{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,11,4]],"date-time":"2025-11-04T16:09:16Z","timestamp":1762272556350,"version":"build-2065373602"},"reference-count":39,"publisher":"MDPI AG","issue":"3","license":[{"start":{"date-parts":[[2020,3,22]],"date-time":"2020-03-22T00:00:00Z","timestamp":1584835200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/100016991","name":"Universidad de Guadalajara","doi-asserted-by":"publisher","award":["PRO-SNI 2013-2015"],"award-info":[{"award-number":["PRO-SNI 2013-2015"]}],"id":[{"id":"10.13039\/100016991","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Genes"],"abstract":"<jats:p>NK and some T cell functions are regulated by the interaction between KIR and HLA molecules. Several studies have shown an association between activating KIR genes and the development of autoimmune diseases, including psoriasis vulgaris (PsV). Our objective was to determine the association between KIR\/HLA genes and genotypes with PsV in the Western mestizo Mexican population. One hundred subjects diagnosed with PsV (SP) and 108 healthy subjects (HS) were genotyped for 14 KIR genes, HLA-Bw4, HLA-C1, and HLA-C2 by PCR-single specific primer (SSP). Positive associations of the KIR3DS1 gene (odds ratio (OR) 1.959, p = 0.021), G11 genotype (OR 19.940, p = 0.008), and KIR3DS1\/HLA-ABw4 (OR 2.265, p = 0.009) were found with susceptibility to PsV. In contrast, the G1 genotype (OR 0.448, p = 0.031) and KIR3DL1\/HLA-Bw4Ile80 (OR 0.522, p = 0.022) were negatively associated with susceptibility to this disease. These results suggest an implication of the KIR3DS1\/HLA-ABw4 genotype in PsV pathology.<\/jats:p>","DOI":"10.3390\/genes11030338","type":"journal-article","created":{"date-parts":[[2020,3,24]],"date-time":"2020-03-24T13:04:04Z","timestamp":1585055044000},"page":"338","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":4,"title":["Diversity of KIR\/HLA Genotypes and Their Association with Psoriasis Vulgaris in the Western Mexican Population"],"prefix":"10.3390","volume":"11","author":[{"given":"Omar","family":"Graciano-Machuca","sequence":"first","affiliation":[{"name":"Doctorate in Biomedical Sciences, Department of Physiology, University Center of Health Sciences (CUCS), University of Guadalajara (UDG), Guadalajara, Jal. 44340, Mexico"},{"name":"Laboratory of Biological Systems, Department of Health Sciences, University Center of the Valleys (CUVALLES), UDG, Ameca, Jal. 4660, Mexico"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5719-1712","authenticated-orcid":false,"given":"Anabell","family":"Alvarado-Navarro","sequence":"additional","affiliation":[{"name":"Research Center in Immunology and Dermatology, Department of Physiology, CUCS, UDG, Guadalajara, Jal. 44340, Mexico"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mar\u00eda Guadalupe","family":"Ram\u00edrez-Due\u00f1as","sequence":"additional","affiliation":[{"name":"Laboratory of Immunology, Department of Physiology, CUCS, UDG, Guadalajara, Jal. 44340, Mexico"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Delfina Guadalupe","family":"Villanueva-Quintero","sequence":"additional","affiliation":[{"name":"Jalisco Dermatology Institute \u201cDr. Jos\u00e9 Barba Rubio\u201d, Ministry of Health; Zapopan, Jal. 45190, Mexico"},{"name":"Inflammatory Diseases Care Center, Guadalajara, Jal. 44630, Mexico"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Erandi Enif","family":"Velarde-de la Cruz","sequence":"additional","affiliation":[{"name":"Doctorate in Biomedical Sciences, Department of Physiology, University Center of Health Sciences (CUCS), University of Guadalajara (UDG), Guadalajara, Jal. 44340, Mexico"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7879-9316","authenticated-orcid":false,"given":"Andrea Carolina","family":"Machado-Sulbar\u00e1n","sequence":"additional","affiliation":[{"name":"Doctorate in Biomedical Sciences, Department of Physiology, University Center of Health Sciences (CUCS), University of Guadalajara (UDG), Guadalajara, Jal. 44340, Mexico"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Margarita","family":"Montoya-Buelna","sequence":"additional","affiliation":[{"name":"Laboratory of Immunology, Department of Physiology, CUCS, UDG, Guadalajara, Jal. 44340, Mexico"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5047-8115","authenticated-orcid":false,"given":"Pedro Ernesto","family":"S\u00e1nchez-Hern\u00e1ndez","sequence":"additional","affiliation":[{"name":"Laboratory of Immunology, Department of Physiology, CUCS, UDG, Guadalajara, Jal. 44340, Mexico"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1968","published-online":{"date-parts":[[2020,3,22]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"205","DOI":"10.1111\/jdv.13854","article-title":"A systematic review of worldwide epidemiology of psoriasis","volume":"31","author":"Michalek","year":"2016","journal-title":"J. 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