{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,19]],"date-time":"2026-08-19T17:40:51Z","timestamp":1787161251802,"version":"build-2736575974"},"reference-count":35,"publisher":"MDPI AG","issue":"9","license":[{"start":{"date-parts":[[2023,9,1]],"date-time":"2023-09-01T00:00:00Z","timestamp":1693526400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"National Natural Science Foundation of China","award":["32171316"],"award-info":[{"award-number":["32171316"]}]},{"name":"National Natural Science Foundation of China","award":["WIUCASQD2019003"],"award-info":[{"award-number":["WIUCASQD2019003"]}]},{"name":"Wenzhou Institute, University of Chinese Academy of Sciences","award":["32171316"],"award-info":[{"award-number":["32171316"]}]},{"name":"Wenzhou Institute, University of Chinese Academy of Sciences","award":["WIUCASQD2019003"],"award-info":[{"award-number":["WIUCASQD2019003"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Gels"],"abstract":"<jats:p>The development of autoclavable hydrogels has been driven by the need for materials that can withstand the rigors of sterilization without compromising their properties or functionality. Many conventional hydrogels cannot withstand autoclave treatment owing to the breakdown of their composition or structure under the high-temperature and high-pressure environment of autoclaving. Here, the effect of autoclaving on the physical, mechanical, and biological properties of bovine serum albumin methacryloyl (BSAMA) cryogels at three protein concentrations (3, 5, and 10%) was extensively studied. We found that BSAMA cryogels at three concentrations remained little changed after autoclaving in terms of gross shape, pore structure, and protein secondary structure. Young\u2019s modulus of autoclaved BSAMA cryogels (BSAMAA) at low concentrations (3 and 5%) was similar to that of BSAMA cryogels, whereas 10% BSAMAA exhibited a higher Young\u2019s modulus value, compared with 10% BSAMA. Interestingly, BSAMAA cryogels prolonged degradation. Importantly, cell viability, drug release, and hemolytic behaviors were found to be similar among the pre- and post-autoclaved cryogels. Above all, autoclaving proved to be more effective in sterilizing BSAMA cryogels from bacteria contamination than UV and ethanol treatments. Thus, autoclavable BSAMA cryogels with uncompromising properties would be useful for biomedical applications.<\/jats:p>","DOI":"10.3390\/gels9090712","type":"journal-article","created":{"date-parts":[[2023,9,4]],"date-time":"2023-09-04T02:43:20Z","timestamp":1693795400000},"page":"712","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":7,"title":["Autoclavable Albumin-Based Cryogels with Uncompromising Properties"],"prefix":"10.3390","volume":"9","author":[{"given":"Kairui","family":"Duan","sequence":"first","affiliation":[{"name":"Postgraduate Training Base Alliance, Wenzhou Medical University, Wenzhou 325011, China"},{"name":"Wenzhou Institute, University of Chinese Academy of Sciences, Wenzhou 325011, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3779-8293","authenticated-orcid":false,"given":"Nabila","family":"Mehwish","sequence":"additional","affiliation":[{"name":"Wenzhou Institute, University of Chinese Academy of Sciences, Wenzhou 325011, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mengdie","family":"Xu","sequence":"additional","affiliation":[{"name":"Wenzhou Institute, University of Chinese Academy of Sciences, Wenzhou 325011, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hu","family":"Zhu","sequence":"additional","affiliation":[{"name":"Wenzhou Institute, University of Chinese Academy of Sciences, Wenzhou 325011, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jiajun","family":"Hu","sequence":"additional","affiliation":[{"name":"Wenzhou Institute, University of Chinese Academy of Sciences, Wenzhou 325011, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mian","family":"Lin","sequence":"additional","affiliation":[{"name":"Wenzhou Institute, University of Chinese Academy of Sciences, Wenzhou 325011, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lu","family":"Yu","sequence":"additional","affiliation":[{"name":"Department of Optometry, Wenzhou Medical University, Wenzhou 325035, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7222-0008","authenticated-orcid":false,"given":"Bae Hoon","family":"Lee","sequence":"additional","affiliation":[{"name":"Postgraduate Training Base Alliance, Wenzhou Medical University, Wenzhou 325011, China"},{"name":"Wenzhou Institute, University of Chinese Academy of Sciences, Wenzhou 325011, China"},{"name":"Department of Optometry, Wenzhou Medical University, Wenzhou 325035, China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2023,9,1]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"122671","DOI":"10.1016\/j.ijpharm.2023.122671","article-title":"A review of conventional and emerging technologies for hydrogels sterilization","volume":"634","author":"Bento","year":"2023","journal-title":"Int. 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