{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,17]],"date-time":"2026-09-17T21:09:17Z","timestamp":1789679357858,"version":"4.0.1"},"reference-count":82,"publisher":"MDPI AG","issue":"2","license":[{"start":{"date-parts":[[2023,2,8]],"date-time":"2023-02-08T00:00:00Z","timestamp":1675814400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"Jiangxi Provincial Natural Science Foundation","award":["20224BAB214030"],"award-info":[{"award-number":["20224BAB214030"]}]},{"name":"Jiangxi Provincial Natural Science Foundation","award":["20224BAB216072"],"award-info":[{"award-number":["20224BAB216072"]}]},{"name":"Jiangxi Provincial Natural Science Foundation","award":["QD202136"],"award-info":[{"award-number":["QD202136"]}]},{"name":"Jiangxi Provincial Natural Science Foundation","award":["QD202132"],"award-info":[{"award-number":["QD202132"]}]},{"name":"doctoral startup fund of Gannan Medical University","award":["20224BAB214030"],"award-info":[{"award-number":["20224BAB214030"]}]},{"name":"doctoral startup fund of Gannan Medical University","award":["20224BAB216072"],"award-info":[{"award-number":["20224BAB216072"]}]},{"name":"doctoral startup fund of Gannan Medical University","award":["QD202136"],"award-info":[{"award-number":["QD202136"]}]},{"name":"doctoral startup fund of Gannan Medical University","award":["QD202132"],"award-info":[{"award-number":["QD202132"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Gels"],"abstract":"<jats:p>Articular cartilage (AC), which covers the ends of bones in joints, particularly the knee joints, provides a robust interface to maintain frictionless movement during daily life due to its remarkable lubricating and load-bearing capacities. However, osteoarthritis (OA), characterized by the progressive degradation of AC, compromises the properties of AC and thus leads to frayed and rough interfaces between the bones, which subsequently accelerates the progression of OA. Hydrogels, composed of highly hydrated and interconnected polymer chains, are potential candidates for AC replacement due to their physical and chemical properties being similar to those of AC. In this review, we summarize the recent progress of hydrogel-based synthetic cartilage, or cartilage-like hydrogels, with a particular focus on their lubrication and load-bearing properties. The different formulations, current limitations, and challenges of such hydrogels are also discussed. Moreover, we discuss the future directions of hydrogel-based synthetic cartilage to repair and even regenerate the damaged AC.<\/jats:p>","DOI":"10.3390\/gels9020144","type":"journal-article","created":{"date-parts":[[2023,2,9]],"date-time":"2023-02-09T01:37:07Z","timestamp":1675906627000},"page":"144","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":26,"title":["Recent Progress in Hydrogel-Based Synthetic Cartilage: Focus on Lubrication and Load-Bearing Capacities"],"prefix":"10.3390","volume":"9","author":[{"given":"Fei","family":"Qiu","sequence":"first","affiliation":[{"name":"Key Laboratory of Prevention and Treatment of Cardiovascular and Cerebrovascular Diseases, Ministry of Education, Gannan Medical University, Ganzhou 341000, China"},{"name":"School of Rehabilitation Medicine, Gannan Medical University, Ganzhou 341000, China"},{"name":"Key Laboratory of Biomaterials and Bio-Fabrication in Tissue Engineering of Jiangxi Province, Ganzhou 341000, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiaopeng","family":"Fan","sequence":"additional","affiliation":[{"name":"School of Materials Science and Engineering, South China University of Technology, Guangzhou 510641, China"},{"name":"National Engineering Research Center for Tissue Restoration and Reconstruction, South China University of Technology, Guangzhou 510006, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wen","family":"Chen","sequence":"additional","affiliation":[{"name":"Key Laboratory of Prevention and Treatment of Cardiovascular and Cerebrovascular Diseases, Ministry of Education, Gannan Medical University, Ganzhou 341000, China"},{"name":"School of Rehabilitation Medicine, Gannan Medical University, Ganzhou 341000, China"},{"name":"Key Laboratory of Biomaterials and Bio-Fabrication in Tissue Engineering of Jiangxi Province, Ganzhou 341000, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chunming","family":"Xu","sequence":"additional","affiliation":[{"name":"Key Laboratory of Prevention and Treatment of Cardiovascular and Cerebrovascular Diseases, Ministry of Education, Gannan Medical University, Ganzhou 341000, China"},{"name":"Key Laboratory of Biomaterials and Bio-Fabrication in Tissue Engineering of Jiangxi Province, Ganzhou 341000, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yumei","family":"Li","sequence":"additional","affiliation":[{"name":"Key Laboratory of Prevention and Treatment of Cardiovascular and Cerebrovascular Diseases, Ministry of Education, Gannan Medical University, Ganzhou 341000, China"},{"name":"Key Laboratory of Biomaterials and Bio-Fabrication in Tissue Engineering of Jiangxi Province, Ganzhou 341000, China"},{"name":"School of Basic Medicine, Gannan Medical University, Ganzhou 341000, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0523-9702","authenticated-orcid":false,"given":"Renjian","family":"Xie","sequence":"additional","affiliation":[{"name":"Key Laboratory of Prevention and Treatment of Cardiovascular and Cerebrovascular Diseases, Ministry of Education, Gannan Medical University, Ganzhou 341000, China"},{"name":"Key Laboratory of Biomaterials and Bio-Fabrication in Tissue Engineering of Jiangxi Province, Ganzhou 341000, China"},{"name":"School of Medical Information Engineering, Gannan Medical University, Ganzhou 341000, China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2023,2,8]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"e2001008","DOI":"10.1002\/adhm.202001008","article-title":"Innovative Tissue-Engineered Strategies for Osteochondral Defect Repair and Regeneration: Current Progress and Challenges","volume":"9","author":"Zhou","year":"2020","journal-title":"Adv. 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