{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,7]],"date-time":"2026-02-07T10:33:54Z","timestamp":1770460434458,"version":"3.49.0"},"reference-count":32,"publisher":"MDPI AG","issue":"8","license":[{"start":{"date-parts":[[2022,8,20]],"date-time":"2022-08-20T00:00:00Z","timestamp":1660953600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"Foundation for Research Support of Rio de Janeiro (FAPERJ) Infinity Farm"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Gels"],"abstract":"<jats:p>The aim of the study was to evaluate the healing process of chronic wounds treated with carboxymethylcellulose loaded with recombinant human epidermal growth factor in patients with diabetes. The case series consisted of 10 patients treated at the university hospital for 12 weeks. Data were analyzed using SPSS version 22.0. according to the intention to treat the principle, without the loss or exclusion of the participants. The sample consisted of 70% (7\/10) males with a mean age of 61.9 years (\u00b19.4); all (100%) had diabetes mellitus and 70% (7\/10) had systolic hypertension associated with diabetes mellitus. Sixty percent (6\/10) presented lesions of diabetic etiology and 40% (4\/10) presented lesions of venous etiology; 70% (7\/10) had had lesions for less than 5 years. The mean glycated hemoglobin was 7.8% (\u00b12.7%), while the mean ankle-arm index (AAI) was 0.94 (\u00b10.21). The mean initial area of all wounds was 13.4 cm\u00b2, and the mean final area was 7.8 cm2, with a reduction rate of 28.9% over the 12 weeks of treatment. The reduction rate of diabetic ulcers was higher (33.4%) than that of venous ulcers (22.1%). Regarding the type of tissue, there was an increase in granulation and epithelialization, and a decrease in slough and the amount of exudate that were statistically significant (p = 0.021). No participant had severe or local adverse events during the study period. Epidermal growth factor was effective in the treatment of chronic wounds, especially diabetic ulcers, resulting in the reduction of the wound area and the improvement of tissue and exudate quality.<\/jats:p>","DOI":"10.3390\/gels8080523","type":"journal-article","created":{"date-parts":[[2022,8,21]],"date-time":"2022-08-21T22:23:13Z","timestamp":1661120593000},"page":"523","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":9,"title":["rhEGF-Loaded Hydrogel in the Treatment of Chronic Wounds in Patients with Diabetes: Clinical Cases"],"prefix":"10.3390","volume":"8","author":[{"given":"Beatriz Guitton Renaud Baptista","family":"de Oliveira","sequence":"first","affiliation":[{"name":"Aurora de Afonso Costa School of Nursing, Universidade Federal Fluminense, Niter\u00f3i 24210-201, Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6348-3287","authenticated-orcid":false,"given":"Bianca Campos","family":"Oliveira","sequence":"additional","affiliation":[{"name":"Aurora de Afonso Costa School of Nursing, Universidade Federal Fluminense, Niter\u00f3i 24210-201, Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4618-439X","authenticated-orcid":false,"given":"Gabriela","family":"Deutsch","sequence":"additional","affiliation":[{"name":"Faculty of Pharmacy, Universidade Federal Fluminense, Niter\u00f3i 24210-201, Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Fernanda Soares","family":"Pessanha","sequence":"additional","affiliation":[{"name":"Faculty of Nursing, Rio de Janeiro State University, Niter\u00f3i 24210-201, Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0026-5431","authenticated-orcid":false,"given":"Rossana Mara da Silva Moreira","family":"Thir\u00e9","sequence":"additional","affiliation":[{"name":"COPPE\/Program of Metallurgical and Materials Engineering\u2014PEMM, University of Rio de Janeiro, Rio de Janeiro 21941-599, Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0272-4777","authenticated-orcid":false,"given":"Selma Rodrigues","family":"de Castilho","sequence":"additional","affiliation":[{"name":"Faculty of Pharmacy, Universidade Federal Fluminense, Niter\u00f3i 24210-201, Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1968","published-online":{"date-parts":[[2022,8,20]]},"reference":[{"key":"ref_1","first-page":"12","article-title":"Clinical assessment of chronic wounds","volume":"1","author":"Armstrong","year":"2019","journal-title":"Wolters Kluwer Up Date"},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"8","DOI":"10.1016\/j.annepidem.2018.10.005","article-title":"Prevalence of chronic wounds in the general population: Systematic review and meta-analysis of observational studies","volume":"29","author":"Martinengo","year":"2019","journal-title":"Ann. 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