{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,13]],"date-time":"2026-10-13T12:46:49Z","timestamp":1791895609367,"version":"4.3.4"},"reference-count":69,"publisher":"MDPI AG","issue":"5","license":[{"start":{"date-parts":[[2023,5,1]],"date-time":"2023-05-01T00:00:00Z","timestamp":1682899200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Gels"],"abstract":"<jats:p>Comedogenic skin care receives little attention compared to the care or treatment of more serious acne manifestations. Traditional therapies may have limited success with potential side effects. Cosmetic care supported by the effect of a biostimulating laser may offer a desirable alternative. The aim of the study was to evaluate the biological effectiveness of combined cosmetic treatment with lasotherapy on comedogenic skin type using noninvasive bioengineering methods. Twelve volunteers with comedogenic skin type underwent a 28-week application of Lasocare Basic 645\u00ae cosmetic gel containing Lactoperoxidase and Lactoferrin in combination with laser therapy (Lasocare\u00ae method). The effect of treatment on skin condition was monitored using noninvasive diagnostic methods. The parameters were the amount of sebum, the pore count, the ultraviolet-induced red fluorescence assessment of comedonic lesions (percentage of the area and quantification of orange-red spots), hydration, transepidermal water loss, and pH. A statistically significant decrease in sebum production was observed on the skin of the treated volunteers, as well as a decrease in porphyrins, indicating the presence of Cutibacterium acnes populating comedones and causing enlarged pores. The balance of epidermal water in the skin was regulated adjusting the acidity of the skin coat in individual zones, which decreased the presence of Cutibacterium acnes. Cosmetic treatment in combination with the Lasocare\u00ae method successfully improved the condition of comedogenic skin. In addition to transient erythema, there were no other adverse effects. The chosen procedure appears to be a suitable and safe alternative to traditional treatment procedures known from dermatological practice.<\/jats:p>","DOI":"10.3390\/gels9050370","type":"journal-article","created":{"date-parts":[[2023,5,1]],"date-time":"2023-05-01T12:10:03Z","timestamp":1682943003000},"page":"370","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":5,"title":["The Effect of Cosmetic Treatment and Gel Laser Therapy on the Improvement of Comedogenic Skin Type"],"prefix":"10.3390","volume":"9","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-4680-0930","authenticated-orcid":false,"given":"Jana","family":"Pavla\u010dkov\u00e1","sequence":"first","affiliation":[{"name":"Department of Fat, Surfactant and Cosmetics Technology, Faculty of Technology, Tomas Bata University in Zl\u00edn, Vavre\u010dkova 275, 760 01 Zl\u00edn, Czech Republic"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hana","family":"Pech\u00e1\u010dkov\u00e1","sequence":"additional","affiliation":[{"name":"Department of Fat, Surfactant and Cosmetics Technology, Faculty of Technology, Tomas Bata University in Zl\u00edn, Vavre\u010dkova 275, 760 01 Zl\u00edn, Czech Republic"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pavl\u00edna","family":"Egner","sequence":"additional","affiliation":[{"name":"Department of Fat, Surfactant and Cosmetics Technology, Faculty of Technology, Tomas Bata University in Zl\u00edn, Vavre\u010dkova 275, 760 01 Zl\u00edn, Czech Republic"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3168-413X","authenticated-orcid":false,"given":"Pavel","family":"Mokrej\u0161","sequence":"additional","affiliation":[{"name":"Department of Polymer Engineering, Faculty of Technology, Tomas Bata University in Zl\u00edn, Vavre\u010dkova 275, 760 01 Zl\u00edn, Czech Republic"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6110-7918","authenticated-orcid":false,"given":"Robert","family":"G\u00e1l","sequence":"additional","affiliation":[{"name":"Department of Food Technology, Faculty of Technology, Tomas Bata University in Zl\u00edn, Vavre\u010dkova 275, 760 01 Zl\u00edn, Czech Republic"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9669-1499","authenticated-orcid":false,"given":"Magda","family":"Janal\u00edkov\u00e1","sequence":"additional","affiliation":[{"name":"Department of Environmental Protection Engineering, Faculty of Technology, Tomas Bata University in Zl\u00edn, Vavre\u010dkova 275, 760 01 Zl\u00edn, Czech Republic"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2023,5,1]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"774","DOI":"10.18203\/issn.2455-4529.IntJResDermatol20194667","article-title":"A Study on the dermatology life quality index in patients with acne vulgaris","volume":"5","author":"Sivaramakrishnan","year":"2019","journal-title":"Int. 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