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In this study, we encapsulated paeonol in a lipid bilayer of liposomes (PAE-L), which delayed drug release and increased drug solubility. When PAE-L was dispersed in gels (PAE-L-G) based on a poloxamer matrix material for local transdermal delivery, we observed amphiphilicity, reversible thermal responsiveness, and micellar self-assembly behavior. These gels can be used for atopic dermatitis (AD), an inflammatory skin disease, to change the surface temperature of the skin. In this study, we prepared PAE-L-G at an appropriate temperature for the treatment of AD. We then assessed the gel\u2019s relevant physicochemical properties, in vitro cumulative drug release, and antioxidant properties. We found that PAE-loaded liposomes could be designed to increase the drug effect of thermoreversible gels. At 32 \u00b0C, PAE-L-G could change from solution state to gelatinous state at 31.70 \u00b1 0.42 s, while the viscosity was 136.98 \u00b1 0.78 MPa.S and the free radical scavenging rates on DPPH and H2O2 were 92.24 \u00b1 5.57% and 92.12 \u00b1 2.71%, respectively. Drug release across the extracorporeal dialysis membrane reached 41.76 \u00b1 3.78%. In AD-like mice, PAE-L-G could also relieve skin damage by the 12th day. In summary, PAE-L-G could play an antioxidant role and relieve inflammation caused by oxidative stress in AD.<\/jats:p>","DOI":"10.3390\/gels9030198","type":"journal-article","created":{"date-parts":[[2023,3,6]],"date-time":"2023-03-06T02:06:43Z","timestamp":1678068403000},"page":"198","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":22,"title":["Design and Evaluation of Paeonol-Loaded Liposomes in Thermoreversible Gels for Atopic Dermatitis"],"prefix":"10.3390","volume":"9","author":[{"given":"Yu","family":"Wang","sequence":"first","affiliation":[{"name":"College of Pharmacy, Anhui University of Chinese Medicine, Hefei 230012, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yan","family":"Yue","sequence":"additional","affiliation":[{"name":"College of Pharmacy, Anhui University of Chinese Medicine, Hefei 230012, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ruoyang","family":"Jia","sequence":"additional","affiliation":[{"name":"College of Pharmacy, Anhui University of Chinese Medicine, Hefei 230012, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xinyi","family":"Liu","sequence":"additional","affiliation":[{"name":"College of Pharmacy, Anhui University of Chinese Medicine, Hefei 230012, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhiqing","family":"Cheng","sequence":"additional","affiliation":[{"name":"College of Pharmacy, Anhui University of Chinese Medicine, Hefei 230012, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yongfeng","family":"Cheng","sequence":"additional","affiliation":[{"name":"Clinical College of Anhui Medical University, Hefei 230031, China"},{"name":"School of Life Science, University of Science and Technology of China, Hefei 230027, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yinxiang","family":"Xu","sequence":"additional","affiliation":[{"name":"Zhaoke (Hefei) Pharmaceutical Co., Ltd., Hefei 230088, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zili","family":"Xie","sequence":"additional","affiliation":[{"name":"Anhui Institute for Food and Drug Control, Hefei 230051, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2011-0840","authenticated-orcid":false,"given":"Hongmei","family":"Xia","sequence":"additional","affiliation":[{"name":"College of Pharmacy, Anhui University of Chinese Medicine, Hefei 230012, China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2023,3,5]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"1109","DOI":"10.1016\/S0140-6736(15)00149-X","article-title":"Atopic dermatitis","volume":"387","author":"Weidinger","year":"2016","journal-title":"Lancet"},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"367","DOI":"10.2340\/00015555-3515","article-title":"A Therapeutic Renaissance\u2014Emerging Treatments for Atopic Dermatitis","volume":"100","author":"Na","year":"2020","journal-title":"Acta Derm. 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