{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,9]],"date-time":"2026-09-09T11:08:18Z","timestamp":1788952098450,"version":"build-2803163510"},"reference-count":82,"publisher":"MDPI AG","issue":"9","license":[{"start":{"date-parts":[[2026,9,6]],"date-time":"2026-09-06T00:00:00Z","timestamp":1788652800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/100016969","name":"Universidad Polit\u00e9cnica Salesiana","doi-asserted-by":"crossref","award":["060-003-2026-04-16"],"award-info":[{"award-number":["060-003-2026-04-16"]}],"id":[{"id":"10.13039\/100016969","id-type":"DOI","asserted-by":"crossref"}]},{"award":["060-003-2026-04-16"],"award-info":[{"award-number":["060-003-2026-04-16"]}],"id":[{"id":"https:\/\/ror.org\/00f11af73","id-type":"ROR","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Gels"],"abstract":"<jats:p>Cutaneous wound healing is governed by dynamically interacting mechanical, redox, and bioelectrical signals that regulate cell migration, inflammation, angiogenesis, extracellular-matrix remodeling, and tissue regeneration. Hydrogels are increasingly engineered to modulate these cues; however, most systems are still described through independently measured properties such as stiffness, antioxidant activity, and conductivity, without demonstrating functional coupling among them. This review examines regenerative hydrogels from a cross-domain perspective, integrating the biological basis of mechanotransduction, redox signaling, endogenous bioelectricity, and their molecular convergence with the network-level mechanisms that control hydrogel behavior. Particular emphasis is placed on dynamic crosslinking, viscoelastic relaxation, hydration, redox-active chemistry, ionic and electronic transport, conductive and piezoelectric phases, and degradation-dependent evolution of material function. A conceptual hierarchy is proposed to distinguish property coexistence, structural integration, directional transduction, and adaptive feedback, together with experimental criteria and quantitative approaches for evaluating coupling. Current evidence indicates that mechanoelectrical coupling is the most mature, whereas mechanoredox and redox\u2013electrical interactions remain less systematically quantified. Moving beyond descriptive multifunctionality toward controllable cross-domain transduction may enable hydrogels to function as adaptive soft interfaces capable of responding to the evolving physicochemical conditions of cutaneous regeneration.<\/jats:p>","DOI":"10.3390\/gels12090818","type":"journal-article","created":{"date-parts":[[2026,9,7]],"date-time":"2026-09-07T13:53:28Z","timestamp":1788789208000},"page":"818","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Mechanical, Redox, and Bioelectrical Coupling in Hydrogels for Cutaneous Regeneration: Network Design and Structure\u2013Property Relationships"],"prefix":"10.3390","volume":"12","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-8205-7729","authenticated-orcid":false,"given":"Luisbel","family":"Gonz\u00e1lez","sequence":"first","affiliation":[{"name":"Instituto de Ciencias Aplicadas, Facultad de Ingenier\u00eda, Universidad Aut\u00f3noma de Chile, Santiago 8581151, Chile"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2723-0079","authenticated-orcid":false,"given":"Antonio","family":"P\u00e9rez-Torres","sequence":"additional","affiliation":[{"name":"Grupo de Investigaci\u00f3n y Desarrollo en Tecnolog\u00edas Industriales, Universidad Polit\u00e9cnica Salesiana, Cuenca 010105, Ecuador"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yenisleidys","family":"Fern\u00e1ndez-Guerrero","sequence":"additional","affiliation":[{"name":"Doctorado en Ingenier\u00eda, Universidad del B\u00edo-B\u00edo, Concepci\u00f3n 4051381, Chile"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Daylenis","family":"P\u00e9rez","sequence":"additional","affiliation":[{"name":"Laboratorio de Biomateriales, Departamento de Ingenier\u00eda Qu\u00edmica, Universidad de Concepci\u00f3n, Concepci\u00f3n 4030000, Chile"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0004-8802-6893","authenticated-orcid":false,"given":"Brenda","family":"L\u00f3pez","sequence":"additional","affiliation":[{"name":"Instituto de Ciencias Aplicadas, Facultad de Ingenier\u00eda, Universidad Aut\u00f3noma de Chile, Santiago 8581151, Chile"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1974-9209","authenticated-orcid":false,"given":"Reinier","family":"Fern\u00e1ndez-L\u00f3pez","sequence":"additional","affiliation":[{"name":"Facultad de Ingenier\u00eda y Arquitectura, Universidad Arturo Prat, Iquique 1100000, Chile"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2026,9,6]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"3770","DOI":"10.1039\/D4QM00562G","article-title":"MoS2-Functionalized Chitosan Hydrogel with Antibacterial and Antioxidant Functions Promotes Healing of Infected Diabetic Wounds","volume":"8","author":"He","year":"2024","journal-title":"Mater. Chem. Front."},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"18345","DOI":"10.1038\/s41598-024-67304-2","article-title":"GelMA Loaded with Platelet Lysate Promotes Skin Regeneration and Angiogenesis in Pressure Ulcers by Activating STAT3","volume":"14","author":"Jin","year":"2024","journal-title":"Sci. Rep."},{"key":"ref_3","doi-asserted-by":"crossref","first-page":"9868","DOI":"10.1021\/acsnano.4c14487","article-title":"Conductive Hydrogel Inspires Neutrophil Extracellular Traps to Combat Bacterial Infections in Wounds","volume":"19","author":"Ouyang","year":"2025","journal-title":"ACS Nano"},{"key":"ref_4","doi-asserted-by":"crossref","first-page":"122841","DOI":"10.1016\/j.biomaterials.2024.122841","article-title":"Versatile Conductive Hydrogel Orchestrating Neuro\u2013Immune Microenvironment for Rapid Diabetic Wound Healing through Peripheral Nerve Regeneration","volume":"314","author":"Bi","year":"2025","journal-title":"Biomaterials"},{"key":"ref_5","doi-asserted-by":"crossref","first-page":"102520","DOI":"10.1016\/j.mtbio.2025.102520","article-title":"Biomimetic Electric Interface-Mediated Cellular Activation Promotes Diabetic Wound Healing via Self-Powered Wearable Thermoelectric Patch","volume":"35","author":"Gao","year":"2025","journal-title":"Mater. Today Bio"},{"key":"ref_6","doi-asserted-by":"crossref","first-page":"22270","DOI":"10.1021\/acsnano.5c04690","article-title":"Silver\u2013Catechol Dynamic Redox Chemistry Provides Hydrogel Dressings with Sustained Antioxidant and Antibacterial Activity for Chronic Wound Care","volume":"19","author":"Huang","year":"2025","journal-title":"ACS Nano"},{"key":"ref_7","doi-asserted-by":"crossref","first-page":"5797","DOI":"10.1038\/s41467-025-61141-1","article-title":"Dimeric Copper Peptide Incorporated Hydrogel for Promoting Diabetic Wound Healing","volume":"16","author":"Cong","year":"2025","journal-title":"Nat. Commun."},{"key":"ref_8","doi-asserted-by":"crossref","first-page":"15069","DOI":"10.1021\/acsnano.5c01864","article-title":"Pd@Au Nanoframe Hydrogels for Closed-Loop Wound Therapy","volume":"19","author":"Wang","year":"2025","journal-title":"ACS Nano"},{"key":"ref_9","doi-asserted-by":"crossref","first-page":"5526","DOI":"10.1038\/s41467-026-72068-6","article-title":"Quinone-Mediated, Tissue-Adaptive Double-Network Hydrogel for Instant Hemostasis and Wet-Tissue Adhesion","volume":"17","author":"Kim","year":"2026","journal-title":"Nat. Commun."},{"key":"ref_10","doi-asserted-by":"crossref","first-page":"6352","DOI":"10.1038\/s41467-026-72968-7","article-title":"Sprayable Nanozyme Hydrogel Epigenetically Remodels Inflammation for Diabetic Wound Regeneration","volume":"17","author":"Kurian","year":"2026","journal-title":"Nat. Commun."},{"key":"ref_11","first-page":"eaar2971","article-title":"Myofibroblast Proliferation and Heterogeneity Are Supported by Macrophages during Skin Repair","volume":"362","author":"Shook","year":"2018","journal-title":"Science (1979)"},{"key":"ref_12","doi-asserted-by":"crossref","first-page":"6349","DOI":"10.1038\/s41467-021-26717-7","article-title":"Agrin-Matrix Metalloproteinase-12 Axis Confers a Mechanically Competent Microenvironment in Skin Wound Healing","volume":"12","author":"Chakraborty","year":"2021","journal-title":"Nat. Commun."},{"key":"ref_13","doi-asserted-by":"crossref","first-page":"3250","DOI":"10.1096\/fj.07-8218com","article-title":"Mechanical Load Initiates Hypertrophic Scar Formation through Decreased Cellular Apoptosis","volume":"21","author":"Aarabi","year":"2007","journal-title":"FASEB J."},{"key":"ref_14","doi-asserted-by":"crossref","first-page":"148","DOI":"10.1038\/nm.2574","article-title":"Focal Adhesion Kinase Links Mechanical Force to Skin Fibrosis via Inflammatory Signaling","volume":"18","author":"Wong","year":"2012","journal-title":"Nat. Med."},{"key":"ref_15","first-page":"eaba2374","article-title":"Preventing Engrailed-1 Activation in Fibroblasts Yields Wound Regeneration without Scarring","volume":"372","author":"Mascharak","year":"2021","journal-title":"Science (1979)"},{"key":"ref_16","doi-asserted-by":"crossref","first-page":"5256","DOI":"10.1038\/s41467-021-25410-z","article-title":"Disrupting Biological Sensors of Force Promotes Tissue Regeneration in Large Organisms","volume":"12","author":"Chen","year":"2021","journal-title":"Nat. Commun."},{"key":"ref_17","doi-asserted-by":"crossref","first-page":"eabj9152","DOI":"10.1126\/scitranslmed.abj9152","article-title":"Disrupting Mechanotransduction Decreases Fibrosis and Contracture in Split-Thickness Skin Grafting","volume":"14","author":"Chen","year":"2022","journal-title":"Sci. Transl. Med."},{"key":"ref_18","doi-asserted-by":"crossref","first-page":"eadt6387","DOI":"10.1126\/scitranslmed.adt6387","article-title":"Inhibiting Mechanotransduction Prevents Scarring and Yields Regeneration in a Large Animal Model","volume":"17","author":"Mascharak","year":"2025","journal-title":"Sci. Transl. Med."},{"key":"ref_19","doi-asserted-by":"crossref","first-page":"e65415","DOI":"10.7554\/eLife.65415","article-title":"Spatiotemporal Dynamics of PIEZO1 Localization Controls Keratinocyte Migration during Wound Healing","volume":"10","author":"Holt","year":"2021","journal-title":"eLife"},{"key":"ref_20","doi-asserted-by":"crossref","first-page":"226","DOI":"10.1038\/s41419-021-03481-6","article-title":"Mechanical Stretch Promotes Hypertrophic Scar Formation through Mechanically Activated Cation Channel Piezo1","volume":"12","author":"He","year":"2021","journal-title":"Cell Death Dis."},{"key":"ref_21","doi-asserted-by":"crossref","first-page":"354","DOI":"10.1038\/s41420-023-01656-y","article-title":"Mechanical Stiffness Promotes Skin Fibrosis through Piezo1-Mediated Arginine and Proline Metabolism","volume":"9","author":"He","year":"2023","journal-title":"Cell Death Discov."},{"key":"ref_22","doi-asserted-by":"crossref","first-page":"84","DOI":"10.1038\/s41419-024-06466-3","article-title":"Mechanical Stiffness Promotes Skin Fibrosis via Piezo1-Wnt2\/Wnt11-CCL24 Positive Feedback Loop","volume":"15","author":"He","year":"2024","journal-title":"Cell Death Dis."},{"key":"ref_23","doi-asserted-by":"crossref","first-page":"3256","DOI":"10.1038\/s41467-021-23482-5","article-title":"Mechanically Activated Ion Channel Piezo1 Modulates Macrophage Polarization and Stiffness Sensing","volume":"12","author":"Atcha","year":"2021","journal-title":"Nat. Commun."},{"key":"ref_24","doi-asserted-by":"crossref","first-page":"82","DOI":"10.1186\/s11658-025-00764-0","article-title":"Non-Monotonic Response of Macrophages to Mechanical Stretch Impacts Skin Wound Healing","volume":"30","author":"Wei","year":"2025","journal-title":"Cell. Mol. Biol. Lett."},{"key":"ref_25","doi-asserted-by":"crossref","first-page":"599","DOI":"10.1038\/s41580-024-00715-1","article-title":"Cellular and Molecular Mechanisms of Skin Wound Healing","volume":"25","author":"Martin","year":"2024","journal-title":"Nat. Rev. Mol. Cell Biol."},{"key":"ref_26","doi-asserted-by":"crossref","first-page":"617","DOI":"10.1038\/s41580-024-00716-0","article-title":"Fibroblast and Myofibroblast Activation in Normal Tissue Repair and Fibrosis","volume":"25","author":"Younesi","year":"2024","journal-title":"Nat. Rev. Mol. Cell Biol."},{"key":"ref_27","doi-asserted-by":"crossref","first-page":"eadv9895","DOI":"10.1126\/sciadv.adv9895","article-title":"Mechanoregulative Hydrogel Facilitates Rapid Scarless Healing by Self-Adaptive Control of Wound Niche at Different Stages","volume":"11","author":"Shu","year":"2025","journal-title":"Sci. Adv."},{"key":"ref_28","doi-asserted-by":"crossref","first-page":"211","DOI":"10.1016\/j.ymthe.2005.07.684","article-title":"Dermal Wound Healing Is Subject to Redox Control","volume":"13","author":"Roy","year":"2006","journal-title":"Mol. Ther."},{"key":"ref_29","doi-asserted-by":"crossref","unstructured":"Loo, A.E.K., Wong, Y.T., Ho, R., Wasser, M., Du, T., Ng, W.T., and Halliwell, B. (2012). Effects of Hydrogen Peroxide on Wound Healing in Mice in Relation to Oxidative Damage. PLoS ONE, 7.","DOI":"10.1371\/journal.pone.0049215"},{"key":"ref_30","doi-asserted-by":"crossref","first-page":"996","DOI":"10.1038\/nature08119","article-title":"A Tissue-Scale Gradient of Hydrogen Peroxide Mediates Rapid Wound Detection in Zebrafish","volume":"459","author":"Niethammer","year":"2009","journal-title":"Nature"},{"key":"ref_31","doi-asserted-by":"crossref","first-page":"109","DOI":"10.1038\/nature10632","article-title":"Lyn Is a Redox Sensor That Mediates Leukocyte Wound Attraction in Vivo","volume":"480","author":"Yoo","year":"2011","journal-title":"Nature"},{"key":"ref_32","doi-asserted-by":"crossref","first-page":"424","DOI":"10.1016\/j.cub.2013.01.058","article-title":"Calcium Flashes Orchestrate the Wound Inflammatory Response through DUOX Activation and Hydrogen Peroxide Release","volume":"23","author":"Razzell","year":"2013","journal-title":"Curr. Biol."},{"key":"ref_33","doi-asserted-by":"crossref","first-page":"6868","DOI":"10.1038\/s41467-025-62272-1","article-title":"Spatiotemporal H2O2 Flashes Coordinate Actin Cytoskeletal Remodeling and Regulate Cell Migration and Wound Healing","volume":"16","author":"Zhang","year":"2025","journal-title":"Nat. Commun."},{"key":"ref_34","doi-asserted-by":"crossref","first-page":"633","DOI":"10.2337\/db15-0453","article-title":"Restoration of Nrf2 Signaling Normalizes the Regenerative Niche","volume":"65","author":"Soares","year":"2016","journal-title":"Diabetes"},{"key":"ref_35","doi-asserted-by":"crossref","first-page":"108417","DOI":"10.1016\/j.celrep.2020.108417","article-title":"Keratinocyte-Macrophage Crosstalk by the Nrf2\/Ccl2\/EGF Signaling Axis Orchestrates Tissue Repair","volume":"33","author":"Tiruneh","year":"2020","journal-title":"Cell Rep."},{"key":"ref_36","doi-asserted-by":"crossref","first-page":"102609","DOI":"10.1016\/j.redox.2023.102609","article-title":"NADPH Oxidase 4 Is Dispensable for Skin Myofibroblast Differentiation and Wound Healing","volume":"60","author":"Siedlar","year":"2023","journal-title":"Redox Biol."},{"key":"ref_37","doi-asserted-by":"crossref","first-page":"20328","DOI":"10.1038\/srep20328","article-title":"Comparative Transcriptomic Profiling of Hydrogen Peroxide Signaling Networks in Zebrafish and Human Keratinocytes: Implications toward Conservation, Migration and Wound Healing","volume":"6","author":"Lisse","year":"2016","journal-title":"Sci. Rep."},{"key":"ref_38","doi-asserted-by":"crossref","first-page":"780","DOI":"10.2337\/db15-0564","article-title":"An Essential Role of NRF2 in Diabetic Wound Healing","volume":"65","author":"Long","year":"2016","journal-title":"Diabetes"},{"key":"ref_39","doi-asserted-by":"crossref","first-page":"107198","DOI":"10.1016\/j.burns.2024.07.002","article-title":"Resveratrol Promotes Diabetic Wound Healing by Inhibiting Ferroptosis in Vascular Endothelial Cells","volume":"50","author":"Xiao","year":"2024","journal-title":"Burns"},{"key":"ref_40","doi-asserted-by":"crossref","first-page":"645","DOI":"10.1111\/j.1524-475X.2011.00723.x","article-title":"The Electric Field near Human Skin Wounds Declines with Age and Provides a Noninvasive Indicator of Wound Healing","volume":"19","author":"Nuccitelli","year":"2011","journal-title":"Wound Repair Regen."},{"key":"ref_41","doi-asserted-by":"crossref","first-page":"199","DOI":"10.1242\/jcs.109.1.199","article-title":"Human Keratinocytes Migrate to the Negative Pole in Direct Current Electric Fields Comparable to Those Measured in Mammalian Wounds","volume":"109","author":"Nishimura","year":"1996","journal-title":"J. Cell Sci."},{"key":"ref_42","doi-asserted-by":"crossref","first-page":"751","DOI":"10.1046\/j.1523-1747.1998.00366.x","article-title":"Migration of Human Keratinocytes in Electric Fields Requires Growth Factors and Extracellular Calcium","volume":"111","author":"Fang","year":"1998","journal-title":"J. Investig. Dermatol."},{"key":"ref_43","doi-asserted-by":"crossref","first-page":"4925","DOI":"10.1091\/mbc.e06-05-0433","article-title":"\u03924 Integrin and Epidermal Growth Factor Coordinately Regulate Electric Field-Mediated Directional Migration via Rac1","volume":"17","author":"Pullar","year":"2006","journal-title":"Mol. Biol. Cell"},{"key":"ref_44","doi-asserted-by":"crossref","first-page":"457","DOI":"10.1038\/nature04925","article-title":"Electrical Signals Control Wound Healing through Phosphatidylinositol-3-OH Kinase-\u03b3 and PTEN","volume":"442","author":"Zhao","year":"2006","journal-title":"Nature"},{"key":"ref_45","doi-asserted-by":"crossref","first-page":"397","DOI":"10.1242\/jcs.00868","article-title":"Electrical Stimulation Directly Induces Pre-Angiogenic Responses in Vascular Endothelial Cells by Signaling through VEGF Receptors","volume":"117","author":"Zhao","year":"2004","journal-title":"J. Cell Sci."},{"key":"ref_46","doi-asserted-by":"crossref","unstructured":"Rouabhia, M., Park, H., Meng, S., Derbali, H., and Zhang, Z. (2013). Electrical Stimulation Promotes Wound Healing by Enhancing Dermal Fibroblast Activity and Promoting Myofibroblast Transdifferentiation. PLoS ONE, 8.","DOI":"10.1371\/journal.pone.0071660"},{"key":"ref_47","doi-asserted-by":"crossref","first-page":"11444","DOI":"10.1038\/s41598-023-38664-y","article-title":"Electrotaxis Evokes Directional Separation of Co-Cultured Keratinocytes and Fibroblasts","volume":"13","author":"Leal","year":"2023","journal-title":"Sci. Rep."},{"key":"ref_48","doi-asserted-by":"crossref","first-page":"432","DOI":"10.1111\/j.1524-475X.2008.00389.x","article-title":"Imaging the Electric Field Associated with Mouse and Human Skin Wounds","volume":"16","author":"Nuccitelli","year":"2008","journal-title":"Wound Repair Regen."},{"key":"ref_49","doi-asserted-by":"crossref","first-page":"2320","DOI":"10.1038\/jid.2010.96","article-title":"Effects of Physiological Electric Fields on Migration of Human Dermal Fibroblasts","volume":"130","author":"Guo","year":"2010","journal-title":"J. Investig. Dermatol."},{"key":"ref_50","doi-asserted-by":"crossref","first-page":"840","DOI":"10.1111\/j.1524-475X.2012.00829.x","article-title":"Electric Fields Guide Migration of Epidermal Stem Cells and Promote Skin Wound Healing","volume":"20","author":"Li","year":"2012","journal-title":"Wound Repair Regen."},{"key":"ref_51","doi-asserted-by":"crossref","first-page":"1166","DOI":"10.1038\/jid.2014.502","article-title":"Electrical Stimulation Enhances Epidermal Proliferation in Human Cutaneous Wounds by Modulating P53\u2013SIVA1 Interaction","volume":"135","author":"Sebastian","year":"2015","journal-title":"J. Investig. Dermatol."},{"key":"ref_52","doi-asserted-by":"crossref","first-page":"181","DOI":"10.1002\/jcp.25070","article-title":"ATP Release and P2Y Receptor Signaling Are Essential for Keratinocyte Galvanotaxis","volume":"231","author":"Riding","year":"2016","journal-title":"J. Cell. Physiol."},{"key":"ref_53","doi-asserted-by":"crossref","first-page":"113","DOI":"10.1016\/j.bioelechem.2019.02.001","article-title":"Keratinocyte Electrotaxis Induced by Physiological Pulsed Direct Current Electric Fields","volume":"127","author":"Ren","year":"2019","journal-title":"Bioelectrochemistry"},{"key":"ref_54","doi-asserted-by":"crossref","first-page":"462","DOI":"10.1038\/s41563-024-02060-2","article-title":"Stretch-Induced Endogenous Electric Fields Drive Directed Collective Cell Migration in Vivo","volume":"24","author":"Ferreira","year":"2025","journal-title":"Nat. Mater."},{"key":"ref_55","doi-asserted-by":"crossref","first-page":"5183","DOI":"10.1021\/acsabm.5c00523","article-title":"Accelerating Wound Healing through a Mechano-Electric Synergistic Conductive Hydrogel","volume":"8","author":"Nie","year":"2025","journal-title":"ACS Appl. Bio Mater."},{"key":"ref_56","doi-asserted-by":"crossref","first-page":"205","DOI":"10.1016\/j.actbio.2024.11.028","article-title":"Construction of Piezoelectric, Conductive and Injectable Hydrogels to Promote Wound Healing through Electrical Stimulation","volume":"191","author":"Wu","year":"2025","journal-title":"Acta Biomater."},{"key":"ref_57","doi-asserted-by":"crossref","unstructured":"Banerjee, J., Das Ghatak, P., Roy, S., Khanna, S., Sequin, E.K., Bellman, K., Dickinson, B.C., Suri, P., Subramaniam, V.V., and Chang, C.J. (2014). Improvement of Human Keratinocyte Migration by a Redox Active Bioelectric Dressing. PLoS ONE, 9.","DOI":"10.1371\/journal.pone.0089239"},{"key":"ref_58","doi-asserted-by":"crossref","first-page":"nwaf118","DOI":"10.1093\/nsr\/nwaf118","article-title":"Piezoelectric Dual-Network Tough Hydrogel with on-Demand Thermal Contraction and Sonopiezoelectric Effect for Promoting Infected-Joint-Skin-Wound Healing via FAK and AKT Signaling Pathways","volume":"12","author":"Luo","year":"2025","journal-title":"Natl. Sci. Rev."},{"key":"ref_59","doi-asserted-by":"crossref","first-page":"15924","DOI":"10.1021\/acsnano.5c01742","article-title":"Self-Powered Thermoelectric Hydrogels Accelerate Wound Healing","volume":"19","author":"Qin","year":"2025","journal-title":"ACS Nano"},{"key":"ref_60","doi-asserted-by":"crossref","first-page":"e2500027","DOI":"10.1002\/adhm.202500027","article-title":"Polyphenol Conductive Nanozyme-Enhanced Redox Hydrogel Coupled with Vagus Nerve Electrical Stimulation for Diabetic Wound Repair","volume":"14","author":"Ran","year":"2025","journal-title":"Adv. Healthc. Mater."},{"key":"ref_61","doi-asserted-by":"crossref","first-page":"101989","DOI":"10.1016\/j.matt.2025.101989","article-title":"Energy Reconversion of Ultrasound on a Piezoelectric Hydrogel Promotes ROS\/CO Generation and Wound Self-Closure for Infected Chronic Wound Healing","volume":"8","author":"Chi","year":"2025","journal-title":"Matter"},{"key":"ref_62","doi-asserted-by":"crossref","first-page":"657","DOI":"10.1016\/j.jare.2025.12.022","article-title":"Motion-Driven Piezoelectric Response in Self-Powered Hydrogel Nanofibers Enhances Wound Healing via Intermediate Filament Remodeling and Modulation of Energy Metabolism","volume":"87","author":"Xu","year":"2025","journal-title":"J. Adv. Res."},{"key":"ref_63","doi-asserted-by":"crossref","first-page":"4243","DOI":"10.1038\/s41467-026-70771-y","article-title":"Low-Intensity Focused Ultrasound-Activated Piezoelectric Gel Bandage for Diabetic Wound Repair and Neuropathic Pain Relief","volume":"17","author":"Li","year":"2026","journal-title":"Nat. Commun."},{"key":"ref_64","doi-asserted-by":"crossref","first-page":"141362","DOI":"10.1016\/j.cej.2023.141362","article-title":"Extracellular Matrix Mimicking Dynamic Interpenetrating Network Hydrogel for Skin Tissue Engineering","volume":"457","author":"Wang","year":"2023","journal-title":"Chem. Eng. J."},{"key":"ref_65","doi-asserted-by":"crossref","first-page":"151","DOI":"10.1038\/s41378-026-01233-0","article-title":"Programmable Viscoelastic Hydrogels Exhibit Antimicrobial and Regenerative Properties to Promote Cell Migration, Wound Healing, and Tissue Remodeling","volume":"12","author":"Wang","year":"2026","journal-title":"Microsyst. Nanoeng."},{"key":"ref_66","doi-asserted-by":"crossref","first-page":"343","DOI":"10.1186\/s12951-023-02113-9","article-title":"Multi-Functional Conductive Hydrogels Based on Heparin\u2013Polydopamine Complex Reduced Graphene Oxide for Epidermal Sensing and Chronic Wound Healing","volume":"21","author":"Dou","year":"2023","journal-title":"J. Nanobiotechnol."},{"key":"ref_67","doi-asserted-by":"crossref","first-page":"110985","DOI":"10.1016\/j.compositesb.2023.110985","article-title":"Photothermal Antibacterial Antioxidant Conductive Self-Healing Hydrogel with Nitric Oxide Release Accelerates Diabetic Wound Healing","volume":"266","author":"He","year":"2023","journal-title":"Compos. B Eng."},{"key":"ref_68","doi-asserted-by":"crossref","first-page":"179253","DOI":"10.1016\/j.cej.2026.179253","article-title":"Sodium Alginate\/Tannic Acid\/PEDOT:PSS Conductive Hydrogels with in-Situ Calcium Release-Mediated Gelation for Accelerating Diabetic Wound Healing","volume":"544","author":"Liu","year":"2026","journal-title":"Chem. Eng. J."},{"key":"ref_69","doi-asserted-by":"crossref","first-page":"2740","DOI":"10.1038\/s41467-018-05222-4","article-title":"Mechanically Tunable Conductive Interpenetrating Network Hydrogels That Mimic the Elastic Moduli of Biological Tissue","volume":"9","author":"Feig","year":"2018","journal-title":"Nat. Commun."},{"key":"ref_70","doi-asserted-by":"crossref","unstructured":"Al Raihan, M., Mikhail, M.M.A., Hijazi, K.M., Yaghoobi, H., Frampton, J.P., Adibnia, V., and Freund, M.S. (2026). Coupled Electronic and Ionic Conductivity in Strain-Stiffening Hydrogels. Adv. Sci., e76247.","DOI":"10.1002\/advs.76247"},{"key":"ref_71","doi-asserted-by":"crossref","first-page":"221","DOI":"10.1016\/S0167-2738(96)00429-8","article-title":"Review of the Limitation of the Hebb-Wagner Polarization Method for Measuring Partial Conductivities in Mixed Ionic Electronic Conductors","volume":"91","author":"Riess","year":"1996","journal-title":"Solid State Ion."},{"key":"ref_72","doi-asserted-by":"crossref","first-page":"2400439","DOI":"10.1002\/smsc.202400439","article-title":"Biodegradable Piezoelectric Micro- and Nanomaterials for Regenerative Medicine, Targeted Therapy, and Microrobotics","volume":"5","author":"Vannozzi","year":"2025","journal-title":"Small Sci."},{"key":"ref_73","doi-asserted-by":"crossref","first-page":"1029","DOI":"10.2217\/nnm-2024-0080","article-title":"Piezoelectric Nanomaterials: Latest Applications in Biomedicine and Challenges in Clinical Translation","volume":"19","author":"Marino","year":"2024","journal-title":"Nanomedicine"},{"key":"ref_74","doi-asserted-by":"crossref","first-page":"138287","DOI":"10.1016\/j.ijbiomac.2024.138287","article-title":"Sodium Alginate Based Piezoelectric Hydrogel for Promoting Healing of Infected Wounds at Movable Parts","volume":"285","author":"Chen","year":"2025","journal-title":"Int. J. Biol. Macromol."},{"key":"ref_75","doi-asserted-by":"crossref","first-page":"174639","DOI":"10.1016\/j.cej.2026.174639","article-title":"Mechanoadaptive Conductive Hydrogels with Dual Functionalities for Epidermal SEMG Monitoring and Diabetic Wound Healing","volume":"533","author":"Ren","year":"2026","journal-title":"Chem. Eng. J."},{"key":"ref_76","doi-asserted-by":"crossref","first-page":"e2207237","DOI":"10.1002\/advs.202207237","article-title":"Intrinsically Nonswellable Multifunctional Hydrogel with Dynamic Nanoconfinement Networks for Robust Tissue-Adaptable Bioelectronics","volume":"10","author":"Park","year":"2023","journal-title":"Adv. Sci."},{"key":"ref_77","doi-asserted-by":"crossref","first-page":"7629","DOI":"10.1039\/D3TB00710C","article-title":"A Nanoscale Inorganic Coating Strategy for Stabilizing Hydrogel Neural Probes in Vivo","volume":"11","author":"Huang","year":"2023","journal-title":"J. Mater. Chem. B"},{"key":"ref_78","doi-asserted-by":"crossref","first-page":"124305","DOI":"10.1016\/j.carbpol.2025.124305","article-title":"A Dual-Layer Chitosan-Based Conductive Hydrogel and Piezoelectric Film for Ultrasound-Driven Wound Repair and Scar Reduction","volume":"370","author":"Yao","year":"2025","journal-title":"Carbohydr. Polym."},{"key":"ref_79","doi-asserted-by":"crossref","first-page":"405","DOI":"10.1103\/PhysRev.37.405","article-title":"Reciprocal Relations in Irreversible Processes. I","volume":"37","author":"Onsager","year":"1931","journal-title":"Phys. Rev."},{"key":"ref_80","doi-asserted-by":"crossref","first-page":"9071","DOI":"10.1038\/s41467-024-53290-6","article-title":"Polyphenol-Mediated Redox-Active Hydrogel with H2S Gaseous-Bioelectric Coupling for Periodontal Bone Healing in Diabetes","volume":"15","author":"Fang","year":"2024","journal-title":"Nat. Commun."},{"key":"ref_81","doi-asserted-by":"crossref","first-page":"214818","DOI":"10.1016\/j.bioadv.2026.214818","article-title":"Coupling Phenolic Redox Chemistry and Graphenic Conductivity in Alginate Hydrogels: Charge Storage Mapped by Impedance as a Biomarker of Wound Healing","volume":"184","author":"Figueroa","year":"2026","journal-title":"Biomater. Adv."},{"key":"ref_82","doi-asserted-by":"crossref","first-page":"e70405","DOI":"10.1002\/agt2.70405","article-title":"Electroactive Hydrogel Enabling Feedback-Responsive Monitoring and Regulation of Inflammation for Chronic Wound Therapy","volume":"7","author":"Wei","year":"2026","journal-title":"Aggregate"}],"container-title":["Gels"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.mdpi.com\/2310-2861\/12\/9\/818\/pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,9,9]],"date-time":"2026-09-09T10:10:49Z","timestamp":1788948649000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.mdpi.com\/2310-2861\/12\/9\/818"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,9,6]]},"references-count":82,"journal-issue":{"issue":"9","published-online":{"date-parts":[[2026,9]]}},"alternative-id":["gels12090818"],"URL":"https:\/\/doi.org\/10.3390\/gels12090818","relation":{},"ISSN":["2310-2861"],"issn-type":[{"value":"2310-2861","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,9,6]]}}}