{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,15]],"date-time":"2026-10-15T01:56:08Z","timestamp":1792029368165,"version":"4.4.0"},"reference-count":171,"publisher":"MDPI AG","issue":"2","license":[{"start":{"date-parts":[[2023,2,9]],"date-time":"2023-02-09T00:00:00Z","timestamp":1675900800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"Research and Develop Program, West China Hospital of Stomatology Sichuan University","award":["LCYJ2020-YJ-3"],"award-info":[{"award-number":["LCYJ2020-YJ-3"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Gels"],"abstract":"<jats:p>Oral and maxillofacial diseases have an important impact on local function, facial appearance, and general health. As a multifunctional platform, hydrogels are widely used in the biomedical field due to their excellent physicochemical properties. In recent years, a large number of studies have been conducted to adapt hydrogels to the complex oral and maxillofacial environment by modulating their pore size, swelling, degradability, stimulus-response properties, etc. Meanwhile, many studies have attempted to use hydrogels as drug delivery carriers to load drugs, cytokines, and stem cells for antibacterial, anticancer, and tissue regeneration applications in oral and maxillofacial regions. This paper reviews the application and research progress of hydrogel-based drug delivery systems in the treatment of oral and maxillofacial diseases such as caries, endodontic diseases, periodontal diseases, maxillofacial bone diseases, mucosal diseases, oral cancer, etc. The characteristics and applications of hydrogels and drug-delivery systems employed for the treatment of different diseases are discussed in order to provide a reference for further research on hydrogel drug-delivery systems in the future.<\/jats:p>","DOI":"10.3390\/gels9020146","type":"journal-article","created":{"date-parts":[[2023,2,10]],"date-time":"2023-02-10T01:35:29Z","timestamp":1675992929000},"page":"146","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":34,"title":["Applications of Hydrogels in Drug Delivery for Oral and Maxillofacial Diseases"],"prefix":"10.3390","volume":"9","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-3916-7444","authenticated-orcid":false,"given":"Lijia","family":"Liu","sequence":"first","affiliation":[{"name":"State Key Laboratory of Oral Diseases, National Clinical Research Center for Oral Diseases, Department of Cariology and Endodontics, West China Hospital of Stomatology, Sichuan University, Chengdu 610041, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dan","family":"Wu","sequence":"additional","affiliation":[{"name":"State Key Laboratory of Oral Diseases, National Clinical Research Center for Oral Diseases, Department of Cariology and Endodontics, West China Hospital of Stomatology, Sichuan University, Chengdu 610041, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Heng","family":"Tu","sequence":"additional","affiliation":[{"name":"State Key Laboratory of Oral Diseases, National Clinical Research Center for Oral Diseases, Department of Cariology and Endodontics, West China Hospital of Stomatology, Sichuan University, Chengdu 610041, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mengjiao","family":"Cao","sequence":"additional","affiliation":[{"name":"State Key Laboratory of Oral Diseases, National Clinical Research Center for Oral Diseases, Department of Cariology and Endodontics, West China Hospital of Stomatology, Sichuan University, Chengdu 610041, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mengxin","family":"Li","sequence":"additional","affiliation":[{"name":"State Key Laboratory of Oral Diseases, National Clinical Research Center for Oral Diseases, Department of Cariology and Endodontics, West China Hospital of Stomatology, Sichuan University, Chengdu 610041, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Li","family":"Peng","sequence":"additional","affiliation":[{"name":"Key Laboratory of Bio-Resource and Eco-Environment of Ministry of Education, College of Life Sciences, Sichuan University, Chengdu 610065, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jing","family":"Yang","sequence":"additional","affiliation":[{"name":"State Key Laboratory of Oral Diseases, National Clinical Research Center for Oral Diseases, Department of Cariology and Endodontics, West China Hospital of Stomatology, Sichuan University, Chengdu 610041, China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2023,2,9]]},"reference":[{"key":"ref_1","first-page":"109","article-title":"Synthesis of nanoparticles for dental drug delivery systems","volume":"100","author":"Bako","year":"2007","journal-title":"Fogorv. Szle."},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"259","DOI":"10.1016\/j.actbio.2020.09.018","article-title":"Antimicrobial and anti-inflammatory thermo-reversible hydrogel for periodontal delivery","volume":"116","author":"Wang","year":"2020","journal-title":"Acta Biomater."},{"key":"ref_3","doi-asserted-by":"crossref","first-page":"427","DOI":"10.1007\/s00520-006-0171-1","article-title":"Comparing pain control and ability to eat and drink with standard therapy vs Gelclair: A preliminary, double centre, randomised controlled trial on patients with radiotherapy-induced oral mucositis","volume":"15","author":"Barber","year":"2007","journal-title":"Support. Care Cancer"},{"key":"ref_4","doi-asserted-by":"crossref","first-page":"669","DOI":"10.1021\/acs.accounts.6b00536","article-title":"Designing Hydrogels for On-Demand Therapy","volume":"50","author":"Oliva","year":"2017","journal-title":"Acc. Chem. Res."},{"key":"ref_5","doi-asserted-by":"crossref","unstructured":"Salar Amoli, M., EzEldeen, M., Jacobs, R., and Bloemen, V. (2021). Materials for Dentoalveolar Bioprinting: Current State of the Art. Biomedicines, 10.","DOI":"10.3390\/biomedicines10010071"},{"key":"ref_6","doi-asserted-by":"crossref","first-page":"70","DOI":"10.1208\/s12249-022-02221-z","article-title":"Transfersome Hydrogel Containing 5-Fluorouracil and Etodolac Combination for Synergistic Oral Cancer Treatment","volume":"23","author":"Bollareddy","year":"2022","journal-title":"Aaps. Pharmscitech."},{"key":"ref_7","doi-asserted-by":"crossref","first-page":"S434","DOI":"10.1080\/21691401.2018.1499660","article-title":"Comparison of covalently and physically cross-linked collagen hydrogels on mediating vascular network formation for engineering adipose tissue","volume":"46","author":"Chuang","year":"2018","journal-title":"Artif. Cells Nanomed. Biotechnol."},{"key":"ref_8","doi-asserted-by":"crossref","first-page":"105","DOI":"10.1016\/j.jare.2013.07.006","article-title":"Hydrogel: Preparation, characterization, and applications: A review","volume":"6","author":"Ahmed","year":"2015","journal-title":"J. Adv. Res."},{"key":"ref_9","doi-asserted-by":"crossref","first-page":"254","DOI":"10.1016\/j.jconrel.2014.03.052","article-title":"Hydrogels in a historical perspective: From simple networks to smart materials","volume":"190","author":"Buwalda","year":"2014","journal-title":"J. Control. Release Off. J. Control. Release Soc."},{"key":"ref_10","doi-asserted-by":"crossref","first-page":"601","DOI":"10.1016\/j.ijbiomac.2022.07.168","article-title":"Preparation, properties, and applications of gelatin-based hydrogels (GHs) in the environmental, technological, and biomedical sectors","volume":"218","author":"Mushtaq","year":"2022","journal-title":"Int. J. Biol. Macromol."},{"key":"ref_11","doi-asserted-by":"crossref","first-page":"167","DOI":"10.1016\/j.addr.2018.03.007","article-title":"In situ forming injectable hydrogels for drug delivery and wound repair","volume":"127","author":"Dimatteo","year":"2018","journal-title":"Adv. Drug Deliv. Rev."},{"key":"ref_12","doi-asserted-by":"crossref","first-page":"1835","DOI":"10.1016\/j.drudis.2016.07.006","article-title":"Injectable hydrogel-based drug delivery systems for local cancer therapy","volume":"21","author":"Norouzi","year":"2016","journal-title":"Drug Discov. Today"},{"key":"ref_13","doi-asserted-by":"crossref","first-page":"6413","DOI":"10.1039\/D2BM01036D","article-title":"Hydrogels for the treatment of oral and maxillofacial diseases: Current research, challenges, and future directions","volume":"10","author":"Huang","year":"2022","journal-title":"Biomater. Sci."},{"key":"ref_14","first-page":"167","article-title":"3D conductive nanocomposite scaffold for bone tissue engineering","volume":"9","author":"Shahini","year":"2014","journal-title":"Int. J. Nanomed."},{"key":"ref_15","doi-asserted-by":"crossref","first-page":"104681","DOI":"10.1016\/j.supflu.2019.104681","article-title":"Production of biodegradable superabsorbent aerogels using a supercritical CO2 assisted drying","volume":"156","author":"Baldino","year":"2020","journal-title":"J. Supercrit. Fluids"},{"key":"ref_16","doi-asserted-by":"crossref","first-page":"3474","DOI":"10.1002\/pat.5358","article-title":"Preparation of bioactive aerogel material based on sodium alginate and chitosan for controlled release of levomycetin","volume":"32","author":"Gorshkova","year":"2021","journal-title":"Polym. Adv. Technol."},{"key":"ref_17","doi-asserted-by":"crossref","unstructured":"Kondiah, P.J., Choonara, Y.E., Kondiah, P.P., Marimuthu, T., Kumar, P., du Toit, L.C., and Pillay, V. (2016). A Review of Injectable Polymeric Hydrogel Systems for Application in Bone Tissue Engineering. Molecules, 21.","DOI":"10.3390\/molecules21111580"},{"key":"ref_18","doi-asserted-by":"crossref","first-page":"111581","DOI":"10.1016\/j.colsurfb.2021.111581","article-title":"Injectable thermosensitive hydrogel-based drug delivery system for local cancer therapy","volume":"200","author":"Xiao","year":"2021","journal-title":"Colloids Surf. B Biointerfaces"},{"key":"ref_19","doi-asserted-by":"crossref","unstructured":"Fan, R., Cheng, Y., Wang, R., Zhang, T., Zhang, H., Li, J., Song, S., and Zheng, A. (2022). Thermosensitive Hydrogels and Advances in Their Application in Disease Therapy. Polymers, 14.","DOI":"10.3390\/polym14122379"},{"key":"ref_20","doi-asserted-by":"crossref","first-page":"86","DOI":"10.1016\/j.ijpharm.2019.01.030","article-title":"Updates on thermosensitive hydrogel for nasal, ocular and cutaneous delivery","volume":"559","author":"Wang","year":"2019","journal-title":"Int. J. Pharm."},{"key":"ref_21","doi-asserted-by":"crossref","first-page":"2001628","DOI":"10.1002\/adma.202001628","article-title":"An Adhesive Hydrogel with \u201cLoad-Sharing\u201d Effect as Tissue Bandages for Drug and Cell Delivery","volume":"32","author":"Chen","year":"2020","journal-title":"Adv. Mater."},{"key":"ref_22","doi-asserted-by":"crossref","first-page":"147","DOI":"10.1016\/j.ijbiomac.2020.06.257","article-title":"Gallic acid modified alginate self-adhesive hydrogel for strain responsive transdermal delivery","volume":"163","author":"Abebe","year":"2020","journal-title":"Int. J. Biol. Macromol."},{"key":"ref_23","doi-asserted-by":"crossref","first-page":"8422","DOI":"10.1039\/D0TB00989J","article-title":"Development of an antibacterial nanocomposite hydrogel for human dental pulp engineering","volume":"8","author":"Bekhouche","year":"2020","journal-title":"J. Mater. Chem. B"},{"key":"ref_24","doi-asserted-by":"crossref","first-page":"155","DOI":"10.1016\/j.actbio.2018.07.035","article-title":"Injectable and tunable hyaluronic acid hydrogels releasing chemotactic and angiogenic growth factors for endodontic regeneration","volume":"77","author":"Silva","year":"2018","journal-title":"Acta Biomater."},{"key":"ref_25","doi-asserted-by":"crossref","first-page":"1339","DOI":"10.1007\/s11517-013-1106-x","article-title":"Enhanced regeneration of rabbit mandibular defects through a combined treatment of electrical stimulation and rhBMP-2 application","volume":"51","author":"Kim","year":"2013","journal-title":"Med. Biol. Eng. Comput."},{"key":"ref_26","doi-asserted-by":"crossref","first-page":"116","DOI":"10.1016\/j.jcms.2015.11.018","article-title":"Effect of sustained release of rhBMP-2 from dried and wet hyaluronic acid hydrogel carriers compared with direct dip coating of rhBMP-2 on peri-implant osteogenesis of dental implants in canine mandibles","volume":"44","author":"Pan","year":"2016","journal-title":"J. Cranio-Maxill. Surg."},{"key":"ref_27","doi-asserted-by":"crossref","first-page":"1478","DOI":"10.1016\/j.jcms.2015.06.035","article-title":"Effect of bone marrow-derived stem cells and bone morphogenetic protein-2 on treatment of osteoradionecrosis in a rat model","volume":"43","author":"Jin","year":"2015","journal-title":"J. Cranio-Maxillo-Facial. Surg."},{"key":"ref_28","doi-asserted-by":"crossref","first-page":"112706","DOI":"10.1016\/j.colsurfb.2022.112706","article-title":"Triple-functional injectable liposome-hydrogel composite enhances bacteriostasis and osteo\/angio-genesis for advanced maxillary sinus floor augmentation","volume":"217","author":"Xun","year":"2022","journal-title":"Colloids Surf. B Biointerfaces"},{"key":"ref_29","doi-asserted-by":"crossref","first-page":"216","DOI":"10.1016\/j.carbpol.2017.10.029","article-title":"Multivalent ion-based in situ gelling polysaccharide hydrogel as an injectable bone graft","volume":"180","author":"Jung","year":"2018","journal-title":"Carbohydr. Polym."},{"key":"ref_30","doi-asserted-by":"crossref","first-page":"23371","DOI":"10.1038\/s41598-021-02637-w","article-title":"Local delivery of hydrogel encapsulated vascular endothelial growth factor for the prevention of medication-related osteonecrosis of the jaw","volume":"11","author":"Sharma","year":"2021","journal-title":"Sci. Rep."},{"key":"ref_31","doi-asserted-by":"crossref","first-page":"61638","DOI":"10.1021\/acsami.1c18701","article-title":"Injectable and Self-Healing Hydrogels with Double-Dynamic Bond Tunable Mechanical, Gel-Sol Transition and Drug Delivery Properties for Promoting Periodontium Regeneration in Periodontitis","volume":"13","author":"Guo","year":"2021","journal-title":"Acs Appl. Mater. Interfaces"},{"key":"ref_32","doi-asserted-by":"crossref","unstructured":"Mohabatpour, F., Yazdanpanah, Z., Papagerakis, S., Chen, X., and Papagerakis, P. (2022). Self-Crosslinkable Oxidized Alginate-Carboxymethyl Chitosan Hydrogels as an Injectable Cell Carrier for In Vitro. J. Funct. Biomater., 13.","DOI":"10.3390\/jfb13020071"},{"key":"ref_33","doi-asserted-by":"crossref","first-page":"1450","DOI":"10.1080\/09205063.2021.1925390","article-title":"Tunable chitosan-calcium phosphate composites as cell-instructive dental pulp capping agents","volume":"32","author":"Osmond","year":"2021","journal-title":"J. Biomater. Sci.-Polym. Ed."},{"key":"ref_34","doi-asserted-by":"crossref","first-page":"377","DOI":"10.17219\/dmp\/125658","article-title":"Preparation and characterization of insulin-loaded injectable hydrogels as potential adjunctive periodontal treatment","volume":"57","author":"Abboud","year":"2020","journal-title":"Dent. Med. Probl."},{"key":"ref_35","doi-asserted-by":"crossref","first-page":"121387","DOI":"10.1016\/j.biomaterials.2022.121387","article-title":"Injectable hydrogels with high drug loading through B-N coordination and ROS-triggered drug release for efficient treatment of chronic periodontitis in diabetic rats","volume":"282","author":"Zhao","year":"2022","journal-title":"Biomaterials"},{"key":"ref_36","doi-asserted-by":"crossref","first-page":"664","DOI":"10.2174\/1567201814666171120120421","article-title":"Minocycline-loaded In situ Hydrogel for Periodontitis Treatment","volume":"15","author":"Wang","year":"2018","journal-title":"Curr. Drug Deliv."},{"key":"ref_37","doi-asserted-by":"crossref","first-page":"751","DOI":"10.1002\/jbm.b.33885","article-title":"New approach for vertical bone regeneration using in situ gelling and sustained BMP-2 releasing poly(phosphazene) hydrogel system on peri-implant site with critical defect in a canine model","volume":"106","author":"Seo","year":"2018","journal-title":"J. Biomed. Mater. Res. B Appl. Biomater."},{"key":"ref_38","doi-asserted-by":"crossref","first-page":"134","DOI":"10.1016\/j.jconrel.2020.05.004","article-title":"A tunable and injectable local drug delivery system for personalized periodontal application","volume":"324","author":"Wang","year":"2020","journal-title":"J. Control. Release"},{"key":"ref_39","doi-asserted-by":"crossref","first-page":"1507","DOI":"10.1016\/j.dental.2022.07.002","article-title":"Photocrosslinkable methacrylated gelatin hydrogel as a cell-friendly injectable delivery system for chlorhexidine in regenerative endodontics","volume":"38","author":"Ribeiro","year":"2022","journal-title":"Dent. Mater"},{"key":"ref_40","doi-asserted-by":"crossref","first-page":"441","DOI":"10.1016\/j.actbio.2021.09.024","article-title":"Platelet lysate functionalized gelatin methacrylate microspheres for improving angiogenesis in endodontic regeneration","volume":"136","author":"Zhang","year":"2021","journal-title":"Acta Biomater."},{"key":"ref_41","doi-asserted-by":"crossref","first-page":"035029","DOI":"10.1088\/1758-5090\/ab9492","article-title":"The effect of BMP-mimetic peptide tethering bioinks on the differentiation of dental pulp stem cells (DPSCs) in 3D bioprinted dental constructs","volume":"12","author":"Park","year":"2020","journal-title":"Biofabrication"},{"key":"ref_42","doi-asserted-by":"crossref","first-page":"13192","DOI":"10.1039\/D2RA00498D","article-title":"Controlled release of silibinin in GelMA hydrogels inhibits inflammation by inducing M2-type macrophage polarization and promotes vascularization in vitro","volume":"12","author":"Xu","year":"2020","journal-title":"RSC Adv."},{"key":"ref_43","doi-asserted-by":"crossref","first-page":"46","DOI":"10.1177\/00220345211020652","article-title":"GSK3 Inhibitor-Induced Dentinogenesis Using a Hydrogel","volume":"101","author":"Alaohali","year":"2022","journal-title":"J. Dent. Res."},{"key":"ref_44","doi-asserted-by":"crossref","first-page":"87","DOI":"10.1111\/jicd.12118","article-title":"Preliminary study of light-cured hydrogel for endodontic drug delivery vehicle","volume":"7","author":"Komabayashi","year":"2016","journal-title":"J. Investig. Clin. Dent."},{"key":"ref_45","doi-asserted-by":"crossref","unstructured":"Bako, J., Toth, F., Gall, J., Kovacs, R., Cs\u00edk, A., Varga, I., Sculean, A., Zelko, R., and Hegedus, C. (2022). Combined Release of Antiseptic and Antibiotic Drugs from Visible Light Polymerized Biodegradable Nanocomposite Hydrogels for Periodontitis Treatment. Pharmaceutics, 14.","DOI":"10.3390\/pharmaceutics14050957"},{"key":"ref_46","doi-asserted-by":"crossref","first-page":"391","DOI":"10.4028\/www.scientific.net\/KEM.856.391","article-title":"Characterization of a Thermo-Sensitive Injectable Hydrogel as an Iloprost Delivery System for Dental Use","volume":"856","author":"Limjeerajarus","year":"2020","journal-title":"Key Eng. Mater."},{"key":"ref_47","doi-asserted-by":"crossref","first-page":"510","DOI":"10.4274\/tjps.galenos.2020.09623","article-title":"Development of Metronidazole-loaded In situ Thermosensitive Hydrogel for Periodontitis Treatment","volume":"18","author":"Pham","year":"2021","journal-title":"Turk. J. Pharm. Sci."},{"key":"ref_48","doi-asserted-by":"crossref","first-page":"1992","DOI":"10.1021\/acs.molpharmaceut.0c01196","article-title":"Thermoresponsive Hydrogel-Based Local Delivery of Simvastatin for the Treatment of Periodontitis","volume":"18","author":"Chen","year":"2021","journal-title":"Mol. Pharm."},{"key":"ref_49","doi-asserted-by":"crossref","first-page":"120293","DOI":"10.1016\/j.biomaterials.2020.120293","article-title":"GSK3 inhibitor-loaded osteotropic Pluronic hydrogel effectively mitigates periodontal tissue damage associated with experimental periodontitis","volume":"261","author":"Almoshari","year":"2020","journal-title":"Biomaterials"},{"key":"ref_50","doi-asserted-by":"crossref","first-page":"121786","DOI":"10.1016\/j.ijpharm.2022.121786","article-title":"Thermosensitive injectable graphene oxide\/chitosan-based nanocomposite hydrogels for controlling the in vivo release of bupivacaine hydrochloride","volume":"621","author":"Eltahir","year":"2022","journal-title":"Int. J. Pharm."},{"key":"ref_51","doi-asserted-by":"crossref","first-page":"1515040","DOI":"10.1155\/2019\/1515040","article-title":"Evaluation of Chitosan Hydrogel for Sustained Delivery of VEGF for Odontogenic Differentiation of Dental Pulp Stem Cells","volume":"2019","author":"Wu","year":"2019","journal-title":"Stem. Cells Int."},{"key":"ref_52","doi-asserted-by":"crossref","first-page":"735","DOI":"10.1097\/SCS.0000000000002588","article-title":"Chitosan-Based Thermosensitive Hydrogel for Controlled Drug Delivery to the Temporomandibular Joint","volume":"27","author":"Talaat","year":"2016","journal-title":"J. Craniofac. Surg."},{"key":"ref_53","doi-asserted-by":"crossref","first-page":"919","DOI":"10.1016\/j.msec.2019.02.024","article-title":"Injectable chitosan\/beta-glycerophosphate hydrogels with sustained release of BMP-7 and ornidazole in periodontal wound healing of class III furcation defects","volume":"99","author":"Zang","year":"2019","journal-title":"Mater. Sci. Eng. C"},{"key":"ref_54","doi-asserted-by":"crossref","first-page":"1656","DOI":"10.1002\/jbm.b.34823","article-title":"Characteristics and biologic effects of thermosensitive quercetin-chitosan\/collagen hydrogel on human periodontal ligament stem cells","volume":"109","author":"Arpornmaeklong","year":"2021","journal-title":"J. Biomed. Mater. Res. B Appl Biomater."},{"key":"ref_55","doi-asserted-by":"crossref","first-page":"114","DOI":"10.1038\/s41598-017-18415-6","article-title":"Promoting Induced Pluripotent Stem Cell-driven Biomineralization and Periodontal Regeneration in Rats with Maxillary-Molar Defects using Injectable BMP-6 Hydrogel","volume":"8","author":"Chien","year":"2018","journal-title":"Sci. Rep."},{"key":"ref_56","doi-asserted-by":"crossref","first-page":"381","DOI":"10.1016\/j.jconrel.2022.09.010","article-title":"Local delivery of gambogic acid to improve anti-tumor immunity against oral squamous cell carcinoma","volume":"351","author":"Chen","year":"2022","journal-title":"J. Control. Release"},{"key":"ref_57","doi-asserted-by":"crossref","first-page":"124446","DOI":"10.1016\/j.cej.2020.124446","article-title":"A multifunctional MOF-based nanohybrid as injectable implant platform for drug synergistic oral cancer therapy","volume":"390","author":"Tan","year":"2020","journal-title":"Chem. Eng. J."},{"key":"ref_58","doi-asserted-by":"crossref","first-page":"227","DOI":"10.1039\/D1BM01466H","article-title":"In situ mucoadhesive hydrogel capturing tripeptide KPV: The anti-inflammatory, antibacterial and repairing effect on chemotherapy-induced oral mucositis","volume":"10","author":"Shao","year":"2021","journal-title":"Biomater. Sci."},{"key":"ref_59","doi-asserted-by":"crossref","first-page":"885","DOI":"10.1111\/jre.12885","article-title":"PTH\/PTHrP in controlled release hydrogel enhances orthodontic tooth movement by regulating periodontal bone remodaling","volume":"56","author":"Lu","year":"2021","journal-title":"J. Periodontal. Res."},{"key":"ref_60","doi-asserted-by":"crossref","first-page":"2722","DOI":"10.1039\/C9TB00025A","article-title":"Injectable colloidal hydrogel with mesoporous silica nanoparticles for sustained co-release of microRNA-222 and aspirin to achieve innervated bone regeneration in rat mandibular defects","volume":"7","author":"Lei","year":"2019","journal-title":"J. Mater. Chemistry. B"},{"key":"ref_61","doi-asserted-by":"crossref","first-page":"3354","DOI":"10.1021\/acsami.9b17335","article-title":"Light-Activable On-Demand Release of Nano-Antibiotic Platforms for Precise Synergy of Thermochemotherapy on Periodontitis","volume":"12","author":"Zhang","year":"2020","journal-title":"ACS Appl. Mater. Interfaces"},{"key":"ref_62","doi-asserted-by":"crossref","first-page":"1900167","DOI":"10.1002\/adhm.201900167","article-title":"A Versatile Biocompatible Antibiotic Delivery System Based on Self-Assembling Peptides with Antimicrobial and Regenerative Potential","volume":"8","author":"Koch","year":"2019","journal-title":"Adv. Healthc. Mater."},{"key":"ref_63","doi-asserted-by":"crossref","first-page":"36880","DOI":"10.1021\/acsami.1c08855","article-title":"Gingipain-Responsive Thermosensitive Hydrogel Loaded with SDF-1 Facilitates In Situ Periodontal Tissue Regeneration","volume":"13","author":"Liu","year":"2021","journal-title":"ACS Appl. Mater. Interfaces"},{"key":"ref_64","doi-asserted-by":"crossref","first-page":"17168","DOI":"10.1039\/D1NR04625J","article-title":"Near-infrared light-responsive hybrid hydrogels for the synergistic chemo-photothermal therapy of oral cancer","volume":"13","author":"Wu","year":"2021","journal-title":"Nanoscale"},{"key":"ref_65","doi-asserted-by":"crossref","unstructured":"Serra, E., Saubade, F., Ligorio, C., Whitehead, K., Sloan, A., Williams, D.W., Hidalgo-Bastida, A., Verran, J., and Malic, S. (2020). Methylcellulose Hydrogel with Melissa officinalis Essential Oil as a Potential Treatment for Oral Candidiasis. Microorganisms, 8.","DOI":"10.3390\/microorganisms8020215"},{"key":"ref_66","doi-asserted-by":"crossref","first-page":"1193","DOI":"10.1016\/j.colsurfb.2015.11.005","article-title":"Needle-free buccal anesthesia using iontophoresis and amino amide salts combined in a mucoadhesive formulation","volume":"136","author":"Cubayachi","year":"2015","journal-title":"Colloids Surf. B Biointerfaces"},{"key":"ref_67","doi-asserted-by":"crossref","first-page":"385","DOI":"10.1186\/s12951-021-01133-7","article-title":"Hydroxypropylmethylcellulose as a film and hydrogel carrier for ACP nanoprecursors to deliver biomimetic mineralization","volume":"19","author":"Wang","year":"2021","journal-title":"J. Nanobiotechnol."},{"key":"ref_68","doi-asserted-by":"crossref","first-page":"4503","DOI":"10.1039\/C9BM00482C","article-title":"Microneedles combined with a sticky and heatable hydrogel for local painless anesthesia","volume":"7","author":"Zhang","year":"2019","journal-title":"Biomater. Sci."},{"key":"ref_69","doi-asserted-by":"crossref","first-page":"17972","DOI":"10.1038\/s41598-018-36382-4","article-title":"Hybrid Hydrogel Composed of Polymeric Nanocapsules Co-Loading Lidocaine and Prilocaine for Topical Intraoral Anesthesia","volume":"8","author":"Muniz","year":"2018","journal-title":"Sci. Rep."},{"key":"ref_70","doi-asserted-by":"crossref","first-page":"32","DOI":"10.1038\/s41551-021-00807-9","article-title":"Biomaterial-mediated modulation of oral microbiota synergizes with PD-1 blockade in mice with oral squamous cell carcinoma","volume":"6","author":"Zheng","year":"2022","journal-title":"Nat. Biomed. Eng."},{"key":"ref_71","doi-asserted-by":"crossref","first-page":"95","DOI":"10.1177\/0883911517710665","article-title":"In vitro evaluation of mucoadhesive and self-disinfection efficiency of (acrylic acid\/polyethylene glycol)-silver nanocomposites for buccal drug delivery","volume":"33","author":"Raafat","year":"2018","journal-title":"J. Bioact. Compat. Polym."},{"key":"ref_72","doi-asserted-by":"crossref","first-page":"12","DOI":"10.1007\/s10856-016-5818-y","article-title":"Hydrogel tissue expanders for stomatology. Part I. Methacrylate-based polymers","volume":"28","author":"Hrib","year":"2017","journal-title":"J. Mater. Sci.-Mater. Med."},{"key":"ref_73","doi-asserted-by":"crossref","first-page":"4285","DOI":"10.1016\/j.actbio.2014.06.016","article-title":"Development of sustained antimicrobial-release systems using poly(2-hydroxyethyl methacrylate)\/trimethylolpropane trimethacrylate hydrogels","volume":"10","author":"Kitagawa","year":"2014","journal-title":"Acta Biomater."},{"key":"ref_74","doi-asserted-by":"crossref","first-page":"121","DOI":"10.1146\/annurev.me.26.020175.001005","article-title":"Dental caries","volume":"26","author":"Gibbons","year":"1975","journal-title":"Annu. Rev. Med."},{"key":"ref_75","doi-asserted-by":"crossref","first-page":"1300","DOI":"10.1016\/j.dental.2019.05.025","article-title":"Effect of biomimetic mineralization on enamel and dentin: A Raman and EDX analysis","volume":"35","author":"Guentsch","year":"2019","journal-title":"Dent. Mater."},{"key":"ref_76","doi-asserted-by":"crossref","first-page":"637","DOI":"10.1016\/j.dental.2017.03.008","article-title":"Dentin on the nanoscale: Hierarchical organization, mechanical behavior and bioinspired engineering","volume":"33","author":"Bertassoni","year":"2017","journal-title":"Dent. Mater."},{"key":"ref_77","doi-asserted-by":"crossref","first-page":"51","DOI":"10.1016\/S0140-6736(07)60031-2","article-title":"Dental caries","volume":"369","author":"Selwitz","year":"2007","journal-title":"Lancet"},{"key":"ref_78","doi-asserted-by":"crossref","first-page":"eaaw9569","DOI":"10.1126\/sciadv.aaw9569","article-title":"Repair of tooth enamel by a biomimetic mineralization frontier ensuring epitaxial growth","volume":"5","author":"Shao","year":"2019","journal-title":"Sci. Adv."},{"key":"ref_79","doi-asserted-by":"crossref","first-page":"8","DOI":"10.1038\/s41368-018-0038-6","article-title":"Enamel biomimetics-fiction or future of dentistry","volume":"11","author":"Pandya","year":"2019","journal-title":"Int. J. Oral. Sci."},{"key":"ref_80","doi-asserted-by":"crossref","first-page":"85","DOI":"10.1680\/jbibn.19.00008","article-title":"Biomimetic chitosan against bioinspired nanohydroxyapatite for repairing enamel surfaces","volume":"9","author":"Hanafy","year":"2020","journal-title":"Bioinspired Biomim. Nanobiomater."},{"key":"ref_81","doi-asserted-by":"crossref","first-page":"556","DOI":"10.1557\/jmr.2016.64","article-title":"Repairing human tooth enamel with leucine-rich amelogenin peptide-chitosan hydrogel","volume":"31","author":"Mukherjee","year":"2016","journal-title":"J. Mater. Res."},{"key":"ref_82","doi-asserted-by":"crossref","first-page":"836","DOI":"10.3389\/fbioe.2020.00836","article-title":"Mimicking Natural Microenvironments: Design of 3D-Aligned Hybrid Scaffold for Dentin Regeneration","volume":"8","author":"Campodoni","year":"2020","journal-title":"Front. Bioeng. Biotechnol."},{"key":"ref_83","doi-asserted-by":"crossref","first-page":"42","DOI":"10.1016\/j.archoralbio.2019.02.004","article-title":"Chitosan hydrogel containing amelogenin-derived peptide: Inhibition of cariogenic bacteria and promotion of remineralization of initial caries lesions","volume":"100","author":"Ren","year":"2019","journal-title":"Arch. Oral. Biol."},{"key":"ref_84","doi-asserted-by":"crossref","first-page":"1406","DOI":"10.1016\/j.dental.2015.09.007","article-title":"Effectiveness of non-biodegradable poly(2-hydroxyethyl methacrylate)-based hydrogel particles as a fibroblast growth factor-2 releasing carrier","volume":"31","author":"Takeda","year":"2015","journal-title":"Dent. Mater."},{"key":"ref_85","doi-asserted-by":"crossref","first-page":"S32","DOI":"10.1080\/01652176.1998.10807395","article-title":"Endodontic treatment","volume":"20","author":"Theyse","year":"1998","journal-title":"Vet. Q."},{"key":"ref_86","doi-asserted-by":"crossref","first-page":"S161","DOI":"10.1016\/j.joen.2020.06.037","article-title":"Clinical Perspectives of Pulp Regeneration","volume":"46","author":"Schmalz","year":"2020","journal-title":"J. Endod."},{"key":"ref_87","doi-asserted-by":"crossref","first-page":"811","DOI":"10.22203\/eCM.v041a51","article-title":"What the future holds for regenerative endodontics: Novel antimicrobials and regenerative strategies","volume":"41","author":"Nazzal","year":"2021","journal-title":"Eur. Cells Mater."},{"key":"ref_88","doi-asserted-by":"crossref","first-page":"102600","DOI":"10.1016\/j.jddst.2021.102600","article-title":"Bioactive hydrogel-based scaffolds for the regeneration of dental pulp tissue","volume":"64","author":"Samiei","year":"2021","journal-title":"J. Drug Deliv. Sci. Technol."},{"key":"ref_89","doi-asserted-by":"crossref","first-page":"415","DOI":"10.22203\/eCM.v042a26","article-title":"Bioactive molecules for regenerative pulp capping","volume":"42","author":"Whitehouse","year":"2021","journal-title":"Eur. Cell Mater."},{"key":"ref_90","doi-asserted-by":"crossref","first-page":"1776","DOI":"10.1016\/j.joen.2017.06.031","article-title":"Direct Pulp Capping with Calcium Hydroxide, Mineral Trioxide Aggregate, and Biodentine in Permanent Young Teeth with Caries: A Randomized Clinical Trial","volume":"43","author":"Brizuela","year":"2017","journal-title":"J. Endod."},{"key":"ref_91","doi-asserted-by":"crossref","first-page":"330","DOI":"10.1111\/iej.13694","article-title":"A critical analysis of research methods and experimental models to study intracanal medicaments","volume":"55","author":"Meire","year":"2022","journal-title":"Int. Endod. J."},{"key":"ref_92","doi-asserted-by":"crossref","unstructured":"Haseeb, R., Lau, M., Sheah, M., Montagner, F., Quiram, G., Palmer, K., Stefan, M.C., and Rodrigues, D.C. (2016). Synthesis and Characterization of New Chlorhexidine-Containing Nanoparticles for Root Canal Disinfection. Materials, 9.","DOI":"10.3390\/ma9060452"},{"key":"ref_93","doi-asserted-by":"crossref","first-page":"1110","DOI":"10.1016\/j.joen.2018.03.001","article-title":"Antibacterial Efficacy and Discoloration Potential of Endodontic Topical Antibiotics","volume":"44","author":"AlSaeed","year":"2018","journal-title":"J. Endod."},{"key":"ref_94","doi-asserted-by":"crossref","unstructured":"Ribeiro, J.S., M\u00fcnchow, E.A., Bordini, E.A.F., Rodrigues, N.S., Dubey, N., Sasaki, H., Fenno, J.C., Schwendeman, S., and Bottino, M.C. (2022). Engineering of Injectable Antibiotic-laden Fibrous Microparticles Gelatin Methacryloyl Hydrogel for Endodontic Infection Ablation. Int. J. Mol. Sci., 23.","DOI":"10.3390\/ijms23020971"},{"key":"ref_95","doi-asserted-by":"crossref","first-page":"111","DOI":"10.1016\/j.cden.2016.08.004","article-title":"Regenerative Endodontic Procedures: Clinical Outcomes","volume":"61","author":"Diogenes","year":"2017","journal-title":"Dent. Clin. North Am."},{"key":"ref_96","doi-asserted-by":"crossref","first-page":"185","DOI":"10.1034\/j.1600-9657.2001.017004185.x","article-title":"Revascularization of an immature permanent tooth with apical periodontitis and sinus tract","volume":"17","author":"Iwaya","year":"2001","journal-title":"Dent. Traumatol."},{"key":"ref_97","doi-asserted-by":"crossref","first-page":"196","DOI":"10.1097\/00004770-200404000-00003","article-title":"Revascularization of immature permanent teeth with apical periodontitis: New treatment protocol?","volume":"30","author":"Banchs","year":"2004","journal-title":"J. Endod."},{"key":"ref_98","doi-asserted-by":"crossref","first-page":"184","DOI":"10.22203\/eCM.v041a13","article-title":"The role of inflammation modulation in dental pulp regeneration","volume":"41","author":"Zaky","year":"2021","journal-title":"Eur. Cells Mater."},{"key":"ref_99","doi-asserted-by":"crossref","first-page":"58","DOI":"10.3389\/fphys.2016.00058","article-title":"Pulp Regeneration: Current Approaches and Future Challenges","volume":"7","author":"Yang","year":"2016","journal-title":"Front. Physiol."},{"key":"ref_100","doi-asserted-by":"crossref","first-page":"472","DOI":"10.1002\/term.3294","article-title":"Pro-angiogenic potential of a functionalized hydrogel scaffold as a secretome delivery platform: An innovative strategy for cell homing-based dental pulp tissue engineering","volume":"16","author":"Carvalho","year":"2022","journal-title":"J. Tissue Eng. Regen. Med."},{"key":"ref_101","doi-asserted-by":"crossref","first-page":"971","DOI":"10.1016\/j.joen.2018.02.014","article-title":"Biological Analysis of Simvastatin-releasing Chitosan Scaffold as a Cell-free System for Pulp-dentin Regeneration","volume":"44","author":"Soares","year":"2018","journal-title":"J. Endod."},{"key":"ref_102","doi-asserted-by":"crossref","first-page":"S20","DOI":"10.4103\/jpbs.JPBS_112_20","article-title":"Regenerative Endodontics: A Paradigm Shift in Clinical Endodontics","volume":"12","author":"Pulyodan","year":"2020","journal-title":"J. Pharm. Bioallied. Sci."},{"key":"ref_103","doi-asserted-by":"crossref","first-page":"121631","DOI":"10.1016\/j.ijpharm.2022.121631","article-title":"Composite alginate-gelatin hydrogels incorporating PRGF enhance human dental pulp cell adhesion, chemotaxis and proliferation","volume":"617","author":"Anitua","year":"2022","journal-title":"Int. J. Pharm."},{"key":"ref_104","doi-asserted-by":"crossref","first-page":"727","DOI":"10.1128\/CMR.14.4.727-752.2001","article-title":"Periodontal disease as a specific, albeit chronic, infection: Diagnosis and treatment","volume":"14","author":"Loesche","year":"2001","journal-title":"Clin. Microbiol. Rev."},{"key":"ref_105","doi-asserted-by":"crossref","first-page":"8","DOI":"10.1034\/j.1600-0757.2001.22250102.x","article-title":"Causation and pathogenesis of periodontal disease","volume":"25","author":"Kinane","year":"2001","journal-title":"Periodontol 2000"},{"key":"ref_106","doi-asserted-by":"crossref","first-page":"7","DOI":"10.1111\/prd.12221","article-title":"Periodontitis: Facts, fallacies and the future","volume":"75","author":"Slots","year":"2017","journal-title":"Periodontol 2000"},{"key":"ref_107","first-page":"124","article-title":"Sustained Release of Risedronate from PLGA Microparticles Embedded in Alginate Hydrogel for Treatment of Bony Lesions","volume":"26","author":"Azari","year":"2022","journal-title":"Iran. Biomed. J."},{"key":"ref_108","doi-asserted-by":"crossref","first-page":"118659","DOI":"10.1016\/j.ijpharm.2019.118659","article-title":"A dual-action chitosan-based nanogel system of triclosan and flurbiprofen for localised treatment of periodontitis","volume":"570","author":"Aminu","year":"2019","journal-title":"Int. J. Pharm."},{"key":"ref_109","doi-asserted-by":"crossref","first-page":"117","DOI":"10.1177\/0883911520911659","article-title":"Multifunctional periodontal membrane for treatment and regeneration purposes","volume":"35","author":"Isik","year":"2020","journal-title":"J. Bioact. Compat. Polym."},{"key":"ref_110","doi-asserted-by":"crossref","first-page":"13726","DOI":"10.1096\/fj.202001248R","article-title":"An injectable hydrogel-formulated inhibitor of prolyl-4-hydroxylase promotes T regulatory cell recruitment and enhances alveolar bone regeneration during resolution of experimental periodontitis","volume":"34","author":"Nagai","year":"2020","journal-title":"Faseb. J."},{"key":"ref_111","doi-asserted-by":"crossref","first-page":"919","DOI":"10.1177\/0885328215614191","article-title":"Thermosensitive hydrogel for periodontal application: In vitro drug release, antibacterial activity and toxicity evaluation","volume":"30","author":"Pakzad","year":"2016","journal-title":"J. Biomater. Appl."},{"key":"ref_112","doi-asserted-by":"crossref","first-page":"235","DOI":"10.1016\/j.actbio.2019.01.001","article-title":"An injectable and thermosensitive hydrogel: Promoting periodontal regeneration by controlled-release of aspirin and erythropoietin","volume":"86","author":"Xu","year":"2019","journal-title":"Acta Biomater."},{"key":"ref_113","doi-asserted-by":"crossref","first-page":"190","DOI":"10.1902\/jop.2016.160189","article-title":"Inhibition of Periodontitis Induction Using a Stimuli-Responsive Hydrogel Carrying Naringin","volume":"88","author":"Chang","year":"2017","journal-title":"J. Periodontol."},{"key":"ref_114","doi-asserted-by":"crossref","first-page":"742","DOI":"10.1902\/jop.2016.150542","article-title":"pH-Responsive Hydrogel With an Anti-Glycation Agent for Modulating Experimental Periodontitis","volume":"87","author":"Yu","year":"2016","journal-title":"J. Periodontol."},{"key":"ref_115","doi-asserted-by":"crossref","first-page":"659","DOI":"10.1007\/s10856-012-4825-x","article-title":"Composition and characterization of in situ usable light cured dental drug delivery hydrogel system","volume":"24","author":"Ujhelyi","year":"2013","journal-title":"J. Mater. Sci. Mater. Med."},{"key":"ref_116","doi-asserted-by":"crossref","first-page":"2109178","DOI":"10.1002\/adma.202109178","article-title":"Hydrogel Transformed from Nanoparticles for Prevention of Tissue Injury and Treatment of Inflammatory Diseases","volume":"34","author":"Li","year":"2022","journal-title":"Adv. Mater."},{"key":"ref_117","doi-asserted-by":"crossref","first-page":"5377","DOI":"10.2147\/IJN.S248538","article-title":"Hybrid Hydrogels for Synergistic Periodontal Antibacterial Treatment with Sustained Drug Release and NIR-Responsive Photothermal Effect","volume":"15","author":"Lin","year":"2020","journal-title":"Int. J. Nanomed."},{"key":"ref_118","doi-asserted-by":"crossref","first-page":"231","DOI":"10.1097\/MOO.0b013e328355d0f3","article-title":"Reconstruction of the segmental mandibular defect: Current state of the art","volume":"20","author":"Hayden","year":"2012","journal-title":"Curr. Opin. Otolaryngol. Head. Neck. Surg."},{"key":"ref_119","doi-asserted-by":"crossref","first-page":"035020","DOI":"10.1088\/1758-5090\/ab906e","article-title":"3D printed composite scaffolds with dual small molecule delivery for mandibular bone regeneration","volume":"12","author":"Zhang","year":"2020","journal-title":"Biofabrication"},{"key":"ref_120","doi-asserted-by":"crossref","first-page":"48","DOI":"10.1016\/j.tripleo.2011.01.021","article-title":"Local injection of nerve growth factor via a hydrogel enhances bone formation during mandibular distraction osteogenesis","volume":"113","author":"Cao","year":"2012","journal-title":"Oral. Surg. Oral. Med. Oral. Pathol. Oral. Radiol."},{"key":"ref_121","doi-asserted-by":"crossref","first-page":"79","DOI":"10.1016\/j.jcms.2004.09.003","article-title":"Mandibular defect repair by TGF-beta and IGF-1 released from a biodegradable osteoconductive hydrogel","volume":"33","author":"Srouji","year":"2005","journal-title":"J. Cranio-maxillofac. Surg."},{"key":"ref_122","doi-asserted-by":"crossref","first-page":"93","DOI":"10.1034\/j.1600-0765.2002.00021.x","article-title":"Peri-implant bone regeneration using recombinant human bone morphogenetic protein-2 in a canine model: A dose-response study","volume":"37","author":"Tatakis","year":"2002","journal-title":"J. Periodontal. Res."},{"key":"ref_123","doi-asserted-by":"crossref","first-page":"676","DOI":"10.1111\/clr.12645","article-title":"Comparison of bone morphogenetic protein-2 delivery systems to induce supracrestal bone guided by titanium implants in the rabbit mandible","volume":"27","author":"Wen","year":"2016","journal-title":"Clin. Oral. Implants Res."},{"key":"ref_124","doi-asserted-by":"crossref","first-page":"820","DOI":"10.1111\/jcpe.12264","article-title":"Mandibular reconstruction using a calcium phosphate\/polyethylene glycol hydrogel carrier with BMP-2","volume":"41","author":"Gruber","year":"2014","journal-title":"J. Clin. Periodontol."},{"key":"ref_125","doi-asserted-by":"crossref","first-page":"S6","DOI":"10.1111\/jcpe.12206","article-title":"Soft tissue wound healing around teeth and dental implants","volume":"41","author":"Sculean","year":"2014","journal-title":"J. Clin. Periodontol."},{"key":"ref_126","doi-asserted-by":"crossref","first-page":"1003","DOI":"10.1097\/SCS.0000000000008102","article-title":"The Effects of Local Alendronate With or Without Recombinant Human Bone Morphogenetic Protein 2 on Dental Implant Stability and Marginal Bone Level: A Randomized Controlled Study","volume":"33","author":"Bede","year":"2022","journal-title":"J. Craniofac. Surg."},{"key":"ref_127","doi-asserted-by":"crossref","first-page":"41","DOI":"10.1016\/j.jpor.2008.08.009","article-title":"Initial bone regeneration around fenestrated implants in Beagle dogs using basic fibroblast growth factor-gelatin hydrogel complex with varying biodegradation rates","volume":"53","author":"Akagawa","year":"2009","journal-title":"J. Prosthodont. Res."},{"key":"ref_128","doi-asserted-by":"crossref","first-page":"726","DOI":"10.1111\/cid.13041","article-title":"A single application of chlorhexidine gel reduces gingival inflammation and interleukin 1-beta following one-stage implant placement: A randomized controlled study","volume":"23","author":"Asbi","year":"2021","journal-title":"Clin. Implant. Dent. Relat. Res."},{"key":"ref_129","first-page":"305","article-title":"The management of dry socket\/alveolar osteitis","volume":"57","author":"Bowe","year":"2011","journal-title":"J. Ir. Dent. Assoc."},{"key":"ref_130","doi-asserted-by":"crossref","first-page":"44","DOI":"10.1016\/j.jobcr.2017.08.005","article-title":"Role of turmeric in management of alveolar osteitis (dry socket): A randomised clinical study","volume":"8","author":"Lone","year":"2018","journal-title":"J. Oral Biol. Craniofacial Res."},{"key":"ref_131","doi-asserted-by":"crossref","first-page":"4448","DOI":"10.1158\/0008-5472.CAN-04-4662","article-title":"Milk thistle and prostate cancer: Differential effects of pure flavonolignans from Silybum marianum on antiproliferative end points in human prostate carcinoma cells","volume":"65","author":"Nakanishi","year":"2005","journal-title":"Cancer Res."},{"key":"ref_132","doi-asserted-by":"crossref","first-page":"134","DOI":"10.1016\/j.ijbiomac.2022.05.094","article-title":"Chitosan-CaP microflowers and metronidazole loaded calcium alginate sponges with enhanced antibacterial, hemostatic and osteogenic properties for the prevention of dry socket after tooth removal","volume":"212","author":"Yan","year":"2022","journal-title":"Int. J. Biol. Macromol."},{"key":"ref_133","doi-asserted-by":"crossref","first-page":"177","DOI":"10.1016\/j.ctrv.2018.06.007","article-title":"Medication-related osteonecrosis of the jaw: Prevention, diagnosis and management in patients with cancer and bone metastases","volume":"69","author":"Otto","year":"2018","journal-title":"Cancer Treat. Rev."},{"key":"ref_134","doi-asserted-by":"crossref","first-page":"1206","DOI":"10.1016\/j.ijrobp.2020.12.043","article-title":"Osteoradionecrosis: Exposing the Evidence Not the Bone","volume":"109","author":"Frankart","year":"2021","journal-title":"Int. J. Radiat. Oncol. Biol. Phys."},{"key":"ref_135","first-page":"196","article-title":"No osteonecrosis in jaws of young patients with osteogenesis imperfecta treated with bisphosphonates","volume":"37","author":"Malmgren","year":"2008","journal-title":"J. Oral. Pathol. Med. Off. Publ. Int. Assoc. Oral. Pathol. Am. Acad. Oral. Pathol."},{"key":"ref_136","doi-asserted-by":"crossref","first-page":"1479","DOI":"10.1359\/jbmr.0707onj","article-title":"Bisphosphonate-associated osteonecrosis of the jaw: Report of a task force of the American Society for Bone and Mineral Research","volume":"22","author":"Khosla","year":"2007","journal-title":"J. Bone. Miner. Res. Off. J. Am. Soc. Bone. Miner. Res."},{"key":"ref_137","doi-asserted-by":"crossref","first-page":"e1900226","DOI":"10.1002\/mabi.201900226","article-title":"Investigation of Sustained BMP Delivery in the Prevention of Medication-Related Osteonecrosis of the Jaw (MRONJ) in a Rat Model","volume":"19","author":"Brierly","year":"2019","journal-title":"Macromol. Biosci."},{"key":"ref_138","doi-asserted-by":"crossref","unstructured":"Imada, M., Yagyuu, T., Ueyama, Y., Maeda, M., Yamamoto, K., Kurokawa, S., Jo, J.I., Tabata, Y., Tanaka, Y., and Kirita, T. (2019). Prevention of tooth extraction-triggered bisphosphonate-related osteonecrosis of the jaws with basic fibroblast growth factor: An experimental study in rats. PLoS ONE, 14.","DOI":"10.1371\/journal.pone.0211928"},{"key":"ref_139","doi-asserted-by":"crossref","first-page":"3","DOI":"10.1007\/s10006-009-0198-9","article-title":"Osteoradionecrosis of the jaws\u2014A current overview\u2014Part 1: Physiopathology and risk and predisposing factors","volume":"14","author":"Chrcanovic","year":"2010","journal-title":"Oral. Maxillofac. Surg."},{"key":"ref_140","doi-asserted-by":"crossref","first-page":"455","DOI":"10.1016\/j.coms.2011.04.011","article-title":"Osteoradionecrosis","volume":"23","author":"Sinha","year":"2011","journal-title":"Oral. Maxillofac. Surg. Clin. North Am."},{"key":"ref_141","doi-asserted-by":"crossref","first-page":"210","DOI":"10.1016\/j.jcms.2007.09.001","article-title":"BMP-2 and bFGF in an irradiated bone model","volume":"36","author":"Springer","year":"2008","journal-title":"J. Cranio-Maxillofac. Surg."},{"key":"ref_142","doi-asserted-by":"crossref","first-page":"1247","DOI":"10.1038\/s41385-021-00413-7","article-title":"Crosstalk between the oral microbiota, mucosal immunity, and the epithelial barrier regulates oral mucosal disease pathogenesis","volume":"14","author":"Lin","year":"2021","journal-title":"Mucosal. Immunol."},{"key":"ref_143","doi-asserted-by":"crossref","first-page":"136580","DOI":"10.1016\/j.cej.2022.136580","article-title":"Barnacle-Inspired robust and aesthetic Janus patch with instinctive wet adhesive for oral ulcer treatment","volume":"444","author":"Xing","year":"2022","journal-title":"Chem. Eng. J."},{"key":"ref_144","doi-asserted-by":"crossref","first-page":"57","DOI":"10.1016\/j.jconrel.2019.11.006","article-title":"Chitosan oral patches inspired by mussel adhesion","volume":"317","author":"Ryu","year":"2020","journal-title":"J. Control. Release Off. J. Control. Release Soc."},{"key":"ref_145","doi-asserted-by":"crossref","first-page":"921","DOI":"10.1177\/00220345221085192","article-title":"Mucoadhesive Nucleoside-Based Hydrogel Delays Oral Leukoplakia Canceration","volume":"101","author":"Ding","year":"2022","journal-title":"J. Dent. Res."},{"key":"ref_146","first-page":"211","article-title":"Predisposing factors endorsing Candida infections","volume":"23","author":"Singh","year":"2015","journal-title":"Infez. Med."},{"key":"ref_147","doi-asserted-by":"crossref","first-page":"e00888-19","DOI":"10.1128\/AAC.00888-19","article-title":"Evaluation of the Antifungal and Wound-Healing Properties of a Novel Peptide-Based Bioadhesive Hydrogel Formulation","volume":"63","author":"Sultan","year":"2019","journal-title":"Antimicrob. Agents Chemother."},{"key":"ref_148","doi-asserted-by":"crossref","first-page":"72","DOI":"10.1016\/j.biopha.2018.07.114","article-title":"Preventive measures in oral cancer: An overview","volume":"107","author":"Addepalli","year":"2018","journal-title":"Biomed. Pharmacother."},{"key":"ref_149","doi-asserted-by":"crossref","first-page":"5568","DOI":"10.1200\/JCO.2005.07.119","article-title":"Phase II multicenter study of the antiepidermal growth factor receptor monoclonal antibody cetuximab in combination with platinum-based chemotherapy in patients with platinum-refractory metastatic and\/or recurrent squamous cell carcinoma of the head and neck","volume":"23","author":"Baselga","year":"2005","journal-title":"J. Clin. Oncol."},{"key":"ref_150","doi-asserted-by":"crossref","first-page":"10705","DOI":"10.7314\/APJCP.2014.15.24.10705","article-title":"Oral and IV dosages of doxorubicin-methotrexate loaded-nanoparticles inhibit progression of oral cancer by down-regulation of matrix Methaloproteinase 2 expression in vivo","volume":"15","author":"Abbasi","year":"2014","journal-title":"Asian Pac. J. Cancer Prev."},{"key":"ref_151","doi-asserted-by":"crossref","first-page":"104492","DOI":"10.1016\/j.oraloncology.2019.104492","article-title":"Management of recurrent and metastatic oral cavity cancer: Raising the bar a step higher","volume":"101","author":"Szturz","year":"2020","journal-title":"Oral. Oncol."},{"key":"ref_152","doi-asserted-by":"crossref","first-page":"618931","DOI":"10.3389\/fbioe.2020.618931","article-title":"Current Trends of Targeted Drug Delivery for Oral Cancer Therapy","volume":"8","author":"Zhang","year":"2020","journal-title":"Front. Bioeng. Biotechnol."},{"key":"ref_153","doi-asserted-by":"crossref","first-page":"62","DOI":"10.1016\/j.ijbiomac.2017.12.137","article-title":"Mucoadhesive alginate pastes with embedded liposomes for local oral drug delivery","volume":"111","author":"Shtenberg","year":"2018","journal-title":"Int. J. Biol. Macromol."},{"key":"ref_154","doi-asserted-by":"crossref","first-page":"2169","DOI":"10.1007\/s00432-022-04028-8","article-title":"Current trends of targeted therapy for oral squamous cell carcinoma","volume":"148","author":"Li","year":"2022","journal-title":"J. Cancer Res. Clin. Oncol."},{"key":"ref_155","doi-asserted-by":"crossref","first-page":"12","DOI":"10.1016\/j.cca.2019.01.027","article-title":"Advanced nanotechnology: An arsenal to enhance immunotherapy in fighting cancer","volume":"492","author":"Cheng","year":"2019","journal-title":"Clin. Chim. Acta"},{"key":"ref_156","doi-asserted-by":"crossref","first-page":"767","DOI":"10.1158\/1940-6207.CAPR-20-0607","article-title":"Local Anti-PD-1 Delivery Prevents Progression of Premalignant Lesions in a 4NQO-Oral Carcinogenesis Mouse Model","volume":"14","author":"Shi","year":"2021","journal-title":"Cancer Prev. Res."},{"key":"ref_157","doi-asserted-by":"crossref","first-page":"415","DOI":"10.1021\/acsbiomaterials.0c01575","article-title":"Biomaterial-Facilitated Immunotherapy for Established Oral Cancers","volume":"7","author":"Leach","year":"2021","journal-title":"ACS Biomater. Sci. Eng."},{"key":"ref_158","doi-asserted-by":"crossref","first-page":"105235","DOI":"10.1016\/j.ejps.2020.105235","article-title":"Gold nanoparticles promote a multimodal synergistic cancer therapy strategy by co-delivery of thermo-chemo-radio therapy","volume":"145","author":"Alamzadeh","year":"2020","journal-title":"Eur. J. Pharm. Sci."},{"key":"ref_159","doi-asserted-by":"crossref","first-page":"673","DOI":"10.1080\/17425247.2016.1227784","article-title":"Recent advances and perspectives in topical oral anesthesia","volume":"14","author":"Volpato","year":"2017","journal-title":"Expert. Opin. Drug Deliv."},{"key":"ref_160","doi-asserted-by":"crossref","first-page":"1760","DOI":"10.3390\/pharmaceutics13111760","article-title":"Mucoadhesive, thermoreversible hydrogel, containing tetracaine-loaded nanostructured lipid carriers for topical, intranasal needle-free anesthesia","volume":"13","author":"Calixto","year":"2021","journal-title":"Pharmaceutics"},{"key":"ref_161","doi-asserted-by":"crossref","first-page":"595","DOI":"10.4155\/tde.15.5","article-title":"Advanced drug delivery systems for local treatment of the oral cavity","volume":"6","author":"Nguyen","year":"2015","journal-title":"Ther. Deliv."},{"key":"ref_162","doi-asserted-by":"crossref","first-page":"1152","DOI":"10.1002\/pi.6052","article-title":"Bupivacaine-loaded chitosan hydrogels for topical anesthesia in dentistry","volume":"69","author":"Mihalache","year":"2020","journal-title":"Polym. Int."},{"key":"ref_163","doi-asserted-by":"crossref","first-page":"6453","DOI":"10.2147\/IJN.S180080","article-title":"Nanohybrid hydrogels designed for transbuccal anesthesia","volume":"13","author":"Ribeiro","year":"2018","journal-title":"Int. J. Nanomed."},{"key":"ref_164","doi-asserted-by":"crossref","first-page":"306","DOI":"10.1016\/j.actbio.2016.12.006","article-title":"RANKL release from self-assembling nanofiber hydrogels for inducing osteoclastogenesis in vitro","volume":"49","author":"Xing","year":"2017","journal-title":"Acta Biomater."},{"key":"ref_165","first-page":"378","article-title":"Diagnosis and treatment of temporomandibular disorders","volume":"91","author":"Gauer","year":"2015","journal-title":"Am. Fam. Physician"},{"key":"ref_166","doi-asserted-by":"crossref","first-page":"134","DOI":"10.1016\/j.ymeth.2008.09.001","article-title":"Emerging intra-articular drug delivery systems for the temporomandibular joint","volume":"47","author":"Mountziaris","year":"2009","journal-title":"Methods"},{"key":"ref_167","doi-asserted-by":"crossref","first-page":"321","DOI":"10.1016\/S0140-6736(05)66990-5","article-title":"Sj\u00f6gren\u2019s syndrome","volume":"366","author":"Fox","year":"2005","journal-title":"Lancet"},{"key":"ref_168","doi-asserted-by":"crossref","first-page":"1027","DOI":"10.1111\/odi.12952","article-title":"Interventions for dry mouth and hyposalivation in Sj\u00f6gren\u2019s syndrome: A systematic review and meta-analysis","volume":"25","author":"Lodi","year":"2019","journal-title":"Oral. Dis."},{"key":"ref_169","doi-asserted-by":"crossref","first-page":"581","DOI":"10.2174\/1567201813666161013150648","article-title":"The Sustained Effects on Tear Volume of Pilocarpine Hydrochloride in Gelatin by Hydrogel Administered by An Implant-mediated Drug Delivery System","volume":"14","author":"Cha","year":"2017","journal-title":"Curr. Drug Deliv."},{"key":"ref_170","doi-asserted-by":"crossref","first-page":"16006","DOI":"10.1021\/acsami.9b22964","article-title":"Injectable MMP-Responsive Nanotube-Modified Gelatin Hydrogel for Dental Infection Ablation","volume":"12","author":"Ribeiro","year":"2020","journal-title":"ACS Appl. Mater. Interfaces"},{"key":"ref_171","doi-asserted-by":"crossref","first-page":"7","DOI":"10.1016\/j.jds.2018.08.010","article-title":"In vitro evaluation of local antibiotic delivery via fibrin hydrogel","volume":"14","author":"Chotitumnavee","year":"2019","journal-title":"J. Dent. Sci."}],"container-title":["Gels"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.mdpi.com\/2310-2861\/9\/2\/146\/pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,10]],"date-time":"2025-10-10T18:28:21Z","timestamp":1760120901000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.mdpi.com\/2310-2861\/9\/2\/146"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,2,9]]},"references-count":171,"journal-issue":{"issue":"2","published-online":{"date-parts":[[2023,2]]}},"alternative-id":["gels9020146"],"URL":"https:\/\/doi.org\/10.3390\/gels9020146","relation":{},"ISSN":["2310-2861"],"issn-type":[{"value":"2310-2861","type":"electronic"}],"subject":[],"published":{"date-parts":[[2023,2,9]]}}}