{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,23]],"date-time":"2026-09-23T05:15:12Z","timestamp":1790140512734,"version":"4.0.1"},"reference-count":85,"publisher":"MDPI AG","issue":"11","license":[{"start":{"date-parts":[[2019,10,30]],"date-time":"2019-10-30T00:00:00Z","timestamp":1572393600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100003725","name":"National Research Foundation of Korea","doi-asserted-by":"publisher","award":["NRF-2018R1D1A1B07042854"],"award-info":[{"award-number":["NRF-2018R1D1A1B07042854"]}],"id":[{"id":"10.13039\/501100003725","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Genes"],"abstract":"<jats:p>Polymyositis (PM) and dermatomyositis (DM) are both classified as idiopathic inflammatory myopathies. They share a few common characteristics such as inflammation and muscle weakness. Previous studies have indicated that these diseases present aspects of an auto-immune disorder; however, their exact pathogenesis is still unclear. In this study, three gene expression datasets (PM: 7, DM: 50, Control: 13) available in public databases were used to conduct meta-analysis. We then conducted expression quantitative trait loci analysis to detect the variant sites that may contribute to the pathogenesis of PM and DM. Six-hundred differentially expressed genes were identified in the meta-analysis (false discovery rate (FDR) &lt; 0.01), among which 317 genes were up-regulated and 283 were down-regulated in the disease group compared with those in the healthy control group. The up-regulated genes were significantly enriched in interferon-signaling pathways in protein secretion, and\/or in unfolded-protein response. We detected 10 single nucleotide polymorphisms (SNPs) which could potentially play key roles in driving the PM and DM. Along with previously reported genes, we identified 4 novel genes and 10 SNP-variant regions which could be used as candidates for potential drug targets or biomarkers for PM and DM.<\/jats:p>","DOI":"10.3390\/genes10110864","type":"journal-article","created":{"date-parts":[[2019,10,31]],"date-time":"2019-10-31T05:18:26Z","timestamp":1572499106000},"page":"864","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":8,"title":["Meta-Analysis of Polymyositis and Dermatomyositis Microarray Data Reveals Novel Genetic Biomarkers"],"prefix":"10.3390","volume":"10","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-2247-3194","authenticated-orcid":false,"given":"Jaeseung","family":"Song","sequence":"first","affiliation":[{"name":"Department of Life Science, Dongguk University-Seoul, Seoul 04620, Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8331-3448","authenticated-orcid":false,"given":"Daeun","family":"Kim","sequence":"additional","affiliation":[{"name":"Department of Life Science, Dongguk University-Seoul, Seoul 04620, Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Juyeon","family":"Hong","sequence":"additional","affiliation":[{"name":"Department of Life Science, Dongguk University-Seoul, Seoul 04620, Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Go Woon","family":"Kim","sequence":"additional","affiliation":[{"name":"Department of Computer Science and Engineering, Dongguk University-Seoul, Seoul 04620, Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Junghyun","family":"Jung","sequence":"additional","affiliation":[{"name":"Department of Life Science, Dongguk University-Seoul, Seoul 04620, Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sejin","family":"Park","sequence":"additional","affiliation":[{"name":"Department of Computer Science and Engineering, Dongguk University-Seoul, Seoul 04620, Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hee Jung","family":"Park","sequence":"additional","affiliation":[{"name":"Western Seoul Center, Korea Basic Science Institute, Seoul 03759, Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jong Wha J.","family":"Joo","sequence":"additional","affiliation":[{"name":"Department of Computer Science and Engineering, Dongguk University-Seoul, Seoul 04620, Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wonhee","family":"Jang","sequence":"additional","affiliation":[{"name":"Department of Life Science, Dongguk University-Seoul, Seoul 04620, Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2019,10,30]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"50","DOI":"10.1093\/rheumatology\/keu289","article-title":"Incidence and prevalence of inflammatory myopathies: A systematic review","volume":"54","author":"Meyer","year":"2015","journal-title":"Rheumatology"},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"595","DOI":"10.1016\/j.ncl.2014.04.007","article-title":"Idiopathic inflammatory myopathies","volume":"32","author":"Dimachkie","year":"2014","journal-title":"Neurol. 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