{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,1]],"date-time":"2026-07-01T13:46:02Z","timestamp":1782913562961,"version":"3.54.5"},"reference-count":53,"publisher":"MDPI AG","issue":"7","license":[{"start":{"date-parts":[[2026,7,1]],"date-time":"2026-07-01T00:00:00Z","timestamp":1782864000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"Key Research and Development Program of Liaoning Provincial Department of Education","award":["2024C011"],"award-info":[{"award-number":["2024C011"]}]},{"name":"Key Research and Development Project of the Liaoning Provincial Science and Technology Joint Program","award":["2025JH2\/101800040"],"award-info":[{"award-number":["2025JH2\/101800040"]}]},{"name":"Sinopec Research Fund","award":["225061"],"award-info":[{"award-number":["225061"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Gels"],"abstract":"<jats:p>Hydrogel dressings are critical in biomedical applications. However, developing multifunctional hydrogel dressings that combine antibacterial action, strong interfacial adhesion, and anti-inflammatory regulation remains a significant challenge. This study presents a novel chitosan-EMA-DMA hydrogel consisting of MgO and chitosan-curcumin nanoparticles. DMA endowed the hydrogel with adhesive performance, and EMA with water sorption enhanced the swelling ratio of the hydrogel which could control the release of the functional ingredient. The multifunctional composite hydrogel containing MgO and Curcumin demonstrated antibacterial activity and inflammatory regulation. The findings from the Fourier transform infrared spectrometer (FTIR), NMR, and SEM confirmed the successful material synthesis and the preparation of the composite hydrogel. The swelling ratio was enhanced by 50% after EMA was introduced. The adhesive strength of the composite hydrogel with skin tissue was enhanced to 90 kPa due to the introduction of DMA. The antibacterial study showed that Mg released from the multifunctional composite hydrogel enhanced the antibacterial efficacy of the composite hydrogel against E. coli and S. aureus. In vitro assessments revealed the biocompatibility and inflammatory regulation of the multifunctional composite hydrogel containing curcumin. This approach offers a strategic solution for wound dressing in biomedical applications.<\/jats:p>","DOI":"10.3390\/gels12070580","type":"journal-article","created":{"date-parts":[[2026,7,1]],"date-time":"2026-07-01T10:41:01Z","timestamp":1782902461000},"page":"580","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Chitosan-Based Adhesive Composite Hydrogel to Provide Antibacterial and Anti-Inflammatory Properties for Biomedical Application"],"prefix":"10.3390","volume":"12","author":[{"given":"Sinuo","family":"Yan","sequence":"first","affiliation":[{"name":"Dalian Medical University, Dalian 116044, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jingna","family":"Xu","sequence":"additional","affiliation":[{"name":"Department of Polymer Science & Materials, Dalian University of Technology, Dalian 116024, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yue","family":"Shen","sequence":"additional","affiliation":[{"name":"Department of Polymer Science & Materials, Dalian University of Technology, Dalian 116024, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chengde","family":"Liu","sequence":"additional","affiliation":[{"name":"Department of Polymer Science & Materials, Dalian University of Technology, Dalian 116024, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xigao","family":"Jian","sequence":"additional","affiliation":[{"name":"Department of Polymer Science & Materials, Dalian University of Technology, Dalian 116024, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhonghai","family":"Li","sequence":"additional","affiliation":[{"name":"Dalian Medical University, Dalian 116044, China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2026,7,1]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"66","DOI":"10.1016\/j.actbio.2021.05.055","article-title":"Engineering nanocomposite hydrogels using dynamic bonds","volume":"130","author":"Lu","year":"2021","journal-title":"Acta Biomater."},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"47323","DOI":"10.1021\/acsami.2c08582","article-title":"Multifunctional Composite Hydrogels for Bacterial Capture, Growth\/Elimination, and Sensing Applications","volume":"14","author":"Dsouza","year":"2022","journal-title":"ACS Appl. Mater. Interfaces"},{"key":"ref_3","doi-asserted-by":"crossref","first-page":"2790","DOI":"10.1080\/09205063.2024.2390745","article-title":"Enhanced osteogenesis and antibacterial activity of dual-functional PEEK implants via biomimetic polydopamine modification with chondroitin sulfate and levofloxacin","volume":"35","author":"Li","year":"2024","journal-title":"J. Biomater. Sci. Polym. Ed."},{"key":"ref_4","doi-asserted-by":"crossref","unstructured":"Jafernik, K., Ladniak, A., Blicharska, E., Czarnek, K., Ekiert, H., Wiacek, A.E., and Szopa, A. (2023). Chitosan-Based Nanoparticles as Effective Drug Delivery Systems-A review. Molecules, 28.","DOI":"10.3390\/molecules28041963"},{"key":"ref_5","doi-asserted-by":"crossref","unstructured":"Popescu, I., Constantin, M., Solcan, G., Ichim, D.L., Rata, D.M., Horodincu, L., and Solcan, C. (2023). Composite Hydrogels with Embedded Silver Nanoparticles and Ibuprofen as Wound Dressing. Gels, 9.","DOI":"10.3390\/gels9080654"},{"key":"ref_6","doi-asserted-by":"crossref","first-page":"3999","DOI":"10.1038\/s41598-025-34127-8","article-title":"A cell-laden methacrylated chitosan-based photocrosslinkable hydrogel for bone tissue engineering and its in vitro structural and biological characterization","volume":"16","author":"Samani","year":"2026","journal-title":"Sci. Rep."},{"key":"ref_7","doi-asserted-by":"crossref","first-page":"528","DOI":"10.1021\/acsapm.9b00950","article-title":"Zwitterionic Porous Conjugated Polymers as a Versatile Platform for Antibiofouling Implantable Bioelectronics","volume":"2","author":"Xu","year":"2020","journal-title":"ACS Appl. Polym. Mater."},{"key":"ref_8","doi-asserted-by":"crossref","first-page":"16772","DOI":"10.1021\/jacs.9b07105","article-title":"Impact of Antifouling PEG Layer on the Performance of Functional Peptides in Regulating Cell Behaviors","volume":"141","author":"Chen","year":"2019","journal-title":"J. Am. Chem. Soc."},{"key":"ref_9","doi-asserted-by":"crossref","first-page":"134","DOI":"10.1016\/j.colsurfb.2014.06.041","article-title":"A correlation study of protein adsorption and cell behaviors on substrates with different densities of PEG chains","volume":"122","author":"Sun","year":"2014","journal-title":"Colloids Surf. B Biointerfaces"},{"key":"ref_10","doi-asserted-by":"crossref","first-page":"1908381","DOI":"10.1002\/adfm.201908381","article-title":"Bioinspired Mineral-Organic Bone Adhesives for Stable Fracture Fixation and Accelerated Bone Regeneration","volume":"30","author":"Bai","year":"2020","journal-title":"Adv. Funct. Mater."},{"key":"ref_11","doi-asserted-by":"crossref","first-page":"11428","DOI":"10.1021\/acsami.6b16779","article-title":"Mussel-Inspired Multifunctional Hydrogel Coating for Prevention of Infections and Enhanced Osteogenesis","volume":"9","author":"Cheng","year":"2017","journal-title":"ACS Appl. Mater. Interfaces"},{"key":"ref_12","doi-asserted-by":"crossref","first-page":"65","DOI":"10.1186\/s12951-017-0308-z","article-title":"Metal nanoparticles: Understanding the mechanisms behind antibacterial activity","volume":"15","author":"Slavin","year":"2017","journal-title":"J. Nanobiotechnol."},{"key":"ref_13","doi-asserted-by":"crossref","unstructured":"Yang, L., Sun, Y., Sun, Y., Wang, J.W., Chen, L., Feng, X.L., Wang, J.G., Wang, N., Zhang, D., and Ma, C.X. (2024). Anti-Biofouling Polyzwitterion-Poly(amidoxime) Composite Hydrogel for Highly Enhanced Uranium Extraction from Seawater. Gels, 10.","DOI":"10.3390\/gels10090603"},{"key":"ref_14","doi-asserted-by":"crossref","first-page":"719","DOI":"10.1515\/epoly-2022-0055","article-title":"Regenerable bacterial killing-releasing ultrathin smart hydrogel surfaces modified with zwitterionic polymer brushes","volume":"22","author":"Xiao","year":"2022","journal-title":"e-Polymers"},{"key":"ref_15","doi-asserted-by":"crossref","unstructured":"Zainuddin, A.N.Z., Mustakim, N.N., Rosemanzailani, F.A., Fadilah, N.I.M., Maarof, M., and Fauzi, M.B. (2025). A Comprehensive Review of Honey-Containing Hydrogel for Wound Healing Applications. Gels, 11.","DOI":"10.3390\/gels11030194"},{"key":"ref_16","doi-asserted-by":"crossref","unstructured":"Ruan, L.H., Pan, C.F., Ran, X.T., Wen, Y.L., Lang, R., Peng, M., Cao, J.F., and Yang, J. (2024). Dual-Delivery Temperature-Sensitive Hydrogel with Antimicrobial and Anti-Inflammatory Brevilin A and Nitric Oxide for Wound Healing in Bacterial Infection. Gels, 10.","DOI":"10.3390\/gels10040219"},{"key":"ref_17","doi-asserted-by":"crossref","first-page":"4601","DOI":"10.1021\/acsbiomaterials.9b00604","article-title":"Fabrication of Hybrid Hydrogels from Silk Fibroin and Tannic Acid with Enhanced Gelation and Antibacterial Activities","volume":"5","author":"Jing","year":"2019","journal-title":"ACS Biomater. Sci. Eng."},{"key":"ref_18","doi-asserted-by":"crossref","unstructured":"Hasanzade, P., Mosayebi, G., Ganji, A., Fahimirad, S., and Ghazavi, A. (2025). Curcumin-loaded chitosan nanoparticles: A promising approach to liver fibrosis prevention. BMC Pharmacol. Toxicol., 26.","DOI":"10.1186\/s40360-025-01031-w"},{"key":"ref_19","doi-asserted-by":"crossref","unstructured":"Gholamali, I., Jo, S.H., Han, W., Lim, J., Rizwan, A., Park, S.H., and Lim, K.T. (2024). The Diels-Alder Cross-Linked Gelatin\/Dextran Nanocomposite Hydrogels with Silver Nanoparticles for Wound Healing Applications: Synthesis, Characterization, and In Vitro Evaluation. Gels, 10.","DOI":"10.3390\/gels10060408"},{"key":"ref_20","doi-asserted-by":"crossref","first-page":"54","DOI":"10.1186\/s12951-016-0202-0","article-title":"Study on the mechanism of antibacterial action of magnesium oxide nanoparticles against foodborne pathogens","volume":"14","author":"He","year":"2016","journal-title":"J. Nanobiotechnol."},{"key":"ref_21","doi-asserted-by":"crossref","first-page":"1869","DOI":"10.1016\/j.actbio.2009.10.007","article-title":"In vitro antibacterial properties of magnesium metal against Escherichia coli, Pseudomonas aeruginosa and Staphylococcus aureus","volume":"6","author":"Robinson","year":"2010","journal-title":"Acta Biomater."},{"key":"ref_22","doi-asserted-by":"crossref","unstructured":"Peng, S.Y., Cao, X.Y., Sun, Y., Chen, L., Ma, C., Yang, L., Zhao, H.L., Liu, Q.J., Liu, Z.Z., and Ma, C.X. (2023). Polyurethane Shape Memory Polymer\/pH-Responsive Hydrogel Hybrid for Bi-Function Synergistic Actuations. Gels, 9.","DOI":"10.3390\/gels9050428"},{"key":"ref_23","doi-asserted-by":"crossref","first-page":"123322","DOI":"10.1016\/j.carbpol.2025.123322","article-title":"pH-responsive and self-adaptive injectable sodium alginate\/carboxymethyl chitosan hydrogel accelerates infected wound healing by bacteriostasis and immunomodulation","volume":"354","author":"Zhang","year":"2025","journal-title":"Carbohydr. Polym."},{"key":"ref_24","doi-asserted-by":"crossref","first-page":"1679","DOI":"10.2147\/IJN.S505918","article-title":"Injectable Nanocomposite Hydrogel for Accelerating Diabetic Wound Healing Through Inflammatory Microenvironment Regulation","volume":"20","author":"Chen","year":"2025","journal-title":"Int. J. Nanomed."},{"key":"ref_25","doi-asserted-by":"crossref","first-page":"2423356","DOI":"10.1002\/adfm.202423356","article-title":"Poly(ectoine)-Based Adhesive Hydrogel with Antimicrobial and Anti-Inflammatory Properties for Wound Treatment","volume":"35","author":"Wang","year":"2025","journal-title":"Adv. Funct. Mater."},{"key":"ref_26","doi-asserted-by":"crossref","first-page":"123380","DOI":"10.1016\/j.carbpol.2025.123380","article-title":"Synergistic adhesion enhancement of double-crosslinking chitosan hydrogel via catechol-Fe3+ coordination and Schiff base","volume":"356","author":"Zhao","year":"2025","journal-title":"Carbohydr. Polym."},{"key":"ref_27","doi-asserted-by":"crossref","first-page":"116760","DOI":"10.1016\/j.carbpol.2020.116760","article-title":"Balanced adhesion and cohesion of chitosan matrices by conjugation and oxidation of catechol for high-performance surgical adhesives","volume":"248","author":"Park","year":"2020","journal-title":"Carbohydr. Polym."},{"key":"ref_28","doi-asserted-by":"crossref","first-page":"110864","DOI":"10.1016\/j.jbiomech.2021.110864","article-title":"Mechanical modeling and characterization of human skin: A review","volume":"130","author":"Yazdi","year":"2022","journal-title":"J. Biomech."},{"key":"ref_29","doi-asserted-by":"crossref","unstructured":"Tyagi, P., Singh, M., Kumari, H., Kumari, A., and Mukhopadhyay, K. (2015). Bactericidal Activity of Curcumin I Is Associated with Damaging of Bacterial Membrane. PLoS ONE, 10.","DOI":"10.1371\/journal.pone.0121313"},{"key":"ref_30","doi-asserted-by":"crossref","first-page":"11264","DOI":"10.1021\/acs.langmuir.7b02434","article-title":"Poly(ectoine) Hydrogels Resist Nonspecific Protein Adsorption","volume":"33","author":"Jain","year":"2017","journal-title":"Langmuir"},{"key":"ref_31","first-page":"546","article-title":"PDA-BPs integrated mussel-inspired multifunctional hydrogel coating on PPENK implants for anti-tumor therapy, antibacterial infection and bone regeneration","volume":"27","author":"Li","year":"2023","journal-title":"Bioact. Mater."},{"key":"ref_32","doi-asserted-by":"crossref","first-page":"10221","DOI":"10.1039\/D4TB00670D","article-title":"Modelling methacrylated chitosan hydrogel properties through an experimental design approach: From composition to material properties","volume":"12","author":"Bucciarelli","year":"2024","journal-title":"J. Mater. Chem. B"},{"key":"ref_33","doi-asserted-by":"crossref","unstructured":"Ma, P.F., Da, J.L., Zhao, G.H., Suo, F.Y., Li, Y., Zhou, X.C., Li, Y., Han, Y.H., Zou, M.Y., and Dou, X.M. (2025). Injectable Light-Responsive Hydrogel Dressing Promotes Diabetic Wound Healing by Enhancing Wound Angiogenesis and Inhibiting Inflammation. Polymers, 17.","DOI":"10.3390\/polym17050607"},{"key":"ref_34","doi-asserted-by":"crossref","first-page":"410","DOI":"10.1016\/j.ijbiomac.2022.02.025","article-title":"Chitosan nanoparticles embedded with curcumin and its application in pork antioxidant edible coating","volume":"204","author":"Shen","year":"2022","journal-title":"Int. J. Biol. Macromol."},{"key":"ref_35","doi-asserted-by":"crossref","first-page":"2404966","DOI":"10.1002\/adhm.202404966","article-title":"A Smart MMP-9-responsive Hydrogel Releasing M2 Macrophage-derived Exosomes for Diabetic Wound Healing","volume":"14","author":"Meng","year":"2025","journal-title":"Adv. Healthc. Mater."},{"key":"ref_36","doi-asserted-by":"crossref","first-page":"124134","DOI":"10.1016\/j.ijpharm.2024.124134","article-title":"A pH\/ROS-responsive antioxidative and antimicrobial GelMA hydrogel for on-demand drug delivery and enhanced osteogenic differentiation in vitro","volume":"657","author":"Qi","year":"2024","journal-title":"Int. J. Pharm."},{"key":"ref_37","doi-asserted-by":"crossref","first-page":"065010","DOI":"10.1088\/1748-605X\/ac9268","article-title":"Design, synthesis, and characterization of a novel dual cross-linked gelatin-based bioadhesive for hard and soft tissues adhesion capability","volume":"17","author":"Pirmoradian","year":"2022","journal-title":"Biomed. Mater."},{"key":"ref_38","doi-asserted-by":"crossref","first-page":"2401369","DOI":"10.1002\/adma.202401369","article-title":"Stem Cell-Derived Nanovesicles Embedded in Dual-Layered Hydrogel for Programmed ROS Regulation and Comprehensive Tissue Regeneration in Burn Wound Healing","volume":"36","author":"Zhao","year":"2024","journal-title":"Adv. Mater."},{"key":"ref_39","doi-asserted-by":"crossref","first-page":"1662","DOI":"10.1002\/jbm.a.37715","article-title":"Evaluating the polymerization effectiveness and biocompatibility of bio-sourced, visible light-based photoinitiator systems","volume":"112","author":"Wendland","year":"2024","journal-title":"J. Biomed. Mater. Res. A"},{"key":"ref_40","doi-asserted-by":"crossref","first-page":"8987","DOI":"10.1021\/jacs.2c00749","article-title":"Acid Neutralization and Immune Regulation by Calcium-Aluminum-Layered Double Hydroxide for Osteoporosis Reversion","volume":"144","author":"Fu","year":"2022","journal-title":"J. Am. Chem. Soc."},{"key":"ref_41","doi-asserted-by":"crossref","first-page":"137649","DOI":"10.1016\/j.ijbiomac.2024.137649","article-title":"Controlled release of magnesium ions from PLA microsphere-chitosan hydrogel complex for enhancing osteogenic and angiogenic activities in vitro","volume":"283","author":"Li","year":"2024","journal-title":"Int. J. Biol. Macromol."},{"key":"ref_42","doi-asserted-by":"crossref","first-page":"122471","DOI":"10.1016\/j.memsci.2024.122471","article-title":"Endothelial membrane mimetic coating modified dialyzer for hemocompatible and anticoagulant-free hemodialysis","volume":"695","author":"Sun","year":"2024","journal-title":"J. Membr. Sci."},{"key":"ref_43","doi-asserted-by":"crossref","unstructured":"Zhou, T., Chen, Y.D., Fu, L.M., Wang, S., Ding, H.H., Bai, Q.S., Guan, J.J., and Mao, Y.J. (2024). In situ MgO nanoparticle-doped Janus electrospun dressing against bacterial invasion and immune imbalance for irregular wound healing. Regen. Biomater., 11.","DOI":"10.1093\/rb\/rbae107"},{"key":"ref_44","doi-asserted-by":"crossref","first-page":"119642","DOI":"10.1016\/j.biomaterials.2019.119642","article-title":"Tuning the surface immunomodulatory functions of polyetheretherketone for enhanced osseointegration","volume":"230","author":"Gao","year":"2020","journal-title":"Biomaterials"},{"key":"ref_45","doi-asserted-by":"crossref","first-page":"17854","DOI":"10.1021\/acsnano.1c06062","article-title":"ZnL2-BPs Integrated Bone Scaffold under Sequential Photothermal Mediation: A Win-Win Strategy Delivering Antibacterial Therapy and Fostering Osteogenesis Thereafter","volume":"15","author":"Wu","year":"2021","journal-title":"ACS Nano"},{"key":"ref_46","doi-asserted-by":"crossref","first-page":"134222","DOI":"10.1016\/j.ijbiomac.2024.134222","article-title":"Sustained-release, antibacterial, adhesive gelatin composite hydrogel with AgNPs double-capped with curdlan derivatives","volume":"277","author":"Zhang","year":"2024","journal-title":"Int. J. Biol. Macromol."},{"key":"ref_47","doi-asserted-by":"crossref","first-page":"2100262","DOI":"10.1002\/mabi.202100262","article-title":"Apatite Formation Induced by Chitosan\/Gelatin Hydrogel Coating Anchored on Poly(aryl ether nitrile ketone) Substrates to Promote Osteoblastic Differentiation","volume":"21","author":"Li","year":"2021","journal-title":"Macromol. Biosci."},{"key":"ref_48","doi-asserted-by":"crossref","first-page":"2308205","DOI":"10.1002\/adfm.202308205","article-title":"Spatiotemporalized Hydrogel Microspheres Promote Vascularized Osteogenesis via Ultrasound Oxygen Delivery","volume":"34","author":"Chen","year":"2024","journal-title":"Adv. Funct. Mater."},{"key":"ref_49","doi-asserted-by":"crossref","first-page":"556","DOI":"10.1186\/s12951-024-02783-z","article-title":"A novel spherical GelMA-HAMA hydrogel encapsulating APETx2 polypeptide and CFIm25-targeting sgRNA for immune microenvironment modulation and nucleus pulposus regeneration in intervertebral discs","volume":"22","author":"Yu","year":"2024","journal-title":"J. Nanobiotechnol."},{"key":"ref_50","doi-asserted-by":"crossref","first-page":"639","DOI":"10.1016\/j.ijbiomac.2022.07.125","article-title":"Tunicate inspired gelatin-based tough hydrogel wound dressing containing twisted phthalazinone with adhesive, self-healing and antibacterial properties","volume":"218","author":"Li","year":"2022","journal-title":"Int. J. Biol. Macromol."},{"key":"ref_51","doi-asserted-by":"crossref","first-page":"2302674","DOI":"10.1002\/advs.202302674","article-title":"Copper-Zinc-Doped Bilayer Bioactive Glasses Loaded Hydrogel with Spatiotemporal Immunomodulation Supports MRSA-Infected Wound Healing","volume":"11","author":"Huo","year":"2024","journal-title":"Adv. Sci."},{"key":"ref_52","doi-asserted-by":"crossref","first-page":"28353","DOI":"10.1021\/acsnano.5c06549","article-title":"An Immunomodulating Regenerating Hydrogel That Rescues the Oxidative Microenvironment and Reverses Cell Senescence for Osteoporotic Bone Defects","volume":"19","author":"Wang","year":"2025","journal-title":"ACS Nano"},{"key":"ref_53","doi-asserted-by":"crossref","first-page":"102474","DOI":"10.1016\/j.mtbio.2025.102474","article-title":"4\u2032-hydroxychalcone nanofiber hydrogel dressing promotes diabetic chronic wound healing by regulating macrophage polarization via the TLR\/IL-17\/ TNF signaling pathway","volume":"35","author":"Li","year":"2025","journal-title":"Mater. 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