{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,10]],"date-time":"2026-09-10T12:18:30Z","timestamp":1789042710531,"version":"build-2803163510"},"reference-count":93,"publisher":"MDPI AG","issue":"9","license":[{"start":{"date-parts":[[2026,9,10]],"date-time":"2026-09-10T00:00:00Z","timestamp":1788998400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100003725","name":"National Research Foundation of Korea","doi-asserted-by":"publisher","award":["RS-2024-00355944"],"award-info":[{"award-number":["RS-2024-00355944"]}],"id":[{"id":"10.13039\/501100003725","id-type":"DOI","asserted-by":"publisher"}]},{"award":["RS-2024-00355944"],"award-info":[{"award-number":["RS-2024-00355944"]}],"id":[{"id":"https:\/\/ror.org\/013aysd81","id-type":"ROR","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Gels"],"abstract":"<jats:p>Tannic acid grafting provides a practical strategy for introducing bioactive phenolic functionality into microbial polysaccharides for multifunctional hydrogel design. Herein, tannic acid-modified succinoglycan (SG-TA) was prepared through an ascorbic acid\/ H2O2-mediated free-radical process. Spectroscopic, thermal, and purification-control analyses were consistent with covalent incorporation of tannic acid-derived moieties into SG, while characteristic structural features of the SG framework remained evident after modification. SG-TA exhibited tannic acid-equivalent phenolic contents of up to 321.9 mg TAE\/g and markedly enhanced antioxidant and antibacterial activities compared with native SG. SG-TA was subsequently incorporated into a poly(vinyl alcohol) (PVA)\/borax network to form dynamic SG-TA\/PVA\/borax (STPB) hydrogels based on reversible interactions. The hydrogels exhibited composition-dependent viscoelasticity, rapid rheological recovery, macroscopic self-rejoining, enhanced deformability, antioxidant and antibacterial functionality, and preliminary cytocompatibility. Time-dependent phenolic release showed that SG-TA-derived phenolic species were partially released from the network, indicating contributions from both matrix-associated and releasable functionality. The reversible network also enabled pH- and glucose-responsive release of 5-fluorouracil as a model small-molecule drug. These findings demonstrate the potential of SG-TA as an intrinsically bioactive microbial polysaccharide for multifunctional, self-healing, and stimuli-responsive drug-delivery hydrogels.<\/jats:p>","DOI":"10.3390\/gels12090828","type":"journal-article","created":{"date-parts":[[2026,9,10]],"date-time":"2026-09-10T11:38:39Z","timestamp":1789040319000},"page":"828","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Intrinsically Bioactive Tannic Acid-Grafted Succinoglycan for Self-Healing and Stimuli-Responsive Drug Delivery Hydrogels"],"prefix":"10.3390","volume":"12","author":[{"given":"Sang-Il","family":"Park","sequence":"first","affiliation":[{"name":"Department of Bioscience and Biotechnology, Microbial Carbohydrate Resource Bank (MCRB), Konkuk University, 120 Neungdong-ro, Gwangjin-gu, Seoul 05029, Republic of Korea"}],"role":[{"vocabulary":"crossref","role":"author"},{"role":"methodology","vocabulary":"credit"},{"role":"investigation","vocabulary":"credit"},{"role":"writing-original-draft","vocabulary":"credit"}]},{"given":"Kyungho","family":"Kim","sequence":"additional","affiliation":[{"name":"Department of Bioscience and Biotechnology, Microbial Carbohydrate Resource Bank (MCRB), Konkuk University, 120 Neungdong-ro, Gwangjin-gu, Seoul 05029, Republic of Korea"}],"role":[{"vocabulary":"crossref","role":"author"},{"role":"investigation","vocabulary":"credit"},{"role":"methodology","vocabulary":"credit"},{"role":"writing-original-draft","vocabulary":"credit"}]},{"given":"Sungmin","family":"Rhyu","sequence":"additional","affiliation":[{"name":"Department of Bioscience and Biotechnology, Microbial Carbohydrate Resource Bank (MCRB), Konkuk University, 120 Neungdong-ro, Gwangjin-gu, Seoul 05029, Republic of Korea"}],"role":[{"vocabulary":"crossref","role":"author"},{"role":"investigation","vocabulary":"credit"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0801-9342","authenticated-orcid":false,"given":"Seunho","family":"Jung","sequence":"additional","affiliation":[{"name":"Department of Bioscience and Biotechnology, Microbial Carbohydrate Resource Bank (MCRB), Konkuk University, 120 Neungdong-ro, Gwangjin-gu, Seoul 05029, Republic of Korea"},{"name":"Department of System Biotechnology, Konkuk University, 120 Neungdong-ro, Gwangjin-gu, Seoul 05029, Republic of Korea"}],"role":[{"vocabulary":"crossref","role":"author"},{"role":"conceptualization","vocabulary":"credit"},{"role":"resources","vocabulary":"credit"},{"role":"supervision","vocabulary":"credit"},{"role":"funding-acquisition","vocabulary":"credit"},{"role":"writing-review-editing","vocabulary":"credit"}]}],"member":"1968","published-online":{"date-parts":[[2026,9,10]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"6300","DOI":"10.1021\/acs.jafc.2c01080","article-title":"Recent advances of stimuli-responsive polysaccharide hydrogels in delivery systems: A review","volume":"70","author":"Zhang","year":"2022","journal-title":"J. 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