{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,7]],"date-time":"2026-06-07T16:58:07Z","timestamp":1780851487125,"version":"3.54.1"},"reference-count":70,"publisher":"MDPI AG","issue":"5","license":[{"start":{"date-parts":[[2019,5,14]],"date-time":"2019-05-14T00:00:00Z","timestamp":1557792000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"Swiss Federal Office for Agriculture","award":["625000469"],"award-info":[{"award-number":["625000469"]}]},{"DOI":"10.13039\/501100004955","name":"Austrian Research Promotion Agency","doi-asserted-by":"publisher","award":["843464"],"award-info":[{"award-number":["843464"]}],"id":[{"id":"10.13039\/501100004955","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Genes"],"abstract":"<jats:p>The evaluation of conformation traits is an important part of selection for breeding stallions and mares. Some of these judged conformation traits involve joint angles that are associated with performance, health, and longevity. To improve our understanding of the genetic background of joint angles in horses, we have objectively measured the angles of the poll, elbow, carpal, fetlock (front and hind), hip, stifle, and hock joints based on one photograph of each of the 300 Franches-Montagnes (FM) and 224 Lipizzan (LIP) horses. After quality control, genome-wide association studies (GWASs) for these traits were performed on 495 horses, using 374,070 genome-wide single nucleotide polymorphisms (SNPs) in a mixed-effect model. We identified two significant quantitative trait loci (QTL) for the poll angle on ECA28 (p = 1.36 \u00d7 10\u22127), 50 kb downstream of the ALX1 gene, involved in cranial morphology, and for the elbow joint on ECA29 (p = 1.69 \u00d7 10\u22127), 49 kb downstream of the RSU1 gene, and 75 kb upstream of the PTER gene. Both genes are associated with bone mineral density in humans. Furthermore, we identified other suggestive QTL associated with the stifle joint on ECA8 (p = 3.10 \u00d7 10\u22127); the poll on ECA1 (p = 6.83 \u00d7 10\u22127); the fetlock joint of the hind limb on ECA27 (p = 5.42 \u00d7 10\u22127); and the carpal joint angle on ECA3 (p = 6.24 \u00d7 10\u22127), ECA4 (p = 6.07 \u00d7 10\u22127), and ECA7 (p = 8.83 \u00d7 10\u22127). The application of angular measurements in genetic studies may increase our understanding of the underlying genetic effects of important traits in equine breeding.<\/jats:p>","DOI":"10.3390\/genes10050370","type":"journal-article","created":{"date-parts":[[2019,5,15]],"date-time":"2019-05-15T11:37:40Z","timestamp":1557920260000},"page":"370","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":23,"title":["Genome-Wide Association Studies Based on Equine Joint Angle Measurements Reveal New QTL Affecting the Conformation of Horses"],"prefix":"10.3390","volume":"10","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-6259-2377","authenticated-orcid":false,"given":"Annik Imogen","family":"Gmel","sequence":"first","affiliation":[{"name":"Agroscope\u2014Swiss National Stud Farm, Les Longs-Pr\u00e9s, 1580 Avenches, Switzerland"},{"name":"Institute of Genetics, Vetsuisse Faculty, University of Bern, Bremgartenstrasse 109a, 3012 Bern, Switzerland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Thomas","family":"Druml","sequence":"additional","affiliation":[{"name":"Institute of Animal Breeding and Genetics, Veterinary University Vienna, Veterin\u00e4rplatz 1, A-1210 Vienna, Austria"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rudolf","family":"von Niederh\u00e4usern","sequence":"additional","affiliation":[{"name":"Agroscope\u2014Swiss National Stud Farm, Les Longs-Pr\u00e9s, 1580 Avenches, Switzerland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0553-4880","authenticated-orcid":false,"given":"Tosso","family":"Leeb","sequence":"additional","affiliation":[{"name":"Institute of Genetics, Vetsuisse Faculty, University of Bern, Bremgartenstrasse 109a, 3012 Bern, Switzerland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Markus","family":"Neuditschko","sequence":"additional","affiliation":[{"name":"Agroscope\u2014Swiss National Stud Farm, Les Longs-Pr\u00e9s, 1580 Avenches, Switzerland"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2019,5,14]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","unstructured":"Bowling, A., and Ruvinsky, A. (2000). Genetics of conformation, locomotion and physiological traits. The Genetics of the Horse, CABI.","DOI":"10.1079\/9780851994291.0000"},{"key":"ref_2","unstructured":"Back, W., and Clayton, H. (2013). The effects of conformation. Equine Locomotion, WB Saunders. [2nd ed.]."},{"key":"ref_3","unstructured":"Thomas, H.S. (2005). The Horse Conformation Handbook, Storey Publishing."},{"key":"ref_4","unstructured":"Reginald Harrison, S., and Goody, P.C. (1993). Horse Structure and Movement, J.A. Allen."},{"key":"ref_5","unstructured":"Smythe, R.H. (1957). What Makes a Good Horse: Its Structure and Performance, Country Life LTD. [1st ed.]."},{"key":"ref_6","doi-asserted-by":"crossref","first-page":"309","DOI":"10.5194\/aab-59-309-2016","article-title":"Ratings of equine conformation\u2013new insights provided by shape analysis using the example of Lipizzan stallions","volume":"59","author":"Druml","year":"2016","journal-title":"Arch. Anim. Breed."},{"key":"ref_7","doi-asserted-by":"crossref","first-page":"186","DOI":"10.1111\/j.2042-3306.1990.tb04245.x","article-title":"Variation in conformation of Swedish Warmblood horses and conformational characteristics of elite sport horses","volume":"22","author":"Magnusson","year":"1990","journal-title":"Equine Vet. J."},{"key":"ref_8","doi-asserted-by":"crossref","first-page":"132","DOI":"10.1111\/j.2042-3306.1995.tb04905.x","article-title":"Variation in angular pattern adaptation from trot in hand to passage and piaffe in the grand prix dressage horse","volume":"27","author":"Fredricson","year":"1995","journal-title":"Equine Vet. J."},{"key":"ref_9","doi-asserted-by":"crossref","first-page":"293","DOI":"10.1016\/0301-6226(93)90009-7","article-title":"Relationships between conformation, performance and health in 4-year-old Swedish warmblood riding horses","volume":"33","author":"Philipsson","year":"1993","journal-title":"Livest. Prod. Sci."},{"key":"ref_10","doi-asserted-by":"crossref","first-page":"97","DOI":"10.1016\/S0301-6226(00)00244-X","article-title":"Phenotypic relationship between test results of Swedish Warmblood horses as 4-year-olds and longevity","volume":"68","author":"Wallin","year":"2001","journal-title":"Livest. Prod. Sci."},{"key":"ref_11","doi-asserted-by":"crossref","first-page":"597","DOI":"10.2746\/042516406X159016","article-title":"Prevalence, heritability and significance of musculoskeletal conformational traits in Thoroughbred yearlings","volume":"38","author":"Love","year":"2006","journal-title":"Equine Vet. J."},{"key":"ref_12","doi-asserted-by":"crossref","first-page":"1449","DOI":"10.2460\/javma.244.12.1449","article-title":"Associations of health status and conformation with longevity and lifetime competition performance in young Swedish warmblood riding horses: 8,238 cases (1983\u20132005)","volume":"244","author":"Egenvall","year":"2014","journal-title":"J. Am. Vet. Med. Assoc."},{"key":"ref_13","doi-asserted-by":"crossref","first-page":"571","DOI":"10.2746\/0425164044864462","article-title":"The role of conformation in musculoskeletal problems in the racing Thoroughbred","volume":"36","author":"Anderson","year":"2004","journal-title":"Equine Vet. J."},{"key":"ref_14","doi-asserted-by":"crossref","first-page":"84","DOI":"10.2746\/042516401776767502","article-title":"Risk factors associated with hindlimb lameness and degenerative joint disease in the distal tarsus of Icelandic horses","volume":"33","author":"Axelsson","year":"2001","journal-title":"Equine Vet. J."},{"key":"ref_15","doi-asserted-by":"crossref","first-page":"378","DOI":"10.1111\/j.1439-0388.2008.00798.x","article-title":"Multi-trait animal model estimation of genetic parameters for linear type and gait traits in the Belgian warmblood horse","volume":"126","author":"Rustin","year":"2009","journal-title":"J. Anim. Breed. Genet."},{"key":"ref_16","doi-asserted-by":"crossref","first-page":"62","DOI":"10.1111\/jbg.12311","article-title":"Genetic analyses of linear profiling data on 3-year-old Swedish Warmblood horses","volume":"135","author":"Viklund","year":"2018","journal-title":"J. Anim. Breed. Genet."},{"key":"ref_17","doi-asserted-by":"crossref","first-page":"105","DOI":"10.1016\/S0301-6226(97)00143-7","article-title":"Genetic parameters and breeding values for linear type traits in the Haflinger horse","volume":"52","author":"Pagnacco","year":"1997","journal-title":"Livest. Prod. Sci."},{"key":"ref_18","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.livsci.2006.01.004","article-title":"Review of genetic parameters estimated at stallion and young horse performance tests and their correlations with later results in dressage and show-jumping competition","volume":"103","author":"Hellsten","year":"2006","journal-title":"Livest. Sci."},{"key":"ref_19","doi-asserted-by":"crossref","first-page":"360","DOI":"10.1016\/j.jevs.2013.09.002","article-title":"Implementation and prospects of linear profiling in the warmblood horse","volume":"34","author":"Duensing","year":"2014","journal-title":"J. Equine Vet. Sci."},{"key":"ref_20","doi-asserted-by":"crossref","unstructured":"Signer-Hasler, H., Flury, C., Haase, B., Burger, D., Simianer, H., Leeb, T., and Rieder, S. (2012). A genome-wide association study reveals loci influencing height and other conformation traits in horses. PLoS ONE, 7.","DOI":"10.1371\/journal.pone.0037282"},{"key":"ref_21","doi-asserted-by":"crossref","first-page":"227","DOI":"10.1111\/age.12406","article-title":"Genome-wide association studies based on sequence-derived genotypes reveal new QTL associated with conformation and performance traits in the Franches\u2013Montagnes horse breed","volume":"47","author":"Frischknecht","year":"2016","journal-title":"Anim. Genet."},{"key":"ref_22","first-page":"657","article-title":"Genetic correlations between conformation traits and radiographic findings in the limbs of German warmblood riding horses","volume":"38","author":"Stock","year":"2006","journal-title":"Gen. Sel. Evol."},{"key":"ref_23","doi-asserted-by":"crossref","first-page":"395","DOI":"10.1111\/j.1439-0388.2010.00856.x","article-title":"Estimates of genetic parameters for conformation measures and scores in finnhorse and standardbred foals","volume":"127","author":"Schroderus","year":"2010","journal-title":"J. Anim. Breed. Gen."},{"key":"ref_24","doi-asserted-by":"crossref","first-page":"273","DOI":"10.1016\/0301-6226(93)90058-P","article-title":"Genetic parameters for linear type traits in Shetland Ponies","volume":"36","year":"1993","journal-title":"Livest. Prod. Sci."},{"key":"ref_25","doi-asserted-by":"crossref","first-page":"1028","DOI":"10.1016\/j.jevs.2014.05.011","article-title":"A genome-wide association study for morphometric traits in quarter horse","volume":"34","author":"Meira","year":"2014","journal-title":"J. Equine Vet. Sci."},{"key":"ref_26","doi-asserted-by":"crossref","first-page":"325","DOI":"10.1152\/physiolgenomics.00100.2015","article-title":"Skeletal variation in Tennessee Walking Horses maps to the LCORL\/NCAPG gene region","volume":"48","author":"Staiger","year":"2016","journal-title":"Physiol. Genomics"},{"key":"ref_27","unstructured":"Pfammatter, M. (2017). Le Syst\u00e8me de Description Lin\u00e9aire au Sein de la Race des Franches-Montagnes. [Bachelor\u2019s Thesis, Haute \u00c9cole des Sciences Agronomiques, Foresti\u00e8res et Alimentaires]."},{"key":"ref_28","doi-asserted-by":"crossref","unstructured":"Gmel, A.I., Druml, T., Portele, K., von Niederh\u00e4usern, R., and Neuditschko, M. (2018). Repeatability, reproducibility and consistency of horse shape data and its association with linearly described conformation traits in Franches-Montagnes stallions. PLoS ONE, 13.","DOI":"10.1371\/journal.pone.0202931"},{"key":"ref_29","doi-asserted-by":"crossref","unstructured":"Druml, T., Dobretsberger, M., and Brem, G. (2015). The use of novel phenotyping methods for validation of equine conformation scoring results. Animal, 1\u201310.","DOI":"10.1017\/S1751731114003309"},{"key":"ref_30","unstructured":"Rohlf, F.J. (2016). The Tps Utility Program, Departement of Ecology & Evolution, State University of New York SUNY at Stony Brook. 1.68 v."},{"key":"ref_31","unstructured":"Rohlf, F.J. (2016). The Tps Dig2, Departement of Ecology & Evolution, State University of New York SUNY at Stony Brook. 2.26 v."},{"key":"ref_32","doi-asserted-by":"crossref","first-page":"129","DOI":"10.1111\/j.2041-210X.2011.00125.x","article-title":"Guidelines for estimating repeatability","volume":"3","author":"Wolak","year":"2012","journal-title":"Methods Ecol. Evol."},{"key":"ref_33","doi-asserted-by":"crossref","first-page":"284","DOI":"10.1037\/1040-3590.6.4.284","article-title":"Guidelines, criteria, and rules of thumb for evaluating normed and standardized assessment instruments in psychology","volume":"6","author":"Cicchetti","year":"1994","journal-title":"Psychol. Assess."},{"key":"ref_34","doi-asserted-by":"crossref","first-page":"63","DOI":"10.1186\/s12711-014-0063-7","article-title":"Imputation of sequence level genotypes in the Franches-Montagnes horse breed","volume":"46","author":"Frischknecht","year":"2014","journal-title":"Gen. Sel. Evol."},{"key":"ref_35","doi-asserted-by":"crossref","unstructured":"Jagannathan, V., Gerber, V., Rieder, S., Tetens, J., Thaller, G., Dr\u00f6gem\u00fcller, C., and Leeb, T. (2018). Comprehensive characterization of horse genome variation by whole-genome sequencing of 88 horses. Anim. Genet.","DOI":"10.1111\/age.12753"},{"key":"ref_36","unstructured":"Purcell, S. (2017). PLINK, Center for Human Genetic Research (CHGR), Massachusetts General Hospital (MGH), the Broad Institute of Harvard & MIT. 1.07, v."},{"key":"ref_37","doi-asserted-by":"crossref","first-page":"559","DOI":"10.1086\/519795","article-title":"PLINK: A tool set for whole-genome association and population-based linkage analyses","volume":"81","author":"Purcell","year":"2007","journal-title":"Am. J. Hum. Genet."},{"key":"ref_38","doi-asserted-by":"crossref","first-page":"1294","DOI":"10.1093\/bioinformatics\/btm108","article-title":"GenABEL: An R library for genome-wide association analysis","volume":"23","author":"Aulchenko","year":"2007","journal-title":"Bioinformatics"},{"key":"ref_39","doi-asserted-by":"crossref","first-page":"20","DOI":"10.32614\/RJ-2010-009","article-title":"hglm: A package for fitting hierarchical generalized linear models","volume":"2","author":"Shen","year":"2010","journal-title":"R J."},{"key":"ref_40","doi-asserted-by":"crossref","first-page":"619","DOI":"10.1111\/j.2517-6161.1996.tb02105.x","article-title":"Hierarchical generalized linear models","volume":"58","author":"Lee","year":"1996","journal-title":"J. R. Stat. Soc. Ser. B"},{"key":"ref_41","doi-asserted-by":"crossref","first-page":"913","DOI":"10.1086\/521580","article-title":"Family-based association tests for genomewide association scans","volume":"81","author":"Chen","year":"2007","journal-title":"Am. J. Hum. Genet."},{"key":"ref_42","doi-asserted-by":"crossref","first-page":"861","DOI":"10.1038\/jhg.2016.72","article-title":"Empirical estimation of genome-wide significance thresholds based on the 1000 Genomes Project data set","volume":"61","author":"Kanai","year":"2016","journal-title":"J. Hum. Genet."},{"key":"ref_43","doi-asserted-by":"crossref","first-page":"76","DOI":"10.1016\/j.ajhg.2010.11.011","article-title":"GCTA: A tool for genome-wide complex trait analysis","volume":"88","author":"Yang","year":"2011","journal-title":"Am. J. Hum. Genet."},{"key":"ref_44","unstructured":"(2019, May 06). Genome Data Viewer, Available online: https:\/\/www.ncbi.nlm.nih.gov\/genome\/gdv\/."},{"key":"ref_45","doi-asserted-by":"crossref","unstructured":"Holland, P.W., Booth, H.A.F., and Bruford, E.A. (2007). Classification and nomenclature of all human homeobox genes. BMC Biol., 5.","DOI":"10.1186\/1741-7007-5-47"},{"key":"ref_46","doi-asserted-by":"crossref","first-page":"789","DOI":"10.1016\/j.ajhg.2010.04.002","article-title":"Disruption of ALX1 causes extreme microphthalmia and severe facial clefting: Expanding the spectrum of autosomal-recessive ALX-related frontonasal dysplasia","volume":"86","author":"Uz","year":"2010","journal-title":"Am. J. Hum. Genet."},{"key":"ref_47","doi-asserted-by":"crossref","first-page":"104","DOI":"10.1038\/ijos.2016.56","article-title":"Identification of shared and unique gene families associated with oral clefts","volume":"9","author":"Funato","year":"2017","journal-title":"Int. J. Oral Sci."},{"key":"ref_48","doi-asserted-by":"crossref","first-page":"287","DOI":"10.1111\/age.12531","article-title":"Deletion of 2.7 kb near HOXD 3 in an Arabian horse with occipitoatlantoaxial malformation","volume":"48","author":"Bordbari","year":"2017","journal-title":"Anim. Genet."},{"key":"ref_49","doi-asserted-by":"crossref","unstructured":"Grilz-Seger, G., Druml, T., Neuditschko, M., Dobretsberger, M., Horna, M., and Brem, G. (2019). High-resolution population structure and runs of homozygosity reveal the genetic architecture of complex traits in the Lipizzan horse. BMC Genomics, 20.","DOI":"10.1186\/s12864-019-5564-x"},{"key":"ref_50","doi-asserted-by":"crossref","first-page":"27","DOI":"10.1016\/j.jevs.2018.09.004","article-title":"Runs of homozygosity and population history of three horse breeds with small population size","volume":"71","author":"Cotman","year":"2018","journal-title":"J. Equine Vet. Sci."},{"key":"ref_51","doi-asserted-by":"crossref","unstructured":"Metzger, J., Karwath, M., Tonda, R., Beltran, S., \u00c1gueda, L., Gut, M., Gut, I.G., and Distl, O. (2015). Runs of homozygosity reveal signatures of positive selection for reproduction traits in breed and non-breed horses. BMC Genomics, 16.","DOI":"10.1186\/s12864-015-1977-3"},{"key":"ref_52","first-page":"651","article-title":"Vertebrate aristaless-related genes","volume":"43","author":"Meijlink","year":"2004","journal-title":"Int. J. Dev. Biol."},{"key":"ref_53","doi-asserted-by":"crossref","first-page":"795","DOI":"10.1534\/genetics.114.165423","article-title":"The \u201cdomestication syndrome\u201d in mammals: A unified explanation based on neural crest cell behavior and genetics","volume":"197","author":"Wilkins","year":"2014","journal-title":"Genetics"},{"key":"ref_54","doi-asserted-by":"crossref","first-page":"442","DOI":"10.1126\/science.aam5298","article-title":"Ancient genomic changes associated with domestication of the horse","volume":"356","author":"Librado","year":"2017","journal-title":"Science"},{"key":"ref_55","first-page":"11","article-title":"Candidate genes for osteoporosis","volume":"1","author":"Niu","year":"2001","journal-title":"Am. J. Pharm."},{"key":"ref_56","doi-asserted-by":"crossref","first-page":"5","DOI":"10.1111\/j.2044-3862.2008.tb00280.x","article-title":"Clinical aspects of the equine shoulder and elbow joints","volume":"13","author":"Garvican","year":"2008","journal-title":"UK Vet. Companion Anim."},{"key":"ref_57","unstructured":"Sprayberry, K.A. (2014). Stress fracture diagnosis in racehorses. Robinson\u2019s Current Therapy in Equine Medicine, Elsevier Inc.. [7th ed.]."},{"key":"ref_58","doi-asserted-by":"crossref","first-page":"170","DOI":"10.1136\/vr.i4427","article-title":"Accessing the equine elbow joint: New insights on an old approach","volume":"179","author":"Baccarin","year":"2016","journal-title":"Vet. Rec."},{"key":"ref_59","doi-asserted-by":"crossref","first-page":"70","DOI":"10.1016\/j.humpath.2015.11.012","article-title":"A new subtype of high-grade mandibular osteosarcoma with RASAL1\/MDM2 amplification","volume":"50","author":"Thariat","year":"2016","journal-title":"Hum. Pathol."},{"key":"ref_60","doi-asserted-by":"crossref","first-page":"48","DOI":"10.1038\/modpathol.2014.80","article-title":"Chromosome 12 long arm rearrangement covering MDM2 and RASAL1 is associated with aggressive craniofacial juvenile ossifying fibroma and extracranial psammomatoid fibro-osseous lesions","volume":"28","author":"Collin","year":"2015","journal-title":"Mod. Pathol."},{"key":"ref_61","doi-asserted-by":"crossref","first-page":"3191","DOI":"10.1242\/dev.02485","article-title":"Lhx5 promotes forebrain development and activates transcription of secreted Wnt antagonists","volume":"133","author":"Peng","year":"2006","journal-title":"Development"},{"key":"ref_62","doi-asserted-by":"crossref","first-page":"67","DOI":"10.1007\/s11033-004-7657-z","article-title":"LIM-homeodomain genes in mammalian development and human disease","volume":"32","author":"Hunter","year":"2005","journal-title":"Mol. Biol. Rep."},{"key":"ref_63","doi-asserted-by":"crossref","first-page":"1502","DOI":"10.1002\/dvdy.21830","article-title":"Muscular dystrophy candidate gene FRG1 is critical for muscle development","volume":"238","author":"Hanel","year":"2009","journal-title":"Dev. Dyn."},{"key":"ref_64","doi-asserted-by":"crossref","first-page":"283","DOI":"10.1016\/0301-6226(94)90208-9","article-title":"Arthritis in the carpal joints of Norwegian trotter\u2014heritability, effects of inbreeding and conformation","volume":"39","author":"Dolvik","year":"1994","journal-title":"Livest. Prod. Sci."},{"key":"ref_65","doi-asserted-by":"crossref","unstructured":"Makvandi-Nejad, S., Hoffman, G.E., Allen, J.J., Chu, E., Gu, E., Chandler, A.M., Loredo, A.I., Bellone, R.R., Mezey, J.G., and Brooks, S.A. (2012). Four loci explain 83% of size variation in the horse. PLoS ONE, 7.","DOI":"10.1371\/journal.pone.0039929"},{"key":"ref_66","doi-asserted-by":"crossref","unstructured":"Boyko, A.R., Brooks, S.A., Behan-Braman, A., Castelhano, M., Corey, E., Oliveira, K.C., Swinburne, J.E., Todhunter, R.J., Zhang, Z., and Ainsworth, D.M. (2014). Genomic analysis establishes correlation between growth and laryngeal neuropathy in Thoroughbreds. BMC Genomics, 15.","DOI":"10.1186\/1471-2164-15-259"},{"key":"ref_67","doi-asserted-by":"crossref","first-page":"467","DOI":"10.1111\/age.12031","article-title":"A genome-wide association study indicates LCORL\/NCAPG as a candidate locus for withers height in German Warmblood horses","volume":"44","author":"Tetens","year":"2013","journal-title":"Anim. Genet."},{"key":"ref_68","doi-asserted-by":"crossref","first-page":"2158","DOI":"10.1101\/gad.286351.116","article-title":"Mutations in genes encoding condensin complex proteins cause microcephaly through decatenation failure at mitosis","volume":"30","author":"Martin","year":"2016","journal-title":"Genes Dev."},{"key":"ref_69","doi-asserted-by":"crossref","first-page":"287","DOI":"10.1016\/S0960-8966(00)00197-8","article-title":"The phenotype of calpainopathy: Diagnosis based on a multidisciplinary approach","volume":"11","author":"Pollitt","year":"2001","journal-title":"Neuromuscul. Disord."},{"key":"ref_70","doi-asserted-by":"crossref","unstructured":"Radzioch, D. (2013). Condensins, chromatin remodeling and gene transcription. Chromatin Remodelling, IntechOpen.","DOI":"10.5772\/50815"}],"container-title":["Genes"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.mdpi.com\/2073-4425\/10\/5\/370\/pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,11]],"date-time":"2025-10-11T12:51:57Z","timestamp":1760187117000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.mdpi.com\/2073-4425\/10\/5\/370"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2019,5,14]]},"references-count":70,"journal-issue":{"issue":"5","published-online":{"date-parts":[[2019,5]]}},"alternative-id":["genes10050370"],"URL":"https:\/\/doi.org\/10.3390\/genes10050370","relation":{},"ISSN":["2073-4425"],"issn-type":[{"value":"2073-4425","type":"electronic"}],"subject":[],"published":{"date-parts":[[2019,5,14]]}}}