{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,31]],"date-time":"2026-03-31T17:50:37Z","timestamp":1774979437828,"version":"3.50.1"},"reference-count":43,"publisher":"MDPI AG","issue":"4","license":[{"start":{"date-parts":[[2026,3,31]],"date-time":"2026-03-31T00:00:00Z","timestamp":1774915200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"Special Funds for Talents of Xinjiang Medical University","award":["0103010211"],"award-info":[{"award-number":["0103010211"]}]},{"name":"Tianchi Elite Young Doctor Fund of Xinjiang Uygur Autonomous Region","award":["030106062536"],"award-info":[{"award-number":["030106062536"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Gels"],"abstract":"<jats:p>The management of diabetic chronic wounds (DFUs) is challenging due to persistent bacterial colonization, impaired neovascularization, and disordered inflammation. We engineered a multifunctional photothermal hydrogel (PPCS) by integrating CuS nanoparticles and high-concentration sucrose to establish a dual-action therapeutic cascade: potent antibacterial eradication followed by pro-angiogenic stimulation. Upon NIR irradiation, the PPCS system executes a combinatorial anti-infective mechanism: CuS-mediated photothermal effect and ROS generation are amplified by sucrose\u2019s hyperosmotic pressure, achieving 99.3% bacterial eradication. Beyond sterilization, the hydrogel acts as a Cu2+ sustained-release depot, significantly promoting HUVEC proliferation and migration. This pro-angiogenic effect is mechanistically linked to the upregulation of HIF-1\u03b1\/VEGF signaling, accelerating neovascularization. Furthermore, sucrose efficiently manages wound exudate, maintaining a repair-conducive microenvironment. In a diabetic rat model, the PPCS dressing demonstrated superior therapeutic efficacy, achieving an accelerated wound closure rate of 99.4% by Day 14, significantly surpassing the control group\u2019s 78.9%. This work presents a tailored hydrogel platform that effectively targets both persistent infection and impaired vascularization, offering a precise and highly efficient therapeutic modality for the clinical management of diabetic chronic wounds.<\/jats:p>","DOI":"10.3390\/gels12040291","type":"journal-article","created":{"date-parts":[[2026,3,31]],"date-time":"2026-03-31T16:34:08Z","timestamp":1774974848000},"page":"291","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Multifunctional NIR-Responsive Composite Hydrogel with Combinatorial Antibacterial and Regenerative Properties for Diabetic Wound Healing"],"prefix":"10.3390","volume":"12","author":[{"ORCID":"https:\/\/orcid.org\/0009-0006-8043-0650","authenticated-orcid":false,"given":"Shaokai","family":"Ji","sequence":"first","affiliation":[{"name":"College of Pharmacy, Xinjiang Medical University, Urumqi 830017, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Chao","family":"Wang","sequence":"additional","affiliation":[{"name":"College of Pharmacy, Xinjiang Medical University, Urumqi 830017, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jie","family":"Song","sequence":"additional","affiliation":[{"name":"The First College of Clinical Medicine, Xinjiang Medical University, Urumqi 830017, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hang","family":"Shi","sequence":"additional","affiliation":[{"name":"College of Pharmacy, Xinjiang Medical University, Urumqi 830017, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Donglei","family":"Wan","sequence":"additional","affiliation":[{"name":"College of Pharmacy, Xinjiang Medical University, Urumqi 830017, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Chan","family":"Huang","sequence":"additional","affiliation":[{"name":"College of Pharmacy, Xinjiang Medical University, Urumqi 830017, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hanzhi","family":"Fu","sequence":"additional","affiliation":[{"name":"College of Pharmacy, Xinjiang Medical University, Urumqi 830017, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xiaohong","family":"Cao","sequence":"additional","affiliation":[{"name":"College of Pharmacy, Xinjiang Medical University, Urumqi 830017, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3779-1670","authenticated-orcid":false,"given":"Heting","family":"Wu","sequence":"additional","affiliation":[{"name":"College of Pharmacy, Xinjiang Medical University, Urumqi 830017, China"},{"name":"Engineering Research Center of Xinjiang and Central Asian Medicine Resources, Ministry of Education, Urumqi 830011, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jian","family":"Yang","sequence":"additional","affiliation":[{"name":"College of Pharmacy, Xinjiang Medical University, Urumqi 830017, China"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1968","published-online":{"date-parts":[[2026,3,31]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","unstructured":"American Diabetes Association (2013). 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