{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,29]],"date-time":"2026-08-29T07:45:59Z","timestamp":1787989559799,"version":"build-2784847793"},"reference-count":122,"publisher":"MDPI AG","issue":"8","license":[{"start":{"date-parts":[[2023,7,25]],"date-time":"2023-07-25T00:00:00Z","timestamp":1690243200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Gels"],"abstract":"<jats:p>Curcumin, a potent active compound found in turmeric and Curcuma xanthorrhiza oil, possesses a wide range of therapeutic properties, including antibacterial, anti-inflammatory, antioxidant, and wound healing activities. However, its clinical effectiveness is hindered by its low bioavailability and rapid elimination from the body. To overcome these limitations, researchers have explored innovative delivery systems for curcumin. Some promising approaches include solid lipid nanoparticles, nanomicelle gels, and transdermal formulations for topical drug delivery. In the field of dentistry, curcumin gels have shown effectiveness against oral disorders and periodontal diseases. Moreover, Pickering emulsions and floating in situ gelling systems have been developed to target gastrointestinal health. Furthermore, curcumin-based systems have demonstrated potential in wound healing and ocular medicine. In addition to its therapeutic applications, curcumin also finds use as a food dye, contraception aid, corrosion-resistant coating, and environmentally friendly stain. This paper primarily focuses on the development of gel compositions of curcumin to address the challenges associated with its clinical use.<\/jats:p>","DOI":"10.3390\/gels9080596","type":"journal-article","created":{"date-parts":[[2023,7,26]],"date-time":"2023-07-26T01:09:01Z","timestamp":1690333741000},"page":"596","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":39,"title":["Enhancing Therapeutic Efficacy of Curcumin: Advances in Delivery Systems and Clinical Applications"],"prefix":"10.3390","volume":"9","author":[{"given":"Hossein","family":"Omidian","sequence":"first","affiliation":[{"name":"Barry and Judy Silverman College of Pharmacy, Nova Southeastern University, Fort Lauderdale, FL 33328, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Renae L.","family":"Wilson","sequence":"additional","affiliation":[{"name":"Barry and Judy Silverman College of Pharmacy, Nova Southeastern University, Fort Lauderdale, FL 33328, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sumana Dey","family":"Chowdhury","sequence":"additional","affiliation":[{"name":"Barry and Judy Silverman College of Pharmacy, Nova Southeastern University, Fort Lauderdale, FL 33328, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2023,7,25]]},"reference":[{"key":"ref_1","unstructured":"(2023, July 20). Curcumin, Available online: https:\/\/pubchem.ncbi.nlm.nih.gov\/compound\/969516#section=2D-Structure."},{"key":"ref_2","unstructured":"(2023, July 20). Curcumin, Available online: https:\/\/pubchem.ncbi.nlm.nih.gov\/compound\/969516."},{"key":"ref_3","doi-asserted-by":"crossref","first-page":"205","DOI":"10.1016\/j.jtcme.2016.05.005","article-title":"Biological activities of curcuminoids, other biomolecules from turmeric and their derivatives","volume":"7","author":"Amalraj","year":"2016","journal-title":"J. Tradit. Complement. Med."},{"key":"ref_4","doi-asserted-by":"crossref","first-page":"587","DOI":"10.1016\/j.xphs.2022.10.022","article-title":"Hyaluronic Acid Gel Incorporating Curcumin-Phospholipid Complex Nanoparticles Prevents Postoperative Peritoneal Adhesion","volume":"112","author":"Akhlaghi","year":"2023","journal-title":"J. Pharm. Sci."},{"key":"ref_5","doi-asserted-by":"crossref","first-page":"267","DOI":"10.1016\/j.foodhyd.2018.07.012","article-title":"Cold gelation of curcumin loaded whey protein aggregates mixed with k-carrageenan: Impact of gel microstructure on the gastrointestinal fate of curcumin","volume":"85","author":"Alavi","year":"2018","journal-title":"Food Hydrocoll."},{"key":"ref_6","first-page":"13","article-title":"Thermoresponsive in situ gel of curcumin loaded solid lipid nanoparticle: Design, optimization and in vitro characterization","volume":"71","author":"Agrawal","year":"2022","journal-title":"J. Drug Deliv. Sci. Technol."},{"key":"ref_7","doi-asserted-by":"crossref","first-page":"285","DOI":"10.1515\/acph-2015-0029","article-title":"Curcumin phytosomal soft gel formulation: Development, optimization and physicochemical characterization","volume":"65","author":"Allam","year":"2015","journal-title":"Acta Pharm."},{"key":"ref_8","doi-asserted-by":"crossref","first-page":"13","DOI":"10.1007\/s10965-022-03319-5","article-title":"Modification of dry-gel synthesized MIL-100(Fe) with carboxymethyl cellulose for curcumin slow-release","volume":"29","author":"Amalia","year":"2022","journal-title":"J. Polym. Res."},{"key":"ref_9","doi-asserted-by":"crossref","first-page":"13","DOI":"10.1016\/j.foodhyd.2022.108336","article-title":"Fabrication of starch-based emulsion gel beads by an inverse gelation technique for loading proanthocyanidin and curcumin","volume":"137","author":"Bu","year":"2023","journal-title":"Food Hydrocoll."},{"key":"ref_10","doi-asserted-by":"crossref","first-page":"133130","DOI":"10.1016\/j.foodchem.2022.133130","article-title":"Curcumin loading and colon release of pectin gel beads: Effect of different de-esterification method","volume":"389","author":"Cai","year":"2022","journal-title":"Food Chem."},{"key":"ref_11","doi-asserted-by":"crossref","first-page":"34","DOI":"10.1016\/j.ejps.2013.08.036","article-title":"Curcumin loaded poly(2-hydroxyethyl methacrylate) nanoparticles from gelled ionic liquid\u2014In vitro cytotoxicity and anti-cancer activity in SKOV-3 cells","volume":"51","author":"Kumar","year":"2014","journal-title":"Eur. J. Pharm. Sci."},{"key":"ref_12","doi-asserted-by":"crossref","first-page":"17","DOI":"10.1016\/j.ijbiomac.2022.12.049","article-title":"The incorporated hydrogel of chitosan-oligoconjugated linoleic acid vesicles and the protective sustained release for curcumin in the gel","volume":"227","author":"Liu","year":"2023","journal-title":"Int. J. Biol. Macromol."},{"key":"ref_13","first-page":"2517","article-title":"Optimization and evaluation of a thermoresponsive ophthalmic in situ gel containing curcumin-loaded albumin nanoparticles","volume":"9","author":"Lou","year":"2014","journal-title":"Int. J. Nanomed."},{"key":"ref_14","first-page":"413","article-title":"Development of Optical pH Sensor Based on Curcumin Reagent Immobilized in Sol-gel\/Chitosan Melamine Hybrid Matrices)","volume":"38","author":"Mohammad","year":"2009","journal-title":"Sains Malays."},{"key":"ref_15","doi-asserted-by":"crossref","unstructured":"Nakagawa, K., Sowasod, N., Charinpanitkul, T., Soottitantawat, A., and Tanthapanichakoon, W. (2011, January 22\u201326). Encapsulation of curcumin loaded oil droplets by cryotropic gel formation from O\/W emulsion. Proceedings of the 11th International Congress on Engineering and Food (ICEF), Athens, Greece.","DOI":"10.1016\/j.profoo.2011.09.290"},{"key":"ref_16","doi-asserted-by":"crossref","first-page":"658","DOI":"10.2174\/1871520620666200407124020","article-title":"Film-Forming Nanogels: Effects of Nanocarriers and Film-Forming Gel on the Sustained Release of Curcumin","volume":"21","author":"Nguyen","year":"2021","journal-title":"Anticancer Agents Med. Chem."},{"key":"ref_17","doi-asserted-by":"crossref","first-page":"418","DOI":"10.2174\/2211738508666200907110444","article-title":"Synthesis of Nanostructured Lipid Carriers Loaded Chitosan\/Carbopol Hybrid Nanocomposite Gel for Oral Delivery of Artemether and Curcumin","volume":"8","author":"Kumar","year":"2020","journal-title":"Pharm. Nanotechnol."},{"key":"ref_18","first-page":"8","article-title":"Formulation Design and Cell Cytotoxicity of Curcumin-Loaded Liposomal Solid Gels for Anti-Hepatitis C Virus","volume":"2022","author":"Yusuf","year":"2022","journal-title":"Adv. Pharm. Pharm. Sci."},{"key":"ref_19","doi-asserted-by":"crossref","unstructured":"Abd El-Halim, S.M., Mamdouh, M.A., El-Haddad, A.E., and Soliman, S.M. (2020). Fabrication of Anti-HSV-1 Curcumin Stabilized Nanostructured Proniosomal Gel: Molecular Docking Studies on Thymidine Kinase Proteins. Sci. Pharm., 88.","DOI":"10.3390\/scipharm88010009"},{"key":"ref_20","doi-asserted-by":"crossref","first-page":"101708","DOI":"10.1016\/j.jebdp.2022.101708","article-title":"Comparative Efficacy of 1% Curcumin Nanomicelle Gel and 2% Curcumin Gel for Treatment of Recurrent Aphthous Stomatitis: A Double-Blind Randomized Clinical Trial","volume":"22","author":"Bakhshi","year":"2022","journal-title":"J. Evid. Based Dent. Pract."},{"key":"ref_21","doi-asserted-by":"crossref","first-page":"580","DOI":"10.1002\/jps.22292","article-title":"Optimization and Formulation Design of Gels of Diclofenac and Curcumin for Transdermal Drug Delivery by Box-Behnken Statistical Design","volume":"100","author":"Chaudhary","year":"2011","journal-title":"J. Pharm. Sci."},{"key":"ref_22","doi-asserted-by":"crossref","first-page":"356","DOI":"10.1016\/j.colsurfa.2016.06.054","article-title":"Development of curcumin loaded nanostructured lipid carrier based thermosensitive in situ gel for dermal delivery","volume":"506","author":"Chen","year":"2016","journal-title":"Colloid Surf. A-Physicochem. Eng. Asp."},{"key":"ref_23","doi-asserted-by":"crossref","first-page":"123","DOI":"10.5650\/jos.ess19212","article-title":"Anti-inflammatory Activity of Curcumin in Gel Carriers on Mice with Atrial Edema","volume":"69","author":"Garcia","year":"2020","journal-title":"J. Oleo Sci."},{"key":"ref_24","doi-asserted-by":"crossref","first-page":"1409","DOI":"10.3109\/10717544.2015.1065524","article-title":"A new approach for treatment of precancerous lesions with curcumin solid-lipid nanoparticle-loaded gels: In vitro and clinical evaluation","volume":"23","author":"Hazzah","year":"2016","journal-title":"Drug Deliv."},{"key":"ref_25","doi-asserted-by":"crossref","first-page":"489","DOI":"10.1007\/s40199-020-00352-x","article-title":"Design & development of nanosponge loaded topical gel of curcumin and caffeine mixture for augmented treatment of psoriasis","volume":"28","author":"Iriventi","year":"2020","journal-title":"Daru"},{"key":"ref_26","doi-asserted-by":"crossref","first-page":"281","DOI":"10.2174\/2211738509666210208225826","article-title":"Curcumin Loaded Ethosomal Gel for Improved Topical Delivery: Formulation, Characterization and Ex-vivo Studies","volume":"9","author":"Kumar","year":"2021","journal-title":"Pharm. Nanotechnol."},{"key":"ref_27","doi-asserted-by":"crossref","first-page":"1303","DOI":"10.1208\/s12249-013-0023-5","article-title":"Molecular inclusion complex of curcumin-beta-cyclodextrin nanoparticle to enhance curcumin skin permeability from hydrophilic matrix gel","volume":"14","author":"Rachmawati","year":"2013","journal-title":"AAPS PharmSciTech"},{"key":"ref_28","doi-asserted-by":"crossref","first-page":"819","DOI":"10.2217\/nnm-2020-0316","article-title":"Topical delivery of curcumin-loaded transfersomes gel ameliorated rheumatoid arthritis by inhibiting NF-kappabeta pathway","volume":"16","author":"Sana","year":"2021","journal-title":"Nanomedicine"},{"key":"ref_29","doi-asserted-by":"crossref","unstructured":"Scomoroscenco, C., Teodorescu, M., Raducan, A., Stan, M., Voicu, S.N., Trica, B., Ninciuleanu, C.M., Nistor, C.L., Mihaescu, C.I., and Petcu, C. (2021). Novel Gel Microemulsion as Topical Drug Delivery System for Curcumin in Dermatocosmetics. Pharmaceutics, 13.","DOI":"10.3390\/pharmaceutics13040505"},{"key":"ref_30","doi-asserted-by":"crossref","first-page":"138","DOI":"10.4103\/2230-973X.138346","article-title":"Comparison of effectiveness of curcumin with triamcinolone acetonide in the gel form in treatment of minor recurrent aphthous stomatitis: A randomized clinical trial","volume":"4","author":"Deshmukh","year":"2014","journal-title":"Int. J. Pharm. Investig."},{"key":"ref_31","doi-asserted-by":"crossref","first-page":"409","DOI":"10.4103\/jiaomr.jiaomr_201_22","article-title":"Comparison of Efficacy of Topical Application of Bleomycin with Adjuvant Antioxidants vs. Topical Curcumin Oral Gel with Adjuvant Antioxidants in the Treatment of Oral Leukoplakia","volume":"34","author":"Fathima","year":"2022","journal-title":"J. Indian Acad. Oral Med. Radiol."},{"key":"ref_32","doi-asserted-by":"crossref","first-page":"1010","DOI":"10.1111\/iej.13092","article-title":"Antimicrobial action of photodynamic therapy in root canals using LED curing light, curcumin and carbopol gel","volume":"52","author":"Oda","year":"2019","journal-title":"Int. Endod. J."},{"key":"ref_33","doi-asserted-by":"crossref","first-page":"90","DOI":"10.4103\/ijabmr.IJABMR_391_19","article-title":"Evaluation of Anti-plaque and Anti-inflammatory Effects of Oral Curcumin Gel as Adjunct to Scaling and Root Planing: A Clinical Study","volume":"11","author":"Pandey","year":"2021","journal-title":"Int. J. Appl. Basic Med. Res."},{"key":"ref_34","first-page":"83","article-title":"Clinical and Anti-Inflammatory Effect of Curcumin Oral Gel as Adjuncts in Treatment of Periodontal Pocket","volume":"8","author":"Farhood","year":"2020","journal-title":"J. Res. Med. Dent. Sci."},{"key":"ref_35","doi-asserted-by":"crossref","first-page":"133","DOI":"10.1080\/10717544.2016.1233591","article-title":"Formulation, in-vitro characterization and clinical evaluation of curcumin in-situ gel for treatment of periodontitis","volume":"24","author":"Nasra","year":"2017","journal-title":"Drug Deliv."},{"key":"ref_36","doi-asserted-by":"crossref","first-page":"1334","DOI":"10.1166\/jbn.2019.2758","article-title":"In-Situ Gelling Liquid Crystal Mucoadhesive Vehicle for Curcumin Buccal Administration and Its Potential Application in the Treatment of Oral Candidiasis","volume":"15","author":"Bonifacio","year":"2019","journal-title":"J. Biomed. Nanotechnol."},{"key":"ref_37","doi-asserted-by":"crossref","first-page":"428","DOI":"10.1016\/j.oooo.2020.12.020","article-title":"A clinicobiochemical evaluation of curcumin as gel and as buccal mucoadhesive patches in the management of oral submucous fibrosis","volume":"131","author":"Chandrashekar","year":"2021","journal-title":"Oral Surg. Oral Med. Oral Pathol. Oral Radiol."},{"key":"ref_38","doi-asserted-by":"crossref","first-page":"83","DOI":"10.5005\/jp-journals-10024-2726","article-title":"Comparison of Efficacy of Topical Curcumin Gel with Triamcinolone-hyaluronidase Gel Individually and in Combination in the Treatment of Oral Submucous Fibrosis","volume":"21","author":"Lanjekar","year":"2020","journal-title":"J. Contemp. Dent. Pract."},{"key":"ref_39","doi-asserted-by":"crossref","first-page":"107","DOI":"10.31557\/APJCP.2021.22.S1.107","article-title":"A Comparative Study to Evaluate Efficacy of Curcumin and Aloe Vera Gel along with Oral Physiotherapy in the Management of Oral Submucous Fibrosis: A Randomized Clinical Trial","volume":"22","author":"Kulkarni","year":"2021","journal-title":"Asian Pac. J. Cancer Prev."},{"key":"ref_40","doi-asserted-by":"crossref","first-page":"178","DOI":"10.1016\/j.crfs.2020.05.001","article-title":"Pickering emulsions stabilized by colloidal gel particles complexed or conjugated with biopolymers to enhance bioaccessibility and cellular uptake of curcumin","volume":"3","author":"Wang","year":"2020","journal-title":"Curr. Res. Food Sci."},{"key":"ref_41","first-page":"11","article-title":"Emulsion gels and oil-filled aerogels as curcumin carriers: Nanostructural characterization of gastrointestinal digestion products","volume":"387","author":"Martinez","year":"2022","journal-title":"Food Chem."},{"key":"ref_42","first-page":"6","article-title":"Formulation of gastroretentive sustained release floating in situ gelling drug delivery system of solubility enhanced curcumin-soy lecithin complex","volume":"53","author":"Kathpalia","year":"2019","journal-title":"J. Drug Deliv. Sci. Technol."},{"key":"ref_43","first-page":"4574","article-title":"Formulation and Evaluation of Gastro Retentive Novel Floating In-Situ Gelling System of Curcumin","volume":"10","author":"Padhan","year":"2019","journal-title":"Int. J. Pharm. Sci. Res."},{"key":"ref_44","doi-asserted-by":"crossref","first-page":"18","DOI":"10.3389\/fnut.2022.839761","article-title":"Fabrication and Characterization of Ultra-High-Pressure (UHP)-Induced Whey Protein Isolate\/kappa-Carrageenan Composite Emulsion Gels for the Delivery of Curcumin","volume":"9","author":"Su","year":"2022","journal-title":"Front. Nutr."},{"key":"ref_45","first-page":"62","article-title":"Preclinical Evaluation of Silver-Curcumin Nano- gel: A complete assessment on a new topical antimicrobial product for burn","volume":"7","author":"Aghamoosa","year":"2020","journal-title":"J. Nanoanal."},{"key":"ref_46","doi-asserted-by":"crossref","first-page":"403","DOI":"10.1016\/j.ijbiomac.2022.04.134","article-title":"Gelatin-lecithin-F127 gel mediated self-assembly of curcumin vesicles for enhanced wound healing","volume":"210","author":"Das","year":"2022","journal-title":"Int. J. Biol. Macromol."},{"key":"ref_47","doi-asserted-by":"crossref","first-page":"88","DOI":"10.1016\/j.ijpharm.2015.03.052","article-title":"Novel curcumin-loaded gel-core hyaluosomes with promising burn-wound healing potential: Development, in-vitro appraisal and in-vivo studies","volume":"486","author":"Elnaggar","year":"2015","journal-title":"Int. J. Pharm."},{"key":"ref_48","doi-asserted-by":"crossref","first-page":"300","DOI":"10.1159\/000512122","article-title":"Curcumin-Loaded Self-Microemulsifying Gel for Enhancing Wound Closure","volume":"33","author":"Guo","year":"2020","journal-title":"Skin Pharmacol. Physiol."},{"key":"ref_49","doi-asserted-by":"crossref","unstructured":"Kotian, V., Koland, M., and Mutalik, S. (2022). Nanocrystal-Based Topical Gels for Improving Wound Healing Efficacy of Curcumin. Crystals, 12.","DOI":"10.3390\/cryst12111565"},{"key":"ref_50","doi-asserted-by":"crossref","first-page":"949","DOI":"10.1177\/0040517514557310","article-title":"Preparation, characterization, and in vitro evaluation of antibacterial sol-gel coated cotton textiles with prolonged release of curcumin","volume":"85","author":"Pisitsak","year":"2015","journal-title":"Text. Res. J."},{"key":"ref_51","doi-asserted-by":"crossref","first-page":"53","DOI":"10.4103\/jiaomr.jiaomr_168_20","article-title":"Correlation of pain score with ulcer size in oral aphthous ulcers using 2% curcumin gel and 0.1% triamcinolone oral paste\u2014A parallel comparison study","volume":"33","author":"Raman","year":"2021","journal-title":"J. Indian Acad. Oral Med. Radiol."},{"key":"ref_52","doi-asserted-by":"crossref","unstructured":"Abdelkader, H., Wertheim, D., Pierscionek, B., and Alany, R.G. (2020). Curcumin In Situ Gelling Polymeric Insert with Enhanced Ocular Performance. Pharmaceutics, 12.","DOI":"10.3390\/pharmaceutics12121158"},{"key":"ref_53","doi-asserted-by":"crossref","first-page":"322","DOI":"10.1016\/j.colsurfb.2015.02.007","article-title":"Novel in situ gel systems based on P123\/TPGS mixed micelles and gellan gum for ophthalmic delivery of curcumin","volume":"128","author":"Duan","year":"2015","journal-title":"Colloid Surf. B-Biointerfaces"},{"key":"ref_54","doi-asserted-by":"crossref","first-page":"759","DOI":"10.1016\/j.foodres.2017.09.071","article-title":"Stability of curcumin encapsulated in solid lipid microparticles incorporated in cold-set emulsion filled gels of soy protein isolate and xanthan gum","volume":"102","author":"Bispo","year":"2017","journal-title":"Food Res. Int."},{"key":"ref_55","doi-asserted-by":"crossref","first-page":"183","DOI":"10.1016\/j.ejps.2014.09.019","article-title":"(Copper-curcumin) beta-cyclodextrin vaginal gel: Delivering a novel metal-herbal approach for the development of topical contraception prophylaxis","volume":"65","author":"Gaurav","year":"2014","journal-title":"Eur. J. Pharm. Sci."},{"key":"ref_56","doi-asserted-by":"crossref","first-page":"1515","DOI":"10.1007\/s11998-020-00364-x","article-title":"Extracts of curcumin-incorporated hybrid sol-gel coatings for the corrosion mitigation of mild steel in 0.5 M HCl","volume":"17","author":"Ishak","year":"2020","journal-title":"J. Coat. Technol. Res."},{"key":"ref_57","doi-asserted-by":"crossref","first-page":"121","DOI":"10.1007\/978-1-4939-8745-0_15","article-title":"Curcumin\/Turmeric as an Environment-Friendly Protein Gel Stain","volume":"1853","author":"Kurien","year":"2018","journal-title":"Methods Mol. Biol."},{"key":"ref_58","doi-asserted-by":"crossref","first-page":"2557","DOI":"10.1021\/acs.jafc.0c07288","article-title":"Investigation of the Formation Mechanism and Curcumin Bioaccessibility of Emulsion Gels Based on Sugar Beet Pectin and Laccase Catalysis","volume":"69","author":"Pan","year":"2021","journal-title":"J. Agric. Food Chem."},{"key":"ref_59","doi-asserted-by":"crossref","first-page":"12","DOI":"10.1016\/j.foodhyd.2021.106692","article-title":"In vitro digestion of curcumin-nanoemulsion-enriched dairy protein matrices: Impact of the type of gel structure on the bioaccessibility of curcumin","volume":"117","author":"Qazi","year":"2021","journal-title":"Food Hydrocoll."},{"key":"ref_60","doi-asserted-by":"crossref","first-page":"13","DOI":"10.1016\/j.jfoodeng.2023.111504","article-title":"Pickering emulsion gel stabilized by pea protein nanoparticle induced by heat-assisted pH-shifting for curcumin delivery","volume":"350","author":"Qiao","year":"2023","journal-title":"J. Food Eng."},{"key":"ref_61","doi-asserted-by":"crossref","unstructured":"Scomoroscenco, C., Teodorescu, M., Burlacu, S.G., Gifu, I.C., Mihaescu, C.I., Petcu, C., Raducan, A., Oancea, P., and Cinteza, L.O. (2022). Synergistic Antioxidant Activity and Enhanced Stability of Curcumin Encapsulated in Vegetal Oil-Based Microemulsion and Gel Microemulsions. Antioxidants, 11.","DOI":"10.3390\/antiox11050854"},{"key":"ref_62","doi-asserted-by":"crossref","first-page":"831","DOI":"10.3109\/1061186X.2012.719230","article-title":"Formulation and evaluation of microemulsion-based in situ ion-sensitive gelling systems for intranasal administration of curcumin","volume":"20","author":"Wang","year":"2012","journal-title":"J. Drug Target."},{"key":"ref_63","doi-asserted-by":"crossref","first-page":"576","DOI":"10.3109\/10837450.2015.1026607","article-title":"Thermosensitive in situ nanogel as ophthalmic delivery system of curcumin: Development, characterization, in vitro permeation and in vivo pharmacokinetic studies","volume":"21","author":"Liu","year":"2016","journal-title":"Pharm. Dev. Technol."},{"key":"ref_64","doi-asserted-by":"crossref","first-page":"116","DOI":"10.1016\/j.jcis.2010.10.024","article-title":"Curcumin-loaded PLGA-PEG-PLGA triblock copolymeric micelles: Preparation, pharmacokinetics and distribution in vivo","volume":"354","author":"Song","year":"2011","journal-title":"J. Colloid Interface Sci."},{"key":"ref_65","doi-asserted-by":"crossref","unstructured":"Gugleva, V., Michailova, V., Mihaylova, R., Momekov, G., Zaharieva, M.M., Najdenski, H., Petrov, P., Rangelov, S., Forys, A., and Trzebicka, B. (2022). Formulation and Evaluation of Hybrid Niosomal In Situ Gel for Intravesical Co-Delivery of Curcumin and Gentamicin Sulfate. Pharmaceutics, 14.","DOI":"10.3390\/pharmaceutics14040747"},{"key":"ref_66","first-page":"4097","article-title":"Stability-indicating densitometric method for simultaneous determination of donepezil hydrochloride and curcumin in insitu nasal gel","volume":"5","author":"Ghodake","year":"2018","journal-title":"Indo Am. J. Pharm. Sci."},{"key":"ref_67","first-page":"81","article-title":"The characterization of the sol-gel encapsulated curcumin as a possible sensor for small biologically important molecules","volume":"53","author":"Iwunze","year":"2007","journal-title":"Cell. Mol. Biol."},{"key":"ref_68","doi-asserted-by":"crossref","first-page":"15","DOI":"10.1016\/j.fhfh.2021.100035","article-title":"Pinto bean protein-based acid-induced cold-set gels as carriers for curcumin delivery: Fabrication and characterization","volume":"1","author":"Aliabbasi","year":"2021","journal-title":"Food Hydrocoll. Health"},{"key":"ref_69","doi-asserted-by":"crossref","first-page":"10","DOI":"10.1016\/j.lwt.2022.113346","article-title":"Low-oil-phase emulsion gel with antioxidant properties prepared by soybean protein isolate and curcumin composite nanoparticles","volume":"161","author":"Du","year":"2022","journal-title":"LWT-Food Sci. Technol."},{"key":"ref_70","doi-asserted-by":"crossref","first-page":"10","DOI":"10.1016\/j.foodchem.2022.134759","article-title":"Formation and characteristics of curcumin-loaded binary gels formed from large yellow croaker (Pseudosciaena crocea) roe protein isolate and gellan gum","volume":"405","author":"Du","year":"2023","journal-title":"Food Chem."},{"key":"ref_71","doi-asserted-by":"crossref","first-page":"166","DOI":"10.1016\/j.lwt.2017.07.063","article-title":"Rheological and mechanical characterization of curcumin-loaded emulsion-filled gels produced with whey protein isolate and xanthan gum","volume":"86","author":"Souki","year":"2017","journal-title":"LWT-Food Sci. Technol."},{"key":"ref_72","doi-asserted-by":"crossref","first-page":"14","DOI":"10.1016\/j.foodres.2022.111877","article-title":"The novel pickering emulsion gels stabilized by zein hydrolysate-chitin nanocrystals coacervates: Improvement on stability and bioaccessibility for curcumin","volume":"161","author":"Lei","year":"2022","journal-title":"Food Res. Int."},{"key":"ref_73","doi-asserted-by":"crossref","first-page":"11","DOI":"10.1016\/j.foodres.2020.109032","article-title":"Pickering emulsion gels stabilized by high hydrostatic pressure-induced whey protein isolate gel particles: Characterization and encapsulation of curcumin","volume":"132","author":"Lv","year":"2020","journal-title":"Food Res. Int."},{"key":"ref_74","doi-asserted-by":"crossref","first-page":"13","DOI":"10.1016\/j.foodhyd.2021.106679","article-title":"Fabrication of polysaccharide-based high internal phase emulsion gels: Enhancement of curcumin stability and bioaccessibility","volume":"117","author":"Miao","year":"2021","journal-title":"Food Hydrocoll."},{"key":"ref_75","doi-asserted-by":"crossref","unstructured":"Tan, K.X., Ng, L.L.E., and Loo, S.C.J. (2021). Formulation Development of a Food-Graded Curcumin-Loaded Medium Chain Triglycerides-Encapsulated Kappa Carrageenan (CUR-MCT-KC) Gel Bead Based Oral Delivery Formulation. Materials, 14.","DOI":"10.3390\/ma14112783"},{"key":"ref_76","doi-asserted-by":"crossref","first-page":"6395","DOI":"10.1002\/jsfa.11310","article-title":"Effect of operating parameters on the physical and chemical stability of an oil gelled-in-water emulsified curcumin delivery system","volume":"101","year":"2021","journal-title":"J. Sci. Food Agric."},{"key":"ref_77","doi-asserted-by":"crossref","first-page":"e20201378","DOI":"10.1590\/0001-3765202220201378","article-title":"Antioxidant and anti-inflammatory activity of curcumin transdermal gel in an IL-10 knockout mouse model of inflammatory bowel disease","volume":"94","author":"Araujo","year":"2022","journal-title":"An. Acad. Bras. Cienc."},{"key":"ref_78","doi-asserted-by":"crossref","first-page":"132","DOI":"10.1016\/j.jconrel.2016.10.004","article-title":"Tacrolimus and curcumin co-loaded liposphere gel: Synergistic combination towards management of psoriasis","volume":"243","author":"Jain","year":"2016","journal-title":"J. Control. Release"},{"key":"ref_79","doi-asserted-by":"crossref","first-page":"975","DOI":"10.1080\/10837450.2022.2142610","article-title":"Topical delivery of Bruton\u2019s tyrosine kinase inhibitor and curcumin-loaded nanostructured lipid carrier gel: Repurposing strategy for the psoriasis management","volume":"27","author":"Jain","year":"2022","journal-title":"Pharm. Dev. Technol."},{"key":"ref_80","doi-asserted-by":"crossref","first-page":"1245","DOI":"10.1007\/s13346-020-00852-y","article-title":"Novel nanoemulsion gel containing triple natural bio-actives combination of curcumin, thymoquinone, and resveratrol improves psoriasis therapy: In vitro and in vivo studies","volume":"11","author":"Khatoon","year":"2021","journal-title":"Drug Deliv. Transl. Res."},{"key":"ref_81","doi-asserted-by":"crossref","first-page":"80","DOI":"10.1080\/10837450802409438","article-title":"Formulation and evaluation of curcumin gel for topical application","volume":"14","author":"Patel","year":"2009","journal-title":"Pharm. Dev. Technol."},{"key":"ref_82","doi-asserted-by":"crossref","unstructured":"Shehata, T.M., Ibrahim, M.M., and Elsewedy, H.S. (2021). Curcumin Niosomes Prepared from Proniosomal Gels: In Vitro Skin Permeability, Kinetic and In Vivo Studies. Polymers, 13.","DOI":"10.3390\/polym13050791"},{"key":"ref_83","doi-asserted-by":"crossref","first-page":"1471","DOI":"10.1080\/21691401.2017.1373659","article-title":"Skin targeting of curcumin solid lipid nanoparticles-engrossed topical gel for the treatment of pigmentation and irritant contact dermatitis","volume":"46","author":"Shrotriya","year":"2018","journal-title":"Artif. Cells Nanomed. Biotechnol."},{"key":"ref_84","doi-asserted-by":"crossref","first-page":"110","DOI":"10.2174\/1573397115666191105142827","article-title":"Controlled Release Gel Encompassing Curcumin Microspheres and Diclofenac Diethylamine for Feat Against Arthritis Inflammation","volume":"16","author":"Singh","year":"2020","journal-title":"Curr. Rheumatol. Rev."},{"key":"ref_85","doi-asserted-by":"crossref","first-page":"26","DOI":"10.2174\/2213346110666221020121020","article-title":"Curcumin-loaded Hydrotropic Solid Dispersion Topical Gel Development and Evaluation: A Greener Approach Towards Transdermal Delivery of Drugs","volume":"9","author":"Tripathi","year":"2022","journal-title":"Curr. Green Chem."},{"key":"ref_86","first-page":"250","article-title":"Nanostructured curcumin with choline and geranic acid ionic liquid (cage-il): Potential for incorporation into pharmaceutical gel formulations","volume":"46","author":"Vila","year":"2023","journal-title":"Qu\u00edm. Nova"},{"key":"ref_87","first-page":"L48","article-title":"INVESTIGATING THE EFFECT OF 1% CURCUMIN GEL AND PLACEBO ON PATIENTS WITH PLAQUE PSORIASIS","volume":"8","author":"Yaghoobi","year":"2018","journal-title":"Int. J. Life Sci. Pharma Res."},{"key":"ref_88","doi-asserted-by":"crossref","first-page":"55","DOI":"10.4103\/jos.jos_143_21","article-title":"Effect of 1% curcumin gel on myeloperoxidase activity in GCF and periodontal status in the initial phase of orthodontic tooth movement","volume":"11","author":"Samita","year":"2022","journal-title":"J. Orthod. Sci."},{"key":"ref_89","first-page":"90","article-title":"Evaluation of Anti-Inflammatory Effects of Curcumin Gel as an Adjunct to Scaling and Root Planing: A Clinical Study","volume":"7","author":"Anuradha","year":"2015","journal-title":"J. Int. Oral Health"},{"key":"ref_90","doi-asserted-by":"crossref","first-page":"79","DOI":"10.4103\/AIHB.AIHB_46_17","article-title":"Comparative Evaluation of Efficacy of Oral Curcumin Gel as an Adjunct to Scaling and Root Planing in the Treatment of Chronic Periodontitis","volume":"8","author":"Dave","year":"2018","journal-title":"Adv. Hum. Biol."},{"key":"ref_91","doi-asserted-by":"crossref","first-page":"326","DOI":"10.4103\/0974-8490.138287","article-title":"Evaluation of the efficacy of 2% curcumin gel in the treatment of experimental periodontitis","volume":"6","author":"Hosadurga","year":"2014","journal-title":"Pharmacogn. Res."},{"key":"ref_92","doi-asserted-by":"crossref","first-page":"6810936","DOI":"10.1155\/2019\/6810936","article-title":"Antibacterial Effect of Curcumin against Clinically Isolated Porphyromonas gingivalis and Connective Tissue Reactions to Curcumin Gel in the Subcutaneous Tissue of Rats","volume":"2019","author":"Sha","year":"2019","journal-title":"Biomed. Res. Int."},{"key":"ref_93","doi-asserted-by":"crossref","first-page":"149","DOI":"10.4103\/0976-9668.184701","article-title":"Influence of application of chlorhexidine gel and curcumin gel as an adjunct to scaling and root planing: A interventional study","volume":"7","author":"Hugar","year":"2016","journal-title":"J. Nat. Sci. Biol. Med."},{"key":"ref_94","doi-asserted-by":"crossref","first-page":"188","DOI":"10.4103\/jphi.JPHI_82_17","article-title":"Effect of local application of curcumin and ornidazole gel in chronic periodontitis patients","volume":"7","author":"Ravishankar","year":"2017","journal-title":"Int. J. Pharm. Investig."},{"key":"ref_95","first-page":"171","article-title":"Evaluation of Curcumin Gel as Adjunct to Scaling & Root Planing in Management of Periodontitis- Randomized Clinical & Biochemical Investigation","volume":"19","author":"Kaur","year":"2019","journal-title":"Infect. Disord. Drug Targets"},{"key":"ref_96","doi-asserted-by":"crossref","first-page":"54","DOI":"10.4103\/jisp.jisp_105_19","article-title":"Comparison of effect of curcumin gel and noneugenol periodontal dressing in tissue response, early wound healing, and pain assessment following periodontal flap surgery in chronic periodontitis patients","volume":"24","author":"Meghana","year":"2020","journal-title":"J. Indian Soc. Periodontol."},{"key":"ref_97","doi-asserted-by":"crossref","first-page":"8850926","DOI":"10.1155\/2020\/8850926","article-title":"Efficacy of Curcumin Gel on Zinc, Magnesium, Copper, IL-1beta, and TNF-alpha in Chronic Periodontitis Patients","volume":"2020","author":"Mohammad","year":"2020","journal-title":"Biomed. Res. Int."},{"key":"ref_98","doi-asserted-by":"crossref","unstructured":"Mohammad, C.A., Ali, K.M., Al-Rawi, R.A., and Gul, S.S. (2022). Effects of Curcumin and Tetracycline Gel on Experimental Induced Periodontitis as an Anti-Inflammatory, Osteogenesis Promoter and Enhanced Bone Density through Altered Iron Levels: Histopathological Study. Antibiotics, 11.","DOI":"10.3390\/antibiotics11040521"},{"key":"ref_99","doi-asserted-by":"crossref","first-page":"7278064","DOI":"10.1155\/2022\/7278064","article-title":"Antioxidant Effects of Curcumin Gel in Experimental Induced Diabetes and Periodontitis in Rats","volume":"2022","author":"Mohammad","year":"2022","journal-title":"Biomed. Res. Int."},{"key":"ref_100","doi-asserted-by":"crossref","first-page":"276","DOI":"10.1080\/10667857.2018.1432171","article-title":"Curcumin-loaded silk fibroin e-gel scaffolds for wound healing applications","volume":"33","author":"Karahaliloglu","year":"2018","journal-title":"Mater. Technol."},{"key":"ref_101","first-page":"1602","article-title":"Formulation and Evaluation of Allicin and Curcumin Gel Improves Normal and Diabetic Ulcers in Rabbits","volume":"37","author":"Khan","year":"2018","journal-title":"Lat. Am. J. Pharm."},{"key":"ref_102","first-page":"387","article-title":"Wound Healing Effect of Curcumin Gel for Transdermal Delivery","volume":"37","author":"Kim","year":"2013","journal-title":"Polymer"},{"key":"ref_103","doi-asserted-by":"crossref","unstructured":"Sai, N., Dong, X., Huang, P.Q., You, L.T., Yang, C.J., Liu, Y., Wang, W.P., Wu, H.M., Yu, Y.C., and Du, Y.Y. (2020). A Novel Gel-Forming Solution Based on PEG-DSPE\/Solutol HS 15 Mixed Micelles and Gellan Gum for Ophthalmic Delivery of Curcumin. Molecules, 25.","DOI":"10.3390\/molecules25010081"},{"key":"ref_104","doi-asserted-by":"crossref","first-page":"40","DOI":"10.4103\/1735-3327.223618","article-title":"Innovative evaluation of local injective gel of curcumin on the orthodontic tooth movement in rats","volume":"15","author":"Asefi","year":"2018","journal-title":"Dent. Res. J."},{"key":"ref_105","doi-asserted-by":"crossref","first-page":"237","DOI":"10.1007\/978-1-4939-8745-0_27","article-title":"Heat\/Pressure Treatment with Detergents Significantly Increases Curcumin Solubility and Stability: Its Use as an Environment-Friendly Protein Gel Stain","volume":"1853","author":"Kurien","year":"2018","journal-title":"Methods Mol. Biol."},{"key":"ref_106","doi-asserted-by":"crossref","unstructured":"Raduly, F.M., Raditoiu, V., Raditoiu, A., Frone, A.N., Nicolae, C.A., Raut, I., Constantin, M., and Grapin, M. (2023). Multifunctional Finishing of Cotton Fabric with Curcumin Derivatives Coatings Obtained by Sol-Gel Method. Gels, 9.","DOI":"10.3390\/gels9050369"},{"key":"ref_107","doi-asserted-by":"crossref","first-page":"14","DOI":"10.1016\/j.ejps.2021.106083","article-title":"Mechanistic insight into gel-induced aggregation of amorphous curcumin during dissolution process","volume":"170","author":"Han","year":"2022","journal-title":"Eur. J. Pharm. Sci."},{"key":"ref_108","doi-asserted-by":"crossref","first-page":"8","DOI":"10.1016\/j.foodhyd.2019.105564","article-title":"Controlled release behavior of curcumin from kappa-carrageenan gels with flexible texture by the addition of metal chlorides","volume":"101","author":"Kadota","year":"2020","journal-title":"Food Hydrocoll."},{"key":"ref_109","doi-asserted-by":"crossref","first-page":"2188","DOI":"10.1208\/s12249-016-0652-6","article-title":"Intravaginal Delivery of Polyphenon 60 and Curcumin Nanoemulsion Gel","volume":"18","author":"Kaur","year":"2017","journal-title":"AAPS PharmSciTech"},{"key":"ref_110","doi-asserted-by":"crossref","first-page":"1863","DOI":"10.1016\/j.ijbiomac.2021.05.174","article-title":"A pH-sensitive curcumin loaded microemulsion-filled alginate and porous starch composite gels: Characterization, in vitro release kinetics and biological activity","volume":"182","author":"Li","year":"2021","journal-title":"Int. J. Biol. Macromol."},{"key":"ref_111","doi-asserted-by":"crossref","first-page":"449","DOI":"10.1016\/j.ijbiomac.2022.01.069","article-title":"Potential low-calorie model that inhibits free fatty acid release and helps curcumin deliver in vitro: Ca2+-induced emulsion gels from low methyl-esterified pectin with the presence of erythritol","volume":"200","author":"Yang","year":"2022","journal-title":"Int. J. Biol. Macromol."},{"key":"ref_112","doi-asserted-by":"crossref","first-page":"282","DOI":"10.1080\/10837450.2022.2039943","article-title":"Glycyrrhizic acid assists anti-psoriatic efficacy of a self-deformable curcumin loaded transdermal gel","volume":"27","author":"Jin","year":"2022","journal-title":"Pharm. Dev. Technol."},{"key":"ref_113","first-page":"9","article-title":"A Water in Oil Gelled Emulsion as a Topical Release Vehicle for Curcumin","volume":"74","author":"Calderas","year":"2022","journal-title":"Starch-Starke"},{"key":"ref_114","first-page":"15","article-title":"Water-responsive gel extends drug retention and facilitates skin penetration for curcumin topical delivery against psoriasis","volume":"18","author":"Yao","year":"2023","journal-title":"Asian J. Pharm. Sci."},{"key":"ref_115","doi-asserted-by":"crossref","first-page":"17","DOI":"10.4103\/jiaomr.jiaomr_225_21","article-title":"Therapeutic Evaluation of 5% Topical Amlexanox Paste and 2% Curcumin Oral Gel in the Management of Recurrent Aphthous Stomatitis-A Randomized Clinical Trial","volume":"34","author":"Gauthaman","year":"2022","journal-title":"J. Indian Acad. Oral Med. Radiol."},{"key":"ref_116","doi-asserted-by":"crossref","first-page":"905","DOI":"10.1016\/j.jds.2020.09.015","article-title":"Effects of curcumin gel on osteoclastogenic bone markers in experimental periodontitis and alveolar bone loss in wistar rats","volume":"16","author":"Sha","year":"2021","journal-title":"J. Dent. Sci."},{"key":"ref_117","doi-asserted-by":"crossref","first-page":"494","DOI":"10.5005\/jp-journals-10024-2828","article-title":"A Comparative Evaluation of Subgingivally Delivered 2% Curcumin and 0.2% Chlorhexidine Gel Adjunctive to Scaling and Root Planing in Chronic Periodontitis","volume":"21","author":"Siddharth","year":"2020","journal-title":"J. Contemp. Dent. Pract."},{"key":"ref_118","doi-asserted-by":"crossref","first-page":"S102","DOI":"10.4103\/0976-9668.166100","article-title":"Comparative evaluation of the efficacy of curcumin gel with and without photo activation as an adjunct to scaling and root planing in the treatment of chronic periodontitis: A split mouth clinical and microbiological study","volume":"6","author":"Sreedhar","year":"2015","journal-title":"J. Nat. Sci. Biol. Med."},{"key":"ref_119","doi-asserted-by":"crossref","first-page":"569","DOI":"10.1016\/j.ijbiomac.2017.03.066","article-title":"Development of Curcumin loaded chitosan polymer based nanoemulsion gel: In vitro, ex vivo evaluation and in vivo wound healing studies","volume":"101","author":"Thomas","year":"2017","journal-title":"Int. J. Biol. Macromol."},{"key":"ref_120","doi-asserted-by":"crossref","first-page":"21525","DOI":"10.1021\/acsomega.1c02441","article-title":"Solid-State Fluorescent Selenium Quantum Dots by a Solvothermal-Assisted Sol-Gel Route for Curcumin Sensing","volume":"6","author":"Anupama","year":"2021","journal-title":"ACS Omega"},{"key":"ref_121","doi-asserted-by":"crossref","first-page":"284","DOI":"10.9734\/jpri\/2021\/v33i58B34204","article-title":"Formulation Development of Novel Curcumin Analogue Loaded Non-aqueous Gel and Curcumin Analogue Loaded Nanoparticle (CA-NP) Gel for Topical Use and In-vitro Antioxidant Study","volume":"33","author":"Gokhale","year":"2021","journal-title":"J. Pharm. Res. 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