{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,10]],"date-time":"2026-10-10T00:23:44Z","timestamp":1791591824424,"version":"4.3.4"},"reference-count":75,"publisher":"MDPI AG","issue":"3","license":[{"start":{"date-parts":[[2020,2,25]],"date-time":"2020-02-25T00:00:00Z","timestamp":1582588800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["31500242, 31670291, 31800249"],"award-info":[{"award-number":["31500242, 31670291, 31800249"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004731","name":"Natural Science Foundation of Zhejiang Province","doi-asserted-by":"publisher","award":["LY16C020004"],"award-info":[{"award-number":["LY16C020004"]}],"id":[{"id":"10.13039\/501100004731","id-type":"DOI","asserted-by":"publisher"}]},{"name":"State Key Laboratory for Quality and Safety of Agro-products","award":["2010DS700124-ZZ1901, 2010DS70124-ZZ1607"],"award-info":[{"award-number":["2010DS700124-ZZ1901, 2010DS70124-ZZ1607"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Genes"],"abstract":"<jats:p>Tea (Camellia sinensis (L.) O. Kuntze) is a widely consumed beverage. Lack of macronutrients is a major cause of tea yield and quality losses. Though the effects of macronutrient starvation on tea metabolism have been studied, little is known about their molecular mechanisms. Hence, we investigated changes in the gene expression of tea plants under nitrogen (N), phosphate (P), and potassium (K) deficient conditions by RNA-sequencing. A total of 9103 differentially expressed genes (DEG) were identified. Function enrichment analysis showed that many biological processes and pathways were common to N, P, and K starvation. In particular, cis-element analysis of promoter of genes uncovered that members of the WRKY, MYB, bHLH, NF-Y, NAC, Trihelix, and GATA families were more likely to regulate genes involved in catechins, l-theanine, and caffeine biosynthetic pathways. Our results provide a comprehensive insight into the mechanisms of responses to N, P, and K starvation, and a global basis for the improvement of tea quality and molecular breeding.<\/jats:p>","DOI":"10.3390\/genes11030241","type":"journal-article","created":{"date-parts":[[2020,2,26]],"date-time":"2020-02-26T04:18:29Z","timestamp":1582690709000},"page":"241","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":25,"title":["Transcriptomic Analysis Reveals the Molecular Adaptation of Three Major Secondary Metabolic Pathways to Multiple Macronutrient Starvation in Tea (Camellia sinensis)"],"prefix":"10.3390","volume":"11","author":[{"given":"Hui","family":"Su","sequence":"first","affiliation":[{"name":"Department of Tea Science, Zhejiang University, Hangzhou 310058, China"},{"name":"State Key Laboratory for Quality and Safety of Agro-products, Institute of Virology and Biotechnology, Zhejiang Academy of Agricultural Sciences, Hangzhou 310021, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xueying","family":"Zhang","sequence":"additional","affiliation":[{"name":"State Key Laboratory for Quality and Safety of Agro-products, Institute of Virology and Biotechnology, Zhejiang Academy of Agricultural Sciences, Hangzhou 310021, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yuqing","family":"He","sequence":"additional","affiliation":[{"name":"State Key Laboratory for Quality and Safety of Agro-products, Institute of Virology and Biotechnology, Zhejiang Academy of Agricultural Sciences, Hangzhou 310021, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Linying","family":"Li","sequence":"additional","affiliation":[{"name":"State Key Laboratory for Quality and Safety of Agro-products, Institute of Virology and Biotechnology, Zhejiang Academy of Agricultural Sciences, Hangzhou 310021, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yuefei","family":"Wang","sequence":"additional","affiliation":[{"name":"Department of Tea Science, Zhejiang University, Hangzhou 310058, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gaojie","family":"Hong","sequence":"additional","affiliation":[{"name":"State Key Laboratory for Quality and Safety of Agro-products, Institute of Virology and Biotechnology, Zhejiang Academy of Agricultural Sciences, Hangzhou 310021, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1599-7408","authenticated-orcid":false,"given":"Ping","family":"Xu","sequence":"additional","affiliation":[{"name":"Department of Tea Science, Zhejiang University, Hangzhou 310058, China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2020,2,25]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"250","DOI":"10.1016\/j.pbi.2009.04.003","article-title":"Physiological functions of mineral macronutrients","volume":"12","author":"Maathuis","year":"2009","journal-title":"Curr. Opin. Plant Biol."},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"e24409","DOI":"10.4161\/psb.24409","article-title":"Global transcriptome profile of rice root in response to essential macronutrient deficiency","volume":"8","author":"Takehisa","year":"2013","journal-title":"Plant Signal. Behav."},{"key":"ref_3","doi-asserted-by":"crossref","first-page":"135","DOI":"10.1111\/nph.15155","article-title":"Rice SPX6 negatively regulates the phosphate starvation response through suppression of the transcription factor PHR2","volume":"219","author":"Zhong","year":"2018","journal-title":"New Phytol."},{"key":"ref_4","doi-asserted-by":"crossref","first-page":"47","DOI":"10.1146\/annurev.arplant.58.032806.103750","article-title":"Nutrient sensing and signaling: NPKS","volume":"58","author":"Schachtman","year":"2007","journal-title":"Annu. Rev. Plant Biol."},{"key":"ref_5","doi-asserted-by":"crossref","first-page":"5567","DOI":"10.1093\/jxb\/eru245","article-title":"The primary nitrate response: A multifaceted signalling pathway","volume":"65","author":"Medici","year":"2014","journal-title":"J. Exp. Bot."},{"key":"ref_6","doi-asserted-by":"crossref","first-page":"1714","DOI":"10.1093\/pcp\/pcy148","article-title":"Sensing and Signaling of Phosphate Starvation\u2014From Local to Long Distance","volume":"59","author":"Chien","year":"2018","journal-title":"Plant Cell Physiol."},{"key":"ref_7","doi-asserted-by":"crossref","first-page":"123","DOI":"10.1016\/j.pbi.2017.06.006","article-title":"Regulation of potassium transport and signaling in plants","volume":"39","author":"Wang","year":"2017","journal-title":"Curr. Opin. Plant Biol."},{"key":"ref_8","doi-asserted-by":"crossref","first-page":"648","DOI":"10.1016\/j.semcdb.2012.01.004","article-title":"Nitrate sensing and signaling in plants","volume":"23","author":"Bouguyon","year":"2012","journal-title":"Semin. Cell Dev. Biol."},{"key":"ref_9","doi-asserted-by":"crossref","first-page":"2020","DOI":"10.1104\/pp.107.115667","article-title":"Systemic signaling of the plant nitrogen status triggers specific transcriptome responses depending on the nitrogen source in Medicago truncatula","volume":"146","author":"Ruffel","year":"2008","journal-title":"Plant Physiol."},{"key":"ref_10","doi-asserted-by":"crossref","first-page":"185","DOI":"10.1146\/annurev-arplant-042110-103849","article-title":"Signaling network in sensing phosphate availability in plants","volume":"62","author":"Chiou","year":"2011","journal-title":"Annu. Rev. Plant Biol."},{"key":"ref_11","doi-asserted-by":"crossref","first-page":"1347","DOI":"10.1016\/j.cell.2006.06.011","article-title":"A protein kinase, interacting with two calcineurin B-like proteins, regulates K+ transporter AKT1 in Arabidopsis","volume":"125","author":"Xu","year":"2006","journal-title":"Cell"},{"key":"ref_12","doi-asserted-by":"crossref","first-page":"1171","DOI":"10.1105\/tpc.18.00656","article-title":"Identification of molecular integrators shows that nitrogen actively controls the phosphate starvation response in plants","volume":"31","author":"Medici","year":"2019","journal-title":"Plant Cell"},{"key":"ref_13","doi-asserted-by":"crossref","first-page":"401","DOI":"10.1038\/s41477-019-0384-1","article-title":"Nitrate\u2013NRT1.1B\u2013SPX4 cascade integrates nitrogen and phosphorus signalling networks in plants","volume":"5","author":"Hu","year":"2019","journal-title":"Nat. Plants."},{"key":"ref_14","doi-asserted-by":"crossref","first-page":"461","DOI":"10.1016\/j.molp.2015.12.015","article-title":"Arabidopsis NRT1.5 Mediates the Suppression of Nitrate Starvation-Induced Leaf Senescence by Modulating Foliar Potassium Level","volume":"9","author":"Meng","year":"2016","journal-title":"Mol. Plant"},{"key":"ref_15","doi-asserted-by":"crossref","first-page":"866","DOI":"10.1016\/j.molp.2017.04.002","article-title":"The Tea Tree Genome Provides Insights into Tea Flavor and Independent Evolution of Caffeine Biosynthesis","volume":"10","author":"Xia","year":"2017","journal-title":"Mol. Plant"},{"key":"ref_16","doi-asserted-by":"crossref","first-page":"30","DOI":"10.3923\/ajps.2008.30.36","article-title":"A high internal phosphorus use efficiency in tea (Camellia sinensis L.) plant","volume":"7","author":"Salehi","year":"2008","journal-title":"Asian J. Plant Sci."},{"key":"ref_17","doi-asserted-by":"crossref","first-page":"48","DOI":"10.1016\/j.plaphy.2019.02.017","article-title":"Effects of nitrogen supply on flavonol glycoside biosynthesis and accumulation in tea leaves (Camellia sinensis)","volume":"138","author":"Dong","year":"2019","journal-title":"Plant Physiol. Biochem."},{"key":"ref_18","doi-asserted-by":"crossref","first-page":"62","DOI":"10.1016\/j.jplph.2016.06.005","article-title":"Genome-wide transcriptome analysis of expression in rice seedling roots in response to supplemental nitrogen","volume":"200","author":"Chandran","year":"2016","journal-title":"J. Plant Physiol."},{"key":"ref_19","doi-asserted-by":"crossref","first-page":"483","DOI":"10.1111\/nph.12375","article-title":"Nitrogen deprivation promotes Populus root growth through global transcriptome reprogramming and activation of hierarchical genetic networks","volume":"200","author":"Wei","year":"2013","journal-title":"New Phytol."},{"key":"ref_20","doi-asserted-by":"crossref","first-page":"4285","DOI":"10.1105\/tpc.113.117325","article-title":"Spatio-temporal transcript profiling of rice roots and shoots in response to pStarvation and recovery","volume":"25","author":"Secco","year":"2013","journal-title":"Plant Cell"},{"key":"ref_21","doi-asserted-by":"crossref","first-page":"947","DOI":"10.1111\/tpj.14160","article-title":"Metabolite profiling and genome-wide association studies reveal response mechanisms of phosphorus deficiency in maize seedling","volume":"97","author":"Luo","year":"2018","journal-title":"Plant J."},{"key":"ref_22","doi-asserted-by":"crossref","first-page":"397","DOI":"10.1007\/s12041-015-0532-y","article-title":"Transcriptome analysis reveals dynamic changes in the gene expression of tobacco seedlings under low potassium stress","volume":"94","author":"Lu","year":"2015","journal-title":"J. Genet."},{"key":"ref_23","doi-asserted-by":"crossref","first-page":"402","DOI":"10.1006\/meth.2001.1262","article-title":"Analysis of relative gene expression data using real-time quantitative PCR and the 2(-Delta Delta C(T)) Method","volume":"25","author":"Livak","year":"2001","journal-title":"Methods"},{"key":"ref_24","doi-asserted-by":"crossref","first-page":"253","DOI":"10.1007\/s10725-015-0090-6","article-title":"Effects of sunlight on gene expression and chemical composition of light-sensitive albino tea plant","volume":"78","author":"Li","year":"2016","journal-title":"Plant Growth Regul."},{"key":"ref_25","doi-asserted-by":"crossref","first-page":"519","DOI":"10.1016\/j.lfs.2007.06.011","article-title":"Tea polyphenols for health promotion","volume":"81","author":"Khan","year":"2007","journal-title":"Life Sci."},{"key":"ref_26","doi-asserted-by":"crossref","first-page":"405","DOI":"10.1146\/annurev.arplant.57.032905.105252","article-title":"Genetics and biochemistry of seed flavonoid","volume":"57","author":"Lepiniec","year":"2006","journal-title":"Annu. Rev. Plant Biol."},{"key":"ref_27","doi-asserted-by":"crossref","unstructured":"Zhou, T.S., Zhou, R., Yu, Y.B., Xiao, Y., Li, D.H., Xiao, B., Yu, O., and Yang, Y.J. (2016). Cloning and Characterization of a Flavonoid 3\u2032-Hydroxylase Gene from Tea Plant (Camellia sinensis). Int. J. Mol. Sci., 17.","DOI":"10.3390\/ijms17020261"},{"key":"ref_28","doi-asserted-by":"crossref","unstructured":"Wang, Y.S., Xu, Y.J., Gao, L.P., Yu, O., Wang, X.Z., He, X.J., Jiang, X.L., Liu, Y.J., and Xia, T. (2014). Functional analysis of Flavonoid 3\u2032,5\u2032-hydroxylase from Tea plant (Camellia sinensis): Critical role in the accumulation of catechins. BMC Plant Biol., 14.","DOI":"10.1186\/s12870-014-0347-7"},{"key":"ref_29","doi-asserted-by":"crossref","first-page":"107","DOI":"10.1016\/j.plaphy.2018.10.029","article-title":"Identification of key genes involved in catechin metabolism in tea seedlings based on transcriptomic and HPLC analysis","volume":"133","author":"Zhang","year":"2018","journal-title":"Plant Physiol. Bioch."},{"key":"ref_30","doi-asserted-by":"crossref","first-page":"830","DOI":"10.1038\/nrg2885","article-title":"Regulation of transcription in plants: Mechanisms controlling developmental switches","volume":"11","author":"Kaufmann","year":"2010","journal-title":"Nat. Rev. Genet."},{"key":"ref_31","doi-asserted-by":"crossref","first-page":"34","DOI":"10.1016\/j.phytochem.2013.12.006","article-title":"Nitrogen depletion and small R3-MYB transcription factors affecting anthocyanin accumulation in Arabidopsis leaves","volume":"98","author":"Olafsdottir","year":"2014","journal-title":"Phytochemistry"},{"key":"ref_32","doi-asserted-by":"crossref","first-page":"499","DOI":"10.1104\/pp.15.01336","article-title":"Arabidopsis PHL2 and PHR1 Act Redundantly as the Key Components of the Central Regulatory System Controlling Transcriptional Responses to Phosphate Starvation","volume":"170","author":"Sun","year":"2016","journal-title":"Plant Physiol."},{"key":"ref_33","doi-asserted-by":"crossref","first-page":"991","DOI":"10.3389\/fpls.2017.00991","article-title":"Potassium Starvation Limits Soybean Growth More than the Photosynthetic Processes across CO2 Levels","volume":"8","author":"Singh","year":"2017","journal-title":"Front. Plant Sci."},{"key":"ref_34","doi-asserted-by":"crossref","first-page":"E4151","DOI":"10.1073\/pnas.1719622115","article-title":"Draft genome sequence of Camellia sinensis var. sinensis provides insights into the evolution of the tea genome and tea quality","volume":"115","author":"Wei","year":"2018","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"ref_35","doi-asserted-by":"crossref","first-page":"127","DOI":"10.1007\/s11738-018-2701-0","article-title":"Transcriptome analysis using RNA-Seq revealed the effects of nitrogen form on major secondary metabolite biosynthesis in tea (Camellia sinensis) plants","volume":"40","author":"Yang","year":"2018","journal-title":"Acta Physiol. Plant"},{"key":"ref_36","doi-asserted-by":"crossref","first-page":"30","DOI":"10.1016\/j.plaphy.2017.09.007","article-title":"Phosphate stresses affect ionome and metabolome in tea plants","volume":"120","author":"Ding","year":"2017","journal-title":"Plant Physiol. Biochem."},{"key":"ref_37","doi-asserted-by":"crossref","first-page":"108570","DOI":"10.1016\/j.scienta.2019.108570","article-title":"Differential transcriptomic changes in low-potassium sensitive and low-potassium tolerant tea plant (Camellia sinensis) genotypes under potassium deprivation","volume":"256","author":"Li","year":"2019","journal-title":"Sci. Hortic."},{"key":"ref_38","doi-asserted-by":"crossref","first-page":"95","DOI":"10.1111\/pce.12842","article-title":"System analysis of metabolism and the transcriptome in Arabidopsis thaliana roots reveals differential co-regulation upon iron, sulfur and potassium deficiency","volume":"40","author":"Forieri","year":"2017","journal-title":"Plant Cell Environ."},{"key":"ref_39","doi-asserted-by":"crossref","unstructured":"Sinha, S.K., Sevanthi, V.A., Chaudhary, S., Tyagi, P., Venkadesan, S., Rani, M., and Mandal, P.K. (2018). Transcriptome Analysis of Two Rice Varieties Contrasting for Nitrogen Use Efficiency under Chronic N Starvation Reveals Differences in Chloroplast and Starch Metabolism-Related Genes. Genes Basel, 9.","DOI":"10.3390\/genes9040206"},{"key":"ref_40","doi-asserted-by":"crossref","unstructured":"Xue, Y., Zhuang, Q., Zhu, S., Xiao, B., Liang, C., Liao, H., and Tian, J. (2018). Genome Wide Transcriptome Analysis Reveals Complex Regulatory Mechanisms Underlying Phosphate Homeostasis in Soybean Nodules. Int. J. Mol. Sci., 19.","DOI":"10.3390\/ijms19102924"},{"key":"ref_41","first-page":"1","article-title":"Transcriptome Analysis of Rice Seedling Roots in Response to Potassium Deficiency","volume":"7","author":"Zhang","year":"2017","journal-title":"Sci. Rep."},{"key":"ref_42","doi-asserted-by":"crossref","first-page":"455","DOI":"10.1093\/pcp\/pcu172","article-title":"RNA-Seq-based transcriptome profiling of early nitrogen deficiency response in cucumber seedlings provides new insight into the putative nitrogen regulatory network","volume":"56","author":"Zhao","year":"2015","journal-title":"Plant Cell Physiol."},{"key":"ref_43","doi-asserted-by":"crossref","first-page":"193","DOI":"10.1016\/j.jplph.2011.09.002","article-title":"Transcriptome profiling characterizes phosphate deficiency effects on carbohydrate metabolism in rice leaves","volume":"169","author":"Park","year":"2012","journal-title":"J. Plant Physiol."},{"key":"ref_44","first-page":"2122","article-title":"A conserved MYB transcription factor","volume":"15","author":"Vicente","year":"2001","journal-title":"Genes Dev."},{"key":"ref_45","doi-asserted-by":"crossref","first-page":"1139","DOI":"10.1093\/aob\/mct080","article-title":"A phosphate starvation response regulator Ta-PHR1 is involved in phosphate signalling and increases grain yield in wheat","volume":"111","author":"Wang","year":"2013","journal-title":"Ann. Bot."},{"key":"ref_46","doi-asserted-by":"crossref","first-page":"1673","DOI":"10.1104\/pp.107.111443","article-title":"OsPHR2 is involved in phosphate-starvation signaling and excessive phosphate accumulation in shoots of plants","volume":"146","author":"Zhou","year":"2008","journal-title":"Plant Physiol."},{"key":"ref_47","doi-asserted-by":"crossref","first-page":"1586","DOI":"10.1105\/tpc.114.123208","article-title":"SPX4 Negatively Regulates Phosphate Signaling and Homeostasis through Its Interaction with PHR2 in Rice","volume":"26","author":"Lv","year":"2014","journal-title":"Plant Cell"},{"key":"ref_48","doi-asserted-by":"crossref","first-page":"14953","DOI":"10.1073\/pnas.1404680111","article-title":"Rice SPX1 and SPX2 inhibit phosphate starvation responses through interacting with PHR2 in a phosphate-dependent manner","volume":"111","author":"Wang","year":"2014","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"ref_49","doi-asserted-by":"crossref","first-page":"341","DOI":"10.1046\/j.1365-313X.2002.01356.x","article-title":"Expression analysis suggests novel roles for members of the Pht1 family of phosphate transporters in Arabidopsis","volume":"31","author":"Mudge","year":"2002","journal-title":"Plant J."},{"key":"ref_50","doi-asserted-by":"crossref","unstructured":"Ma, T.L., Wu, W.H., and Wang, Y. (2012). Transcriptome analysis of rice root responses to potassium deficiency. BMC Plant Biol., 12.","DOI":"10.1186\/1471-2229-12-161"},{"key":"ref_51","doi-asserted-by":"crossref","unstructured":"Li, C.F., Zhu, Y., Yu, Y., Zhao, Q.Y., Wang, S.J., Wang, X.C., Yao, M.Z., Luo, D., Li, X., and Chen, L. (2015). Global transcriptome and gene regulation network for secondary metabolite biosynthesis of tea plant (Camellia sinensis). BMC Genom., 16.","DOI":"10.1186\/s12864-015-1773-0"},{"key":"ref_52","doi-asserted-by":"crossref","first-page":"125","DOI":"10.1007\/s11032-015-0319-0","article-title":"Genome-wide analysis of basic helix\u2212loop\u2212helix family transcription factors and their role in responses to abiotic stress in carrot","volume":"35","author":"Chen","year":"2015","journal-title":"Mol. Breed."},{"key":"ref_53","doi-asserted-by":"crossref","unstructured":"Quan, X., Zeng, J., Ye, L., Chen, G., Han, Z., Shah, J.M., and Zhang, G. (2016). Transcriptome profiling analysis for two Tibetan wild barley genotypes in responses to low nitrogen. BMC Plant Biol., 16.","DOI":"10.1186\/s12870-016-0721-8"},{"key":"ref_54","doi-asserted-by":"crossref","unstructured":"Zhao, X.M., Liu, Y., Liu, X., and Jiang, J. (2018). Comparative Transcriptome Profiling of Two Tomato Genotypes in Response to Potassium-Deficiency Stress. Int. J. Mol. Sci., 19.","DOI":"10.3390\/ijms19082402"},{"key":"ref_55","doi-asserted-by":"crossref","first-page":"3207","DOI":"10.1007\/s11738-014-1687-5","article-title":"Transcriptome responses to phosphate deficiency in Poncirus trifoliata (L.) Raf","volume":"36","author":"Bai","year":"2014","journal-title":"Acta Physiol. Plant"},{"key":"ref_56","doi-asserted-by":"crossref","first-page":"639","DOI":"10.1111\/nph.12291","article-title":"APETALA2\/Ethylene Responsive Factor (AP2\/ERF) transcription factors: Mediators of stress responses and developmental programs","volume":"199","author":"Licausi","year":"2013","journal-title":"New Phytol."},{"key":"ref_57","doi-asserted-by":"crossref","first-page":"1484","DOI":"10.1104\/pp.113.231183","article-title":"Ethylene Response Factor070 regulates root development and phosphate starvation-mediated responses","volume":"164","author":"Ramaiah","year":"2014","journal-title":"Plant Physiol."},{"key":"ref_58","doi-asserted-by":"crossref","first-page":"1042","DOI":"10.1093\/mp\/sss003","article-title":"The Arabidopsis AP2\/ERF transcription factor RAP2.11 modulates plant response to low-potassium conditions","volume":"5","author":"Kim","year":"2012","journal-title":"Mol. Plant"},{"key":"ref_59","doi-asserted-by":"crossref","first-page":"946","DOI":"10.1016\/j.bbrc.2018.03.087","article-title":"Protective role of anthocyanins in plants under low nitrogen stress","volume":"498","author":"Liang","year":"2018","journal-title":"Biochem. Biophys. Res. Commun."},{"key":"ref_60","doi-asserted-by":"crossref","first-page":"1245","DOI":"10.1007\/s00425-006-0414-x","article-title":"Nitrogen deficiency enhances expression of specific MYB and bHLH transcription factors and accumulation of end products in the flavonoid pathway","volume":"225","author":"Lea","year":"2007","journal-title":"Planta"},{"key":"ref_61","doi-asserted-by":"crossref","first-page":"1076","DOI":"10.1104\/pp.15.00298","article-title":"The rice high-affinity potassium transporter1;1 is involved in salt tolerance and regulated by an MYB-Type transcription factor","volume":"168","author":"Wang","year":"2015","journal-title":"Plant Physiol."},{"key":"ref_62","doi-asserted-by":"crossref","first-page":"191","DOI":"10.1042\/BJ20070102","article-title":"BHLH32 modulates several biochemical and morphological processes that respond to Pi starvation in Arabidopsis","volume":"405","author":"Chen","year":"2007","journal-title":"Biochem. J."},{"key":"ref_63","doi-asserted-by":"crossref","first-page":"747","DOI":"10.1007\/s00425-009-0978-3","article-title":"The endogenous GL3, but not EGL3, gene is necessary for anthocyanin accumulation as induced by nitrogen depletion in Arabidopsis rosette stage leaves","volume":"230","author":"Dugassa","year":"2009","journal-title":"Planta"},{"key":"ref_64","doi-asserted-by":"crossref","first-page":"1789","DOI":"10.1104\/pp.106.093971","article-title":"WRKY75 transcription factor is a modulator of phosphate acquisition and root development in Arabidopsis","volume":"143","author":"Devaiah","year":"2007","journal-title":"Plant Physiol."},{"key":"ref_65","doi-asserted-by":"crossref","first-page":"372","DOI":"10.1111\/tpj.14038","article-title":"TaWRKY51 promotes lateral root formation through negative regulation of ethylene biosynthesis in wheat (Triticum aestivum L.)","volume":"96","author":"Hu","year":"2018","journal-title":"Plant J."},{"key":"ref_66","doi-asserted-by":"crossref","first-page":"947","DOI":"10.1093\/jxb\/erv515","article-title":"OsWRKY74, a WRKY transcription factor, modulates tolerance to phosphate starvation in rice","volume":"67","author":"Dai","year":"2016","journal-title":"J. Exp. Bot."},{"key":"ref_67","doi-asserted-by":"crossref","first-page":"1579","DOI":"10.1104\/pp.114.253799","article-title":"WRKY42 modulates phosphate homeostasis through regulating phosphate translocation and acquisition in Arabidopsis","volume":"167","author":"Su","year":"2015","journal-title":"Plant Physiol."},{"key":"ref_68","doi-asserted-by":"crossref","first-page":"1330","DOI":"10.3389\/fpls.2018.01330","article-title":"OsWRKY28 Regulates Phosphate and Arsenate Accumulation, Root System Architecture and Fertility in Rice","volume":"9","author":"Wang","year":"2018","journal-title":"Front. Plant Sci."},{"key":"ref_69","doi-asserted-by":"crossref","first-page":"17","DOI":"10.1007\/s13258-018-0734-9","article-title":"Genome-wide identification of WRKY family genes and their response to abiotic stresses in tea plant (Camellia sinensis)","volume":"41","author":"Wang","year":"2019","journal-title":"Gene Genom."},{"key":"ref_70","first-page":"2045","article-title":"The Arabidopsis thaliana Nuclear Factor Y Transcription Factors","volume":"7","author":"Zhao","year":"2016","journal-title":"Front. Plant Sci."},{"key":"ref_71","doi-asserted-by":"crossref","first-page":"489","DOI":"10.1007\/s10142-018-0608-x","article-title":"Transcriptome-wide identification and expression profile analysis of the bHLH family genes in Camellia sinensis","volume":"18","author":"Cui","year":"2018","journal-title":"Funct. Integr. Genom."},{"key":"ref_72","doi-asserted-by":"crossref","first-page":"130","DOI":"10.1038\/s41598-017-18133-z","article-title":"Isolation and Characterization of Key Genes that Promote Flavonoid Accumulation in Purple-leaf Tea (Camellia sinensis L.)","volume":"8","author":"He","year":"2018","journal-title":"Sci. Rep."},{"key":"ref_73","doi-asserted-by":"crossref","first-page":"32534","DOI":"10.1038\/srep32534","article-title":"Purple foliage coloration in tea (Camellia sinensis L.) arises from activation of the R2R3-MYB transcription factor CsAN1","volume":"6","author":"Sun","year":"2016","journal-title":"Sci. Rep."},{"key":"ref_74","doi-asserted-by":"crossref","unstructured":"Liu, Y., Hou, H., Jiang, X., Wang, P., Dai, X., Chen, W., Gao, L., and Xia, T. (2018). A WD40 Repeat Protein from Camellia sinensis Regulates Anthocyanin and Proanthocyanidin Accumulation through the Formation of MYB-bHLH-WD40 Ternary Complexes. Int. J. Mol. Sci., 19.","DOI":"10.3390\/ijms19061686"},{"key":"ref_75","doi-asserted-by":"crossref","unstructured":"Chen, W., Hao, W.J., Xu, Y.X., Zheng, C., Ni, D.J., Yao, M.Z., and Chen, L. (2019). Isolation and Characterization of CsWRKY7, a Subgroup IId WRKY Transcription Factor from Camellia sinensis, Linked to Development in Arabidopsis. Int. J. Mol. Sci., 20.","DOI":"10.3390\/ijms20112815"}],"container-title":["Genes"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.mdpi.com\/2073-4425\/11\/3\/241\/pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,11]],"date-time":"2025-10-11T09:01:42Z","timestamp":1760173302000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.mdpi.com\/2073-4425\/11\/3\/241"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020,2,25]]},"references-count":75,"journal-issue":{"issue":"3","published-online":{"date-parts":[[2020,3]]}},"alternative-id":["genes11030241"],"URL":"https:\/\/doi.org\/10.3390\/genes11030241","relation":{},"ISSN":["2073-4425"],"issn-type":[{"value":"2073-4425","type":"electronic"}],"subject":[],"published":{"date-parts":[[2020,2,25]]}}}