{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,20]],"date-time":"2026-09-20T03:35:09Z","timestamp":1789875309734,"version":"4.0.1"},"reference-count":52,"publisher":"MDPI AG","issue":"7","license":[{"start":{"date-parts":[[2022,7,1]],"date-time":"2022-07-01T00:00:00Z","timestamp":1656633600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"Natural Science Foundation of Guangdong Province","award":["2022A1515012189"],"award-info":[{"award-number":["2022A1515012189"]}]},{"name":"Natural Science Foundation of Guangdong Province","award":["202002030306"],"award-info":[{"award-number":["202002030306"]}]},{"name":"Natural Science Foundation of Guangdong Province","award":["51673071"],"award-info":[{"award-number":["51673071"]}]},{"name":"Natural Science Foundation of Guangdong Province","award":["QD202136"],"award-info":[{"award-number":["QD202136"]}]},{"name":"Science and Technology Program of Guangzhou, China","award":["2022A1515012189"],"award-info":[{"award-number":["2022A1515012189"]}]},{"name":"Science and Technology Program of Guangzhou, China","award":["202002030306"],"award-info":[{"award-number":["202002030306"]}]},{"name":"Science and Technology Program of Guangzhou, China","award":["51673071"],"award-info":[{"award-number":["51673071"]}]},{"name":"Science and Technology Program of Guangzhou, China","award":["QD202136"],"award-info":[{"award-number":["QD202136"]}]},{"name":"National Natural Science Foundation of China","award":["2022A1515012189"],"award-info":[{"award-number":["2022A1515012189"]}]},{"name":"National Natural Science Foundation of China","award":["202002030306"],"award-info":[{"award-number":["202002030306"]}]},{"name":"National Natural Science Foundation of China","award":["51673071"],"award-info":[{"award-number":["51673071"]}]},{"name":"National Natural Science Foundation of China","award":["QD202136"],"award-info":[{"award-number":["QD202136"]}]},{"name":"doctoral startup fund of Gannan Medical University","award":["2022A1515012189"],"award-info":[{"award-number":["2022A1515012189"]}]},{"name":"doctoral startup fund of Gannan Medical University","award":["202002030306"],"award-info":[{"award-number":["202002030306"]}]},{"name":"doctoral startup fund of Gannan Medical University","award":["51673071"],"award-info":[{"award-number":["51673071"]}]},{"name":"doctoral startup fund of Gannan Medical University","award":["QD202136"],"award-info":[{"award-number":["QD202136"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Gels"],"abstract":"<jats:p>Articular cartilage provides ultralow friction to maintain the physiological function of the knee joint, which arises from the hierarchical complex composed of hyaluronic acid, phospholipids, and lubricin, covering the cartilage surface as boundary lubrication layers. Cartilage-lubricating polymers (HA\/PA and HA\/PM) mimicking this complex have been demonstrated to restore the lubrication of cartilage via hydration lubrication, thus contributing to the treatment of early osteoarthritis (OA) in vivo. Here, biomimetic cartilage-lubricating hydrogels (HPX\/PVA) were constructed by blending HA\/PA and HA\/PM (HPX) with polyvinyl alcohol (PVA) to improve the boundary lubrication and wear properties, so that the obtained hydrogels may offer a solution to the main drawbacks of PVA hydrogels used as cartilage implants. The HPX\/PVA hydrogels exhibited good physicochemical and mechanical properties through hydrogen-bonding interactions, and showed lower friction and wear under the boundary lubrication and fluid film lubrication mechanisms, which remained when the hydrogels were rehydrated. Our strategy may provide new insights into exploring cartilage-inspired lubricating hydrogels.<\/jats:p>","DOI":"10.3390\/gels8070415","type":"journal-article","created":{"date-parts":[[2022,7,2]],"date-time":"2022-07-02T11:12:35Z","timestamp":1656760355000},"page":"415","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":21,"title":["Construction and Tribological Properties of Biomimetic Cartilage-Lubricating Hydrogels"],"prefix":"10.3390","volume":"8","author":[{"given":"Qiuyi","family":"Chen","sequence":"first","affiliation":[{"name":"School of Biomedical Science and Engineering, South China University of Technology, Guangzhou 510006, China"},{"name":"National Engineering Research Center for Tissue Restoration and Reconstruction, South China University of Technology, Guangzhou 510006, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8106-0392","authenticated-orcid":false,"given":"Sa","family":"Liu","sequence":"additional","affiliation":[{"name":"National Engineering Research Center for Tissue Restoration and Reconstruction, South China University of Technology, Guangzhou 510006, China"},{"name":"School of Materials Science and Engineering, South China University of Technology, Guangzhou 510006, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhongrun","family":"Yuan","sequence":"additional","affiliation":[{"name":"National Engineering Research Center for Tissue Restoration and Reconstruction, South China University of Technology, Guangzhou 510006, China"},{"name":"School of Materials Science and Engineering, South China University of Technology, Guangzhou 510006, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hai","family":"Yang","sequence":"additional","affiliation":[{"name":"National Engineering Research Center for Tissue Restoration and Reconstruction, South China University of Technology, Guangzhou 510006, China"},{"name":"School of Materials Science and Engineering, South China University of Technology, Guangzhou 510006, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0523-9702","authenticated-orcid":false,"given":"Renjian","family":"Xie","sequence":"additional","affiliation":[{"name":"School of Medical Information Engineering, Gannan Medical University, Ganzhou 341000, China"},{"name":"Key Laboratory of Prevention and Treatment of Cardiovascular and Cerebrovascular Diseases, Ministry of Education, Gannan Medical University, Ganzhou 341000, China"},{"name":"Key Laboratory of Biomaterials and Bio-Fabrication in Tissue Engineering of Jiangxi Province, Ganzhou 341000, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Li","family":"Ren","sequence":"additional","affiliation":[{"name":"National Engineering Research Center for Tissue Restoration and Reconstruction, South China University of Technology, Guangzhou 510006, China"},{"name":"School of Materials Science and Engineering, South China University of Technology, Guangzhou 510006, China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2022,7,1]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"109","DOI":"10.1243\/PIME_PROC_1996_210_399_02","article-title":"The influence of loading time and lubricant on the friction of articular cartilage","volume":"210","author":"Forster","year":"1996","journal-title":"Proc. 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