{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,28]],"date-time":"2026-05-28T11:06:31Z","timestamp":1779966391020,"version":"3.53.1"},"reference-count":43,"publisher":"MDPI AG","issue":"6","license":[{"start":{"date-parts":[[2026,5,28]],"date-time":"2026-05-28T00:00:00Z","timestamp":1779926400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Gels"],"abstract":"<jats:p>In this study, a novel composite hydrogel was developed based on oxidized sodium alginate (OSA), synthesized via sodium periodate oxidation, and incorporated into a carboxymethyl chitosan (CMCS) matrix. Scallop active peptides (SAPs), a marine-derived bioactive component with outstanding antioxidant and pro-regenerative activities, was introduced to endow the hydrogel with enhanced biological functions, which is of great significance for breaking the functional limitations of traditional single-component hydrogels. The construction of a dynamic covalent network, driven by the Schiff base reaction, was confirmed through structural characterization using FT-IR and 1H-NMR. The hydrogel exhibited favorable physicochemical properties, including shear-thinning behavior, significant self-healing capability, and a uniform porous microstructure that effectively mimics the extracellular matrix (ECM). In vitro evaluations revealed excellent biocompatibility and potent pro-angiogenic potential, as evidenced by enhanced HUVEC migration and tube formation. In a rat model of full-thickness skin wounds, the CMCS\/OSA\/SAPs hydrogel significantly accelerated wound closure and promoted re-epithelialization and organized collagen deposition. Furthermore, immunohistochemical analysis confirmed upregulated VEGF and \u03b1-SMA expression, alongside reduced inflammatory levels (decreased iNOS), indicating potent tissue-regenerative and immunomodulatory functions. Overall, this work presents a multifunctional hydrogel system that integrates antioxidant, anti-inflammatory, and tissue-regenerative properties, offering a promising strategy for deep-wound healing. This study highlights the significant potential of marine-derived bioactive proteins\/peptides in the development of advanced biomedical materials.<\/jats:p>","DOI":"10.3390\/gels12060467","type":"journal-article","created":{"date-parts":[[2026,5,28]],"date-time":"2026-05-28T09:57:43Z","timestamp":1779962263000},"page":"467","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["A Scallop Active Peptide-Incorporated Carboxymethyl Chitosan\/Oxidized Sodium Alginate Hydrogel for Accelerating Skin Wound Healing and Tissue Regeneration"],"prefix":"10.3390","volume":"12","author":[{"given":"Lingfeng","family":"Kou","sequence":"first","affiliation":[{"name":"College of Chemistry, Fuzhou University, No. 2 Xueyuan Road, Fuzhou 350108, China"},{"name":"Fujian Key Laboratory of Medical Instrument and Pharmaceutical Technology, Fuzhou University, No. 2 Xueyuan Road, Fuzhou 350108, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Huan","family":"Yang","sequence":"additional","affiliation":[{"name":"College of Chemistry, Fuzhou University, No. 2 Xueyuan Road, Fuzhou 350108, China"},{"name":"Fujian Key Laboratory of Medical Instrument and Pharmaceutical Technology, Fuzhou University, No. 2 Xueyuan Road, Fuzhou 350108, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5571-2898","authenticated-orcid":false,"given":"Yunquan","family":"Zheng","sequence":"additional","affiliation":[{"name":"College of Chemistry, Fuzhou University, No. 2 Xueyuan Road, Fuzhou 350108, China"},{"name":"Fujian Key Laboratory of Medical Instrument and Pharmaceutical Technology, Fuzhou University, No. 2 Xueyuan Road, Fuzhou 350108, China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2026,5,28]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"100634","DOI":"10.1016\/j.pmatsci.2019.100634","article-title":"The Materials Science of Skin: Analysis, Characterization, and Modeling","volume":"110","author":"Pissarenko","year":"2020","journal-title":"Prog. 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