{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,15]],"date-time":"2026-09-15T01:20:58Z","timestamp":1789435258649,"version":"build-2803163510"},"reference-count":62,"publisher":"MDPI AG","issue":"1","license":[{"start":{"date-parts":[[2020,1,9]],"date-time":"2020-01-09T00:00:00Z","timestamp":1578528000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"Maxine Adler Endowed Chair Funds","award":["n\/a"],"award-info":[{"award-number":["n\/a"]}]},{"name":"Maxine Adler Graduate Fellowship","award":["2019-2020"],"award-info":[{"award-number":["2019-2020"]}]},{"DOI":"10.13039\/100016512","name":"Center for Companion Animal Health, University of California - Davis","doi-asserted-by":"crossref","award":["2019-8-F"],"award-info":[{"award-number":["2019-8-F"]}],"id":[{"id":"10.13039\/100016512","id-type":"DOI","asserted-by":"crossref"}]}],"content-domain":{"domain":["www.mdpi.com"],"crossmark-restriction":true},"short-container-title":["Genes"],"abstract":"<jats:p>Dogs exhibit a wide variety of coat color types, and many genes have been identified that control pigment production, appearance, and distribution. Some breeds, such as the Nova Scotia Duck Tolling Retriever (NSDTR), exhibit variation in pheomelanin pigment intensity that is not explained by known genetic variants. A genome-wide association study comparing light red to dark red in the NSDTR identified a significantly associated region on canine chromosome 15 (CFA 15:23 Mb\u201338 Mb). Coverage analysis of whole genome sequence data from eight dogs identified a 6 kb copy number variant (CNV) 152 kb upstream of KITLG. Genotyping with digital droplet PCR (ddPCR) confirmed a significant association between an increased copy number with the dark-red coat color in NSDTR (p = 6.1 \u00d7 10\u22127). The copy number of the CNV was also significantly associated with coat color variation in both eumelanin and pheomelanin-based Poodles (p = 1.5 \u00d7 10\u22128, 4.0 \u00d7 10\u22129) and across other breeds. Moreover, the copy number correlated with pigment intensity along the hair shaft in both pheomelanin and eumelanin coats. KITLG plays an important role in melanogenesis, and variants upstream of KITLG have been associated with coat color variation in mice as well as hair color in humans consistent with its role in the domestic dog.<\/jats:p>","DOI":"10.3390\/genes11010075","type":"journal-article","created":{"date-parts":[[2020,1,10]],"date-time":"2020-01-10T04:06:51Z","timestamp":1578629211000},"page":"75","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":36,"title":["Pigment Intensity in Dogs is Associated with a Copy Number Variant Upstream of KITLG"],"prefix":"10.3390","volume":"11","author":[{"given":"Kalie","family":"Weich","sequence":"first","affiliation":[{"name":"Department of Population Health and Reproduction, University of California-Davis, Davis, CA 95616, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1118-9016","authenticated-orcid":false,"given":"Verena","family":"Affolter","sequence":"additional","affiliation":[{"name":"Department of Pathology, Microbiology, and Immunology, University of California-Davis, Davis, CA 95616, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Daniel","family":"York","sequence":"additional","affiliation":[{"name":"Department of Surgical and Radiological Sciences, University of California-Davis, Davis, CA 95616, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Robert","family":"Rebhun","sequence":"additional","affiliation":[{"name":"Department of Surgical and Radiological Sciences, University of California-Davis, Davis, CA 95616, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Robert","family":"Grahn","sequence":"additional","affiliation":[{"name":"Veterinary Genetics Laboratory, University of California-Davis, Davis, CA 95616, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7993-6597","authenticated-orcid":false,"given":"Angelica","family":"Kallenberg","sequence":"additional","affiliation":[{"name":"Veterinary Genetics Laboratory, University of California-Davis, Davis, CA 95616, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7614-7207","authenticated-orcid":false,"given":"Danika","family":"Bannasch","sequence":"additional","affiliation":[{"name":"Department of Population Health and Reproduction, University of California-Davis, Davis, CA 95616, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2020,1,9]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"8878","DOI":"10.1073\/pnas.1203005109","article-title":"Rethinking dog domestication by integrating genetics, archeology, and biogeography","volume":"109","author":"Larson","year":"2012","journal-title":"Proc. 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