{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,11]],"date-time":"2026-10-11T18:49:56Z","timestamp":1791744596040,"version":"4.3.4"},"reference-count":52,"publisher":"MDPI AG","issue":"8","license":[{"start":{"date-parts":[[2020,8,10]],"date-time":"2020-08-10T00:00:00Z","timestamp":1597017600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100004359","name":"Swedish Research Council","doi-asserted-by":"publisher","award":["2016-03798"],"award-info":[{"award-number":["2016-03798"]}],"id":[{"id":"10.13039\/501100004359","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Genes"],"abstract":"<jats:p>(1) Background: Psoriasis is a multifactorial chronic inflammatory disorder of the skin, with significant morbidity, characterized by hyperproliferation of the epidermis. Even though psoriasis\u2019 etiology is not fully understood, it is believed to be multifactorial, with numerous key components. (2) Methods: In order to cast light on the complex molecular interactions in psoriasis vulgaris at both protein\u2013protein interactions and transcriptomics levels, we studied a set of microarray gene expression analyses consisting of 170 paired lesional and non-lesional samples. Afterwards, a network analysis was conducted on the protein\u2013protein interaction network of differentially expressed genes based on micro- and macro-level network metrics at a systemic level standpoint. (3) Results: We found 17 top communicative genes, all of which were experimentally proven to be pivotal in psoriasis, which were identified in two modules, namely the cell cycle and immune system. Intra- and inter-gene interaction subnetworks from the top communicative genes might provide further insight into the corresponding characteristic interactions. (4) Conclusions: Potential gene combinations for therapeutic\/diagnostics purposes were identified. Moreover, our proposed workflow could be of interest to a broader range of future biological network analysis studies.<\/jats:p>","DOI":"10.3390\/genes11080914","type":"journal-article","created":{"date-parts":[[2020,8,10]],"date-time":"2020-08-10T09:04:16Z","timestamp":1597050256000},"page":"914","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":5,"title":["Using Micro- and Macro-Level Network Metrics Unveils Top Communicative Gene Modules in Psoriasis"],"prefix":"10.3390","volume":"11","author":[{"given":"Reyhaneh","family":"Naderi","sequence":"first","affiliation":[{"name":"Department of Artificial Intelligence and Robotics, Faculty of Computer Engineering, Iran University of Science and Technology, Tehran 1684613114, Iran"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Homa","family":"Saadati Mollaei","sequence":"additional","affiliation":[{"name":"Department of Advanced Sciences and Technology, Islamic Azad University Tehran Medical Sciences, Tehran 1916893813, Iran"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7115-9751","authenticated-orcid":false,"given":"Arne","family":"Elofsson","sequence":"additional","affiliation":[{"name":"Department of Biochemistry and Biophysics and Science for Life Laboratory, Stockholm University, 106 91 Stockholm, Sweden"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Saman","family":"Hosseini Ashtiani","sequence":"additional","affiliation":[{"name":"Department of Biochemistry and Biophysics and Science for Life Laboratory, Stockholm University, 106 91 Stockholm, Sweden"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2020,8,10]]},"reference":[{"key":"ref_1","first-page":"7","article-title":"Current knowledge on psoriasis and autoimmune diseases","volume":"6","author":"Soler","year":"2016","journal-title":"Psoriasis"},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"355","DOI":"10.1016\/j.cpm.2016.02.004","article-title":"Psoriasis: Pathogenesis, Assessment, and Therapeutic Update","volume":"33","author":"Schleicher","year":"2016","journal-title":"Clin. 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