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In this study, acrylamide, 2-acrylamide-2-methylpropanesulfonic acid, diallyl dimethyl ammonium chloride, and N-vinylpyrrolidone were synthesized by free radical copolymerization in an aqueous solution to form a temperature and salt-resistant zwitterionic polymer gel filtration loss reducer (AADN). The zwitterionic polymer had excellent adsorption and hydration groups, which could effectively combine with bentonite through hydrogen bonds and electrostatic attraction, strengthening the hydration film thickness on the surface of bentonite, and promoting the stable dispersion of drilling fluid. In addition, the reverse polyelectrolyte effect of zwitterionic polymers strengthened the drilling fluid\u2019s ability to resist high-temperature and high-salt. The AADN-based drilling fluid showed excellent rheological and filtration control properties (FLAPI &lt; 8 mL, FLHTHP &lt; 29.6 mL) even after aging at high-temperature (200 \u00b0C) and high-salt (20 wt% NaCl) conditions. This study provides a new strategy for simultaneously improving the high-temperature and high-salt tolerance of WBDFs, presenting the potential for application in drilling in high-temperature and high-salt deep formations.<\/jats:p>","DOI":"10.3390\/gels8120826","type":"journal-article","created":{"date-parts":[[2022,12,14]],"date-time":"2022-12-14T03:21:52Z","timestamp":1670988112000},"page":"826","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":19,"title":["Investigation on Filtration Control of Zwitterionic Polymer AADN in High Temperature High Pressure Water-Based Drilling Fluids"],"prefix":"10.3390","volume":"8","author":[{"given":"Ren","family":"Wang","sequence":"first","affiliation":[{"name":"CNPC Engineering Technology R&D Company Ltd., Beijing 102206, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8773-8718","authenticated-orcid":false,"given":"Jie","family":"Yang","sequence":"additional","affiliation":[{"name":"CNPC Engineering Technology R&D Company Ltd., Beijing 102206, China"},{"name":"College of Chemistry and Chemical Engineering, Southwest Petroleum University, Chengdu 610500, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Luman","family":"Liu","sequence":"additional","affiliation":[{"name":"CNPC Engineering Technology R&D Company Ltd., Beijing 102206, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4891-4891","authenticated-orcid":false,"given":"Jianlong","family":"Wang","sequence":"additional","affiliation":[{"name":"CNPC Engineering Technology R&D Company Ltd., Beijing 102206, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhenbo","family":"Feng","sequence":"additional","affiliation":[{"name":"Daqing Drilling & Exploration Engineering Corporation No. 2 Drilling Co., Daqing 163413, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Die","family":"Zhang","sequence":"additional","affiliation":[{"name":"CNPC Engineering Technology R&D Company Ltd., Beijing 102206, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shan","family":"Gao","sequence":"additional","affiliation":[{"name":"CNPC Engineering Technology R&D Company Ltd., Beijing 102206, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jiao","family":"Wang","sequence":"additional","affiliation":[{"name":"Gas Storage Company of Liaohe Oilfield Company, Panjin 124000, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Han","family":"Ren","sequence":"additional","affiliation":[{"name":"CNPC Engineering Technology R&D Company Ltd., Beijing 102206, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Baotong","family":"Hui","sequence":"additional","affiliation":[{"name":"CNPC Engineering Technology R&D Company Ltd., Beijing 102206, China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2022,12,14]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"506","DOI":"10.1016\/j.petrol.2017.12.009","article-title":"Effect of cationic copolyelectrolyte additives on drilling fluids for shales","volume":"161","author":"Beg","year":"2018","journal-title":"J. Pet. Sci. Eng."},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"103576","DOI":"10.1016\/j.jngse.2020.103576","article-title":"Synthesis and performance evaluation of a novel polymeric fluid loss controller in water-based drilling fluids: High-temperature and high-salinity conditions","volume":"83","author":"Aghdam","year":"2020","journal-title":"J. Nat. Gas Sci. Eng."},{"key":"ref_3","doi-asserted-by":"crossref","first-page":"1064","DOI":"10.2118\/209195-PA","article-title":"Modified Corn Starch as an Environmentally Friendly Rheology Enhancer and Fluid Loss Reducer for Water-Based Drilling Mud","volume":"27","author":"Ricky","year":"2022","journal-title":"SPE J."},{"key":"ref_4","doi-asserted-by":"crossref","unstructured":"Jiang, G., Sun, J., He, Y., Cui, K., Dong, T., Yang, L., Yang, X., and Wang, X. (Engineering, 2021). Novel water-based drilling and completion fluid technology to improve wellbore quality during drilling and protect unconventional reservoirs, Engineering, in press.","DOI":"10.1016\/j.eng.2021.11.014"},{"key":"ref_5","doi-asserted-by":"crossref","unstructured":"Li, J., Sun, J., Lv, K., Ji, Y., Ji, J., Bai, Y., Wang, J., Jin, J., Shi, S., and Huang, X. (2022). A zwitterionic copolymer as fluid loss reducer for water-based drilling fluids in high temperature and high salinity conditions. J. Pet. Sci. Eng., 111200. in press.","DOI":"10.1016\/j.petrol.2022.111200"},{"key":"ref_6","doi-asserted-by":"crossref","first-page":"1333","DOI":"10.2118\/200487-PA","article-title":"Optimal synthesis, characterization, and performance evaluation of high-pressure high-temperature polymer-based drilling fluid: The effect of viscoelasticity on cutting transport, filtration loss, and lubricity","volume":"25","author":"Gautam","year":"2020","journal-title":"SPE J."},{"key":"ref_7","doi-asserted-by":"crossref","first-page":"129730","DOI":"10.1016\/j.colsurfa.2022.129730","article-title":"Synthesis of a new high temperature and salt resistant zwitterionic filtrate reducer and its application in water-based drilling fluid","volume":"651","author":"Liu","year":"2022","journal-title":"Colloids Surf. Physicochem. Eng. Asp."},{"key":"ref_8","doi-asserted-by":"crossref","first-page":"11963","DOI":"10.1021\/acs.energyfuels.7b02354","article-title":"Novel acrylamide\/2-acrylamide-2-methylpropanesulfonic acid\/4-vinylpyridine terpolymer as an anti-calcium contamination fluid-loss additive for water-based drilling fluids","volume":"31","author":"Cao","year":"2017","journal-title":"Energy Fuels"},{"key":"ref_9","doi-asserted-by":"crossref","first-page":"687","DOI":"10.1016\/S1876-3804(13)60093-2","article-title":"Formation, distribution and potential of deep hydrocarbon resources in China","volume":"40","author":"Longde","year":"2013","journal-title":"Pet. Explor. Dev."},{"key":"ref_10","doi-asserted-by":"crossref","first-page":"458","DOI":"10.1016\/j.eng.2019.01.012","article-title":"Theoretical progress and key technologies of onshore ultra-deep oil\/gas exploration","volume":"5","author":"Guo","year":"2019","journal-title":"Engineering"},{"key":"ref_11","doi-asserted-by":"crossref","first-page":"7221","DOI":"10.1021\/acs.energyfuels.6b01567","article-title":"Amphoteric polymer as an anti-calcium contamination fluid-loss additive in water-based drilling fluids","volume":"30","author":"Liu","year":"2016","journal-title":"Energy Fuels"},{"key":"ref_12","doi-asserted-by":"crossref","first-page":"51001","DOI":"10.1002\/app.51001","article-title":"Novel N, N-dimethylacrylamide copolymer containing multiple rigid comonomers as a filtrate reducer in water-based drilling fluids and mechanism study","volume":"138","author":"Wang","year":"2021","journal-title":"J. Appl. Polym. Sci."},{"key":"ref_13","doi-asserted-by":"crossref","first-page":"108821","DOI":"10.1016\/j.petrol.2021.108821","article-title":"A high-temperature resistant colloid gas aphron drilling fluid system prepared by using a novel graft copolymer xanthan gum-AA\/AM\/AMPS","volume":"205","author":"Zhu","year":"2021","journal-title":"J. Pet. Sci. Eng."},{"key":"ref_14","doi-asserted-by":"crossref","first-page":"130261","DOI":"10.1016\/j.colsurfa.2022.130261","article-title":"Laponite-polymer composite as a rheology modifier and filtration loss reducer for water-based drilling fluids at high temperature","volume":"655","author":"Yang","year":"2022","journal-title":"Colloids Surf. Physicochem. Eng. Asp."},{"key":"ref_15","doi-asserted-by":"crossref","first-page":"51831","DOI":"10.1002\/app.51831","article-title":"Highly effective utilization of vinyl copolymer as filtrate reducer of water-bentonite drilling fluid under ultrasonic oscillations","volume":"139","author":"Guo","year":"2022","journal-title":"J. Appl. Polym. Sci."},{"key":"ref_16","doi-asserted-by":"crossref","first-page":"6362","DOI":"10.1007\/s10853-017-0870-7","article-title":"Application of ionic liquid to a high-performance calcium-resistant additive for filtration control of bentonite\/water-based drilling fluids","volume":"52","author":"Yang","year":"2017","journal-title":"J. Mater. Sci."},{"key":"ref_17","doi-asserted-by":"crossref","first-page":"1197","DOI":"10.1007\/s11696-020-01379-9","article-title":"Synthesis and assessment of a hydrophobically associating heteropolymer in water-based mud","volume":"75","author":"Nagre","year":"2021","journal-title":"Chem. Pap."},{"key":"ref_18","doi-asserted-by":"crossref","first-page":"126482","DOI":"10.1016\/j.colsurfa.2021.126482","article-title":"Environmentally friendly and salt-responsive polymer brush based on lignin nanoparticle as fluid-loss additive in water-based drilling fluids","volume":"621","author":"Sun","year":"2021","journal-title":"Colloids Surf. Physicochem. Eng. Asp."},{"key":"ref_19","doi-asserted-by":"crossref","first-page":"115221","DOI":"10.1016\/j.molliq.2020.115221","article-title":"Preparation, characterization and filtration control properties of cross-linked starch nanospheres in water-based drilling fluids","volume":"325","author":"Zhong","year":"2021","journal-title":"J. Mol. Liq."},{"key":"ref_20","doi-asserted-by":"crossref","first-page":"39","DOI":"10.1016\/j.petlm.2021.02.001","article-title":"Minimizing the filtration loss of water-based drilling fluid with sustainable basil seed powder","volume":"8","author":"Zhong","year":"2022","journal-title":"Petroleum"},{"key":"ref_21","doi-asserted-by":"crossref","first-page":"7039","DOI":"10.1021\/acsanm.8b01830","article-title":"Surface-chemistry-tuned cellulose nanocrystals in a bentonite suspension for water-based drilling fluids","volume":"1","author":"Li","year":"2018","journal-title":"ACS Appl. Nano Mater."},{"key":"ref_22","doi-asserted-by":"crossref","first-page":"109808","DOI":"10.1016\/j.petrol.2021.109808","article-title":"Synthesis of hydrophobic associative polymers to improve the rheological and filtration performance of drilling fluids under high temperature and high salinity conditions","volume":"209","author":"Sun","year":"2022","journal-title":"J. Pet. Sci. Eng."},{"key":"ref_23","doi-asserted-by":"crossref","first-page":"1056","DOI":"10.1021\/acs.langmuir.8b01789","article-title":"Molecular design of zwitterionic polymer interfaces: Searching for the difference","volume":"35","author":"Laschewsky","year":"2018","journal-title":"Langmuir"},{"key":"ref_24","doi-asserted-by":"crossref","first-page":"757","DOI":"10.1039\/C8CS00508G","article-title":"An introduction to zwitterionic polymer behavior and applications in solution and at surfaces","volume":"48","author":"Blackman","year":"2019","journal-title":"Chem. Soc. Rev."},{"key":"ref_25","doi-asserted-by":"crossref","unstructured":"Chang, X., Sun, J., Zhang, F., Lv, K., Zhou, X., Wang, J., and Zhao, J. (2020). A novel zwitterionic quaternary copolymer as a fluid-loss additive for water-based drilling fluids. Energy Sources Part A, 1\u201314.","DOI":"10.1080\/15567036.2020.1766600"},{"key":"ref_26","doi-asserted-by":"crossref","unstructured":"Liu, L., Sun, J., Wang, R., Liu, F., Gao, S., Yang, J., Ren, H., Qu, Y., Cheng, R., and Geng, Y. (2022). New Zwitterionic Polymer as a Highly Effective Salt-and Calcium-Resistant Fluid Loss Reducer in Water-Based Drilling Fluids. Gels, 8.","DOI":"10.3390\/gels8110735"},{"key":"ref_27","doi-asserted-by":"crossref","first-page":"41762","DOI":"10.1002\/app.41762","article-title":"Synthesis, characterization, and performance evaluation of the AM\/AMPS\/DMDAAC\/SSS quadripolymer as a fluid loss additive for water-based drilling fluid","volume":"132","author":"Bai","year":"2015","journal-title":"J. Appl. Polym. Sci."},{"key":"ref_28","doi-asserted-by":"crossref","first-page":"110318","DOI":"10.1016\/j.petrol.2022.110318","article-title":"A state of the art review on the performance of high-pressure and high-temperature drilling fluids: Towards understanding the structure-property relationship of drilling fluid additives","volume":"213","author":"Gautam","year":"2022","journal-title":"J. Pet. Sci. Eng."},{"key":"ref_29","doi-asserted-by":"crossref","unstructured":"Li, J., Sun, J., Lv, K., Ji, Y., Liu, J., Huang, X., Bai, Y., Wang, J., Jin, J., and Shi, S. (2022). Temperature-and Salt-Resistant Micro-Crosslinked Polyampholyte Gel as Fluid-Loss Additive for Water-Based Drilling Fluids. Gels, 8.","DOI":"10.3390\/gels8050289"},{"key":"ref_30","doi-asserted-by":"crossref","first-page":"121994","DOI":"10.1016\/j.conbuildmat.2020.121994","article-title":"Inhibitory effects of functionalized polycarboxylate retarder on aberrant thickening phenomena of oil well cement at high temperature","volume":"274","author":"Zhang","year":"2021","journal-title":"Constr. Build. Mater."},{"key":"ref_31","doi-asserted-by":"crossref","first-page":"98","DOI":"10.1016\/j.petrol.2018.05.003","article-title":"A novel star-shaped copolymer as a rheology modifier in water-based drilling fluids","volume":"168","author":"Luo","year":"2018","journal-title":"J. Pet. Sci. Eng."},{"key":"ref_32","doi-asserted-by":"crossref","first-page":"41581","DOI":"10.1002\/app.41581","article-title":"Amphoteric hydrolyzed poly (acrylamide\/dimethyl diallyl ammonium chloride) as a filtration reducer under high temperatures and high salinities","volume":"132","author":"Lin","year":"2015","journal-title":"J. Appl. Polym. Sci."},{"key":"ref_33","unstructured":"Thaemlitz, C.J. (2006). Synthetic Filtration Control Polymers for Wellbore Fluids. (7,098,171), U.S. Patent."},{"key":"ref_34","doi-asserted-by":"crossref","first-page":"83","DOI":"10.1080\/10601325.2019.1671771","article-title":"Thermal stability of poly (diallyldimethylammonium chloride) with different molecular weight","volume":"57","author":"Jia","year":"2020","journal-title":"J. Macromol. Sci. Part A"},{"key":"ref_35","doi-asserted-by":"crossref","first-page":"2483","DOI":"10.1007\/s00289-020-03227-y","article-title":"Synthesis, characterization and properties of an anionic polymer for water-based drilling fluid as an anti-high temperature and anti-salt contamination fluid loss control additive","volume":"78","author":"Mao","year":"2021","journal-title":"Polym. Bull."},{"key":"ref_36","doi-asserted-by":"crossref","unstructured":"Loh, X.J., and Scherman, O.A. (2012). Polymeric and Self Assembled Hydrogels: From Fundamental Understanding to Applications, Royal Society of Chemistry.","DOI":"10.1039\/9781849735629"},{"key":"ref_37","doi-asserted-by":"crossref","first-page":"3350","DOI":"10.1039\/C5NJ02404H","article-title":"Enhanced mechanical stability and sensitive swelling performance of chitosan\/yeast hybrid hydrogel beads","volume":"40","author":"Feng","year":"2016","journal-title":"New J. Chem."},{"key":"ref_38","doi-asserted-by":"crossref","first-page":"427","DOI":"10.1080\/03602550903414019","article-title":"Electrospinning of polymers, their modeling and applications","volume":"49","author":"Kulkarni","year":"2010","journal-title":"Polym.-Plast. Technol. Eng."},{"key":"ref_39","doi-asserted-by":"crossref","first-page":"22","DOI":"10.1002\/app.1819","article-title":"Synthesis of water-soluble polymers containing sulfonic acid and amine moieties for the recovery of metal ions using ultrafiltration","volume":"82","author":"Rivas","year":"2001","journal-title":"J. Appl. Polym. Sci."},{"key":"ref_40","doi-asserted-by":"crossref","first-page":"3068","DOI":"10.1002\/app.2335","article-title":"Properties of high-temperature drilling fluids incorporating disodium itaconate\/acrylamide\/sodium 2-acrylamido-2-methylpropanesulfonate terpolymers as fluid-loss reducers","volume":"83","author":"Wu","year":"2002","journal-title":"J. Appl. Polym. Sci."},{"key":"ref_41","doi-asserted-by":"crossref","first-page":"45989","DOI":"10.1002\/app.45989","article-title":"Comb-shaped copolymer as filtrate loss reducer for water-based drilling fluid","volume":"135","author":"Liu","year":"2018","journal-title":"J. Appl. Polym. Sci."},{"key":"ref_42","doi-asserted-by":"crossref","first-page":"23788","DOI":"10.1021\/acsomega.1c02617","article-title":"Effective Modified Xanthan Gum Fluid Loss Agent for High-Temperature Water-Based Drilling Fluid and the Filtration Control Mechanism","volume":"6","author":"Zhu","year":"2021","journal-title":"ACS Omega"},{"key":"ref_43","doi-asserted-by":"crossref","first-page":"11052","DOI":"10.1021\/acsanm.1c02504","article-title":"Zwitterionic Silica-Based Hybrid Nanoparticles for Filtration Control in Oil Drilling Conditions","volume":"4","author":"Ao","year":"2021","journal-title":"ACS Appl. Nano Mater."},{"key":"ref_44","doi-asserted-by":"crossref","first-page":"403","DOI":"10.1016\/j.fuel.2019.02.018","article-title":"Investigation of inhibition mechanism of three deep eutectic solvents as potential shale inhibitors in water-based drilling fluids","volume":"244","author":"Jia","year":"2019","journal-title":"Fuel"},{"key":"ref_45","doi-asserted-by":"crossref","first-page":"114345","DOI":"10.1016\/j.molliq.2020.114345","article-title":"Salt-responsive zwitterionic copolymer as tackifier in brine drilling fluids","volume":"319","author":"Sun","year":"2020","journal-title":"J. Mol. Liq."},{"key":"ref_46","doi-asserted-by":"crossref","first-page":"125","DOI":"10.1515\/polyeng-2013-0257","article-title":"Synthesis and properties of acrylamide 2-acrylamido-2-methypropane sulfonic acid sodium styrene sulfonate N-vinyl pyrrolidone quadripolymer and its reduction of drilling fluid filtration at high temperature and high salinity","volume":"34","author":"Li","year":"2014","journal-title":"J. Polym. Eng."},{"key":"ref_47","doi-asserted-by":"crossref","first-page":"75","DOI":"10.1016\/j.clay.2004.01.001","article-title":"Colloidal behavior of aqueous montmorillonite suspensions: The specific role of pH in the presence of indifferent electrolytes","volume":"27","author":"Tombacz","year":"2004","journal-title":"Appl. Clay Sci."},{"key":"ref_48","unstructured":"Institute, A.P. (2009). Recommended Practice for Laboratory Testing of Drilling Fluids, American Petroleum Institute."}],"container-title":["Gels"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.mdpi.com\/2310-2861\/8\/12\/826\/pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,11]],"date-time":"2025-10-11T01:40:54Z","timestamp":1760146854000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.mdpi.com\/2310-2861\/8\/12\/826"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,12,14]]},"references-count":48,"journal-issue":{"issue":"12","published-online":{"date-parts":[[2022,12]]}},"alternative-id":["gels8120826"],"URL":"https:\/\/doi.org\/10.3390\/gels8120826","relation":{},"ISSN":["2310-2861"],"issn-type":[{"value":"2310-2861","type":"electronic"}],"subject":[],"published":{"date-parts":[[2022,12,14]]}}}