{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,6]],"date-time":"2026-10-06T04:56:29Z","timestamp":1791262589351,"version":"4.1.0"},"reference-count":46,"publisher":"MDPI AG","issue":"8","license":[{"start":{"date-parts":[[2026,8,17]],"date-time":"2026-08-17T00:00:00Z","timestamp":1786924800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"Shaanxi Provincial Department of Science and Technology Key Research and Development Program for Social Development Challenges","award":["2024SF2-GJHX-60"],"award-info":[{"award-number":["2024SF2-GJHX-60"]}]},{"name":"Shaanxi University of Technology Qinba Biological Resources and Ecological Environment National Key Laboratory","award":["SXC-2111:SXZC-2301"],"award-info":[{"award-number":["SXC-2111:SXZC-2301"]}]},{"award":["SXC-2111:SXZC-2301"],"award-info":[{"award-number":["SXC-2111:SXZC-2301"]}],"id":[{"id":"https:\/\/ror.org\/056m91h77","id-type":"ROR","asserted-by":"publisher"}]},{"name":"Shaanxi University of Technology Talent Launch Project","award":["SLGRCQD2002"],"award-info":[{"award-number":["SLGRCQD2002"]}]},{"award":["SLGRCQD2002"],"award-info":[{"award-number":["SLGRCQD2002"]}],"id":[{"id":"https:\/\/ror.org\/056m91h77","id-type":"ROR","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Gels"],"abstract":"<jats:p>Plant-mediated green synthesis of silver nanoparticles (AgNPs) predominantly relies on single botanical sources, constraining reduction efficiency and forfeiting the therapeutic potential of residual biomass. This study employed aloe vera and birch bark extracts as reducing agents. A combination of single-factor analysis and response surface methodology was employed to prepare monodisperse 30 nm AgNPs (with a Zeta potential of \u221235.3 mV and confirmed by XPS as metallic Ag0). It was loaded into carboxymethyl chitosan-vanillin-polyvinyl alcohol (CVP) gel microneedles using the vacuum casting method. The mechanical strength of these microneedles reaches 0.302 N\/needle, exceeding the skin penetration threshold. Throughout the entire preparation process, both its Ag0 chemical state and crystal structure were maintained (by FT-IR and XRD). The MIC values of AgNPs@CVP against four pathogens ranged from 0.977 to 7.813 \u03bcg\/mL, with a biofilm disruption rate exceeding 70%, and demonstrated excellent biocompatibility (hemolytic rate &lt; 1.6%, cell survival rate &gt; 80%). In a rat wound infection model, high-dose microneedle therapy reduced the residual wound area to 10.9% by day 9. This strategy inhibited the secretion of TNF-\u03b1 and IL-6 while promoting epithelial regeneration, angiogenesis, and collagen deposition. This bifunctional Aloe-Birch strategy converges green nanomaterial synthesis with therapeutic delivery within a single bio-based platform, advancing sustainable nanomedicine paradigms and providing a resource-efficient blueprint for clinical infectious wound management.<\/jats:p>","DOI":"10.3390\/gels12080736","type":"journal-article","created":{"date-parts":[[2026,8,17]],"date-time":"2026-08-17T13:42:17Z","timestamp":1786974137000},"page":"736","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Bifunctional Aloe-Birch Extracts for Green Silver Nanoparticle Synthesis and Synergistic Antimicrobial Microneedles Toward Infected Wound Healing"],"prefix":"10.3390","volume":"12","author":[{"given":"Shun","family":"Zhang","sequence":"first","affiliation":[{"name":"School of Biological Science and Engineering, Shaanxi University of Technology, Hanzhong 723000, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xu","family":"Liu","sequence":"additional","affiliation":[{"name":"School of Biological Science and Engineering, Shaanxi University of Technology, Hanzhong 723000, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yiyun","family":"Wei","sequence":"additional","affiliation":[{"name":"School of Biological Science and Engineering, Shaanxi University of Technology, Hanzhong 723000, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kun","family":"Bao","sequence":"additional","affiliation":[{"name":"School of Biological Science and Engineering, Shaanxi University of Technology, Hanzhong 723000, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiaojuan","family":"Zhang","sequence":"additional","affiliation":[{"name":"School of Biological Science and Engineering, Shaanxi University of Technology, Hanzhong 723000, China"},{"name":"Shaanxi Province Key Laboratory of Bio-Resources, Hanzhong 723000, China"},{"name":"Qinba State Key Laboratory of Biological Resources and Ecological Environment (Incubation), Hanzhong 723000, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chenlu","family":"Zhang","sequence":"additional","affiliation":[{"name":"School of Biological Science and Engineering, Shaanxi University of Technology, Hanzhong 723000, China"},{"name":"Shaanxi Province Key Laboratory of Bio-Resources, Hanzhong 723000, China"},{"name":"Qinba State Key Laboratory of Biological Resources and Ecological Environment (Incubation), Hanzhong 723000, China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2026,8,17]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"e25438","DOI":"10.1016\/j.heliyon.2024.e25438","article-title":"Aloe Vera Assisted Green Synthesis of Ag and Cu Co-Doped ZnO Nanoparticles and a Comprehensive Analysis of Their Structural, Morphological, Optical, Electrical and Antibacterial Properties","volume":"10","author":"Rashid","year":"2024","journal-title":"Heliyon"},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"1309","DOI":"10.1007\/s40265-023-01935-z","article-title":"Birch Bark Extract: A Review in Epidermolysis Bullosa","volume":"83","author":"Heo","year":"2023","journal-title":"Drugs"},{"key":"ref_3","doi-asserted-by":"crossref","first-page":"187","DOI":"10.1007\/s42114-026-01733-7","article-title":"Novel Green-Engineered Hierarchical PLA-Ag Nanohybrids for Antimicrobial Environmental Purification","volume":"9","author":"Gattucci","year":"2026","journal-title":"Adv. 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