injuries using naturally derived bioadhesive hydrogels","volume":"5","author":"Kheirkhah","year":"2019","journal-title":"Sci. Adv."},{"key":"ref_289","doi-asserted-by":"crossref","first-page":"632","DOI":"10.1038\/s41551-019-0380-9","article-title":"A viscoelastic adhesive epicardial patch for treating myocardial infarction","volume":"3","author":"Lin","year":"2019","journal-title":"Nat. Biomed. Eng."},{"key":"ref_290","doi-asserted-by":"crossref","first-page":"611","DOI":"10.1038\/s41551-019-0442-z","article-title":"Use of a supramolecular polymeric hydrogel as an effective post-operative pericardial adhesion barrier","volume":"3","author":"Stapleton","year":"2019","journal-title":"Nat. Biomed. Eng."},{"key":"ref_291","doi-asserted-by":"crossref","first-page":"2005689","DOI":"10.1002\/adfm.202005689","article-title":"A janus hydrogel wet adhesive for internal tissue repair and anti-postoperative adhesion","volume":"30","author":"Cui","year":"2020","journal-title":"Adv. Funct. Mater."},{"key":"ref_292","doi-asserted-by":"crossref","first-page":"2303802","DOI":"10.1002\/adhm.202303802","article-title":"PAA-PU Janus Hydrogels Stabilized by Janus Particles and its Interfacial Performance During Hemostatic Processing","volume":"13","author":"Fang","year":"2024","journal-title":"Adv. Healthc. Mater."},{"key":"ref_293","doi-asserted-by":"crossref","first-page":"7692","DOI":"10.1039\/D4TB00397G","article-title":"Nanocellulose-based hydrogels as versatile materials with interesting functional properties for tissue engineering applications","volume":"12","author":"Tamo","year":"2024","journal-title":"J. Mater. Chem. B"},{"key":"ref_294","doi-asserted-by":"crossref","unstructured":"Prakashini, R.S., Thangam, T., Hemamalani, A.U., and Parthasarathy, K. (2025). Role of Natural Polymers in Hydrogel-Based Scaffolds for Tissue Engineering Applications. Regen. Eng. Transl. Med., 1\u201320.","DOI":"10.1007\/s40883-025-00462-5"},{"key":"ref_295","doi-asserted-by":"crossref","first-page":"012076","DOI":"10.1088\/1757-899X\/288\/1\/012076","article-title":"Biocompatible hydrogel film of polyethylene oxide-polyethylene glycol dimetacrylate for wound dressing application","volume":"Volume 288","author":"Mahardian","year":"2018","journal-title":"IOP Conference Series: Materials Science and Engineering"},{"key":"ref_296","doi-asserted-by":"crossref","unstructured":"Sharma, G., George Joy, J., Sharma, A.R., and Kim, J.-C. (2024). Accelerated full-thickness skin wound tissue regeneration by self-crosslinked chitosan hydrogel films reinforced by oxidized CNC-AgNPs stabilized Pickering emulsion for quercetin delivery. J. Nanobiotechnol., 22.","DOI":"10.1186\/s12951-024-02596-0"},{"key":"ref_297","doi-asserted-by":"crossref","unstructured":"Ragab, A., El-Badry, N., Tamer, N., Naas, A., Hamdy, A., Tawakey, S.H., Hassan, A.H., and Salim, A.I. (2025). Biodegradable chitosan\/PVA-based hydrogel incorporating green synthesized silver nanoparticles for wound healing applications. BMC Chem., 19.","DOI":"10.1186\/s13065-025-01564-5"},{"key":"ref_298","doi-asserted-by":"crossref","unstructured":"Guill\u00e9n-Carvajal, K., Valdez-Salas, B., Beltr\u00e1n-Partida, E., Salom\u00f3n-Carlos, J., and Cheng, N. (2023). Chitosan, Gelatin, and Collagen Hydrogels for Bone Regeneration. Polymers, 15.","DOI":"10.3390\/polym15132762"},{"key":"ref_299","doi-asserted-by":"crossref","first-page":"129","DOI":"10.1093\/rb\/rbz022","article-title":"Advances of injectable hydrogel-based scaffolds for cartilage regeneration","volume":"6","author":"Li","year":"2019","journal-title":"Regen. Biomater."},{"key":"ref_300","doi-asserted-by":"crossref","unstructured":"Li, C.-S., Xu, Y., Li, J., Qin, S.-H., Huang, S.-W., Chen, X.-M., Luo, Y., Gao, C.-T., and Xiao, J.-H. (2025). Ultramodern natural and synthetic polymer hydrogel scaffolds for articular cartilage repair and regeneration. Biomed. Eng. OnLine, 24.","DOI":"10.1186\/s12938-025-01342-3"},{"key":"ref_301","doi-asserted-by":"crossref","first-page":"105313","DOI":"10.1016\/j.reactfunctpolym.2022.105313","article-title":"Hydrogel-based scaffolds for bone and cartilage tissue engineering and regeneration","volume":"177","author":"Amiryaghoubi","year":"2022","journal-title":"React. Funct. Polym."},{"key":"ref_302","doi-asserted-by":"crossref","first-page":"7791","DOI":"10.1007\/s00289-023-05113-9","article-title":"Ocular contact lenses: Smart materials for biomedical applications","volume":"81","author":"Hajirasouliha","year":"2024","journal-title":"Polym. Bull."},{"key":"ref_303","doi-asserted-by":"crossref","unstructured":"Adrus, N., bin Mohd Farizal, M.A., Jamaluddin, J., bin Syaiful Azim, F.S., Mizi, F.M., Nanda Kumar, S., and Govindasamy, J.J. (2025). Hydrogel as a Foundational Material for Contact Lens. Contact Lenses: Research, Industry, and User Perspectives, Springer.","DOI":"10.1007\/978-981-96-3636-5"},{"key":"ref_304","doi-asserted-by":"crossref","first-page":"564","DOI":"10.1002\/cnma.202100008","article-title":"Recent advances in new copolymer hydrogel-formed contact lenses for ophthalmic drug delivery","volume":"7","author":"Li","year":"2021","journal-title":"ChemNanoMat"},{"key":"ref_305","doi-asserted-by":"crossref","first-page":"7920","DOI":"10.1021\/acsnano.9b02305","article-title":"Gas-permeable, irritation-free, transparent hydrogel contact lens devices with metal-coated nanofiber mesh for eye interfacing","volume":"13","author":"Wei","year":"2019","journal-title":"ACS Nano"},{"key":"ref_306","doi-asserted-by":"crossref","first-page":"1318","DOI":"10.1039\/D2BM01013E","article-title":"Development and optimization of an ocular hydrogel adhesive patch using definitive screening design (DSD)","volume":"11","author":"Gholizadeh","year":"2023","journal-title":"Biomater. Sci."},{"key":"ref_307","doi-asserted-by":"crossref","unstructured":"Tighsazzadeh, M., and Boateng, J. (2024). Matrix hyaluronic acid and bilayer poly-hydroxyethyl methacrylate-hyaluronic acid films as potential ocular drug delivery platforms. Int. J. Biol. Macromol., 260.","DOI":"10.1016\/j.ijbiomac.2024.129496"},{"key":"ref_308","doi-asserted-by":"crossref","first-page":"7324","DOI":"10.1021\/acsabm.4c00975","article-title":"Hydrogel-embedded polydimethylsiloxane contact lens for ocular drug delivery","volume":"7","author":"Manjeri","year":"2024","journal-title":"ACS Appl. Bio Mater."},{"key":"ref_309","doi-asserted-by":"crossref","first-page":"e20230021","DOI":"10.1002\/smo.20230021","article-title":"Smart molecules in ophthalmology: Hydrogels as responsive systems for ophthalmic applications","volume":"2","author":"Kulbay","year":"2024","journal-title":"Smart Mol."},{"key":"ref_310","doi-asserted-by":"crossref","unstructured":"Wei, R., Wang, Y., Feng, Z., Liu, R., Liu, C., Hu, X., Liu, Y., Kong, B., Zhou, X., and Li, M. (2025). Self-healing adhesive oxidized guar gum hydrogel loaded with mesenchymal stem cell exosomes for corneal wound healing. J. Nanobiotechnol., 23.","DOI":"10.1186\/s12951-025-03366-2"},{"key":"ref_311","doi-asserted-by":"crossref","first-page":"9287","DOI":"10.1007\/s11696-024-03785-9","article-title":"Chitosan-and heparin-based advanced hydrogels: Their chemistry, structure and biomedical applications","volume":"78","author":"Safi","year":"2024","journal-title":"Chem. Pap."},{"key":"ref_312","doi-asserted-by":"crossref","first-page":"331","DOI":"10.37349\/ebmx.2024.00023","article-title":"Advancements in hydrogel technology for ocular drug delivery","volume":"1","author":"Truong","year":"2024","journal-title":"Explor. BioMat-X"},{"key":"ref_313","doi-asserted-by":"crossref","unstructured":"Lynch, C.R., Kondiah, P.P.D., Choonara, Y.E., du Toit, L.C., Ally, N., and Pillay, V. (2020). Hydrogel Biomaterials for Application in Ocular Drug Delivery. Front. Bioeng. Biotechnol., 8.","DOI":"10.3389\/fbioe.2020.00228"},{"key":"ref_314","unstructured":"Chattopadhyay, D., Orasugh, J.T., Adhikari, A., and Ray, S.S. (2024). Stimuli-Responsive Hydrogels for Ophthalmic Drug Delivery, Elsevier."},{"key":"ref_315","doi-asserted-by":"crossref","unstructured":"Arabpour, Z., Salehi, M., An, S., Moghtader, A., Anwar, K.N., Baharnoori, S.M., Shah, R.J., Abedi, F., and Djalilian, A.R. (2024). Exploring Hydrogel Nanoparticle Systems for Enhanced Ocular Drug Delivery. Gels, 10.","DOI":"10.3390\/gels10090589"},{"key":"ref_316","doi-asserted-by":"crossref","first-page":"104250","DOI":"10.1016\/j.jddst.2023.104250","article-title":"Hydrogel-based formulations for drug delivery to the anterior segment of the eye","volume":"81","author":"Akbari","year":"2023","journal-title":"J. Drug Deliv. Sci. Technol."},{"key":"ref_317","doi-asserted-by":"crossref","first-page":"915","DOI":"10.7150\/thno.103266","article-title":"Advances in adhesive hydrogels applied for ophthalmology: An overview focused on the treatment","volume":"15","author":"Yan","year":"2025","journal-title":"Theranostics"},{"key":"ref_318","unstructured":"(2025, November 12). A Study to Evaluate the Efficacy and Safety of Treatment with CsA-PG Ophthalmic Gel in Dry Eye Patients, Available online: https:\/\/clinicaltrials.gov\/study\/NCT06942793."},{"key":"ref_319","doi-asserted-by":"crossref","unstructured":"Ullah, A., Kim, D.Y., Lim, S.I., and Lim, H.-R. (2025). Hydrogel-Based Biointerfaces: Recent Advances, Challenges, and Future Directions in Human\u2013Machine Integration. Gels, 11.","DOI":"10.3390\/gels11040232"},{"key":"ref_320","doi-asserted-by":"crossref","first-page":"2100062","DOI":"10.1002\/adhm.202100062","article-title":"Hydrogels and their role in biosensing applications","volume":"10","author":"Herrmann","year":"2021","journal-title":"Adv. Healthc. Mater."},{"key":"ref_321","doi-asserted-by":"crossref","first-page":"495","DOI":"10.1557\/s43577-023-00536-1","article-title":"Hydrogels and conductive hydrogels for implantable bioelectronics","volume":"48","author":"Sagdic","year":"2023","journal-title":"MRS Bull."},{"key":"ref_322","doi-asserted-by":"crossref","unstructured":"Wang, M., Zheng, Y., Yin, C., Dai, S., Fan, X., Jiang, Y., Liu, X., Fang, J., Yi, B., and Zhou, Q. (2023). Recent Progress in antibacterial hydrogel coatings for targeting biofilm to prevent orthopedic implant-associated infections. Front. Microbiol., 14.","DOI":"10.3389\/fmicb.2023.1343202"},{"key":"ref_323","first-page":"4670","article-title":"Enzymatically-degradable hydrogel coatings on titanium for bacterial infection inhibition and enhanced soft tissue compatibility via a self-adaptive strategy","volume":"6","author":"Leng","year":"2021","journal-title":"Bioact. Mater."},{"key":"ref_324","doi-asserted-by":"crossref","first-page":"139","DOI":"10.1007\/s40820-023-01096-4","article-title":"Biological Tissue-Inspired Ultrasoft, Ultrathin, and Mechanically Enhanced Microfiber Composite Hydrogel for Flexible Bioelectronics","volume":"15","author":"Gao","year":"2023","journal-title":"Nano-Micro Lett."},{"key":"ref_325","doi-asserted-by":"crossref","first-page":"4494","DOI":"10.1021\/acsbiomaterials.1c00852","article-title":"Antifouling and Mechanical Properties of Photografted Zwitterionic Hydrogel Thin-Film Coatings Depend on the Cross-Link Density","volume":"7","author":"Jensen","year":"2021","journal-title":"ACS Biomater. Sci. Eng."},{"key":"ref_326","doi-asserted-by":"crossref","first-page":"2649","DOI":"10.1021\/acs.analchem.9b04606","article-title":"Target microRNA-responsive DNA hydrogel-based surface-enhanced Raman scattering sensor arrays for microRNA-marked cancer screening","volume":"92","author":"Si","year":"2020","journal-title":"Anal. Chem."},{"key":"ref_327","doi-asserted-by":"crossref","unstructured":"Tavakoli, J., and Tang, Y. (2017). Hydrogel Based Sensors for Biomedical Applications: An Updated Review. Polymers, 9.","DOI":"10.3390\/polym9080364"},{"key":"ref_328","doi-asserted-by":"crossref","unstructured":"Saeidi, M., Chenani, H., Orouji, M., Adel Rastkhiz, M., Bolghanabadi, N., Vakili, S., Mohamadnia, Z., Hatamie, A., and Simchi, A. (2023). Electrochemical Wearable Biosensors and Bioelectronic Devices Based on Hydrogels: Mechanical Properties and Electrochemical Behavior. Biosensors, 13.","DOI":"10.20944\/preprints202306.0187.v1"},{"key":"ref_329","doi-asserted-by":"crossref","first-page":"2595","DOI":"10.1039\/D4CS00220B","article-title":"Advances in conducting nanocomposite hydrogels for wearable biomonitoring","volume":"54","author":"Roy","year":"2025","journal-title":"Chem. Soc. Rev."},{"key":"ref_330","doi-asserted-by":"crossref","first-page":"2109764","DOI":"10.1002\/adma.202109764","article-title":"Combinatorial polyacrylamide hydrogels for preventing biofouling on implantable biosensors","volume":"34","author":"Chan","year":"2022","journal-title":"Adv. Mater."},{"key":"ref_331","doi-asserted-by":"crossref","first-page":"2402565","DOI":"10.1002\/adhm.202402565","article-title":"Development of Substrate-Independent Antifouling and Bactericidal Surfaces Using Visible Light Cross-Linked Hydrogel Coatings for Biomedical Applications","volume":"14","author":"Roh","year":"2025","journal-title":"Adv. Healthc. Mater."},{"key":"ref_332","doi-asserted-by":"crossref","first-page":"206","DOI":"10.1016\/j.actbio.2024.12.038","article-title":"Super-hydrophilic and super-lubricating Zwitterionic hydrogel coatings coupled with polyurethane to reduce postoperative dura mater adhesions and infections","volume":"192","author":"Rong","year":"2025","journal-title":"Acta Biomater."},{"key":"ref_333","doi-asserted-by":"crossref","first-page":"6146","DOI":"10.1039\/D2BM01244H","article-title":"Advanced antifouling and antibacterial hydrogels enabled by controlled thermo-responses of a biocompatible polymer composite","volume":"10","author":"Pan","year":"2022","journal-title":"Biomater. Sci."},{"key":"ref_334","doi-asserted-by":"crossref","first-page":"1804","DOI":"10.1007\/s10439-023-03154-9","article-title":"PEG-Based Hydrogel Coatings: Design Tools for Biomedical Applications","volume":"52","author":"Wancura","year":"2024","journal-title":"Ann. Biomed. Eng."},{"key":"ref_335","doi-asserted-by":"crossref","first-page":"nwae316","DOI":"10.1093\/nsr\/nwae316","article-title":"Engineered Janus hydrogels: Biomimetic surface engineering and biomedical applications","volume":"11","author":"Pan","year":"2024","journal-title":"Natl. Sci. Rev."},{"key":"ref_336","doi-asserted-by":"crossref","first-page":"080603","DOI":"10.1063\/5.0228692","article-title":"Immunomodulatory hydrogels for tissue repair and regeneration","volume":"12","author":"Liu","year":"2024","journal-title":"APL Mater."},{"key":"ref_337","doi-asserted-by":"crossref","unstructured":"Quazi, M.Z., Hwang, J., Song, Y., and Park, N. (2023). Hydrogel-Based Biosensors for Effective Therapeutics. Gels, 9.","DOI":"10.3390\/gels9070545"},{"key":"ref_338","doi-asserted-by":"crossref","first-page":"993","DOI":"10.1007\/s00216-021-03746-1","article-title":"Hydrogel-based holographic sensors and biosensors: Past, present, and future","volume":"414","author":"Maquieira","year":"2022","journal-title":"Anal. Bioanal. Chem."},{"key":"ref_339","doi-asserted-by":"crossref","first-page":"11485","DOI":"10.1021\/jacs.5c01718","article-title":"Molecularly responsive aptamer-functionalized hydrogel for continuous plasmonic biomonitoring","volume":"147","author":"Park","year":"2025","journal-title":"J. Am. Chem. Soc."},{"key":"ref_340","doi-asserted-by":"crossref","unstructured":"Chen, B., Zhu, Y., Yu, R., Feng, Y., Han, Z., Liu, C., Zhu, P., Lu, L., and Mao, Y. (2025). Recent Progress of Biomaterial-Based Hydrogels for Wearable and Implantable Bioelectronics. Gels, 11.","DOI":"10.3390\/gels11060442"},{"key":"ref_341","doi-asserted-by":"crossref","first-page":"eadw6166","DOI":"10.1126\/sciadv.adw6166","article-title":"A reusable hydrogel biosensor array with electrically responsive hydrogel interfaces for noninvasive locating of perforating arteries","volume":"11","author":"Yang","year":"2025","journal-title":"Sci. Adv."},{"key":"ref_342","first-page":"97","article-title":"Enzyme-Responsive Hydrogels for Targeted Therapeutic Delivery and Diagnostic Applications","volume":"3","author":"Zahid","year":"2025","journal-title":"Front. Med. Health Res."},{"key":"ref_343","doi-asserted-by":"crossref","unstructured":"Solanki, R., and Bhatia, D. (2024). Stimulus-Responsive Hydrogels for Targeted Cancer Therapy. Gels, 10.","DOI":"10.20944\/preprints202406.0984.v1"},{"key":"ref_344","doi-asserted-by":"crossref","first-page":"15705","DOI":"10.1039\/D1NJ02260A","article-title":"Multi-stimuli-responsive hydrogels and their medical applications","volume":"45","author":"Pourjavadi","year":"2021","journal-title":"New J. Chem."},{"key":"ref_345","doi-asserted-by":"crossref","first-page":"66","DOI":"10.1186\/s40712-025-00283-y","article-title":"Stimuli-responsive hydrogels, their mass transfer, intermolecular interactions, and applications in biomedical devices","volume":"20","author":"Toews","year":"2025","journal-title":"J. Mater. Sci. Mater. Eng."},{"key":"ref_346","doi-asserted-by":"crossref","unstructured":"Sojdeh, S., Panjipour, A., Yaghmour, A., Arabpour, Z., and Djalilian, A.R. (2025). Click Chemistry-Based Hydrogels for Tissue Engineering. Gels, 11.","DOI":"10.3390\/gels11090724"},{"key":"ref_347","doi-asserted-by":"crossref","first-page":"5348","DOI":"10.1039\/D3TA06779C","article-title":"DLP 3D printing of electrically conductive hybrid hydrogels via polymerization-induced phase separation and subsequent in situ assembly of polypyrrole","volume":"12","author":"Song","year":"2024","journal-title":"J. Mater. Chem. A"},{"key":"ref_348","doi-asserted-by":"crossref","first-page":"7757","DOI":"10.1039\/D2MA00527A","article-title":"Intelligent hydrogels and their biomedical applications","volume":"3","author":"Chakrapani","year":"2022","journal-title":"Mater. Adv."},{"key":"ref_349","doi-asserted-by":"crossref","unstructured":"Bordbar-Khiabani, A., and Gasik, M. (2022). Smart Hydrogels for Advanced Drug Delivery Systems. Int. J. Mol. Sci., 23.","DOI":"10.3390\/ijms23073665"},{"key":"ref_350","doi-asserted-by":"crossref","unstructured":"Cao, J., Zhang, Z., Li, K., Ma, C., Zhou, W., Lin, T., Xu, J., and Liu, X. (2023). Self-Healable PEDOT:PSS-PVA Nanocomposite Hydrogel Strain Sensor for Human Motion Monitoring. Nanomaterials, 13.","DOI":"10.3390\/nano13172465"},{"key":"ref_351","doi-asserted-by":"crossref","first-page":"8202","DOI":"10.1039\/D3RA00584D","article-title":"Revealing the improved sensitivity of PEDOT:PSS\/PVA thin films through secondary doping and their strain sensors application","volume":"13","author":"Maurya","year":"2023","journal-title":"RSC Adv."},{"key":"ref_352","doi-asserted-by":"crossref","unstructured":"Jurin, F.E., Buron, C.C., Frau, E., del Rossi, S., and Schintke, S. (2024). The Electrical and Mechanical Characteristics of Conductive PVA\/PEDOT:PSS Hydrogel Foams for Soft Strain Sensors. Sensors, 24.","DOI":"10.3390\/s24020570"},{"key":"ref_353","doi-asserted-by":"crossref","unstructured":"Bhowmik, P.K. (2024). Perspective Chapter: Introduction to Hydrogels\u2013Definition, Classifications, Applications and Methods of Preparation. Ionic Liquids-Recent Advances, IntechOpen.","DOI":"10.5772\/intechopen.1002097"},{"key":"ref_354","first-page":"47","article-title":"Hydrogels: Introduction, preparation, characterization and applications","volume":"1","author":"Shetye","year":"2015","journal-title":"Hum. J."},{"key":"ref_355","unstructured":"Brenneman, R.J., and Baumann, B.C. (2025, November 12). Space OAR Vue\u2122 Hydrogel: The Next-Generation Radiopaque Hydrogel Spacer. Boston Scientific, Available online: https:\/\/www.bostonscientific.com\/en-US\/medical-specialties\/urology\/prostate-health\/prostate-cancer\/spaceoar-hydrogel\/clinical-results\/spaceoar-vue-hydrogel.html."},{"key":"ref_356","unstructured":"U.S. Food and Drug Administration (2025, November 12). FDA-Approved Dermal Fillers, Available online: https:\/\/www.fda.gov\/medical-devices\/aesthetic-cosmetic-devices\/fda-approved-dermal-fillers."},{"key":"ref_357","unstructured":"(2018). Biological Evaluation of Medical Devices\u2014Part 1: Evaluation and Testing Within a Risk Management Process (Standard No. ISO 10993-1:2018)."},{"key":"ref_358","unstructured":"(2025). Standard Guide for Characterization of Hydrogels Used in Regenerative Medicine (Standard No. ASTM F2900-25)."},{"key":"ref_359","unstructured":"(2019). Premarket Notification [510(k)] Guidance Documents (Standard No. FDA 510(k))."},{"key":"ref_360","unstructured":"(2017). Medical Device Regulation (Standard No. EU MDR 2017\/745)."},{"key":"ref_361","doi-asserted-by":"crossref","unstructured":"Mohapatra, S., Mirza, M.A., Hilles, A.R., Zakir, F., Gomes, A.C., Ansari, M.J., Iqbal, Z., and Mahmood, S. (2021). Biomedical Application, Patent Repository, Clinical Trial and Regulatory Updates on Hydrogel: An Extensive Review. Gels, 7.","DOI":"10.3390\/gels7040207"},{"key":"ref_362","doi-asserted-by":"crossref","first-page":"5","DOI":"10.1007\/s43939-025-00178-x","article-title":"Progress in hydrogel toughening: Addressing structural and crosslinking challenges for biomedical applications","volume":"5","author":"Rumon","year":"2025","journal-title":"Discov. Mater."},{"key":"ref_363","doi-asserted-by":"crossref","first-page":"380","DOI":"10.1038\/s41578-024-00672-3","article-title":"Design principles for strong and tough hydrogels","volume":"9","author":"Li","year":"2024","journal-title":"Nat. Rev. Mater."},{"key":"ref_364","doi-asserted-by":"crossref","first-page":"2525","DOI":"10.1002\/pol.20220154","article-title":"Progress in the mechanical enhancement of hydrogels: Fabrication strategies and underlying mechanisms","volume":"60","author":"Lin","year":"2022","journal-title":"J. Polym. Sci."},{"key":"ref_365","doi-asserted-by":"crossref","unstructured":"Heinemann, C., Buchner, F., Lee, P.S., Bernhardt, A., Kruppke, B., Wiesmann, H.-P., and Hintze, V. (2023). Effects of Gamma Irradiation and Supercritical Carbon Dioxide Sterilization on Methacrylated Gelatin\/Hyaluronan Hydrogels. J. Funct. Biomater., 14.","DOI":"10.3390\/jfb14060317"},{"key":"ref_366","doi-asserted-by":"crossref","unstructured":"Jana, S., and Jana, S. (2022). Stimuli-Responsive Hydrogels in Drug Delivery. Functional Biomaterials: Drug Delivery and Biomedical Applications, Springer.","DOI":"10.1007\/978-981-16-7152-4"},{"key":"ref_367","doi-asserted-by":"crossref","first-page":"3512","DOI":"10.1007\/s10924-025-03620-6","article-title":"Recent Advances in Injectable Stimuli-Responsive Hydrogels for Biomedical Applications","volume":"33","author":"Khonakdar","year":"2025","journal-title":"J. Polym. Environ."},{"key":"ref_368","doi-asserted-by":"crossref","first-page":"1981","DOI":"10.1007\/s00289-023-04862-x","article-title":"Stimuli-responsive hydrogel for disease therapy","volume":"81","author":"Fang","year":"2024","journal-title":"Polym. Bull."},{"key":"ref_369","unstructured":"FDA (2025, November 12). Regulatory Controls and Device Classification under the FD&C Act, Available online: https:\/\/www.fda.gov\/medical-devices\/overview-device-regulation\/regulatory-controls."},{"key":"#cr-split#-ref_370.1","unstructured":"European Parliament and Council (2017). Regulation"},{"key":"#cr-split#-ref_370.2","unstructured":"(EU) 2017\/745 on Medical Devices and Directive 2001\/83\/EC, Official Journal of the European Union. Available online: https:\/\/eur-lex.europa.eu\/eli\/reg\/2017\/745\/oj."},{"key":"ref_371","unstructured":"European Parliament and Council (2001). Directive 2001\/83\/EC on the Community Code Relating to Medicinal Products for Human Use, Official Journal of the European Union. Available online: https:\/\/eur-lex.europa.eu\/eli\/dir\/2001\/83\/oj\/eng."},{"key":"ref_372","unstructured":"(2009). Biological Evaluation of Medical Devices\u2014Part 5: Tests for In Vitro Cytotoxicity (Standard No. ISO 10993-5:2009). Available online: https:\/\/www.iso.org\/standard\/36406.html."},{"key":"ref_373","unstructured":"(2010). Biological Evaluation of Medical Devices\u2014Part 10: Tests for Irritation and Skin Sensitization (Standard No. ISO 10993-10:2010). Available online: https:\/\/www.iso.org\/standard\/75279.html."},{"key":"ref_374","unstructured":"(2017). Biological Evaluation of Medical Devices\u2014Part 11: Tests for Systemic Toxicity (Standard No. ISO 10993-11:2017). Available online: https:\/\/www.iso.org\/standard\/68426.html."},{"key":"ref_375","unstructured":"FDA (2025, November 12). Requests for Feedback and Meetings for Medical Device Submissions: The Q-Submission Program; Guidance for Industry and Food and Drug Administration Staff, Available online: https:\/\/www.fda.gov\/media\/114034\/download."},{"key":"ref_376","unstructured":"EMA (2025). Medical Devices\u2014Regulatory and Procedural Guidance, European Medicines Agency. Available online: https:\/\/www.ema.europa.eu\/en\/human-regulatory-overview\/medical-devices."},{"key":"ref_377","doi-asserted-by":"crossref","first-page":"64","DOI":"10.1007\/s10856-020-06401-w","article-title":"Natural hydrogels R&D process: Technical and regulatory aspects for industrial implementation","volume":"31","author":"Catoira","year":"2020","journal-title":"J. Mater. Sci. Mater. Med."},{"key":"ref_378","unstructured":"(2025). Standard Practice for Selecting Biological Test Methods for Materials and Devices (Standard No. ASTM F748-25). Available online: https:\/\/www.astm.org\/f0748-25.html."},{"key":"ref_379","unstructured":"(2016). Standard Guide for Characterization and Testing of Raw or Starting Materials for Tissue-Engineered Medical Products (Standard No. ASTM F2027-16). Available online: https:\/\/www.astm.org\/f2027-16.html."},{"key":"ref_380","unstructured":"(2017). Standard Guide for Characterization and Testing of Alginates as Starting Materials Intended for Use in Biomedical and Tissue-Engineered Medical Product Applications (Standard No. ASTM F2064-17). Available online: https:\/\/www.astm.org\/f2064-17.html."},{"key":"ref_381","unstructured":"(2018). Standard Guide for Characterization and Testing of Chitosan Salts as Starting Materials Intended for Use in Biomedical and Tissue-Engineered Medical Product Applications (Standard No. ASTM F2103-18). Available online: https:\/\/www.astm.org\/f2103-18.html."},{"key":"ref_382","unstructured":"(2011). Standard Guide for Characterization of Hydrogels Used in Regenerative Medicine (Standard No. ASTM F2900-11). Available online: https:\/\/www.astm.org\/f2900-11.html."},{"key":"ref_383","doi-asserted-by":"crossref","unstructured":"Clegg, J.R., Adebowale, K., Zhao, Z., and Mitragotri, S. (2024). Hydrogels in the clinic: An update. Bioeng. Transl. Med., 9.","DOI":"10.1002\/btm2.10680"},{"key":"ref_384","doi-asserted-by":"crossref","first-page":"2855","DOI":"10.1007\/s10924-023-02796-z","article-title":"Production of polymer hydrogel composites and their applications","volume":"31","year":"2023","journal-title":"J. Polym. Environ."},{"key":"ref_385","doi-asserted-by":"crossref","unstructured":"Li, B., Wang, Z., Huang, C., Xu, L., Huang, S., Qu, M., Xu, Z., Zhang, D., Guo, B., and Ji, C. (2024, January 7\u201310). Optimization of 3D Printing Process for Hydrogel-Based Thermal Management Patches in Engineering Machinery. Proceedings of the 9th International Conference on Advances in Construction Machinery and Vehicle Engineering, Singapore.","DOI":"10.1007\/978-981-96-5527-4_20"},{"key":"ref_386","doi-asserted-by":"crossref","first-page":"426","DOI":"10.1038\/s41392-021-00830-x","article-title":"Current hydrogel advances in physicochemical and biological response-driven biomedical application diversity","volume":"6","author":"Cao","year":"2021","journal-title":"Signal Transduct. Target. Ther."},{"key":"ref_387","doi-asserted-by":"crossref","unstructured":"Sharma, A. (2024). Biomaterials-Based Hydrogels for Therapeutic Applications. Biomaterials in Microencapsulation, IntechOpen.","DOI":"10.5772\/intechopen.1002081"},{"key":"ref_388","doi-asserted-by":"crossref","unstructured":"Negut, I., and Bita, B. (2023). Exploring the Potential of Artificial Intelligence for Hydrogel Development\u2014A Short Review. Gels, 9.","DOI":"10.3390\/gels9110845"},{"key":"ref_389","doi-asserted-by":"crossref","unstructured":"Xu, S., Chen, X., Wang, S., Chen, Z., Pan, P., and Huang, Q. (2024). Integrating machine learning for the optimization of polyacrylamide\/alginate hydrogel. Regen. Biomater., 11.","DOI":"10.1093\/rb\/rbae109"},{"key":"ref_390","doi-asserted-by":"crossref","unstructured":"Li, Z., Song, P., Li, G., Han, Y., Ren, X., Bai, L., and Su, J. (2024). AI energized hydrogel design, optimization and application in biomedicine. Mater. Today Bio, 25.","DOI":"10.1016\/j.mtbio.2024.101014"},{"key":"ref_391","doi-asserted-by":"crossref","unstructured":"Romano, S., Yazdanpanah, S., Petillo, O., Conte, R., Sepe, F., Peluso, G., and Calarco, A. (2025). Sustainable Hydrogels for Medical Applications: Biotechnological Innovations Supporting One Health. Gels, 11.","DOI":"10.3390\/gels11070559"},{"key":"ref_392","doi-asserted-by":"crossref","first-page":"6","DOI":"10.1007\/s44347-025-00017-5","article-title":"Advances in natural polymer-based hydrogels: Synthesis, applications, and future directions in biomedical and environmental fields","volume":"2","author":"Nanda","year":"2025","journal-title":"Discov. Polym."},{"key":"ref_393","doi-asserted-by":"crossref","unstructured":"Bhattacharyya, A., Janarthanan, G., Kang, J., and Noh, I. (2021). Status for Commercialization of FDA-Approved Hydrogels and Their Intellectual Properties, The Royal Society of Chemistry.","DOI":"10.1039\/9781839163975-00439"}],"container-title":["Gels"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.mdpi.com\/2310-2861\/11\/11\/918\/pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,11,19]],"date-time":"2025-11-19T13:39:48Z","timestamp":1763559588000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.mdpi.com\/2310-2861\/11\/11\/918"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,11,17]]},"references-count":394,"journal-issue":{"issue":"11","published-online":{"date-parts":[[2025,11]]}},"alternative-id":["gels11110918"],"URL":"https:\/\/doi.org\/10.3390\/gels11110918","relation":{},"ISSN":["2310-2861"],"issn-type":[{"value":"2310-2861","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,11,17]]}}}