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Hydrogels, with their highly tunable network structures, offer a unique platform to program release kinetics in synchrony with these healing timelines. This review systematically examines design strategies for phase-synchronized hydrogel systems, categorized into three hierarchical paradigms: intrinsic network control (crosslinking density, degradation kinetics, and architectural engineering) that pre-programs release profiles; extrinsic\/responsive control (endogenous pH\/ROS\/MMP\/glucose and exogenous NIR\/ultrasound\/electro\/magnetic triggers) that enables on-demand phase-shifting; and integrated systems that combine passive spatial compartmentalization with active responsiveness. We survey representative applications across cutaneous wounds, bone defects, cartilage, tendon, myocardial, and neural tissues, highlighting both common design principles and tissue-specific adaptations. Key translational bottlenecks\u2014including in vivo\u2013in vitro discrepancies, cargo stability, sterilization challenges, and regulatory complexity\u2014are critically examined, alongside emerging frontiers such as closed-loop biosensing, artificial intelligence-driven design, and four-dimensional printing. We conclude that the field is evolving from passive drug depots toward active therapeutic synchronizers, where material programming is set to the body\u2019s biological clock, offering a transformative paradigm for regenerative medicine.<\/jats:p>","DOI":"10.3390\/gels12090805","type":"journal-article","created":{"date-parts":[[2026,9,3]],"date-time":"2026-09-03T11:08:53Z","timestamp":1788433733000},"page":"805","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Programming Hydrogel Release Kinetics to Tissue Healing Phases: From Network Design to Therapeutic Synchronization"],"prefix":"10.3390","volume":"12","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-1369-6153","authenticated-orcid":false,"given":"Qiao","family":"Chen","sequence":"first","affiliation":[{"name":"School of Pharmacy, Hubei University of Chinese Medicine, Wuhan 430065, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tong","family":"Wang","sequence":"additional","affiliation":[{"name":"School of Pharmacy, Hubei University of Chinese Medicine, Wuhan 430065, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2700-1770","authenticated-orcid":false,"given":"Lusi","family":"Zou","sequence":"additional","affiliation":[{"name":"College of Chemistry and Chemical Engineering, Hubei University, Wuhan 430062, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qi","family":"Dong","sequence":"additional","affiliation":[{"name":"School of Biomedical Engineering and Health, Wuhan Textile University, Wuhan 430200, China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2026,9,3]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"355","DOI":"10.1016\/j.jcis.2023.12.156","article-title":"Toward chronopharmaceutical drug delivery patches and biomaterial coatings for the facilitation of wound healing","volume":"659","author":"Uskokovic","year":"2024","journal-title":"J. Colloid Interface Sci."},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"101116","DOI":"10.1016\/j.apmt.2021.101116","article-title":"Spatiotemporal manipulation of L-arginine release from bioactive hydrogels initiates rapid skin wound healing accompanied with repressed scar formation","volume":"24","author":"Ling","year":"2021","journal-title":"Appl. Mater. Today"},{"key":"ref_3","doi-asserted-by":"crossref","first-page":"178","DOI":"10.1016\/j.actbio.2026.05.002","article-title":"Rocket propulsion-inspired two-stage nitric oxide-releasing hydrogel for phase-matched therapy of diabetic wounds","volume":"217","author":"Chen","year":"2026","journal-title":"Acta Biomater."},{"key":"ref_4","doi-asserted-by":"crossref","first-page":"107","DOI":"10.1016\/j.ijpharm.2009.12.063","article-title":"Migration of marrow stromal cells in response to sustained release of stromal-derived factor-1\u03b1 from poly(lactide ethylene oxide fumarate) hydrogels","volume":"390","author":"He","year":"2010","journal-title":"Int. J. Pharm."},{"key":"ref_5","doi-asserted-by":"crossref","first-page":"360","DOI":"10.1016\/j.jiec.2017.05.007","article-title":"Preparation and evaluation of visible-light cured glycol chitosan hydrogel dressing containing dual growth factors for accelerated wound healing","volume":"53","author":"Yang","year":"2017","journal-title":"J. Ind. Eng. Chem."},{"key":"ref_6","doi-asserted-by":"crossref","first-page":"438","DOI":"10.1016\/j.msec.2019.03.080","article-title":"Bi-layered \u03b1-tocopherol acetate loaded membranes for potential wound healing and skin regeneration","volume":"101","author":"Zahid","year":"2019","journal-title":"Mater. Sci. Eng. C"},{"key":"ref_7","doi-asserted-by":"crossref","first-page":"148661","DOI":"10.1016\/j.ijbiomac.2025.148661","article-title":"Development of gelatin\/pectin bioactive composite films loaded with thymol and phytosynthesized magnesium oxide nanoparticles for enhanced wound healing","volume":"332","author":"Manaa","year":"2025","journal-title":"Int. J. Biol. Macromol."},{"key":"ref_8","doi-asserted-by":"crossref","unstructured":"Xu, F., Peng, J.C., Li, Y.L., Huang, Z.X., Teng, M.J., Gan, C.L., and Liao, T. (2026). Ononin-modified Chitosan\/\u03b2-glycerophosphate hydrogel-loaded adipose-derived stem cells promote the repair of diabetic wounds in rats. BMC Biotechnol., 26.","DOI":"10.1186\/s12896-026-01135-z"},{"key":"ref_9","doi-asserted-by":"crossref","first-page":"9166","DOI":"10.1039\/D5TB00579E","article-title":"Dual and sequential drug delivery systems with antimicrobial and bone regenerative therapeutic effects","volume":"13","author":"Rodrigues","year":"2025","journal-title":"J. Mater. Chem. B"},{"key":"ref_10","doi-asserted-by":"crossref","first-page":"80","DOI":"10.1016\/j.jconrel.2021.11.017","article-title":"Fabricating scalable, personalized wound dressings with customizable drug loadings via 3D printing","volume":"341","author":"Teoh","year":"2022","journal-title":"J. Control. Release"},{"key":"ref_11","doi-asserted-by":"crossref","first-page":"9098","DOI":"10.1016\/j.actbio.2013.07.008","article-title":"The influence of collagen and hyaluronan matrices on the delivery and bioactivity of bone morphogenetic protein-2 and ectopic bone formation","volume":"9","author":"Bhakta","year":"2013","journal-title":"Acta Biomater."},{"key":"ref_12","doi-asserted-by":"crossref","first-page":"100095","DOI":"10.1016\/j.fhfh.2022.100095","article-title":"Development of dietary fibers moringa-sterculia gum hydrogel for drug delivery applications","volume":"2","author":"Singh","year":"2022","journal-title":"Food Hydrocoll. Health"},{"key":"ref_13","doi-asserted-by":"crossref","first-page":"1136","DOI":"10.1016\/j.ijbiomac.2016.08.011","article-title":"Radiation formation of functionalized polysaccharide-protein based skin mimicking semi-inter penetrating network for biomedical application","volume":"92","author":"Singh","year":"2016","journal-title":"Int. J. Biol. Macromol."},{"key":"ref_14","doi-asserted-by":"crossref","first-page":"295","DOI":"10.1039\/C3TB21103G","article-title":"Injectable and redox-responsive hydrogel with adaptive degradation rate for bone regeneration","volume":"2","author":"Yang","year":"2014","journal-title":"J. Mater. Chem. B"},{"key":"ref_15","doi-asserted-by":"crossref","first-page":"1502","DOI":"10.1039\/C2PY20889J","article-title":"Microgels or microcapsules? Role of morphology on the release kinetics of thermoresponsive PNIPAm-co-PEGMa hydrogels","volume":"4","author":"Trongsatitkul","year":"2013","journal-title":"Polym. Chem."},{"key":"ref_16","doi-asserted-by":"crossref","first-page":"1722","DOI":"10.1039\/D5TB01773D","article-title":"pH-Triggered antibiotic release from nanofiber-hydrogel hybrid dressings for infected wound healing","volume":"14","author":"Yu","year":"2026","journal-title":"J. Mater. Chem. B"},{"key":"ref_17","doi-asserted-by":"crossref","first-page":"e21475","DOI":"10.1002\/adma.202521475","article-title":"Micropore-Confined ROS-Responsive 3D-Printed Shell-Core Scaffolds for Long-Term NO Release to Orchestrate Immunomodulation and Angiogenesis in Diabetic Bone Defect Repair","volume":"38","author":"Guo","year":"2026","journal-title":"Adv. Mater."},{"key":"ref_18","doi-asserted-by":"crossref","first-page":"e2404966","DOI":"10.1002\/adhm.202404966","article-title":"A Smart MMP-9-responsive Hydrogel Releasing M2 Macrophage-derived Exosomes for Diabetic Wound Healing","volume":"14","author":"Meng","year":"2025","journal-title":"Adv. Healthc. Mater."},{"key":"ref_19","doi-asserted-by":"crossref","first-page":"e17906","DOI":"10.1002\/adfm.202517906","article-title":"Biomimetic Mineralized Hydrogel with Sequential Multifactor Release Capability for Bone Regeneration","volume":"36","author":"Zhao","year":"2026","journal-title":"Adv. Funct. Mater."},{"key":"ref_20","doi-asserted-by":"crossref","first-page":"176349","DOI":"10.1016\/j.cej.2025.168177","article-title":"Spatiotemporally-graded BHP\/G@met scaffold system enables sequential angiogenesis-osteogenesis coupling for accelerated bone regeneration","volume":"522","author":"Zhang","year":"2025","journal-title":"Chem. Eng. J."},{"key":"ref_21","doi-asserted-by":"crossref","first-page":"596","DOI":"10.1089\/wound.2020.1183","article-title":"Advancements in the Delivery of Growth Factors and Cytokines for the Treatment of Cutaneous Wound Indications","volume":"10","author":"Cabral","year":"2021","journal-title":"Adv. Wound Care"},{"key":"ref_22","doi-asserted-by":"crossref","first-page":"122388","DOI":"10.1016\/j.biomaterials.2023.122388","article-title":"Architecturally designed sequential-release hydrogels","volume":"303","author":"Zhang","year":"2023","journal-title":"Biomaterials"},{"key":"ref_23","doi-asserted-by":"crossref","first-page":"846","DOI":"10.1016\/j.jconrel.2024.06.065","article-title":"Spatiotemporal controlled released hydrogels for multi-system regulated bone regeneration","volume":"372","author":"Chen","year":"2024","journal-title":"J. Control. Release"},{"key":"ref_24","doi-asserted-by":"crossref","first-page":"199e","DOI":"10.1097\/01.prs.0000437224.02985.f9","article-title":"Wound Healing","volume":"133","author":"Janis","year":"2014","journal-title":"Plast. Reconstr. Surg."},{"key":"ref_25","doi-asserted-by":"crossref","first-page":"817","DOI":"10.1186\/s13018-024-05304-8","article-title":"Mechanisms of tendon-bone interface healing: Biomechanics, cell mechanics, and tissue engineering approaches","volume":"19","author":"Xu","year":"2024","journal-title":"J. Orthop. Surg. Res."},{"key":"ref_26","doi-asserted-by":"crossref","first-page":"998","DOI":"10.1186\/s13018-025-06436-1","article-title":"Anti-adhesive agents in tendon repair: Mechanisms, preclinical evidence, clinical challenges, and future perspectives\u2014A narrative review","volume":"20","author":"Kadkhodaei","year":"2025","journal-title":"J. Orthop. Surg. Res."},{"key":"ref_27","doi-asserted-by":"crossref","first-page":"4494","DOI":"10.1021\/acs.biomac.2c01408","article-title":"Release Kinetics of Dexamethasone Phosphate from Porous Chitosan: Comparison of Aerogels and Cryogels","volume":"24","author":"Chartier","year":"2023","journal-title":"Biomacromolecules"},{"key":"ref_28","doi-asserted-by":"crossref","first-page":"385","DOI":"10.1016\/j.ijbiomac.2021.03.169","article-title":"A pH-sensitive oxidized-dextran based double drug-loaded hydrogel with high antibacterial properties","volume":"182","author":"Zhang","year":"2021","journal-title":"Int. J. Biol. Macromol."},{"key":"ref_29","doi-asserted-by":"crossref","first-page":"107418","DOI":"10.1016\/j.jddst.2025.107418","article-title":"Quality by Design (QbD) accredited naringenin-loaded chitosan nanoparticles impregnated gel for diabetic wound healing: Formulation, optimization, In silico and In vitro characterization","volume":"114","author":"Abraham","year":"2025","journal-title":"J. Drug Deliv. Sci. Technol."},{"key":"ref_30","doi-asserted-by":"crossref","first-page":"3994","DOI":"10.1039\/D3TB00463E","article-title":"A spatiotemporal release hydrogel based on an M1-to-M2 immunoenvironment for wound management","volume":"11","author":"Xiao","year":"2023","journal-title":"J. Mater. Chem. B"},{"key":"ref_31","doi-asserted-by":"crossref","first-page":"176451","DOI":"10.1016\/j.cej.2026.176451","article-title":"Multifunctional hydrogel with dynamic phase-adaptive regulation for expediting infected diabetic wound repair","volume":"538","author":"Hu","year":"2026","journal-title":"Chem. Eng. J."},{"key":"ref_32","doi-asserted-by":"crossref","first-page":"126","DOI":"10.1016\/j.jconrel.2015.12.031","article-title":"Spatiotemporal release of BMP-2 and VEGF enhances osteogenic and vasculogenic differentiation of human mesenchymal stem cells and endothelial colony-forming cells co-encapsulated in a patterned hydrogel","volume":"223","author":"Barati","year":"2016","journal-title":"J. Control. Release"},{"key":"ref_33","doi-asserted-by":"crossref","first-page":"358","DOI":"10.1016\/j.ijpharm.2018.01.006","article-title":"Growth factor delivery strategies for rotator cuff repair and regeneration","volume":"544","author":"Prabhath","year":"2018","journal-title":"Int. J. Pharm."},{"key":"ref_34","doi-asserted-by":"crossref","first-page":"110264","DOI":"10.1016\/j.compositesb.2022.110264","article-title":"3D printed hydrogel\/wesselsite-PCL composite scaffold with structural change from core\/shell fibers to microchannels for enhanced bone regeneration","volume":"246","author":"Dong","year":"2022","journal-title":"Compos. Part B"},{"key":"ref_35","doi-asserted-by":"crossref","first-page":"e04347","DOI":"10.1016\/j.heliyon.2020.e04347","article-title":"Local SDF-1\u03b1 application enhances the therapeutic efficacy of BMSCs transplantation in osteoporotic bone healing","volume":"6","author":"Liu","year":"2020","journal-title":"Heliyon"},{"key":"ref_36","doi-asserted-by":"crossref","first-page":"132742","DOI":"10.1016\/j.ijbiomac.2024.132742","article-title":"Injectable thermo-responsive Poloxamer hydrogel\/methacrylate gelatin microgels stimulates bone regeneration through biomimetic programmed release of SDF-1a and IGF-1","volume":"271","author":"Zhong","year":"2024","journal-title":"Int. J. Biol. Macromol."},{"key":"ref_37","doi-asserted-by":"crossref","first-page":"485","DOI":"10.1016\/j.actbio.2025.05.072","article-title":"Improving tendon repair through spatiotemporal modulation of TGF-\u03b21 expression using an ultrasound-responsive hydrogel carrying siRNA-loaded nanoparticles","volume":"201","author":"Liu","year":"2025","journal-title":"Acta Biomater."},{"key":"ref_38","doi-asserted-by":"crossref","first-page":"102","DOI":"10.1016\/j.actbio.2019.12.011","article-title":"A self-assembling peptide hydrogel-based drug co-delivery platform to improve tissue repair after ischemia-reperfusion injury","volume":"103","author":"Liu","year":"2020","journal-title":"Acta Biomater."},{"key":"ref_39","doi-asserted-by":"crossref","first-page":"113893","DOI":"10.1016\/j.jconrel.2025.113893","article-title":"Multifunctional nanocomposite hydrogel with dual-factor controlled release for stem cell recruitment, immunomodulation and bone remodeling","volume":"384","author":"Jiao","year":"2025","journal-title":"J. Control. Release"},{"key":"ref_40","doi-asserted-by":"crossref","first-page":"122848","DOI":"10.1016\/j.biomaterials.2024.122848","article-title":"Immunomodulatory hydrogel orchestrates pro-regenerative response of macrophages and angiogenesis for chronic wound healing","volume":"314","author":"Kuan","year":"2025","journal-title":"Biomaterials"},{"key":"ref_41","doi-asserted-by":"crossref","first-page":"8083","DOI":"10.1039\/D4TB02857K","article-title":"A MMP9-responsive nanozyme hydrogel to promote diabetic wound healing by reconstructing the balance of pro-inflammation and anti-inflammation","volume":"13","author":"Wang","year":"2025","journal-title":"J. Mater. Chem. B"},{"key":"ref_42","doi-asserted-by":"crossref","unstructured":"Zhang, X.Y., Zu, Q.H., Deng, C.L., Gao, X., Liu, H.X., Jin, Y., Yang, X.J., and Wang, E.J. (2025). Biodegradable Double-Layer Hydrogels with Sequential Drug Release for Multi-Phase Collaborative Regulation in Scar-Free Wound Healing. J. Funct. Biomater., 16.","DOI":"10.3390\/jfb16050164"},{"key":"ref_43","first-page":"240","article-title":"MMP-9 responsive hydrogel promotes diabetic wound healing by suppressing ferroptosis of endothelial cells","volume":"43","author":"Lin","year":"2025","journal-title":"Bioact. Mater."},{"key":"ref_44","doi-asserted-by":"crossref","first-page":"126469","DOI":"10.1016\/j.ijpharm.2025.126469","article-title":"Design of pH-sensitive alginate-carbopol hydrogel patches for wound healing applications","volume":"688","author":"Barra","year":"2026","journal-title":"Int. J. Pharm."},{"key":"ref_45","doi-asserted-by":"crossref","first-page":"148943","DOI":"10.1016\/j.ijbiomac.2025.148943","article-title":"Isorhynchophylline-loaded silk sericin\/gelatin methacrylate crosslinked hydrogel: A synergistic platform for accelerated wound healing","volume":"334","author":"Chen","year":"2025","journal-title":"Int. J. Biol. Macromol."},{"key":"ref_46","doi-asserted-by":"crossref","first-page":"125347","DOI":"10.1016\/j.carbpol.2026.125347","article-title":"Research progress on modified chitosan hydrogels for tissue repair and regeneration","volume":"385","author":"Chen","year":"2026","journal-title":"Carbohydr. Polym."},{"key":"ref_47","doi-asserted-by":"crossref","first-page":"114640","DOI":"10.1016\/j.eurpolymj.2026.114640","article-title":"Engineering printable and mechanically robust hyaluronic acid biomaterial inks through cellulose material selection","volume":"249","author":"Chen","year":"2026","journal-title":"Eur. Polym. J."},{"key":"ref_48","doi-asserted-by":"crossref","unstructured":"Aljaber, M.B., Alageel, O., Chau, D.Y.S., and Knowles, J.C. (2025). Optimizing Gelatin Methacryloyl for Craniofacial Muscle Regeneration: Material Design and Application. Gels, 11.","DOI":"10.3390\/gels11120945"},{"key":"ref_49","doi-asserted-by":"crossref","first-page":"150162","DOI":"10.1016\/j.ijbiomac.2026.150162","article-title":"Engineered injectable alginate hydrogel for radiotherapy spacing: Achieving controllable degradation and real-time imaging tracking","volume":"340","author":"He","year":"2026","journal-title":"Int. J. Biol. Macromol."},{"key":"ref_50","doi-asserted-by":"crossref","first-page":"5374","DOI":"10.1021\/acs.biomac.4c00817","article-title":"Modulating the Thermoresponsive Characteristics of PLGA-PEG-PLGA Hydrogels via Manipulation of PLGA Monomer Sequences","volume":"25","author":"Jo","year":"2024","journal-title":"Biomacromolecules"},{"key":"ref_51","doi-asserted-by":"crossref","first-page":"5827","DOI":"10.1039\/C9RA08162C","article-title":"Mechanical and physicochemical behavior of a 3D hydrogel scaffold during cell growth and proliferation","volume":"10","author":"Rivero","year":"2020","journal-title":"RSC Adv."},{"key":"ref_52","doi-asserted-by":"crossref","unstructured":"Ragab, A., El-Badry, N., Tamer, N., Naas, A., Hamdy, A., Tawakey, S.H., Hassan, A.H.A., and Salim, A.I. (2025). Biodegradable chitosan\/PVA-based hydrogel incorporating green synthesized silver nanoparticles for wound healing applications. BMC Chem., 19.","DOI":"10.1186\/s13065-025-01564-5"},{"key":"ref_53","doi-asserted-by":"crossref","first-page":"64568","DOI":"10.1021\/acsami.4c15185","article-title":"Modulation of Short-Term Delivery of Proteins from Hydrogels","volume":"16","author":"Ahrens","year":"2024","journal-title":"ACS Appl. Mater. Interfaces"},{"key":"ref_54","doi-asserted-by":"crossref","unstructured":"Encinas-Basurto, D., Ruiz, V.H., Schnellmann, R.G., and Mansour, H.M. (2025). Evaluation of Carboxymethyl Chitosan\u2013Genipin Hydrogels as Reservoir Systems for Suramin Delivery in Epithelial Tissues. Gels, 11.","DOI":"10.3390\/gels11050312"},{"key":"ref_55","doi-asserted-by":"crossref","first-page":"100303","DOI":"10.1016\/j.medntd.2024.100303","article-title":"Designing of tragacanth gum-poly(2-(methacryloyloxy) ethyl] dimethyl-(3-sulfopropyl) ammonium hydroxide) and poly(acrylamide) based hydrogels for drug delivery and wound dressing applications","volume":"22","author":"Devi","year":"2024","journal-title":"Med. Nov. Technol. Devices"},{"key":"ref_56","doi-asserted-by":"crossref","unstructured":"Browne, D., Briggs, F., and Asuri, P. (2023). Role of Polymer Concentration on the Release Rates of Proteins from Single- and Double-Network Hydrogels. Int. J. Mol. Sci., 24.","DOI":"10.3390\/ijms242316970"},{"key":"ref_57","doi-asserted-by":"crossref","first-page":"51","DOI":"10.4015\/S1016237211002372","article-title":"Chitosan in applications of biomedical devices","volume":"23","author":"Lan","year":"2011","journal-title":"Biomed. Eng.-Appl. Basis Commun."},{"key":"ref_58","doi-asserted-by":"crossref","first-page":"129385","DOI":"10.1016\/j.polymer.2025.129385","article-title":"Network theory and recent developments in networks formed by the freeze-thawing process","volume":"344","author":"Duggal","year":"2026","journal-title":"Polymer"},{"key":"ref_59","doi-asserted-by":"crossref","first-page":"100474","DOI":"10.1016\/j.bcdf.2025.100474","article-title":"Exploring potential of aloe vera and sterculia gum dietary fibers to develop functional hydrogels for drug delivery applications","volume":"33","author":"Sharma","year":"2025","journal-title":"Bioact. Carbohydr. Diet. Fibre"},{"key":"ref_60","doi-asserted-by":"crossref","first-page":"198","DOI":"10.1002\/pat.4103","article-title":"Hydrophobically modified alginate for extended release of pharmaceuticals","volume":"29","author":"Choudhary","year":"2017","journal-title":"Polym. Adv. Technol."},{"key":"ref_61","doi-asserted-by":"crossref","first-page":"449","DOI":"10.1016\/j.actbio.2006.12.001","article-title":"Effects of neighboring sulfides and pH on ester hydrolysis in thiol-acrylate photopolymers","volume":"3","author":"Rydholm","year":"2007","journal-title":"Acta Biomater."},{"key":"ref_62","doi-asserted-by":"crossref","first-page":"1730","DOI":"10.1023\/B:PHAM.0000003368.66471.6a","article-title":"Gene delivery in tissue engineering: A photopolymer platform to coencapsulate cells and plasmid DNA","volume":"20","author":"Quick","year":"2003","journal-title":"Pharm. Res."},{"key":"ref_63","doi-asserted-by":"crossref","unstructured":"Ding, X., Yang, B., Ni, L., Niu, G., Si, X., Lu, N., and Hou, Z. (2025). Dual-Crosslinked Gelatin\/Dextran Medical Hydrogels Based on Aldimine Condensation and Photopolymerization. Gels, 11.","DOI":"10.3390\/gels11110871"},{"key":"ref_64","doi-asserted-by":"crossref","unstructured":"Lei, L., Bai, Y., Qin, X., Liu, J., Huang, W., and Lv, Q. (2022). Current Understanding of Hydrogel for Drug Release and Tissue Engineering. Gels, 8.","DOI":"10.3390\/gels8050301"},{"key":"ref_65","doi-asserted-by":"crossref","first-page":"105","DOI":"10.1116\/1.3046123","article-title":"Concurrent elution of calcium phosphate and macromolecules from alginate\/chitosan hydrogel coatings","volume":"3","author":"Peng","year":"2008","journal-title":"Biointerphases"},{"key":"ref_66","doi-asserted-by":"crossref","first-page":"105243","DOI":"10.1016\/j.reactfunctpolym.2022.105243","article-title":"Preparation of biodegradable sodium alginate\/carboxymethylchitosan hydrogels for the slow-release of urea fertilizer and their antimicrobial activity","volume":"174","author":"Arafa","year":"2022","journal-title":"React. Funct. Polym."},{"key":"ref_67","doi-asserted-by":"crossref","first-page":"5005316","DOI":"10.1155\/2023\/5005316","article-title":"Evaluation of Ibuprofen Prolonged Release of Biomedical PLA-PEG-PLA Hydrogel via Degradation Mechanism","volume":"2023","author":"Nguyen","year":"2023","journal-title":"Int. J. Biomater."},{"key":"ref_68","doi-asserted-by":"crossref","unstructured":"L\u00f3pez-Cano, J.J., Sigen, A., Andr\u00e9s-Guerrero, V., Tai, H., Bravo-Osuna, I., Molina-Mart\u00ednez, I.T., Wang, W., and Herrero-Vanrell, R. (2021). Thermo-Responsive PLGA-PEG-PLGA Hydrogels as Novel Injectable Platforms for Neuroprotective Combined Therapies in the Treatment of Retinal Degenerative Diseases. Pharmaceutics, 13.","DOI":"10.3390\/pharmaceutics13020234"},{"key":"ref_69","doi-asserted-by":"crossref","first-page":"121374","DOI":"10.1016\/j.carbpol.2023.121374","article-title":"Supramolecular chitin-based hydrogels with self-adapting and fast-degradation properties for enhancing wound healing","volume":"323","author":"Shi","year":"2024","journal-title":"Carbohydr. Polym."},{"key":"ref_70","doi-asserted-by":"crossref","first-page":"3223","DOI":"10.1007\/s13346-023-01383-y","article-title":"UV-polymerizable methacrylated gelatin (GelMA)-based hydrogel containing tannic acids for wound healing","volume":"13","author":"Nascimento","year":"2023","journal-title":"Drug Deliv. Transl. Res."},{"key":"ref_71","doi-asserted-by":"crossref","first-page":"104","DOI":"10.1016\/j.actbio.2023.12.003","article-title":"In vitro dose-dependent effects of matrix metalloproteinases on ECM hydrogel biodegradation","volume":"174","author":"Didwischus","year":"2024","journal-title":"Acta Biomater."},{"key":"ref_72","doi-asserted-by":"crossref","first-page":"653","DOI":"10.1038\/nmat3922","article-title":"Injectable and bioresponsive hydrogels for on-demand matrix metalloproteinase inhibition","volume":"13","author":"Purcell","year":"2014","journal-title":"Nat. Mater."},{"key":"ref_73","doi-asserted-by":"crossref","first-page":"126255","DOI":"10.1016\/j.polymer.2023.126255","article-title":"Rapid on-demand in-situ gelling and dissociation of PEG bottlebrush hydrogel via light-mediated grafting-through polymerization for full-thickness skin wound repair","volume":"283","author":"Chen","year":"2023","journal-title":"Polymer"},{"key":"ref_74","doi-asserted-by":"crossref","first-page":"186","DOI":"10.1016\/j.biomaterials.2015.11.018","article-title":"Poly(ethylene glycol) hydrogels with cell cleavable groups for autonomous cell delivery","volume":"77","author":"Kar","year":"2016","journal-title":"Biomaterials"},{"key":"ref_75","doi-asserted-by":"crossref","first-page":"961","DOI":"10.1016\/j.jconrel.2024.12.055","article-title":"Intelligent sequential degradation hydrogels by releasing bimetal-phenolic for enhanced diabetic wound healing","volume":"378","author":"Zhang","year":"2025","journal-title":"J. Control. Release"},{"key":"ref_76","doi-asserted-by":"crossref","first-page":"10470","DOI":"10.1021\/acsami.4c20592","article-title":"Metal-Phenolic Network (MPN) Modified Janus Fibrous Hydrogel Scaffold for Infected Diabetic Wound Healing","volume":"17","author":"Ullah","year":"2025","journal-title":"ACS Appl. Mater. Interfaces"},{"key":"ref_77","doi-asserted-by":"crossref","first-page":"3972","DOI":"10.1002\/jps.21310","article-title":"In situ gelling hydrogels incorporating microparticles as drug delivery carriers for regenerative medicine","volume":"97","author":"Hou","year":"2008","journal-title":"J. Pharm. Sci."},{"key":"ref_78","doi-asserted-by":"crossref","first-page":"16071","DOI":"10.1038\/natrevmats.2016.71","article-title":"Designing hydrogels for controlled drug delivery","volume":"1","author":"Li","year":"2016","journal-title":"Nat. Rev. Mater."},{"key":"ref_79","doi-asserted-by":"crossref","first-page":"102519","DOI":"10.1016\/j.mtbio.2025.102519","article-title":"pH-responsive bilayer hydrogel with sequential release of morin-based nanoparticles and bFGF for the treatment of the \u201cice and fire\u201d wounds","volume":"35","author":"Yi","year":"2025","journal-title":"Mater. Today Bio"},{"key":"ref_80","doi-asserted-by":"crossref","first-page":"e00471","DOI":"10.1002\/admt.202500471","article-title":"A Plaster-Like, Sequentially Triggered Bilayer Hydrogel Patch for Enhanced Diabetic Wound Management","volume":"10","author":"Mi","year":"2025","journal-title":"Adv. Mater. Technol."},{"key":"ref_81","doi-asserted-by":"crossref","first-page":"1332","DOI":"10.1039\/D5BM01823D","article-title":"pH-responsive polydopamine-shelled 3D-printed chitosan\/collagen hydrogel integrating exosomes and an enzyme\/peptide cascade for diabetic wound healing","volume":"14","author":"Du","year":"2026","journal-title":"Biomater. Sci."},{"key":"ref_82","doi-asserted-by":"crossref","first-page":"123376","DOI":"10.1016\/j.biomaterials.2025.123376","article-title":"Controlled release of ionic carrier hydrogels for sequential immunomodulation to facilitate stage-specific treatment of infectious wound","volume":"322","author":"Lyu","year":"2025","journal-title":"Biomaterials"},{"key":"ref_83","doi-asserted-by":"crossref","first-page":"235","DOI":"10.1016\/j.actbio.2019.01.001","article-title":"An injectable and thermosensitive hydrogel: Promoting periodontal regeneration by controlled-release of aspirin and erythropoietin","volume":"86","author":"Xu","year":"2019","journal-title":"Acta Biomater."},{"key":"ref_84","doi-asserted-by":"crossref","first-page":"139910","DOI":"10.1016\/j.jcis.2026.139910","article-title":"Asymmetric double layer Janus hydrogels with programmed nitric oxide release for chronic diabetic wound healing","volume":"709","author":"Huang","year":"2026","journal-title":"J. Colloid Interface Sci."},{"key":"ref_85","doi-asserted-by":"crossref","first-page":"114795","DOI":"10.1016\/j.eurpolymj.2026.114795","article-title":"A Janus hydrogel with thermostatic photothermal regulation and temperature-responsive drug release for infected wound management","volume":"254","author":"Lyu","year":"2026","journal-title":"Eur. Polym. J."},{"key":"ref_86","doi-asserted-by":"crossref","first-page":"214152","DOI":"10.1016\/j.bioadv.2024.214152","article-title":"Biomimetic gradient hydrogel with fibroblast spheroids for full-thickness skin regeneration","volume":"169","author":"Kwon","year":"2025","journal-title":"Biomater. Adv."},{"key":"ref_87","doi-asserted-by":"crossref","first-page":"4346","DOI":"10.1021\/acs.biomac.5c00351","article-title":"Gradient pH Hydrogel Promotes Infected Wound Healing through pH Regulation of Microenvironment","volume":"26","author":"Yang","year":"2025","journal-title":"Biomacromolecules"},{"key":"ref_88","doi-asserted-by":"crossref","first-page":"122750","DOI":"10.1016\/j.carbpol.2024.122750","article-title":"Injectable Salecan\/hyaluronic acid-based hydrogels with antibacterial, rapid self-healing, pH-responsive and controllable drug release capability for infected wound repair","volume":"347","author":"Wang","year":"2025","journal-title":"Carbohydr. Polym."},{"key":"ref_89","doi-asserted-by":"crossref","first-page":"124406","DOI":"10.1016\/j.ijpharm.2024.124406","article-title":"Novel theranostic wounds dressing based on pH responsive alginate hydrogel\/graphene oxide\/levofloxacin modified silk","volume":"661","author":"Punnoy","year":"2024","journal-title":"Int. J. Pharm."},{"key":"ref_90","doi-asserted-by":"crossref","first-page":"126165","DOI":"10.1016\/j.ijpharm.2025.126165","article-title":"pH-sensitive P\u03b2AE\/PGS hydrogels for controlled release of SMV and CIP: Enhanced wound healing and targeted immunomodulatory properties for efficient skin regeneration","volume":"684","author":"Heydari","year":"2025","journal-title":"Int. J. Pharm."},{"key":"ref_91","doi-asserted-by":"crossref","first-page":"147372","DOI":"10.1016\/j.ijbiomac.2025.147372","article-title":"Zinc ions coordinated carboxymethyl chitosan hydrogel doped with ellagic acid for accelerative diabetic wound healing","volume":"327","author":"Zhao","year":"2025","journal-title":"Int. J. Biol. Macromol."},{"key":"ref_92","doi-asserted-by":"crossref","first-page":"e02349","DOI":"10.1002\/adhm.202502349","article-title":"Injectable ROS\/pH-Responsive Hydrogel for Synergistic Chemo-Photodynamic Tumor Therapy and Enhanced Wound Healing","volume":"15","author":"Yi","year":"2026","journal-title":"Adv. Healthc. Mater."},{"key":"ref_93","doi-asserted-by":"crossref","first-page":"16362","DOI":"10.1021\/jacs.5c02184","article-title":"Self-Adaptive Release of Stem Cell-Derived Exosomes from a Multifunctional Hydrogel for Accelerating MRSA-Infected Diabetic Wound Repair","volume":"147","author":"Wang","year":"2025","journal-title":"J. Am. Chem. Soc."},{"key":"ref_94","doi-asserted-by":"crossref","first-page":"114392","DOI":"10.1016\/j.jconrel.2025.114392","article-title":"A smart ROS-responsive hydrogel for on-demand antibacterial and platelet-rich plasma (PRP) activation in diabetic wound healing","volume":"388","author":"Li","year":"2025","journal-title":"J. Control. Release"},{"key":"ref_95","doi-asserted-by":"crossref","first-page":"11075","DOI":"10.1039\/D5TB01508A","article-title":"A dual-network supramolecular hydrogel dressing encapsulating Cu\/EGCG nanoenzyme and glucose oxidase for closed cascade catalytic therapy of diabetic wounds","volume":"13","author":"Yu","year":"2025","journal-title":"J. Mater. Chem. B"},{"key":"ref_96","doi-asserted-by":"crossref","first-page":"115573","DOI":"10.1016\/j.matdes.2026.115573","article-title":"MMP-responsive hydrogel: A new approach for tissue repair and regeneration","volume":"263","author":"Sun","year":"2026","journal-title":"Mater. Des."},{"key":"ref_97","doi-asserted-by":"crossref","first-page":"e24714","DOI":"10.1002\/adfm.202524714","article-title":"An MMP-Responsive Isoquercitrin-Loaded Bilayer Hydrogel Promotes Osteochondral Defect Repair via Activation of the CXCL12\/CXCR4\u2013CDC42 Axis","volume":"36","author":"Lu","year":"2025","journal-title":"Adv. Funct. Mater."},{"key":"ref_98","doi-asserted-by":"crossref","first-page":"103016","DOI":"10.1016\/j.mtbio.2026.103016","article-title":"Stage-matched conductive hydrogel with pH\/ROS\/MMP9 triple-responsive salidroside release for post-infarction myocardial repair","volume":"38","author":"Song","year":"2026","journal-title":"Mater. Today Bio"},{"key":"ref_99","doi-asserted-by":"crossref","first-page":"1902900","DOI":"10.1002\/adma.201902900","article-title":"Myocardial-Infarction-Responsive Smart Hydrogels Targeting Matrix Metalloproteinase for On-Demand Growth Factor Delivery","volume":"31","author":"Fan","year":"2019","journal-title":"Adv. Mater."},{"key":"ref_100","doi-asserted-by":"crossref","first-page":"114797","DOI":"10.1016\/j.colsurfb.2025.114797","article-title":"Metalloproteinase-responsive gelatin\/polylysine hydrogel microneedles for on-demand curcumin delivery in bacteria-infected wound healing","volume":"254","author":"Wang","year":"2025","journal-title":"Colloids Surf. B Biointerfaces"},{"key":"ref_101","doi-asserted-by":"crossref","first-page":"167205","DOI":"10.1016\/j.cej.2025.167205","article-title":"Development of a glucose-responsive smart hydrogel for diabetic wound healing","volume":"522","author":"Zhai","year":"2025","journal-title":"Chem. Eng. J."},{"key":"ref_102","doi-asserted-by":"crossref","first-page":"124533","DOI":"10.1016\/j.carbpol.2025.124533","article-title":"Injectable glucose-responsive hydrogels with hemorrhage control and microenvironmental regulation for diabetic wound repair","volume":"372","author":"Liu","year":"2026","journal-title":"Carbohydr. Polym."},{"key":"ref_103","doi-asserted-by":"crossref","first-page":"123641","DOI":"10.1016\/j.biomaterials.2025.123641","article-title":"Glucose-responsive hydrogel with adaptive insulin release to modulate hyperglycemic microenvironment and promote wound healing","volume":"326","author":"Zhou","year":"2026","journal-title":"Biomaterials"},{"key":"ref_104","doi-asserted-by":"crossref","first-page":"tkaf059","DOI":"10.1093\/burnst\/tkaf059","article-title":"Multiple dynamic crosslinked multifunctional hydrogels with glucose\/pH dual-responsive adipose-derived stem cells-exosomes-releasing for diabetic wound healing","volume":"13","author":"Zhang","year":"2025","journal-title":"Burns Trauma"},{"key":"ref_105","doi-asserted-by":"crossref","first-page":"148316","DOI":"10.1016\/j.ijbiomac.2025.148316","article-title":"Photothermally triggered double-layer hydrogels containing curcumin-loaded pullulan derivatives for controlled drug delivery and wound healing","volume":"330","author":"Nonsuwan","year":"2025","journal-title":"Int. J. Biol. Macromol."},{"key":"ref_106","doi-asserted-by":"crossref","first-page":"140939","DOI":"10.1016\/j.colsurfa.2026.140939","article-title":"NIR-responsive lactoferrin@PNIPAM\/SA\/GO hydrogel with integrated anti-inflammatory, antioxidant, and angiogenic functions in wound healing","volume":"747","author":"Wang","year":"2026","journal-title":"Colloids Surf. A Physicochem. Eng. Asp."},{"key":"ref_107","doi-asserted-by":"crossref","first-page":"8241","DOI":"10.1039\/D6TB00537C","article-title":"NIR-triggered photothermal nanocomposite hydrogels integrating polydopamine carbon dots and dynamic multi-networks for infected wound healing","volume":"14","author":"Huang","year":"2026","journal-title":"J. Mater. Chem. B"},{"key":"ref_108","doi-asserted-by":"crossref","first-page":"139250","DOI":"10.1016\/j.jcis.2025.139250","article-title":"Near-infrared and pH dual-responsive chitosan\/epigallocatechin gallate\/hollow CuS hydrogel reprograms ROS dynamics for infected wound healing","volume":"703","author":"Yang","year":"2026","journal-title":"J. Colloid Interface Sci."},{"key":"ref_109","doi-asserted-by":"crossref","first-page":"106682","DOI":"10.1016\/j.jddst.2025.106682","article-title":"A mechanistic understanding to photophysical phenomenon in development of near-infrared (NIR) responsive hydrogels: Advancements in precision drug delivery","volume":"106","author":"Pandey","year":"2025","journal-title":"J. Drug Deliv. Sci. Technol."},{"key":"ref_110","doi-asserted-by":"crossref","first-page":"9720","DOI":"10.1039\/D5TB00911A","article-title":"Recent advances in NIR-II emitting nanomaterials: Design and biomedical applications of lanthanide complexes and functionalized mesoporous silica nanoparticles (MSNs)","volume":"13","author":"Bandyopadhyay","year":"2025","journal-title":"J. Mater. Chem. B"},{"key":"ref_111","doi-asserted-by":"crossref","first-page":"123828","DOI":"10.1016\/j.biomaterials.2025.123828","article-title":"Ultrasound-responsive piezoelectric hydrogel attenuates oxidative stress-induced nucleus pulposus senescence via AMPK-FOXO1a-mediated mitophagy for intervertebral disc regeneration","volume":"328","author":"Wu","year":"2026","journal-title":"Biomaterials"},{"key":"ref_112","doi-asserted-by":"crossref","first-page":"e03471","DOI":"10.1002\/adhm.202503471","article-title":"Staged Low-Frequency Ultrasound Synergized with Composite Hydrogel to Achieve \u201cRapid Antimicrobial-Ordered Regeneration\u201d of Infected Wounds","volume":"15","author":"Li","year":"2025","journal-title":"Adv. Healthc. Mater."},{"key":"ref_113","doi-asserted-by":"crossref","first-page":"102796","DOI":"10.1016\/j.mtbio.2026.102796","article-title":"Ultrasound-responsive hydrogel with ROS scavenging and NO controllable release capabilities for accelerated healing of diabetic wounds","volume":"37","author":"Luo","year":"2026","journal-title":"Mater. Today Bio"},{"key":"ref_114","doi-asserted-by":"crossref","first-page":"60182","DOI":"10.1021\/acsami.5c13378","article-title":"Liquid Metal Microsphere-Embedded Conductive Hydrogel Enables Electro-Responsive Drug Release for Wound Healing","volume":"17","author":"Cui","year":"2025","journal-title":"ACS Appl. Mater. Interfaces"},{"key":"ref_115","doi-asserted-by":"crossref","first-page":"113760","DOI":"10.1016\/j.jconrel.2025.113760","article-title":"Hierarchically structured conductive hydrogels for electrically programmable drug delivery in a diabetic wound healing electronic patch","volume":"383","author":"Lin","year":"2025","journal-title":"J. Control. Release"},{"key":"ref_116","doi-asserted-by":"crossref","first-page":"3824","DOI":"10.1007\/s10924-025-03618-0","article-title":"Development of Starch-g-Oleic Acid, Gelatin and Alginate Based Magnetic Core-Shell Hydrogel Beads as Dual-Stimuli Responsive and Synergistic Tumour-Targeting Drug Delivery System","volume":"33","author":"Sampath","year":"2025","journal-title":"J. Polym. Environ."},{"key":"ref_117","doi-asserted-by":"crossref","first-page":"216916","DOI":"10.1016\/j.ccr.2025.216916","article-title":"Magnetically responsive hydrogel systems: Fundamental features, emerging applications, and future horizons","volume":"543","author":"Suhail","year":"2025","journal-title":"Coord. Chem. Rev."},{"key":"ref_118","doi-asserted-by":"crossref","first-page":"867","DOI":"10.1007\/s42452-026-08607-z","article-title":"Programmable multi-stimuli photonic hydrogels for intelligent and adaptive transdermal drug delivery","volume":"8","author":"Omar","year":"2026","journal-title":"Discov. Appl. Sci."},{"key":"ref_119","doi-asserted-by":"crossref","first-page":"114997","DOI":"10.1016\/j.jconrel.2026.114997","article-title":"Ultrasound-responsive composite hydrogels: Design rules for spatiotemporally controlled drug delivery","volume":"395","author":"Xiao","year":"2026","journal-title":"J. Control. Release"},{"key":"ref_120","doi-asserted-by":"crossref","first-page":"214928","DOI":"10.1016\/j.bioadv.2026.214928","article-title":"Electroactive hydrogel for force-to-electricity conversion: Emerging engineered frameworks for advanced bio-interfaces","volume":"186","author":"Wang","year":"2026","journal-title":"Biomater. Adv."},{"key":"ref_121","doi-asserted-by":"crossref","first-page":"151874","DOI":"10.1016\/j.ijbiomac.2026.151874","article-title":"Theranostic magnetic hydrogels for treatment, recurrence prevention, tumour modelling and emerging applications in breast cancer management: A review","volume":"359","author":"Sampath","year":"2026","journal-title":"Int. J. Biol. Macromol."},{"key":"ref_122","doi-asserted-by":"crossref","first-page":"144862","DOI":"10.1016\/j.ijbiomac.2025.144862","article-title":"A review of stimuli-responsive hydrogels for RNA delivery: From material innovations to clinical barriers","volume":"318","author":"Luo","year":"2025","journal-title":"Int. J. Biol. Macromol."},{"key":"ref_123","doi-asserted-by":"crossref","first-page":"155","DOI":"10.1186\/s12951-022-01368-y","article-title":"A multifunctional composite hydrogel as an intrinsic and extrinsic coregulator for enhanced therapeutic efficacy for psoriasis","volume":"20","author":"Xu","year":"2022","journal-title":"J. Nanobiotechnol."},{"key":"ref_124","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1007\/s10965-025-04709-1","article-title":"Recent advances in self-healing hydrogels based on extrinsic and intrinsic mechanisms and their applications: A review","volume":"33","author":"Meghana","year":"2025","journal-title":"J. Polym. Res."},{"key":"ref_125","doi-asserted-by":"crossref","first-page":"114611","DOI":"10.1016\/j.jconrel.2026.114611","article-title":"Photo-controlled spatiotemporal sequential release of MXenes\/NO gas from bilayer (clean-cure) hydrogel promotes healing of MRSA biofilm-infected diabetic ulcer wounds","volume":"391","author":"Ye","year":"2026","journal-title":"J. Control. Release"},{"key":"ref_126","doi-asserted-by":"crossref","unstructured":"Shamszadeh, S., Asgary, S., Akrami, M., Mashhadiabbas, F., Baghban, A.A., and Shams, F. (2024). Development of a Thermoresponsive Core\u2013Shell Hydrogel for Sequential Delivery of Antibiotics and Growth Factors in Regenerative Endodontics. Front. Biosci.-Elite, 16.","DOI":"10.31083\/j.fbe1604032"},{"key":"ref_127","doi-asserted-by":"crossref","unstructured":"Wei, H., Luo, Y., Ma, R., and Li, Y. (2023). Three-Dimensional Printing Multi-Drug Delivery Core\/Shell Fiber Systems with Designed Release Capability. Pharmaceutics, 15.","DOI":"10.3390\/pharmaceutics15092336"},{"key":"ref_128","doi-asserted-by":"crossref","first-page":"151948","DOI":"10.1016\/j.ijbiomac.2026.151948","article-title":"A carboxymethyl chitosan-based responsive dual-crosslinked hydrogel loaded with diosmetin for traumatic wound healing","volume":"361","author":"Zhang","year":"2026","journal-title":"Int. J. Biol. Macromol."},{"key":"ref_129","doi-asserted-by":"crossref","first-page":"115883","DOI":"10.1016\/j.matdes.2026.115883","article-title":"A dual-crosslinked hydrogel with time-sequential drug release for stage-specific therapy of corneal alkali burns","volume":"265","author":"Zhu","year":"2026","journal-title":"Mater. Des."},{"key":"ref_130","doi-asserted-by":"crossref","first-page":"213100","DOI":"10.1016\/j.bioadv.2022.213100","article-title":"Bottom-up design of hydrogels for programmable drug release","volume":"141","author":"Owh","year":"2022","journal-title":"Biomater. Adv."},{"key":"ref_131","doi-asserted-by":"crossref","unstructured":"Sutradhar, S.C., Shin, H., Kim, W., and Jang, H. (2025). Hydrogel Films in Biomedical Applications: Fabrication, Properties and Therapeutic Potential. Gels, 11.","DOI":"10.20944\/preprints202510.0610.v1"},{"key":"ref_132","doi-asserted-by":"crossref","first-page":"e2210707","DOI":"10.1002\/adma.202210707","article-title":"Hydrogel-Based Growth Factor Delivery Platforms: Strategies and Recent Advances","volume":"36","author":"Shan","year":"2023","journal-title":"Adv. Mater."},{"key":"ref_133","doi-asserted-by":"crossref","unstructured":"Hwang, H.S., and Lee, C.-S. (2024). Exosome-Integrated Hydrogels for Bone Tissue Engineering. Gels, 10.","DOI":"10.3390\/gels10120762"},{"key":"ref_134","doi-asserted-by":"crossref","unstructured":"Xu, H., Fei, Y., Wang, X., Jiao, W., and Jin, Y. (2025). Advances in Hydrogel-Based Delivery of RNA Drugs for Antitumor Therapy. Gels, 11.","DOI":"10.3390\/gels11080633"},{"key":"ref_135","doi-asserted-by":"crossref","unstructured":"Dinh, L., Hwang, S.-J., and Yan, B. (2025). Hydrogel Conjugation: Engineering of Hydrogels for Drug Delivery. Pharmaceutics, 17.","DOI":"10.3390\/pharmaceutics17070897"},{"key":"ref_136","doi-asserted-by":"crossref","first-page":"140902","DOI":"10.1016\/j.ijbiomac.2025.140902","article-title":"Hydrogels as drug delivery platforms for orthopedic diseases treatment: A review","volume":"304","author":"Ge","year":"2025","journal-title":"Int. J. Biol. Macromol."},{"key":"ref_137","doi-asserted-by":"crossref","first-page":"70","DOI":"10.1186\/s12929-025-01166-2","article-title":"Smart hydrogels for in situ tissue drug delivery","volume":"32","author":"Lin","year":"2025","journal-title":"J. Biomed. Sci."},{"key":"ref_138","doi-asserted-by":"crossref","first-page":"100311","DOI":"10.1016\/j.cobme.2021.100311","article-title":"Smart biomaterials\u2014A proposed definition and overview of the field","volume":"19","author":"Amukarimi","year":"2021","journal-title":"Curr. Opin. Biomed. Eng."},{"key":"ref_139","doi-asserted-by":"crossref","first-page":"137377","DOI":"10.1016\/j.snb.2025.137377","article-title":"Hydrogel-polymer hybrid actuator with soft lattice skeleton for excellent connectivity","volume":"430","author":"Kozuki","year":"2025","journal-title":"Sens. Actuators B"},{"key":"ref_140","doi-asserted-by":"crossref","first-page":"4819","DOI":"10.1039\/D5MH01852H","article-title":"Hydrogel-integrated multimodal physiological and modulation systems","volume":"13","author":"Yao","year":"2026","journal-title":"Mater. Horiz."},{"key":"ref_141","doi-asserted-by":"crossref","first-page":"100027","DOI":"10.1016\/j.nxbio.2026.100027","article-title":"Next-generation smart drug delivery: Biosensor-integrated closed-loop therapeutics (CLT) for regenerative medicine","volume":"2","author":"Chowdhury","year":"2026","journal-title":"Next Bioeng."},{"key":"ref_142","doi-asserted-by":"crossref","first-page":"266","DOI":"10.1631\/bdm.2500275","article-title":"Development of a next-generation closed-loop precision system: Multiscale-engineered nanocomposite hydrogel microneedles","volume":"9","author":"Meng","year":"2026","journal-title":"Bio-Des. Manuf."},{"key":"ref_143","doi-asserted-by":"crossref","first-page":"8","DOI":"10.1039\/D3BM01352A","article-title":"Injectable smart stimuli-responsive hydrogels: Pioneering advancements in biomedical applications","volume":"12","author":"Liu","year":"2024","journal-title":"Biomater. Sci."},{"key":"ref_144","doi-asserted-by":"crossref","first-page":"7757","DOI":"10.1039\/D2MA00527A","article-title":"Intelligent hydrogels and their biomedical applications","volume":"3","author":"Chakrapani","year":"2022","journal-title":"Mater. Adv."},{"key":"ref_145","doi-asserted-by":"crossref","first-page":"764","DOI":"10.1186\/s12951-025-03786-0","article-title":"Triple-targeting miRNA-loaded core-shell nanoparticles in injectable hydrogel enable coordinated diabetic wound repair","volume":"23","author":"Guo","year":"2025","journal-title":"J. Nanobiotechnol."},{"key":"ref_146","doi-asserted-by":"crossref","first-page":"101","DOI":"10.1016\/j.ijpharm.2018.12.083","article-title":"A thermo-responsive and self-healing liposome-in-hydrogel system as an antitubercular drug carrier for localized bone tuberculosis therapy","volume":"558","author":"Liu","year":"2019","journal-title":"Int. J. Pharm."},{"key":"ref_147","doi-asserted-by":"crossref","first-page":"120605","DOI":"10.1016\/j.biomaterials.2020.120605","article-title":"Well-dispersed platelet lysate entrapped nanoparticles incorporate with injectable PDLLA-PEG-PDLLA triblock for preferable cartilage engineering application","volume":"268","author":"Tang","year":"2021","journal-title":"Biomaterials"},{"key":"ref_148","doi-asserted-by":"crossref","first-page":"147416","DOI":"10.1016\/j.ijbiomac.2025.147416","article-title":"Quaternary ammonium chitosan\/N-isopropylacrylamide-based Janus hydrogel with asymmetric adhesive, shrinkable, and antimicrobial properties for wound healing","volume":"327","author":"Deng","year":"2025","journal-title":"Int. J. Biol. Macromol."},{"key":"ref_149","doi-asserted-by":"crossref","first-page":"e2400358","DOI":"10.1002\/adbi.202400358","article-title":"Development of a pH-Responsive Antimicrobial and Potent Antioxidant Hydrogel for Accelerated Wound Healing: A Game Changer in Drug Delivery","volume":"9","author":"Gui","year":"2024","journal-title":"Adv. Biol."},{"key":"ref_150","first-page":"62","article-title":"A lignin-based controlled\/sustained release hydrogel by integrating mechanical strengthening and bioactivities of lignin","volume":"10","author":"Wang","year":"2024","journal-title":"J. Bioresour. Bioprod."},{"key":"ref_151","doi-asserted-by":"crossref","first-page":"124530","DOI":"10.1016\/j.carbpol.2025.124530","article-title":"Mechanically adaptive injectable hydrogels with dual-role oxidized cyclodextrin for pH-responsive drug delivery in chronic infected wound healing","volume":"372","author":"Wang","year":"2025","journal-title":"Carbohydr. Polym."},{"key":"ref_152","doi-asserted-by":"crossref","first-page":"171032","DOI":"10.1016\/j.cej.2025.171032","article-title":"A pH\/ROS dual-responsive hydrogel promotes diabetic wound healing by controlled release of O2 and EGCG to induce angiogenesis and immunomodulation","volume":"526","author":"Chen","year":"2025","journal-title":"Chem. Eng. J."},{"key":"ref_153","doi-asserted-by":"crossref","first-page":"144865","DOI":"10.1016\/j.ijbiomac.2025.144865","article-title":"Dextran based dual-dynamic-network hydrogel for chronic wound healing with mechanically adaptive, antibacterial, and pH-responsive drug delivery","volume":"322","author":"Geng","year":"2025","journal-title":"Int. J. Biol. Macromol."},{"key":"ref_154","doi-asserted-by":"crossref","first-page":"113063","DOI":"10.1016\/j.colsurfb.2022.113063","article-title":"Dual drug-loaded hydrogels with pH-responsive and antibacterial activity for skin wound dressing","volume":"222","author":"Du","year":"2023","journal-title":"Colloids Surf. B Biointerfaces"},{"key":"ref_155","doi-asserted-by":"crossref","first-page":"587","DOI":"10.1039\/D5TB01828E","article-title":"Effective diabetic wound prohealing by supramolecular ROS-responsive hyaluronic acid hydrogels via in situ production of nitric oxide and oxygen","volume":"14","author":"Chen","year":"2026","journal-title":"J. Mater. Chem. B"},{"key":"ref_156","doi-asserted-by":"crossref","first-page":"111981","DOI":"10.1016\/j.cclet.2025.111981","article-title":"Glucose\/ROS dual-responsive hydrogel loaded with mangiferin accelerates diabetic wound healing","volume":"37","author":"Meng","year":"2026","journal-title":"Chin. Chem. Lett."},{"key":"ref_157","doi-asserted-by":"crossref","first-page":"147091","DOI":"10.1016\/j.ijbiomac.2025.147091","article-title":"Aucubin-loaded BSAMA\/GelMA hydrogel accelerates diabetic wound healing via ROS scavenging","volume":"323","author":"Mu","year":"2025","journal-title":"Int. J. Biol. Macromol."},{"key":"ref_158","doi-asserted-by":"crossref","first-page":"114494","DOI":"10.1016\/j.jconrel.2025.114494","article-title":"A dual responsive nanohydrogel system for sustained drug delivery and cartilage penetration in osteoarthritis therapy","volume":"389","author":"Zhou","year":"2026","journal-title":"J. Control. Release"},{"key":"ref_159","doi-asserted-by":"crossref","unstructured":"Xu, Z., Liu, J., Hu, H., Ma, J., Yang, H., Chen, J., Xu, H., Hu, H., Luo, H., and Chen, G. (2025). Recent applications of stimulus-responsive smart hydrogels for osteoarthritis therapy. Front. Bioeng. Biotechnol., 13.","DOI":"10.3389\/fbioe.2025.1539566"},{"key":"ref_160","doi-asserted-by":"crossref","first-page":"140823","DOI":"10.1016\/j.ijbiomac.2025.140823","article-title":"Development of a dual-responsive injectable GelMA\/F127DA hydrogel for enhanced cartilage regeneration in osteoarthritis: Harnessing MMP-triggered and mechanical stress-induced release of therapeutic agents","volume":"304","author":"Sun","year":"2025","journal-title":"Int. J. Biol. Macromol."},{"key":"ref_161","doi-asserted-by":"crossref","first-page":"107643","DOI":"10.1016\/j.jddst.2025.107643","article-title":"pH-responsive HA\/P\u03b2AE hydrogels couple enzyme release kinetics to inflammatory acidity to modulate cytokines and promote healing","volume":"115","author":"Chermahini","year":"2026","journal-title":"J. Drug Deliv. Sci. Technol."},{"key":"ref_162","doi-asserted-by":"crossref","first-page":"124446","DOI":"10.1016\/j.carbpol.2025.124446","article-title":"Chitosan-based glucose-responsive hydrogel with spatiotemporally controlled bactericidal release for diabetic wound regeneration via multimodal therapy","volume":"373","author":"He","year":"2026","journal-title":"Carbohydr. Polym."},{"key":"ref_163","doi-asserted-by":"crossref","first-page":"e2403304","DOI":"10.1002\/adhm.202403304","article-title":"Exos-Loaded Gox-Modified Smart-Response Self-Healing Hydrogel Improves the Microenvironment and Promotes Wound Healing in Diabetic Wounds","volume":"14","author":"Yang","year":"2024","journal-title":"Adv. Healthc. Mater."},{"key":"ref_164","doi-asserted-by":"crossref","first-page":"149772","DOI":"10.1016\/j.ijbiomac.2025.149772","article-title":"Glucose-responsive hyaluronic acid\/carboxymethyl chitosan-based hydrogel with on-demand berberine release for diabetic wound healing","volume":"339","author":"Li","year":"2026","journal-title":"Int. J. Biol. Macromol."},{"key":"ref_165","doi-asserted-by":"crossref","first-page":"138520","DOI":"10.1016\/j.jcis.2025.138520","article-title":"Chitosan-based double-network hydrogel with synergistic photothermal\/nitric oxide therapy for methicillin-resistance Staphylococcus aureus infected wound healing","volume":"700","author":"Zhang","year":"2025","journal-title":"J. Colloid Interface Sci."},{"key":"ref_166","doi-asserted-by":"crossref","first-page":"102084","DOI":"10.1016\/j.mtbio.2025.102084","article-title":"A smart CO-releasing MnSiO3-based hydrogel enhances diabetic wound healing through NIR-triggered antibacterial, anti-inflammatory, and pro-regenerative mechanisms","volume":"34","author":"Liu","year":"2025","journal-title":"Mater. Today Bio"},{"key":"ref_167","doi-asserted-by":"crossref","first-page":"369","DOI":"10.1016\/j.jcis.2023.02.078","article-title":"Near-infrared light-responsive multifunctional hydrogel releasing peptide-functionalized gold nanorods sequentially for diabetic wound healing","volume":"639","author":"Huang","year":"2023","journal-title":"J. Colloid Interface Sci."},{"key":"ref_168","doi-asserted-by":"crossref","first-page":"161","DOI":"10.1039\/D5BM01191D","article-title":"Core\u2013shell hydrogel microspheres with sequential drug release and magnetothermal synergy for drug-resistant ovarian cancer","volume":"14","author":"Yin","year":"2026","journal-title":"Biomater. Sci."},{"key":"ref_169","doi-asserted-by":"crossref","first-page":"149841","DOI":"10.1016\/j.foodchem.2026.149841","article-title":"Internal\u2013external dual cross-linked alginate\/gelatin composite hydrogel beads: Structure and pH-responsive gastrointestinal delivery of bioactives","volume":"521","author":"Zhang","year":"2026","journal-title":"Food Chem."},{"key":"ref_170","doi-asserted-by":"crossref","first-page":"426","DOI":"10.1038\/s41392-021-00830-x","article-title":"Current hydrogel advances in physicochemical and biological response-driven biomedical application diversity","volume":"6","author":"Cao","year":"2021","journal-title":"Signal Transduct. Target. Ther."},{"key":"ref_171","doi-asserted-by":"crossref","first-page":"115130","DOI":"10.1016\/j.jconrel.2026.115130","article-title":"Hydrogel-based cellular drug delivery systems as living therapeutics: Micro\/nanogel design, fabrication, and controlled release","volume":"397","author":"Yilmaz","year":"2026","journal-title":"J. Control. Release"},{"key":"ref_172","doi-asserted-by":"crossref","first-page":"114920","DOI":"10.1016\/j.jconrel.2026.114920","article-title":"Engineering dynamic hydrogels to overcome translational bottlenecks in therapeutic delivery","volume":"395","author":"Pashuck","year":"2026","journal-title":"J. Control. Release"},{"key":"ref_173","doi-asserted-by":"crossref","first-page":"166","DOI":"10.1038\/s41392-024-01852-x","article-title":"Harnessing the potential of hydrogels for advanced therapeutic applications: Current achievements and future directions","volume":"9","author":"Lu","year":"2024","journal-title":"Signal Transduct. Target. Ther."},{"key":"ref_174","doi-asserted-by":"crossref","first-page":"113825","DOI":"10.1016\/j.jconrel.2025.113825","article-title":"Programmable hierarchical hydrogel dressing for sequential release of growth factor and DNase to accelerate diabetic wound healing","volume":"383","author":"Zhang","year":"2025","journal-title":"J. Control. Release"},{"key":"ref_175","doi-asserted-by":"crossref","first-page":"4360","DOI":"10.1021\/acsmaterialslett.4c01242","article-title":"Glucose\/ROS\/pH Triple Editing \u201cDomino Hydrogel\u201d Accelerates Diabetic Wound Healing via Hypoglycemic, Antioxidant, Antibacterial, and Macrophage Polarization","volume":"6","author":"Li","year":"2024","journal-title":"ACS Mater. Lett."},{"key":"ref_176","doi-asserted-by":"crossref","first-page":"112553","DOI":"10.1016\/j.compositesb.2025.112553","article-title":"Sequential angiogenic-osteogenic coupling via a spatiotemporally graded hydrogel enables vascularized bone organoids for critical-sized calvarial defect reconstruction","volume":"302","author":"Lou","year":"2025","journal-title":"Compos. Part B"},{"key":"ref_177","first-page":"179","article-title":"Self-assembled hybrid hydrogel microspheres create a bone marrow-mimicking niche for bone regeneration","volume":"54","author":"He","year":"2025","journal-title":"Bioact. Mater."},{"key":"ref_178","doi-asserted-by":"crossref","first-page":"4395","DOI":"10.1021\/acsabm.5c00581","article-title":"Design and Development of ZnO\/BMP-2 Sustained-Release Hydrogel for Enhanced Bone Tissue Repair","volume":"8","author":"Liu","year":"2025","journal-title":"ACS Appl. Bio Mater."},{"key":"ref_179","doi-asserted-by":"crossref","first-page":"102598","DOI":"10.1016\/j.mtbio.2025.102598","article-title":"EXO\/hydrogel system for sequential regulation of endogenous hyaline cartilage regeneration","volume":"35","author":"Wu","year":"2025","journal-title":"Mater. Today Bio"},{"key":"ref_180","doi-asserted-by":"crossref","first-page":"115062","DOI":"10.1016\/j.matdes.2025.115062","article-title":"A time-programmed therapy for enhanced cartilage regeneration in immunocompetent animals","volume":"260","author":"Chen","year":"2025","journal-title":"Mater. Des."},{"key":"ref_181","doi-asserted-by":"crossref","first-page":"e2412410","DOI":"10.1002\/advs.202412410","article-title":"ROS-Activated Nanohydrogel Scaffolds with Multi-Factors Controlled Release for Targeted Dual-Lineage Repair of Osteochondral Defects","volume":"12","author":"Wang","year":"2025","journal-title":"Adv. Sci."},{"key":"ref_182","doi-asserted-by":"crossref","first-page":"32063","DOI":"10.1021\/acsnano.4c16049","article-title":"An Aggrecanase-Responsive Delivery Hydrogel System of miRNA-17 Facilitates Microfracture-Mediated Articular Cartilage Regeneration by Reprogramming Hostile Inflammatory Niche","volume":"19","author":"Gao","year":"2025","journal-title":"ACS Nano"},{"key":"ref_183","doi-asserted-by":"crossref","first-page":"e2404091","DOI":"10.1002\/adhm.202404091","article-title":"Inflammation-Responsive Functional Core\u2013Shell Micro-Hydrogels Promote Rotator Cuff Tendon-To-Bone Healing by Recruiting MSCs and Immuno-Modulating Macrophages in Rats","volume":"14","author":"Chen","year":"2024","journal-title":"Adv. Healthc. Mater."},{"key":"ref_184","doi-asserted-by":"crossref","first-page":"123246","DOI":"10.1016\/j.biomaterials.2025.123246","article-title":"SDF-1\u03b1\/BMP-12 loaded biphasic sustained-release SIS hydrogel\/SA microspheres composite for tendon regeneration","volume":"320","author":"Qin","year":"2025","journal-title":"Biomaterials"},{"key":"ref_185","doi-asserted-by":"crossref","first-page":"214617","DOI":"10.1016\/j.bioadv.2025.214617","article-title":"Bioactive cardiac ECM hydrogel sequentially released VEGF and Ang-1 mimic peptides to promote the recovery of myocardial infarction","volume":"180","author":"Song","year":"2025","journal-title":"Biomater. Adv."},{"key":"ref_186","doi-asserted-by":"crossref","first-page":"166294","DOI":"10.1016\/j.cej.2025.166294","article-title":"An injectable hydrogel loaded with deferoxamine and carvedilol for the treatment of acute myocardial infarction","volume":"520","author":"Wu","year":"2025","journal-title":"Chem. Eng. J."},{"key":"ref_187","doi-asserted-by":"crossref","first-page":"609","DOI":"10.1016\/j.jconrel.2025.01.039","article-title":"ROS-differentiated release of Apelin-13 from hydrogel comprehensively treats myocardial ischemia-reperfusion injury","volume":"379","author":"Zhen","year":"2025","journal-title":"J. Control. Release"},{"key":"ref_188","doi-asserted-by":"crossref","first-page":"38","DOI":"10.1186\/s42825-025-00212-x","article-title":"Injectable hydrogels with tailored recombinant humanized collagen type I for the repair of damaged hearts by remodeling the myocardial microenvironment","volume":"7","author":"Hu","year":"2025","journal-title":"Collagen Leather"},{"key":"ref_189","doi-asserted-by":"crossref","first-page":"160861","DOI":"10.1016\/j.cej.2025.160861","article-title":"Core-shell hydrogel microspheres with sequential delivery of cerium oxide nanoparticles and spinal white matter extracellular matrix for improved functional recovery in spinal cord injury","volume":"508","author":"Ai","year":"2025","journal-title":"Chem. Eng. J."},{"key":"ref_190","doi-asserted-by":"crossref","first-page":"126423","DOI":"10.1016\/j.ijpharm.2025.126423","article-title":"Controlled-release hybrid hydrogels delivering synergistic N-acetyl cysteine, ibuprofen, and progesterone combinations for enhanced peripheral nerve regeneration","volume":"687","author":"Devine","year":"2026","journal-title":"Int. J. Pharm."},{"key":"ref_191","doi-asserted-by":"crossref","first-page":"124579","DOI":"10.1016\/j.carbpol.2025.124579","article-title":"A microenvironment-responsive chitosan based injectable hydrogel with synergistic anti-inflammatory effects of triptolide and copper ions for spinal cord injury repair","volume":"373","author":"Hu","year":"2026","journal-title":"Carbohydr. Polym."},{"key":"ref_192","doi-asserted-by":"crossref","first-page":"e13232","DOI":"10.1111\/wrr.13232","article-title":"The Wound Reporting in Animal and Human Preclinical Studies (WRAHPS) Guidelines","volume":"33","author":"Ojeh","year":"2024","journal-title":"Wound Repair Regen."},{"key":"ref_193","doi-asserted-by":"crossref","unstructured":"Zhang, Y., Leng, K., Dong, M., Wu, J., Wang, Z., Zhu, Q., Gao, X., and Sun, Y. (2026). Establishment and translational evaluation of animal models for skin wound healing: A systematic review. Front. Physiol., 17.","DOI":"10.3389\/fphys.2026.1800001"},{"key":"ref_194","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1089\/wound.2012.0367","article-title":"Preclinical Models of Wound Healing: Is Man the Model? Proceedings of the Wound Healing Society Symposium","volume":"2","author":"Gordillo","year":"2012","journal-title":"Adv. Wound Care"},{"key":"ref_195","doi-asserted-by":"crossref","first-page":"122671","DOI":"10.1016\/j.ijpharm.2023.122671","article-title":"A review of conventional and emerging technologies for hydrogels sterilization","volume":"634","author":"Bento","year":"2023","journal-title":"Int. J. Pharm."},{"key":"ref_196","doi-asserted-by":"crossref","first-page":"6270","DOI":"10.1039\/D5BM01305D","article-title":"Effects of irradiation sterilization on the physicochemical and functional properties of commercial biomedical hydrogels","volume":"13","author":"Zhou","year":"2025","journal-title":"Biomater. Sci."},{"key":"ref_197","doi-asserted-by":"crossref","unstructured":"Alonso, J.M., Olmo, J.A.d., Gonzalez, R.P., and Saez-Martinez, V. (2021). Injectable Hydrogels: From Laboratory to Industrialization. Polymers, 13.","DOI":"10.3390\/polym13040650"},{"key":"ref_198","doi-asserted-by":"crossref","unstructured":"El-Sehrawy, A.A.M.A., Alkhayyat, S., Baig, M.R., Kubaev, A., Gajjar, T.B., Hanumanthayya, M., Maharana, L., Kaur, I., Smerat, A., and Fereydouni, N. (2026). Injectable bioactive hydrogels as pharmacological drug delivery platforms for post-myocardial infarction cardiac repair: Therapeutic cargo engineering, stimuli-responsive release mechanisms, and translational perspectives. Naunyn-Schmiedeberg\u2019s Arch. Pharmacol., Online ahead of print.","DOI":"10.1007\/s00210-026-05604-2"},{"key":"ref_199","doi-asserted-by":"crossref","unstructured":"Wang, S., Huang, S., Chen, Q., Li, Y., Duan, L., Yu, Z., Li, W., Luo, H., Li, S., and Fan, B. (2025). Emergency Wound Infection Monitoring and Treatment Based on Wearable Electrochemical Detection and Drug Release with Conductive Hydrogel. Chemosensors, 13.","DOI":"10.3390\/chemosensors13070267"},{"key":"ref_200","doi-asserted-by":"crossref","first-page":"124326","DOI":"10.1016\/j.biomaterials.2026.124326","article-title":"Multifunctional antibacterial intelligent hydrogel for infection detection and inflammation regulation to promote diabetic wound healing","volume":"334","author":"Yang","year":"2026","journal-title":"Biomaterials"},{"key":"ref_201","doi-asserted-by":"crossref","first-page":"14967","DOI":"10.1039\/D5TB01944C","article-title":"Artificial intelligence-enabled hydrogels: Innovations and applications","volume":"13","author":"Zhang","year":"2025","journal-title":"J. Mater. Chem. B"},{"key":"ref_202","doi-asserted-by":"crossref","unstructured":"Urifa, J., and Shah, K.W. (2025). Early Insights into AI and Machine Learning Applications in Hydrogel Microneedles: A Short Review. 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Sci."},{"key":"ref_206","doi-asserted-by":"crossref","first-page":"124020","DOI":"10.1016\/j.biomaterials.2026.124020","article-title":"Spatiotemporal 4D-printed shape-memory scaffold with a triple-acting liposomal strategy for the treatment of infectious bone defects","volume":"330","author":"Hu","year":"2026","journal-title":"Biomaterials"}],"container-title":["Gels"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.mdpi.com\/2310-2861\/12\/9\/805\/pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,9,5]],"date-time":"2026-09-05T04:52:41Z","timestamp":1788583961000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.mdpi.com\/2310-2861\/12\/9\/805"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,9,3]]},"references-count":206,"journal-issue":{"issue":"9","published-online":{"date-parts":[[2026,9]]}},"alternative-id":["gels12090805"],"URL":"https:\/\/doi.org\/10.3390\/gels12090805","relation":{},"ISSN":["2310-2861"],"issn-type":[{"value":"2310-2861","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,9,3]]}}}