{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,18]],"date-time":"2026-08-18T15:53:19Z","timestamp":1787068399280,"version":"build-2736575974"},"reference-count":68,"publisher":"MDPI AG","issue":"1","license":[{"start":{"date-parts":[[2019,12,30]],"date-time":"2019-12-30T00:00:00Z","timestamp":1577664000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Genes"],"abstract":"<jats:p>Skin is the body\u2019s largest organ, and the main function of skin is to protect underlying organs from possible external damage. Melanocytes play an important role in skin pigmentation. The Bama pig has a \u201ctwo-end-black\u201d phenotype with different coat colors across skin regions, e.g., white skin (without melanocytes) and black skin (with melanocytes), which could be a model to investigate skin-related disorders, specifically loss of melanocytes. Here, we generated expression profiles of mRNAs and long noncoding RNAs in Bama pig skins with different coat colors. In total, 14,900 mRNAs and 7549 lncRNAs were expressed. Overall, 2338 mRNAs\/113 lncRNAs with FDR-adjusted p-value \u2264 0.05 were considered to be differentially expressed (DE) mRNAs\/lncRNAs, with 1305 down-regulated mRNAs and 1033 up-regulated mRNAs in white skin with|log2(fold change)| &gt; 1. The genes down-regulated in white skin were associated with pigmentation, melanocyte\u2013keratinocyte interaction, and keratin, while up-regulated ones were mainly associated with cellular energy metabolisms. Furthermore, those DE lncRNAs were predicted to be implicated in pigmentation, keratin synthesis and cellular energy metabolism. In general, this study provides insight into the transcriptional difference involved in melanocyte-loss-induced keratinocyte changes and promotes the Bama pig as a biomedical model in skin research.<\/jats:p>","DOI":"10.3390\/genes11010047","type":"journal-article","created":{"date-parts":[[2020,1,3]],"date-time":"2020-01-03T03:28:53Z","timestamp":1578022133000},"page":"47","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":9,"title":["Transcriptional Differences of Coding and Non-Coding Genes Related to the Absence of Melanocyte in Skins of Bama Pig"],"prefix":"10.3390","volume":"11","author":[{"given":"Long","family":"Jin","sequence":"first","affiliation":[{"name":"Farm Animal Genetic Resource Exploration and Innovation Key Laboratory of Sichuan Province, Sichuan Agricultural University, Chengdu 611130, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lirui","family":"Zhao","sequence":"additional","affiliation":[{"name":"College of Animal Science and Technology, Sichuan Agricultural University, Chengdu 611130, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Silu","family":"Hu","sequence":"additional","affiliation":[{"name":"Farm Animal Genetic Resource Exploration and Innovation Key Laboratory of Sichuan Province, Sichuan Agricultural University, Chengdu 611130, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6366-7633","authenticated-orcid":false,"given":"Keren","family":"Long","sequence":"additional","affiliation":[{"name":"Farm Animal Genetic Resource Exploration and Innovation Key Laboratory of Sichuan Province, Sichuan Agricultural University, Chengdu 611130, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pengliang","family":"Liu","sequence":"additional","affiliation":[{"name":"Farm Animal Genetic Resource Exploration and Innovation Key Laboratory of Sichuan Province, Sichuan Agricultural University, Chengdu 611130, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rui","family":"Liu","sequence":"additional","affiliation":[{"name":"Farm Animal Genetic Resource Exploration and Innovation Key Laboratory of Sichuan Province, Sichuan Agricultural University, Chengdu 611130, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xuan","family":"Zhou","sequence":"additional","affiliation":[{"name":"Farm Animal Genetic Resource Exploration and Innovation Key Laboratory of Sichuan Province, Sichuan Agricultural University, Chengdu 611130, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yixin","family":"Wang","sequence":"additional","affiliation":[{"name":"Farm Animal Genetic Resource Exploration and Innovation Key Laboratory of Sichuan Province, Sichuan Agricultural University, Chengdu 611130, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5092-9297","authenticated-orcid":false,"given":"Zhiqing","family":"Huang","sequence":"additional","affiliation":[{"name":"Key Laboratory for Animal Disease-Resistance Nutrition of China Ministry of Education, Institute of Animal Nutrition, Sichuan Agricultural University, Chengdu 611130, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xuxu","family":"Lin","sequence":"additional","affiliation":[{"name":"Farm Animal Genetic Resource Exploration and Innovation Key Laboratory of Sichuan Province, Sichuan Agricultural University, Chengdu 611130, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qianzi","family":"Tang","sequence":"additional","affiliation":[{"name":"College of Animal Science and Technology, Sichuan Agricultural University, Chengdu 611130, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8681-7684","authenticated-orcid":false,"given":"Mingzhou","family":"Li","sequence":"additional","affiliation":[{"name":"Farm Animal Genetic Resource Exploration and Innovation Key Laboratory of Sichuan Province, Sichuan Agricultural University, Chengdu 611130, China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2019,12,30]]},"reference":[{"key":"ref_1","first-page":"390","article-title":"Anatomy, histology and immunohistochemistry of normal human skin","volume":"12","author":"Kanitakis","year":"2002","journal-title":"Eur. J. Dermatol."},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"30","DOI":"10.5114\/pdia.2013.33376","article-title":"Skin melanocytes: Biology and development","volume":"30","author":"Cichorek","year":"2013","journal-title":"Adv. Dermatol. Allergol."},{"key":"ref_3","doi-asserted-by":"crossref","first-page":"380","DOI":"10.1111\/j.1600-0749.2007.00397.x","article-title":"Melanocyte-keratinocyte interaction induces calcium signalling and melanin transfer to keratinocytes","volume":"20","author":"Joshi","year":"2007","journal-title":"Pigment Cell Res."},{"key":"ref_4","doi-asserted-by":"crossref","first-page":"134","DOI":"10.1111\/j.1600-0749.2007.00362.x","article-title":"Quantification of Ca2+ binding to melanin supports the hypothesis that melanosomes serve a functional role in regulating calcium homeostasis","volume":"20","author":"Bush","year":"2007","journal-title":"Pigment Cell Res."},{"key":"ref_5","first-page":"142","article-title":"Light microscopic, electron microscopic, and immunohistochemical comparison of bama minipig (sus scrofa domestica) and human skin","volume":"60","author":"Liu","year":"2010","journal-title":"Comp. Med."},{"key":"ref_6","doi-asserted-by":"crossref","first-page":"11831","DOI":"10.1038\/s41598-018-29840-6","article-title":"Rna-seq-based analysis of the hypertrophic scarring with and without pressure therapy in a bama minipig model","volume":"8","author":"Liu","year":"2018","journal-title":"Sci. Rep."},{"key":"ref_7","doi-asserted-by":"crossref","first-page":"843","DOI":"10.1038\/nature05660","article-title":"Melanocyte biology and skin pigmentation","volume":"445","author":"Lin","year":"2007","journal-title":"Nature"},{"key":"ref_8","doi-asserted-by":"crossref","first-page":"448","DOI":"10.1034\/j.1600-0749.2003.00066.x","article-title":"Mouse models for four types of waardenburg syndrome","volume":"16","author":"Tachibana","year":"2003","journal-title":"Pigment Cell Res."},{"key":"ref_9","doi-asserted-by":"crossref","first-page":"299","DOI":"10.1111\/1523-1747.ep12524353","article-title":"A mouse model for vitiligo","volume":"87","author":"Lerner","year":"1986","journal-title":"J. Investig. Dermatol."},{"key":"ref_10","doi-asserted-by":"crossref","first-page":"46","DOI":"10.1016\/j.cell.2010.09.001","article-title":"Long noncoding rnas with enhancer-like function in human cells","volume":"143","author":"Orom","year":"2010","journal-title":"Cell"},{"key":"ref_11","doi-asserted-by":"crossref","first-page":"239","DOI":"10.1016\/j.tig.2015.03.007","article-title":"The landscape of long noncoding rna classification","volume":"31","author":"Wahlestedt","year":"2015","journal-title":"Trends Genet."},{"key":"ref_12","doi-asserted-by":"crossref","unstructured":"Fan, R., Xie, J., Bai, J., Wang, H., Tian, X., Bai, R., Jia, X., Yang, L., Song, Y., and Herrid, M. (2013). Skin transcriptome profiles associated with coat color in sheep. BMC Genom., 14.","DOI":"10.1186\/1471-2164-14-389"},{"key":"ref_13","doi-asserted-by":"crossref","first-page":"243","DOI":"10.1007\/978-1-4939-7493-1_12","article-title":"Profiling tumor infiltrating immune cells with cibersort","volume":"1711","author":"Chen","year":"2018","journal-title":"Methods Mol. Biol."},{"key":"ref_14","doi-asserted-by":"crossref","first-page":"339","DOI":"10.1007\/978-1-4939-3167-5_18","article-title":"Analysis of rna-seq data using tophat and cufflinks","volume":"1374","author":"Ghosh","year":"2016","journal-title":"Methods Mol. Biol."},{"key":"ref_15","doi-asserted-by":"crossref","first-page":"D222","DOI":"10.1093\/nar\/gkt1223","article-title":"Pfam: The protein families database","volume":"42","author":"Finn","year":"2014","journal-title":"Nucleic Acids Res."},{"key":"ref_16","doi-asserted-by":"crossref","first-page":"W30","DOI":"10.1093\/nar\/gkv397","article-title":"Hmmer web server: 2015 update","volume":"43","author":"Finn","year":"2015","journal-title":"Nucleic Acids Res."},{"key":"ref_17","doi-asserted-by":"crossref","first-page":"W345","DOI":"10.1093\/nar\/gkm391","article-title":"Cpc: Assess the protein-coding potential of transcripts using sequence features and support vector machine","volume":"35","author":"Kong","year":"2007","journal-title":"Nucleic Acids Res."},{"key":"ref_18","first-page":"e57","article-title":"Feelnc: A tool for long non-coding rna annotation and its application to the dog transcriptome","volume":"45","author":"Wucher","year":"2017","journal-title":"Nucleic Acids Res."},{"key":"ref_19","doi-asserted-by":"crossref","first-page":"290","DOI":"10.1038\/nbt.3122","article-title":"Stringtie enables improved reconstruction of a transcriptome from rna-seq reads","volume":"33","author":"Pertea","year":"2015","journal-title":"Nat. Biotechnol."},{"key":"ref_20","doi-asserted-by":"crossref","unstructured":"Reemann, P., Reimann, E., Ilmj\u00e4rv, S., Porosaar, O., Silm, H., Jaks, V., Vasar, E., Kingo, K., and K\u00f5ks, S. (2014). Melanocytes in the skin--comparative whole transcriptome analysis of main skin cell types. PLoS ONE, 9.","DOI":"10.1371\/journal.pone.0115717"},{"key":"ref_21","doi-asserted-by":"crossref","unstructured":"Langfelder, P., and Horvath, S. (2008). Wgcna: An r package for weighted correlation network analysis. BMC Bioinform., 9.","DOI":"10.1186\/1471-2105-9-559"},{"key":"ref_22","doi-asserted-by":"crossref","first-page":"2498","DOI":"10.1101\/gr.1239303","article-title":"Cytoscape: A software environment for integrated models of biomolecular interaction networks","volume":"13","author":"Shannon","year":"2003","journal-title":"Genome Res."},{"key":"ref_23","doi-asserted-by":"crossref","unstructured":"Jin, L., Hu, S., Tu, T., Huang, Z., Tang, Q., Ma, J., Wang, X., Li, X., Zhou, X., and Shuai, S. (2018). Global long noncoding rna and mrna expression changes between prenatal and neonatal lung tissue in pigs. Genes, 9.","DOI":"10.3390\/genes9090443"},{"key":"ref_24","doi-asserted-by":"crossref","first-page":"637","DOI":"10.1016\/j.stem.2016.01.024","article-title":"Divergent lncrnas regulate gene expression and lineage differentiation in pluripotent cells","volume":"18","author":"Luo","year":"2016","journal-title":"Cell Stem Cell"},{"key":"ref_25","doi-asserted-by":"crossref","first-page":"1828","DOI":"10.1038\/jid.2014.28","article-title":"Transcriptome analysis of psoriasis in a large case-control sample: Rna-seq provides insights into disease mechanisms","volume":"134","author":"Li","year":"2014","journal-title":"J. Investig. Dermatol."},{"key":"ref_26","doi-asserted-by":"crossref","first-page":"24","DOI":"10.1186\/s13059-014-0570-4","article-title":"Analysis of long non-coding rnas highlights tissue-specific expression patterns and epigenetic profiles in normal and psoriatic skin","volume":"16","author":"Tsoi","year":"2015","journal-title":"Genome Biol."},{"key":"ref_27","doi-asserted-by":"crossref","first-page":"22","DOI":"10.1006\/dbio.2001.0222","article-title":"Wnt and bmp signaling govern lineage segregation of melanocytes in the avian embryo","volume":"233","author":"Jin","year":"2001","journal-title":"Dev. Biol."},{"key":"ref_28","doi-asserted-by":"crossref","first-page":"941","DOI":"10.1016\/j.cell.2011.05.004","article-title":"Coordinated activation of wnt in epithelial and melanocyte stem cells initiates pigmented hair regeneration","volume":"145","author":"Rabbani","year":"2011","journal-title":"Cell"},{"key":"ref_29","doi-asserted-by":"crossref","first-page":"1084","DOI":"10.1038\/sj.cdd.4401475","article-title":"Pi3k mediates protection against trail-induced apoptosis in primary human melanocytes","volume":"11","author":"Larribere","year":"2004","journal-title":"Cell Death Differ."},{"key":"ref_30","doi-asserted-by":"crossref","first-page":"22","DOI":"10.1016\/j.abb.2014.07.003","article-title":"Cyclic amp (camp) signaling in melanocytes and melanoma","volume":"563","author":"Rodriguez","year":"2014","journal-title":"Arch. Biochem. Biophys."},{"key":"ref_31","doi-asserted-by":"crossref","first-page":"8","DOI":"10.4161\/cc.10.1.14292","article-title":"Central role for camp signaling in pigmentation and uv resistance","volume":"10","author":"Fisher","year":"2011","journal-title":"Cell Cycle"},{"key":"ref_32","doi-asserted-by":"crossref","first-page":"6361","DOI":"10.1038\/s41598-019-42676-y","article-title":"Comparative transcriptome analysis reveals the genetic basis of coat color variation in pashmina goat","volume":"9","author":"Bhat","year":"2019","journal-title":"Sci. Rep."},{"key":"ref_33","doi-asserted-by":"crossref","first-page":"1022","DOI":"10.1038\/s41467-017-01122-1","article-title":"Oct4 impedes cell fate redirection by the melanocyte lineage master regulator mitf in mouse escs","volume":"8","author":"Sheinboim","year":"2017","journal-title":"Nat. Commun."},{"key":"ref_34","doi-asserted-by":"crossref","first-page":"C679","DOI":"10.1152\/ajpcell.00092.2009","article-title":"Calcium homeostasis in human melanocytes: Role of transient receptor potential melastatin 1 (trpm1) and its regulation by ultraviolet light","volume":"297","author":"Devi","year":"2009","journal-title":"Am. J. Physiol.-Cell Physiol."},{"key":"ref_35","doi-asserted-by":"crossref","first-page":"14006","DOI":"10.1074\/jbc.M413692200","article-title":"Mart-1 is required for the function of the melanosomal matrix protein pmel17\/gp100 and the maturation of melanosomes","volume":"280","author":"Toshihiko","year":"2005","journal-title":"J. Biol. Chem."},{"key":"ref_36","doi-asserted-by":"crossref","unstructured":"Hellstrom, A.R., Watt, B., Fard, S.S., Tenza, D., Mannstrom, P., Narfstrom, K., Ekesten, B., Ito, S., Wakamatsu, K., and Larsson, J. (2011). Inactivation of pmel alters melanosome shape but has only a subtle effect on visible pigmentation. PLoS Genet., 7.","DOI":"10.1371\/journal.pgen.1002285"},{"key":"ref_37","doi-asserted-by":"crossref","unstructured":"Seberg, H.E., Van Otterloo, E., Loftus, S.K., Liu, H., Bonde, G., Sompallae, R., Gildea, D.E., Santana, J.F., Manak, J.R., and Pavan, W.J. (2017). Tfap2 paralogs regulate melanocyte differentiation in parallel with mitf. PLoS Genet., 13.","DOI":"10.1371\/journal.pgen.1006636"},{"key":"ref_38","doi-asserted-by":"crossref","first-page":"300","DOI":"10.1016\/j.ydbio.2015.04.012","article-title":"The transcription factors ets1 and sox10 interact during murine melanocyte development","volume":"407","author":"Perera","year":"2015","journal-title":"Dev. Biol."},{"key":"ref_39","doi-asserted-by":"crossref","first-page":"649","DOI":"10.1038\/labinvest.2017.9","article-title":"The master role of microphthalmia-associated transcription factor in melanocyte and melanoma biology","volume":"97","author":"Kawakami","year":"2017","journal-title":"Lab. Investig. A J. Tech. Methods Pathol."},{"key":"ref_40","doi-asserted-by":"crossref","first-page":"282","DOI":"10.1002\/dvdy.21000","article-title":"Notch1 and notch2 receptors influence progressive hair graying in a dose-dependent manner","volume":"236","author":"Schouwey","year":"2007","journal-title":"Dev. Dyn."},{"key":"ref_41","doi-asserted-by":"crossref","first-page":"555","DOI":"10.1038\/ncomms1560","article-title":"P-rex1 is required for efficient melanoblast migration and melanoma metastasis","volume":"2","author":"Lindsay","year":"2011","journal-title":"Nat. Commun."},{"key":"ref_42","doi-asserted-by":"crossref","first-page":"551","DOI":"10.1038\/jid.2014.423","article-title":"Substance p stimulates endothelin 1 secretion via endothelin-converting enzyme 1 and promotes melanogenesis in human melanocytes","volume":"135","author":"Park","year":"2015","journal-title":"J. Investig. Dermatol."},{"key":"ref_43","doi-asserted-by":"crossref","first-page":"28015","DOI":"10.1074\/jbc.M501465200","article-title":"Functional analysis of slac2-c\/myrip as a linker protein between melanosomes and myosin viia","volume":"280","author":"Kuroda","year":"2005","journal-title":"J. Biol. Chem."},{"key":"ref_44","doi-asserted-by":"crossref","first-page":"99","DOI":"10.1016\/j.cellsig.2017.09.004","article-title":"Recent development of signaling pathways inhibitors of melanogenesis","volume":"40","author":"Pillaiyar","year":"2017","journal-title":"Cell. Signal."},{"key":"ref_45","doi-asserted-by":"crossref","first-page":"1291","DOI":"10.1016\/j.celrep.2016.04.006","article-title":"Ednrb governs regenerative response of melanocyte stem cells by crosstalk with wnt signaling","volume":"15","author":"Takeo","year":"2016","journal-title":"Cell Rep."},{"key":"ref_46","doi-asserted-by":"crossref","first-page":"862","DOI":"10.1038\/hdy.2010.129","article-title":"A 6-bp deletion in the tyrp1 gene causes the brown colouration phenotype in chinese indigenous pigs","volume":"106","author":"Ren","year":"2011","journal-title":"Heredity"},{"key":"ref_47","doi-asserted-by":"crossref","first-page":"305","DOI":"10.1093\/genetics\/160.1.305","article-title":"Unexpectedly high allelic diversity at the kit locus causing dominant white color in the domestic pig","volume":"160","author":"Pielberg","year":"2002","journal-title":"Genetics"},{"key":"ref_48","doi-asserted-by":"crossref","first-page":"60","DOI":"10.1038\/ng0198-60","article-title":"Sox10 mutation disrupts neural crest development in dom hirschsprung mouse model","volume":"18","author":"Kos","year":"1998","journal-title":"Nat. Genet."},{"key":"ref_49","doi-asserted-by":"crossref","first-page":"744","DOI":"10.1101\/gad.298703.117","article-title":"Identification of hair shaft progenitors that create a niche for hair pigmentation","volume":"31","author":"Liao","year":"2017","journal-title":"Genes Dev."},{"key":"ref_50","doi-asserted-by":"crossref","unstructured":"Andersson, L.S., Wilbe, M., Viluma, A., Cothran, G., Ekesten, B., Ewart, S., and Lindgren, G. (2013). Equine multiple congenital ocular anomalies and silver coat colour result from the pleiotropic effects of mutant pmel. PLoS ONE, 8.","DOI":"10.1371\/journal.pone.0075639"},{"key":"ref_51","doi-asserted-by":"crossref","first-page":"809","DOI":"10.1111\/1523-1747.ep12292263","article-title":"A mutation in the v1 domain of keratin 5 causes epidermolysis bullosa simplex with mottled pigmentation","volume":"108","author":"Irvine","year":"1997","journal-title":"J. Investig. Dermatol."},{"key":"ref_52","doi-asserted-by":"crossref","first-page":"631","DOI":"10.1111\/pde.12206","article-title":"Epidermolysis bullosa simplex with mottled pigmentation due to a rare keratin 5 mutation: Cutaneous findings in infancy","volume":"30","author":"Geller","year":"2013","journal-title":"Pediatr. Dermatol."},{"key":"ref_53","doi-asserted-by":"crossref","first-page":"7506","DOI":"10.1038\/ncomms8506","article-title":"Exosomes released by keratinocytes modulate melanocyte pigmentation","volume":"6","author":"Delevoye","year":"2015","journal-title":"Nat. Commun."},{"key":"ref_54","doi-asserted-by":"crossref","first-page":"1227","DOI":"10.1016\/j.celrep.2014.04.006","article-title":"Appl1 potentiates insulin sensitivity by facilitating the binding of irs1\/2 to the insulin receptor","volume":"7","author":"Ryu","year":"2014","journal-title":"Cell Rep."},{"key":"ref_55","doi-asserted-by":"crossref","first-page":"227","DOI":"10.1677\/jme.0.0220227","article-title":"Unique multifunctional hsd17b4 gene product: 17beta-hydroxysteroid dehydrogenase 4 and d-3-hydroxyacyl-coenzyme a dehydrogenase\/hydratase involved in zellweger syndrome","volume":"22","author":"Adamski","year":"1999","journal-title":"J. Mol. Endocrinol."},{"key":"ref_56","doi-asserted-by":"crossref","unstructured":"Fujita, Y., Koinuma, S., De Velasco, M.A., Bolz, J., Togashi, Y., Terashima, M., Hayashi, H., Matsuo, T., and Nishio, K. (2014). Melanoma transition is frequently accompanied by a loss of cytoglobin expression in melanocytes: A novel expression site of cytoglobin. PLoS ONE, 9.","DOI":"10.1371\/journal.pone.0094772"},{"key":"ref_57","doi-asserted-by":"crossref","first-page":"397","DOI":"10.1074\/mcp.M113.035600","article-title":"Analysis of the human tissue-specific expression by genome-wide integration of transcriptomics and antibody-based proteomics","volume":"13","author":"Fagerberg","year":"2014","journal-title":"Mol. Cell. Proteom."},{"key":"ref_58","doi-asserted-by":"crossref","first-page":"183","DOI":"10.1007\/s00276-002-0034-5","article-title":"Skin thickness of korean adults","volume":"24","author":"Lee","year":"2002","journal-title":"Surg. Radiol. Anat."},{"key":"ref_59","doi-asserted-by":"crossref","first-page":"1806","DOI":"10.1001\/archderm.1991.04520010052006","article-title":"Skin aging. Effect on transepidermal water loss, stratum corneum hydration, skin surface ph, and casual sebum content","volume":"127","author":"Wilhelm","year":"1991","journal-title":"Arch. Dermatol."},{"key":"ref_60","doi-asserted-by":"crossref","first-page":"S46","DOI":"10.1111\/j.1524-475X.2007.00225.x","article-title":"Role of keratinocyte-fibroblast cross-talk in development of hypertrophic scar","volume":"15","author":"Ghahary","year":"2007","journal-title":"Wound Repair Regen."},{"key":"ref_61","doi-asserted-by":"crossref","first-page":"436","DOI":"10.1016\/j.mehy.2010.04.017","article-title":"Is uv radiation beneficial in postburn wound healing?","volume":"75","author":"Rennekampff","year":"2010","journal-title":"Med. Hypotheses"},{"key":"ref_62","first-page":"609","article-title":"The contribution of melanocytes to pathological scar formation during wound healing","volume":"6","author":"Gao","year":"2013","journal-title":"Int. J. Clin. Exp. Med."},{"key":"ref_63","doi-asserted-by":"crossref","first-page":"180","DOI":"10.1016\/j.burns.2005.10.012","article-title":"Skin wound healing in the first generation (f1) offspring of yorkshire and red duroc pigs: Evidence for genetic inheritance of wound phenotype","volume":"32","author":"Tsao","year":"2006","journal-title":"Burn. J. Int. Soc. Burn Inj."},{"key":"ref_64","doi-asserted-by":"crossref","first-page":"822","DOI":"10.1007\/s003359900244","article-title":"Pigs with the dominant white coat color phenotype carry a duplication of the kit gene encoding the mast\/stem cell growth factor receptor","volume":"7","author":"Chaudhary","year":"1996","journal-title":"Mamm. Genome"},{"key":"ref_65","doi-asserted-by":"crossref","first-page":"46","DOI":"10.1111\/j.1524-475X.2005.00087.x","article-title":"Genetic analysis of skin wound healing and scarring in a porcine model","volume":"14","author":"Hart","year":"2006","journal-title":"Wound Repair Regen."},{"key":"ref_66","doi-asserted-by":"crossref","unstructured":"Ren, H., Wang, G., Chen, L., Jiang, J., Liu, L., Li, N., Zhao, J., Sun, X., and Zhou, P. (2016). Genome-wide analysis of long non-coding rnas at early stage of skin pigmentation in goats (capra hircus). BMC Genom., 17.","DOI":"10.1186\/s12864-016-2365-3"},{"key":"ref_67","doi-asserted-by":"crossref","first-page":"195","DOI":"10.1016\/j.gene.2018.05.120","article-title":"Long non-coding rna expression profile in cdk5-knockdown mouse skin","volume":"672","author":"Ji","year":"2018","journal-title":"Gene"},{"key":"ref_68","doi-asserted-by":"crossref","first-page":"e3174","DOI":"10.1038\/cddis.2017.516","article-title":"H19 lncrna regulates keratinocyte differentiation by targeting mir-130b-3p","volume":"8","author":"Li","year":"2017","journal-title":"Cell Death Dis."}],"container-title":["Genes"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.mdpi.com\/2073-4425\/11\/1\/47\/pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,11]],"date-time":"2025-10-11T13:46:52Z","timestamp":1760190412000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.mdpi.com\/2073-4425\/11\/1\/47"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2019,12,30]]},"references-count":68,"journal-issue":{"issue":"1","published-online":{"date-parts":[[2020,1]]}},"alternative-id":["genes11010047"],"URL":"https:\/\/doi.org\/10.3390\/genes11010047","relation":{},"ISSN":["2073-4425"],"issn-type":[{"value":"2073-4425","type":"electronic"}],"subject":[],"published":{"date-parts":[[2019,12,30]]}}}