{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,19]],"date-time":"2026-10-19T20:16:32Z","timestamp":1792440992843,"version":"4.5.0"},"reference-count":103,"publisher":"MDPI AG","issue":"6","license":[{"start":{"date-parts":[[2026,5,24]],"date-time":"2026-05-24T00:00:00Z","timestamp":1779580800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82460701"],"award-info":[{"award-number":["82460701"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"award":["82460701"],"award-info":[{"award-number":["82460701"]}],"id":[{"id":"https:\/\/ror.org\/01h0zpd94","id-type":"ROR","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100011789","name":"Jilin Province Science and Technology Department","doi-asserted-by":"crossref","award":["YDZJ202501ZYTS188"],"award-info":[{"award-number":["YDZJ202501ZYTS188"]}],"id":[{"id":"10.13039\/501100011789","id-type":"DOI","asserted-by":"crossref"}]},{"award":["YDZJ202501ZYTS188"],"award-info":[{"award-number":["YDZJ202501ZYTS188"]}],"id":[{"id":"https:\/\/ror.org\/049x38272","id-type":"ROR","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100010211","name":"Department of Education of Jilin Province","doi-asserted-by":"publisher","award":["JJKH20250411KJ"],"award-info":[{"award-number":["JJKH20250411KJ"]}],"id":[{"id":"10.13039\/501100010211","id-type":"DOI","asserted-by":"publisher"}]},{"award":["JJKH20250411KJ"],"award-info":[{"award-number":["JJKH20250411KJ"]}],"id":[{"id":"https:\/\/ror.org\/05782e512","id-type":"ROR","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100019594","name":"Yanbian University","doi-asserted-by":"publisher","award":["602024006"],"award-info":[{"award-number":["602024006"]}],"id":[{"id":"10.13039\/501100019594","id-type":"DOI","asserted-by":"publisher"}]},{"award":["602024006"],"award-info":[{"award-number":["602024006"]}],"id":[{"id":"https:\/\/ror.org\/039xnh269","id-type":"ROR","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Gels"],"abstract":"<jats:p>Wound healing is a complex physiological process involving multiple stages, including hemostasis, inflammation, proliferation, and remodeling, which imposes high demands on the functionality and adaptability of wound repair materials. Hydrogels, as a class of novel materials, have become ideal wound dressings due to their excellent biocompatibility, breathability, and conformability. Sodium alginate-based composite hydrogels offer advantages such as readily available raw materials and mild preparation conditions. They can also endow materials with properties including antibacterial, anti-inflammatory, hemostatic, and pro-angiogenic effects, meeting the application requirements for multifunctional and highly efficient wound dressings. As a result, they have attracted considerable attention in the field of wound repair. This article introduces the preparation methods of physically and chemically crosslinked sodium alginate-based composite hydrogels, as well as the drug release mechanisms from these hydrogels. It elaborates on their applications in wound dressings, discusses key challenges including difficulties in large-scale preparation, high barriers to clinical translation, insufficient long-term in vivo stability, and low integration of intelligent functions, and outlines future research directions in terms of large-scale fabrication, regulatory compliance, long-term safety, and intelligent design. This review aims to provide a theoretical basis for the development of novel sodium alginate-based composite hydrogels for wound dressings and to promote their clinical translation and practical application in this field.<\/jats:p>","DOI":"10.3390\/gels12060458","type":"journal-article","created":{"date-parts":[[2026,5,25]],"date-time":"2026-05-25T01:45:08Z","timestamp":1779673508000},"page":"458","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["Preparation and Application of Sodium Alginate-Based Composite Hydrogels in Wound Dressings"],"prefix":"10.3390","volume":"12","author":[{"given":"Dandan","family":"Chen","sequence":"first","affiliation":[{"name":"Key Laboratory of Natural Medicines of the Changbai Mountain, Ministry of Education, College of Pharmacy, Yanbian University, Yanji 133002, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yan","family":"He","sequence":"additional","affiliation":[{"name":"Jilin Collaborative Innovation Center for Antibody Engineering, Jilin Medical University, Jilin 132013, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xinyue","family":"Zhang","sequence":"additional","affiliation":[{"name":"Key Laboratory of Natural Medicines of the Changbai Mountain, Ministry of Education, College of Pharmacy, Yanbian University, Yanji 133002, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Longyi","family":"Nan","sequence":"additional","affiliation":[{"name":"Key Laboratory of Natural Medicines of the Changbai Mountain, Ministry of Education, College of Pharmacy, Yanbian University, Yanji 133002, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xin","family":"Jin","sequence":"additional","affiliation":[{"name":"Key Laboratory of Natural Medicines of the Changbai Mountain, Ministry of Education, College of Pharmacy, Yanbian University, Yanji 133002, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yan","family":"Zheng","sequence":"additional","affiliation":[{"name":"Key Laboratory of Natural Medicines of the Changbai Mountain, Ministry of Education, College of Pharmacy, Yanbian University, Yanji 133002, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6994-1317","authenticated-orcid":false,"given":"Chao","family":"Sun","sequence":"additional","affiliation":[{"name":"Department of Physics, Jilin University, Changchun 130012, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jianpeng","family":"Guo","sequence":"additional","affiliation":[{"name":"Key Laboratory of Natural Medicines of the Changbai Mountain, Ministry of Education, College of Pharmacy, Yanbian University, Yanji 133002, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xinyu","family":"Li","sequence":"additional","affiliation":[{"name":"Key Laboratory of Natural Medicines of the Changbai Mountain, Ministry of Education, College of Pharmacy, Yanbian University, Yanji 133002, China"},{"name":"Department of Polymer Materials & Engineering, College of Engineering, Yanbian University, Yanji 133002, China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2026,5,24]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"4639","DOI":"10.1039\/D5BM00095E","article-title":"Multifunctional bilayer dressings: A next generation biomaterial for enhanced wound healing","volume":"13","author":"Bhardwaj","year":"2025","journal-title":"Biomater. 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