{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,25]],"date-time":"2026-04-25T23:15:11Z","timestamp":1777158911077,"version":"3.51.4"},"reference-count":36,"publisher":"MDPI AG","issue":"2","license":[{"start":{"date-parts":[[2023,2,1]],"date-time":"2023-02-01T00:00:00Z","timestamp":1675209600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Gels"],"abstract":"<jats:p>Hyaluronic acid (HA) is a glycosaminoglycan widely utilised in different fields of medicine. We aimed to provide a comprehensive overview of the scientific evidence on the use of HA in andrology. A review of the literature to identify pertinent studies concerning the use of HA in andrology was carried out on the Medline, EMBASE, and the Cochrane databases, with no time restriction up to December 2022. Penile girth enlargement (PGE) using HA proved to be safe and effective in enhancing the diameter of the penis, with durable and satisfactory outcomes in long-term follow-up. Injection of HA in the glans seems to represent an alternative treatment option for those patients with premature ejaculation (PE) who fail to respond to conventional medications. HA intra-plaque injections represent a valid option which may contribute to restore sexual activity in patients with Peyronie\u2019s disease (PD). The adoption of HA filler injections should always be tailored to the patient\u2019s peculiar anatomy and underlying condition. More robust evidence is required to achieve a uniformed consensus regarding the use of HA in andrology, and further efforts should continue to improve the current injection techniques and HA products.<\/jats:p>","DOI":"10.3390\/gels9020118","type":"journal-article","created":{"date-parts":[[2023,2,1]],"date-time":"2023-02-01T03:22:47Z","timestamp":1675221767000},"page":"118","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":11,"title":["The Application of Hyaluronic Acid Injections in Functional and Aesthetic Andrology: A Narrative Review"],"prefix":"10.3390","volume":"9","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-4828-4316","authenticated-orcid":false,"given":"Nicol\u00f2","family":"Schifano","sequence":"first","affiliation":[{"name":"ASST Sette Laghi\u2013Circolo e Fondazione Macchi Hospital, 21100 Varese, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Paolo","family":"Capogrosso","sequence":"additional","affiliation":[{"name":"ASST Sette Laghi\u2013Circolo e Fondazione Macchi Hospital, 21100 Varese, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Gabriele","family":"Antonini","sequence":"additional","affiliation":[{"name":"ASST Sette Laghi\u2013Circolo e Fondazione Macchi Hospital, 21100 Varese, Italy"},{"name":"Antonini Urology, 00185 Rome, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sara","family":"Baldini","sequence":"additional","affiliation":[{"name":"ASST Sette Laghi\u2013Circolo e Fondazione Macchi Hospital, 21100 Varese, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Fabrizio","family":"Scroppo","sequence":"additional","affiliation":[{"name":"ASST Sette Laghi\u2013Circolo e Fondazione Macchi Hospital, 21100 Varese, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Andrea","family":"Salonia","sequence":"additional","affiliation":[{"name":"Department of Urology, Universit\u00e0 Vita-Salute San Raffaele, 20132 Milan, Italy"},{"name":"Unit of Urology, Division of Experimental Oncology, Urology Research Institute (URI), IRCCS Ospedale San Raffaele, 20132 Milan, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Nicola","family":"Zerbinati","sequence":"additional","affiliation":[{"name":"ASST Sette Laghi\u2013Circolo e Fondazione Macchi Hospital, 21100 Varese, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0453-5710","authenticated-orcid":false,"given":"Federico","family":"Deh\u00f2","sequence":"additional","affiliation":[{"name":"ASST Sette Laghi\u2013Circolo e Fondazione Macchi Hospital, 21100 Varese, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1968","published-online":{"date-parts":[[2023,2,1]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"434","DOI":"10.1038\/s41443-021-00444-5","article-title":"Multidisciplinary approach and management of patients who seek medical advice for penile size concerns: A narrative review","volume":"34","author":"Schifano","year":"2021","journal-title":"Int. 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