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Due to the inherent shortcomings of existing therapeutic strategies and the rapid progress of material engineering, developing advanced functional materials has emerged as a promising approach for SCI treatment. This review comprehensively summarizes the applications of polymeric materials, inorganic materials, bioactive materials, and composite biomaterials for SCI treatment and regeneration, with a focus on their underlying mechanisms, therapeutic performance, and research trends. Cumulative evidence indicates that these materials possess versatile biological functions and great application potential in facilitating nerve regeneration and tissue reconstruction after SCI. In short, in-depth understanding of material-based therapeutic systems can offer innovative references for the optimization of SCI treatment regimens. Nevertheless, more preclinical and translational investigations are still indispensable to accelerate their clinical transformation and widespread practical use.<\/jats:p>","DOI":"10.3390\/gels12070566","type":"journal-article","created":{"date-parts":[[2026,6,30]],"date-time":"2026-06-30T00:55:11Z","timestamp":1782780911000},"page":"566","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Recent Advances in Diversified Materials for Spinal Cord Injury Repair and Regeneration"],"prefix":"10.3390","volume":"12","author":[{"ORCID":"https:\/\/orcid.org\/0009-0000-5246-9212","authenticated-orcid":false,"given":"Yun","family":"Wang","sequence":"first","affiliation":[{"name":"School of Life and Health Technology, Dongguan University of Technology, Dongguan 523808, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xingtao","family":"Wang","sequence":"additional","affiliation":[{"name":"School of Special Education and Rehabilitation Medicine, Shandong Medical and Pharmaceutical University, Yantai 264003, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yaqing","family":"Liu","sequence":"additional","affiliation":[{"name":"School of Life and Health Technology, Dongguan University of Technology, Dongguan 523808, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xueting","family":"Xuan","sequence":"additional","affiliation":[{"name":"School of Medicine, Xinjiang College of Science & Technology, Korla 841000, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yonghao","family":"Luo","sequence":"additional","affiliation":[{"name":"College of Chemistry and Chemical Engineering, Shihezi University, Shihezi 832000, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jihui","family":"Wang","sequence":"additional","affiliation":[{"name":"School of Life and Health Technology, Dongguan University of Technology, Dongguan 523808, China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2026,6,26]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"65","DOI":"10.1007\/s11910-019-0984-1","article-title":"Modern Medical Management of Spinal Cord Injury","volume":"19","author":"Karsy","year":"2019","journal-title":"Curr. 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