{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,11,5]],"date-time":"2025-11-05T06:34:56Z","timestamp":1762324496216,"version":"build-2065373602"},"reference-count":23,"publisher":"MDPI AG","issue":"6","license":[{"start":{"date-parts":[[2019,6,12]],"date-time":"2019-06-12T00:00:00Z","timestamp":1560297600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Genes"],"abstract":"<jats:p>This paper reports on the successful management of hyperphagia (exaggerated hunger) in a 14yr-old female with Prader\u2013Willi syndrome (PWS). This child was diagnosed with PWS, (maternal uniparental disomy) at 18 months due to developmental delay, hypertonia, weight gain and extreme eating behaviour. Treatment of a supplement for appetite suppression commenced at 2 years of age. This single-case records ingestion of an Indian cactus succulent Caralluma fimbriata extract (CFE) over 12 years, resulting in anecdotal satiety, free access to food and management of weight within normal range. CFE was administered in a drink daily and dose was slowly escalated by observation for appetite suppression. Rigorous testing determined blood count, vitamins, key minerals, HbA1c, IGF-1 and function of the liver and thyroid all within normal range. The report suggests a strategy for early intervention against hyperphagia and obesity in PWS. This case was the instigator of the successful Australian PWS\/CFE pilot and though anecdotal, the adolescent continues to ingest CFE followed by paediatricians at the Royal Children\u2019s Hospital Melbourne, Victoria, Australia. Future clinical trials are worth considering, to determine an appropriate dose for individuals with PWS.<\/jats:p>","DOI":"10.3390\/genes10060447","type":"journal-article","created":{"date-parts":[[2019,6,13]],"date-time":"2019-06-13T11:15:58Z","timestamp":1560424558000},"page":"447","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":8,"title":["Single-Case Study of Appetite Control in Prader-Willi Syndrome, Over 12-Years by the Indian Extract Caralluma fimbriata"],"prefix":"10.3390","volume":"10","author":[{"given":"Joanne","family":"Griggs","sequence":"first","affiliation":[{"name":"Institute of Health and Sports, College of Health and Biomedicine, Victoria University, P.O. Box 14428, Melbourne, VIC 8001, Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1968","published-online":{"date-parts":[[2019,6,12]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"1064","DOI":"10.1016\/j.jpeds.2014.01.039","article-title":"Prevalence of Prader\u2013Willi syndrome among infants with hypotonia","volume":"164","author":"Tuysuz","year":"2014","journal-title":"J. Pediatr."},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"438","DOI":"10.1002\/ajmg.c.30283","article-title":"Neurobehavioral phenotype in Prader-Willi syndrome","volume":"154","author":"Whittington","year":"2010","journal-title":"Am. J. Med. Genet. Part. C"},{"key":"ref_3","first-page":"27","article-title":"Central Control of Energy Metabolism and Hypothalamic Obesity Pediatric Obesity","volume":"30","author":"Haliloglu","year":"2018","journal-title":"Springer"},{"key":"ref_4","unstructured":"Lee, J.M., Shin, J., Kim, S., Gee, H.Y., Lee, J.S., Cha, D.H., and U\u00e7ar, A. (2018). Rapid-onset obesity with hypoventilation, hypothalamic, autonomic dysregulation, and neuroendocrine tumors (ROHHADNET) Syndrome: A systematic review. BioMed. Res. Int."},{"key":"ref_5","doi-asserted-by":"crossref","first-page":"1564","DOI":"10.1038\/ijo.2011.274","article-title":"Appetite hormones and the transition to hyperphagia in children with Prader-Willi syndrome","volume":"36","author":"Goldstone","year":"2012","journal-title":"Int. J. Obes."},{"key":"ref_6","doi-asserted-by":"crossref","first-page":"126","DOI":"10.1111\/j.1467-3010.2009.01753.x","article-title":"Satiation, satiety and their effects on eating behaviour","volume":"34","author":"Benelam","year":"2009","journal-title":"Nutr. Bull."},{"key":"ref_7","doi-asserted-by":"crossref","first-page":"811","DOI":"10.1111\/j.1365-2788.2008.01118_5.x","article-title":"The Paradox of Prader Willi syndrome: A genetic model of starvation","volume":"52","author":"Holland","year":"2008","journal-title":"J. Int. Disabil. Res."},{"key":"ref_8","doi-asserted-by":"crossref","unstructured":"Ramos-Molina, B., Molina-Vega, M., Fern\u00e1ndez-Garc\u00eda, J., and Creemers, J. (2018). Hyperphagia and obesity in Prader-Willi syndrome: PCSK1 deficiency and beyond?. Genes, 9.","DOI":"10.3390\/genes9060288"},{"key":"ref_9","doi-asserted-by":"crossref","first-page":"155","DOI":"10.1016\/j.neubiorev.2015.10.003","article-title":"Prader\u2013Willi syndrome: From genetics to behaviour, with special focus on appetite treatments","volume":"59","author":"Griggs","year":"2015","journal-title":"Neurosci. Biobehav. Rev."},{"key":"ref_10","doi-asserted-by":"crossref","first-page":"509","DOI":"10.4103\/1947-2714.170611","article-title":"Caralluma fimbriata supplementation improves the appetite behavior of children and adolescents with Prader-Willi syndrome","volume":"7","author":"Griggs","year":"2015","journal-title":"N. Am. J. Med. Sci."},{"key":"ref_11","doi-asserted-by":"crossref","first-page":"592","DOI":"10.1038\/ncpendmet0320","article-title":"Management of obesity in Prader-Willi syndrome","volume":"2","author":"Butler","year":"2006","journal-title":"Nat. Rev. Endocrinol."},{"key":"ref_12","doi-asserted-by":"crossref","first-page":"2","DOI":"10.1111\/j.1365-277X.2012.01275.x","article-title":"A reduced-energy intake, well-balanced diet improves weight control in children with Prader-Willi syndrome","volume":"26","author":"Miller","year":"2013","journal-title":"J. Hum. Nutr. Diet."},{"key":"ref_13","doi-asserted-by":"crossref","first-page":"338","DOI":"10.1016\/j.appet.2006.09.013","article-title":"Effect of caralluma fimbriata extract on appetite, food intake and anthropometry in adult Indian men and women","volume":"48","author":"Kuriyan","year":"2007","journal-title":"Appetite"},{"key":"ref_14","unstructured":"Kamalakkannan, S., Rajendran, R., Venkatesh, R.V., Clayton, P., and Akbarsha, M.A. (2010). Antiobesogenic and antiatherosclerotic properties of caralluma fimbriata extract. J. Nutr. Metab., 285301."},{"key":"ref_15","doi-asserted-by":"crossref","first-page":"6800","DOI":"10.1093\/nar\/gks321","article-title":"The SNORD115 (H\/MBII-52) and SNORD116 (H\/MBII-85) gene clusters at the imprinted Prader-Willi locus generate canonical box C\/D snoRNAs","volume":"40","year":"2012","journal-title":"Nucleic Acids Res."},{"key":"ref_16","doi-asserted-by":"crossref","first-page":"266","DOI":"10.1016\/j.gene.2015.07.023","article-title":"SNORD116 and SNORD115 change expression of multiple genes and modify each other\u2019s activity","volume":"572","author":"Falaleeva","year":"2015","journal-title":"Gene"},{"key":"ref_17","doi-asserted-by":"crossref","unstructured":"Polex-Wolf, J., Lam, B.Y., Larder, R., Tadross, J., Rimmington, D., Bosch, F., and Rainbow, K. (2018). Hypothalamic loss of Snord116 recapitulates the hyperphagia of Prader-Willi syndrome. J. Clin. Investig., 128.","DOI":"10.1172\/JCI97007"},{"key":"ref_18","doi-asserted-by":"crossref","first-page":"e01102","DOI":"10.1002\/brb3.1102","article-title":"Caralluma fimbriata extract activity involves the 5-HT2c receptor in PWS Snord116 deletion mouse model","volume":"8","author":"Griggs","year":"2018","journal-title":"Brain Behav."},{"key":"ref_19","doi-asserted-by":"crossref","first-page":"398","DOI":"10.1542\/peds.91.2.398","article-title":"Prader-Willi syndrome: Consensus diagnostic criteria","volume":"91","author":"Holm","year":"1993","journal-title":"Pediatrics"},{"key":"ref_20","doi-asserted-by":"crossref","first-page":"926","DOI":"10.1136\/jmg.39.12.926","article-title":"Relationship between clinical and genetic diagnosis of Prader-Willi syndrome","volume":"34","author":"Whittington","year":"2002","journal-title":"J. Med. Genet."},{"key":"ref_21","unstructured":"Griggs, J. (2010). Miracle in Potential, Braidwood Press."},{"key":"ref_22","doi-asserted-by":"crossref","first-page":"1028","DOI":"10.1038\/oby.2006.118","article-title":"Neural mechanisms underlying hyperphagia in Prader-Willi syndrome","volume":"14","author":"Holson","year":"2006","journal-title":"Obesity"},{"key":"ref_23","doi-asserted-by":"crossref","first-page":"385","DOI":"10.1177\/1091581813492827","article-title":"Safety assessment of a hydroethanolic extract of caralluma fimbriata","volume":"32","author":"Odendaal","year":"2013","journal-title":"Int. J. 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