{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,13]],"date-time":"2026-08-13T09:29:54Z","timestamp":1786613394256,"version":"build-2736575974"},"reference-count":40,"publisher":"MDPI AG","issue":"8","license":[{"start":{"date-parts":[[2026,8,13]],"date-time":"2026-08-13T00:00:00Z","timestamp":1786579200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"Hubei Provincial Natural Science Foundation Xiaogan Innovation Development Joint Fund","award":["2026AFC0674"],"award-info":[{"award-number":["2026AFC0674"]}]},{"name":"Central Guidance for Local Science and Technology Development Fund Project","award":["2025CSA127"],"award-info":[{"award-number":["2025CSA127"]}]},{"name":"Youth Talent Program of the Scientific Research Plan of Hubei Provincial Department of Education","award":["Q20242704"],"award-info":[{"award-number":["Q20242704"]}]},{"award":["Q20242704"],"award-info":[{"award-number":["Q20242704"]}],"id":[{"id":"https:\/\/ror.org\/05yaa9j15","id-type":"ROR","asserted-by":"publisher"}]},{"name":"Xiaogan Natural Science Program Project","award":["XGKJ2024010017"],"award-info":[{"award-number":["XGKJ2024010017"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Gels"],"abstract":"<jats:p>Conventional wound dressings suffer from unbalanced tissue adhesion, skin-mismatched mechanical properties, and insufficient long-term bioactivity. Herein, a dual physically cross-linked multifunctional tissue adhesive lentinan\u2013polyvinyl alcohol (PVA)\u2013tannic acid membrane (LPTM) was fabricated via a freeze\u2013thaw-assisted immersion strategy. The optimized LPTM-3 hydrogel patch, with a stable network formed by PVA crystalline cross-linking and hydrogen bond cross-linking, achieved a balanced tensile strength of 16.1 MPa and an elongation at break of 149.3%, robust yet non-damaging porcine skin adhesion of 163.17 kPa, antibacterial activity, and good biocompatibility with a hemolysis rate below 2.24%. Notably, LPTM-3 promoted fibroblast migration and modulated inflammatory cytokine expression in vitro, and achieved 99.06% full-thickness wound closure in rats on day 14, matching a commercial dressing. This work provides a promising candidate for clinical wound repair and a facile design strategy for polysaccharide-based bioadhesive materials.<\/jats:p>","DOI":"10.3390\/gels12080716","type":"journal-article","created":{"date-parts":[[2026,8,13]],"date-time":"2026-08-13T08:06:16Z","timestamp":1786608376000},"page":"716","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Lentinan-Based Multifunctional Composite Hydrogel for Wound Healing"],"prefix":"10.3390","volume":"12","author":[{"given":"Niu","family":"Liu","sequence":"first","affiliation":[{"name":"Hubei Key Laboratory of Resource Utilization and Quality Control of Characteristic Crops, College of Life Science and Technology, Hubei Engineering University, Xiaogan 432000, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wengui","family":"Xu","sequence":"additional","affiliation":[{"name":"Hubei Key Laboratory of Resource Utilization and Quality Control of Characteristic Crops, College of Life Science and Technology, Hubei Engineering University, Xiaogan 432000, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xinmiao","family":"He","sequence":"additional","affiliation":[{"name":"Hubei Key Laboratory of Resource Utilization and Quality Control of Characteristic Crops, College of Life Science and Technology, Hubei Engineering University, Xiaogan 432000, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jinwang","family":"Zou","sequence":"additional","affiliation":[{"name":"Hubei Key Laboratory of Resource Utilization and Quality Control of Characteristic Crops, College of Life Science and Technology, Hubei Engineering University, Xiaogan 432000, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jinhao","family":"Pan","sequence":"additional","affiliation":[{"name":"Hubei Key Laboratory of Resource Utilization and Quality Control of Characteristic Crops, College of Life Science and Technology, Hubei Engineering University, Xiaogan 432000, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chenyi","family":"Feng","sequence":"additional","affiliation":[{"name":"Hubei Key Laboratory of Resource Utilization and Quality Control of Characteristic Crops, College of Life Science and Technology, Hubei Engineering University, Xiaogan 432000, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yao","family":"Wu","sequence":"additional","affiliation":[{"name":"Hubei Key Laboratory of Resource Utilization and Quality Control of Characteristic Crops, College of Life Science and Technology, Hubei Engineering University, Xiaogan 432000, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4699-8609","authenticated-orcid":false,"given":"Changchun","family":"Li","sequence":"additional","affiliation":[{"name":"Hubei Key Laboratory of Resource Utilization and Quality Control of Characteristic Crops, College of Life Science and Technology, Hubei Engineering University, Xiaogan 432000, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hairong","family":"Xiong","sequence":"additional","affiliation":[{"name":"Hubei Key Laboratory of Resource Utilization and Quality Control of Characteristic Crops, College of Life Science and Technology, Hubei Engineering University, Xiaogan 432000, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5944-2693","authenticated-orcid":false,"given":"Zongbao","family":"Zhou","sequence":"additional","affiliation":[{"name":"Hubei Key Laboratory of Resource Utilization and Quality Control of Characteristic Crops, College of Life Science and Technology, Hubei Engineering University, Xiaogan 432000, China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2026,8,13]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"100918","DOI":"10.1016\/j.mtbio.2023.100918","article-title":"Advanced function, design and application of skin substitutes for skin regeneration","volume":"24","author":"Zhang","year":"2023","journal-title":"Mater. 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