{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,9]],"date-time":"2026-07-09T06:21:41Z","timestamp":1783578101714,"version":"3.55.0"},"reference-count":23,"publisher":"MDPI AG","issue":"6","license":[{"start":{"date-parts":[[2023,5,26]],"date-time":"2023-05-26T00:00:00Z","timestamp":1685059200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Gels"],"abstract":"<jats:p>The aim of this study was to test the effect of hyaluronic acid cross-linked with polyethylene glycol containing micronized portions of calcium hydroxyapatite (Neauvia Stimulate) on both local tissue and systemic consequences, which are crucial from the perspective of long-term safety, in patients suffering from Hashimoto\u2019s disease. This most common autoimmune disease is a frequently mentioned contraindication to the use of fillers based on hyaluronic acid as well as biostimulants based on calcium hydroxyapatite. Broad-spectrum aspects of histopathology were analyzed to identify key features of inflammatory infiltration before the procedure and 5, 21, and 150 days after the procedure. A statistically significant effect on the reduction of the intensity of the inflammatory infiltration in the tissue in relation to the state before the procedure was demonstrated, combined with a reduction in the occurrence of both antigen-recognizing (CD4) and cytotoxic (CD8) T lymphocytes. With complete statistical certainty, it was demonstrated that the treatment with Neauvia Stimulate had no effect on the levels of these antibodies. All this corresponds with the risk analysis that showed no alarming symptoms during the time of observation. The choice of hyaluronic acid fillers cross-linked with polyethylene glycol should be considered justified and safe in the case of patients suffering from Hashimoto\u2019s disease.<\/jats:p>","DOI":"10.3390\/gels9060440","type":"journal-article","created":{"date-parts":[[2023,5,27]],"date-time":"2023-05-27T16:17:33Z","timestamp":1685204253000},"page":"440","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":5,"title":["Evaluation of the Safety of Neauvia Stimulate Injectable Product in Patients with Autoimmune Thyroid Diseases Based on Histopathological Examinations and Retrospective Analysis of Medical Records"],"prefix":"10.3390","volume":"9","author":[{"given":"Pawe\u0142","family":"Kubik","sequence":"first","affiliation":[{"name":"K-LAB Badania i Rozw\u00f3j, 81-312 Gdynia, Poland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1873-3048","authenticated-orcid":false,"given":"Daniela","family":"Gallo","sequence":"additional","affiliation":[{"name":"Endocrine Unit, Department of Medicine and Surgery, University of Insubria, ASST dei Sette Laghi, 21100 Varese, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7551-1751","authenticated-orcid":false,"given":"Maria Laura","family":"Tanda","sequence":"additional","affiliation":[{"name":"Endocrine Unit, Department of Medicine and Surgery, University of Insubria, ASST dei Sette Laghi, 21100 Varese, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jerzy","family":"Jankau","sequence":"additional","affiliation":[{"name":"Department of Plastic Surgery, Medical University of Gdansk, 80-210 Gda\u0144sk, Poland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4497-3563","authenticated-orcid":false,"given":"Raffaele","family":"Rauso","sequence":"additional","affiliation":[{"name":"Maxillofacial Surgery Unit, University of Campania \u201cLuigi Vanvitelli\u201d, 80138 Naples, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wojciech","family":"Gruszczy\u0144ski","sequence":"additional","affiliation":[{"name":"K-LAB Badania i Rozw\u00f3j, 81-312 Gdynia, Poland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Aleksandra","family":"Paw\u0142owska","sequence":"additional","affiliation":[{"name":"K-LAB Badania i Rozw\u00f3j, 81-312 Gdynia, Poland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pawe\u0142","family":"Chrapczy\u0144ski","sequence":"additional","affiliation":[{"name":"K-LAB Badania i Rozw\u00f3j, 81-312 Gdynia, 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Clinical Pathomorphology, Nicolaus Copernicus University, 85-094 Bydgoszcz, Poland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maria-Luiza","family":"Piesiak\u00f3w","sequence":"additional","affiliation":[{"name":"K-LAB Badania i Rozw\u00f3j, 81-312 Gdynia, Poland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bart\u0142omiej","family":"\u0141ukasik","sequence":"additional","affiliation":[{"name":"Medical Department, Matex Lab Switzerland SA, 1228 Geneve, Switzerland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7379-8645","authenticated-orcid":false,"given":"Agnieszka","family":"Paw\u0142owska-Kubik","sequence":"additional","affiliation":[{"name":"Division of History & Philosophy of Medical Sciences, Medical University of Gdansk, 80-210 Gda\u0144sk, 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Poland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1929-2010","authenticated-orcid":false,"given":"Tom","family":"Decates","sequence":"additional","affiliation":[{"name":"Department of Dermatology, Erasmus Medical Center, 3000 Rotterdam, The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nicola","family":"Zerbinati","sequence":"additional","affiliation":[{"name":"Dermatologic Unit, Department of Medicine and Surgery, University of Insubria, 21100 Varese, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2023,5,26]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"2041731417726464","DOI":"10.1177\/2041731417726464","article-title":"Crosslinking method of hyaluronic-based hydrogel for biomedical applications","volume":"8","author":"Khunmanee","year":"2017","journal-title":"J. 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