{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,11]],"date-time":"2026-10-11T02:01:56Z","timestamp":1791684116724,"version":"4.3.4"},"reference-count":83,"publisher":"MDPI AG","issue":"7","license":[{"start":{"date-parts":[[2019,6,28]],"date-time":"2019-06-28T00:00:00Z","timestamp":1561680000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100004955","name":"\u00d6sterreichische Forschungsf\u00f6rderungsgesellschaft","doi-asserted-by":"publisher","award":["843464"],"award-info":[{"award-number":["843464"]}],"id":[{"id":"10.13039\/501100004955","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100007182","name":"Bundesministerium f\u00fcr Land- und Forstwirtschaft, Umwelt und Wasserwirtschaft","doi-asserted-by":"publisher","award":["101332"],"award-info":[{"award-number":["101332"]}],"id":[{"id":"10.13039\/501100007182","id-type":"DOI","asserted-by":"publisher"}]},{"name":"Slovenian Research Agency program","award":["P4-0053"],"award-info":[{"award-number":["P4-0053"]}]},{"DOI":"10.13039\/501100000783","name":"Research Executive Agency","doi-asserted-by":"publisher","award":["606142"],"award-info":[{"award-number":["606142"]}],"id":[{"id":"10.13039\/501100000783","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Genes"],"abstract":"<jats:p>Intensive artificial and natural selection have shaped substantial variation among European horse breeds. Whereas most equine selection signature studies employ divergent genetic population structures in order to derive specific inter-breed targets of selection, we screened a total of 1476 horses originating from 12 breeds for the loss of genetic diversity by runs of homozygosity (ROH) utilizing a 670,000 single nucleotide polymorphism (SNP) genotyping array. Overlapping homozygous regions (ROH islands) indicating signatures of selection were identified by breed and similarities\/dissimilarities between populations were evaluated. In the entire dataset, 180 ROH islands were identified, whilst 100 islands were breed specific, all other overlapped in 36 genomic regions with at least one ROH island of another breed. Furthermore, two ROH hot spots were determined at horse chromosome 3 (ECA3) and ECA11. Besides the confirmation of previously documented target genes involved in selection for coat color (MC1R, STX17, ASIP), body size (LCORL\/NCAPG, ZFAT, LASP1, HMGA2), racing ability (PPARGC1A), behavioral traits (GRIN2B, NTM\/OPCML) and gait patterns (DMRT3), several putative target genes related to embryonic morphogenesis (HOXB), energy metabolism (IGFBP-1, IGFBP-3), hair follicle morphogenesis (KRT25, KRT27, INTU) and autophagy (RALB) were highlighted. Furthermore, genes were pinpointed which might be involved in environmental adaptation of specific habitats (UVSSA, STXBP4, COX11, HLF, MMD).<\/jats:p>","DOI":"10.3390\/genes10070491","type":"journal-article","created":{"date-parts":[[2019,6,28]],"date-time":"2019-06-28T11:20:26Z","timestamp":1561720826000},"page":"491","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":60,"title":["Genome-Wide Homozygosity Patterns and Evidence for Selection in a Set of European and Near Eastern Horse Breeds"],"prefix":"10.3390","volume":"10","author":[{"given":"Gertrud","family":"Grilz-Seger","sequence":"first","affiliation":[{"name":"Institute of Animal Breeding and Genetics, University of Veterinary Sciences Vienna, Veterin\u00e4rplatz 1, 1210 Vienna, Austria"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Markus","family":"Neuditschko","sequence":"additional","affiliation":[{"name":"Agroscope, Swiss National Stud Farm, Les Longs Pr\u00e9s, CH-1580 Avenches, Switzerland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anne","family":"Ricard","sequence":"additional","affiliation":[{"name":"UMR 1313 G\u00e9n\u00e9tique Animale et Biologie Int\u00e9grative, Institut National de la Recherche Agronomique, Domaine de Vilvert, Bat 211, 78352 Jouy-en-Josas, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Brandon","family":"Velie","sequence":"additional","affiliation":[{"name":"Department of Animal Breeding &amp; Genetics, Swedish University of Agricultural Sciences, Ulls v\u00e4g 26, 750 07 Uppsala, Sweden"},{"name":"School of Life and Environmental Sciences, University of Sydney, Eastern Ave, Sydney, NSW 2006, Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6046-9669","authenticated-orcid":false,"given":"Gabriella","family":"Lindgren","sequence":"additional","affiliation":[{"name":"Department of Animal Breeding &amp; Genetics, Swedish University of Agricultural Sciences, Ulls v\u00e4g 26, 750 07 Uppsala, Sweden"},{"name":"Livestock Genetics, Department of Biosystems, KU Leuven, 3001 Leuven, Belgium"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Matjaz","family":"Mesari\u010d","sequence":"additional","affiliation":[{"name":"Clinic for Reproduction and Large Animals, University of Ljubljana, Veterinary, Faculty, Cesta v Mestni log 47, 1000 Ljubljana, Slovenia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marko","family":"Cotman","sequence":"additional","affiliation":[{"name":"Institute for Preclinical Sciences, University of Ljubljana, Veterinary Faculty, Gerbi\u010deva 60, 1000 Ljubljana, Slovenia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michaela","family":"Horna","sequence":"additional","affiliation":[{"name":"Department of Animal Husbandry, Slovak University of Agriculture in Nitra, Tr. 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Hlinku 2, 949 76 Nitra, Slovakia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Max","family":"Dobretsberger","sequence":"additional","affiliation":[{"name":"Institute of Animal Breeding and Genetics, University of Veterinary Sciences Vienna, Veterin\u00e4rplatz 1, 1210 Vienna, Austria"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gottfried","family":"Brem","sequence":"additional","affiliation":[{"name":"Institute of Animal Breeding and Genetics, University of Veterinary Sciences Vienna, Veterin\u00e4rplatz 1, 1210 Vienna, Austria"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Thomas","family":"Druml","sequence":"additional","affiliation":[{"name":"Institute of Animal Breeding and Genetics, University of Veterinary Sciences Vienna, Veterin\u00e4rplatz 1, 1210 Vienna, Austria"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2019,6,28]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","unstructured":"Gu, J., Orr, N., Park, S.D., Katz, L.M., Sulimova, G., MacHugh, D.E., and Hill, E.W. 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