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While traditional dressings offer basic protection, they fail to address the complex pathophysiology of non-healing wounds. This review critically examines cellulose-based hydrogels as next-generation therapeutic platforms, analyzing their structure\u2013property relationships, biofunctionalization strategies, and stimuli-responsive capabilities. We synthesize recent advances in antimicrobial, anti-inflammatory, and pro-regenerative hydrogels, highlighting how cellulose\u2019s inherent tunability enables precision wound management. Finally, we confront the translational barriers\u2014including scalability, sterilization, and regulatory hurdles\u2014that must be overcome to bridge the gap between promising biomaterial research and clinical reality. By integrating materials science with wound pathophysiology, this review provides a roadmap for developing clinically viable cellulose-based hydrogels.<\/jats:p>","DOI":"10.3390\/gels12050410","type":"journal-article","created":{"date-parts":[[2026,5,8]],"date-time":"2026-05-08T19:10:52Z","timestamp":1778267452000},"page":"410","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":10,"title":["Cellulose-Based Hydrogels for Chronic Wound Healing: Bridging Biomaterial Design and Clinical Unmet Needs"],"prefix":"10.3390","volume":"12","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-4038-7548","authenticated-orcid":false,"given":"Irina","family":"Negut","sequence":"first","affiliation":[{"name":"National Institute for Laser, Plasma and Radiation Physics (INFLPR), Atomistilor 409, 077125 Magurele, Romania"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0539-4160","authenticated-orcid":false,"given":"Anita Ioana","family":"Visan","sequence":"additional","affiliation":[{"name":"National Institute for Laser, Plasma and Radiation Physics (INFLPR), Atomistilor 409, 077125 Magurele, Romania"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2026,5,8]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"599","DOI":"10.1007\/s12325-017-0478-y","article-title":"Chronic Wound Healing: A Review of Current Management and Treatments","volume":"34","author":"Han","year":"2017","journal-title":"Adv. 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