{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,30]],"date-time":"2026-01-30T23:44:53Z","timestamp":1769816693547,"version":"3.49.0"},"reference-count":16,"publisher":"MDPI AG","issue":"9","license":[{"start":{"date-parts":[[2020,8,20]],"date-time":"2020-08-20T00:00:00Z","timestamp":1597881600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100005010","name":"Associazione Italiana per la Ricerca sul Cancro","doi-asserted-by":"publisher","award":["IG 2014 n.16105"],"award-info":[{"award-number":["IG 2014 n.16105"]}],"id":[{"id":"10.13039\/501100005010","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Genes"],"abstract":"<jats:p>Here, we describe the immunoglobulin and T cell receptor (Ig\/TCR) molecular rearrangements identified as a leukemic clone hallmark for minimal residual disease assessment in relation to TP53 mutational status in 171 Ph-negative Acute Lymphoblastic Leukemia (ALL) adult patients at diagnosis. The presence of a TP53 alterations, which represents a marker of poor prognosis, was strictly correlated with an immature DH\/JH rearrangement of the immunoglobulin receptor (p &lt; 0.0001). Furthermore, TP53-mutated patients were classified as pro-B ALL more frequently than their wild-type counterpart (46% vs. 25%, p = 0.05). Although the reasons for the co-presence of immature Ig rearrangements and TP53 mutation need to be clarified, this can suggest that the alteration in TP53 is acquired at an early stage of B-cell maturation or even at the level of pre-leukemic transformation.<\/jats:p>","DOI":"10.3390\/genes11090960","type":"journal-article","created":{"date-parts":[[2020,8,20]],"date-time":"2020-08-20T21:13:42Z","timestamp":1597958022000},"page":"960","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":4,"title":["Immature Immunoglobulin Gene Rearrangements Are Recurrent in B Precursor Adult Acute Lymphoblastic Leukemia Carrying TP53 Molecular Alterations"],"prefix":"10.3390","volume":"11","author":[{"given":"Silvia","family":"Salmoiraghi","sequence":"first","affiliation":[{"name":"Hematology and Bone Marrow Transplant Unit, ASST Papa Giovanni XXIII, piazza OMS 1, 24127 Bergamo, Italy"},{"name":"FROM Research Foundation, ASST Papa Giovanni XXIII, piazza OMS 1, 24127 Bergamo, Italy"},{"name":"DIMET PhD program, Universit\u00e0 di Milano Bicocca, 20126 Milan, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4353-2210","authenticated-orcid":false,"given":"Roberta","family":"Cavagna","sequence":"additional","affiliation":[{"name":"Hematology and Bone Marrow Transplant Unit, ASST Papa Giovanni XXIII, piazza OMS 1, 24127 Bergamo, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Marie Lorena","family":"Guinea Montalvo","sequence":"additional","affiliation":[{"name":"Hematology and Bone Marrow Transplant Unit, ASST Papa Giovanni XXIII, piazza OMS 1, 24127 Bergamo, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Greta","family":"Ubiali","sequence":"additional","affiliation":[{"name":"Hematology and Bone Marrow Transplant Unit, ASST Papa Giovanni XXIII, piazza OMS 1, 24127 Bergamo, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Manuela","family":"Tosi","sequence":"additional","affiliation":[{"name":"Hematology and Bone Marrow Transplant Unit, ASST Papa Giovanni XXIII, piazza OMS 1, 24127 Bergamo, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Barbara","family":"Peruta","sequence":"additional","affiliation":[{"name":"Hematology and Bone Marrow Transplant Unit, ASST Papa Giovanni XXIII, piazza OMS 1, 24127 Bergamo, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tamara","family":"Intermesoli","sequence":"additional","affiliation":[{"name":"Hematology and Bone Marrow Transplant Unit, ASST Papa Giovanni XXIII, piazza OMS 1, 24127 Bergamo, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Elena","family":"Oldani","sequence":"additional","affiliation":[{"name":"Hematology and Bone Marrow Transplant Unit, ASST Papa Giovanni XXIII, piazza OMS 1, 24127 Bergamo, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Anna","family":"Salvi","sequence":"additional","affiliation":[{"name":"Hematology and Bone Marrow Transplant Unit, ASST Papa Giovanni XXIII, piazza OMS 1, 24127 Bergamo, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5767-8942","authenticated-orcid":false,"given":"Chiara","family":"Pavoni","sequence":"additional","affiliation":[{"name":"Hematology and Bone Marrow Transplant Unit, ASST Papa Giovanni XXIII, piazza OMS 1, 24127 Bergamo, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ursula","family":"Giussani","sequence":"additional","affiliation":[{"name":"Medical Genetics Laboratory, ASST Papa Giovanni XXIII, piazza OMS 1, 24127 Bergamo, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8214-2894","authenticated-orcid":false,"given":"Renato","family":"Bassan","sequence":"additional","affiliation":[{"name":"Unit\u00e0 Operativa Complessa di Ematologia, Ospedale dell\u2019Angelo e Ospedale SS. Giovanni e Paolo, via Don Tosatto 147, 30172 Mestre (VE), Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3739-7502","authenticated-orcid":false,"given":"Alessandro","family":"Rambaldi","sequence":"additional","affiliation":[{"name":"Hematology and Bone Marrow Transplant Unit, ASST Papa Giovanni XXIII, piazza OMS 1, 24127 Bergamo, Italy"},{"name":"Department of Oncology and Hematology, Universit\u00e0 degli Studi di Milano, Via S. Sofia, 9\/1, 20122 Milan, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0374-1536","authenticated-orcid":false,"given":"Orietta","family":"Spinelli","sequence":"additional","affiliation":[{"name":"Hematology and Bone Marrow Transplant Unit, ASST Papa Giovanni XXIII, piazza OMS 1, 24127 Bergamo, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1968","published-online":{"date-parts":[[2020,8,20]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"4014","DOI":"10.1182\/blood.V90.10.4014","article-title":"Early onset of immunoglobulin heavy chain gene rearrangements in normal human bone marrow CD34+ cells","volume":"90","author":"Davi","year":"1997","journal-title":"Blood"},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"19","DOI":"10.1146\/annurev.immunol.18.1.19","article-title":"Receptor selection in B and T lymphocytes","volume":"18","author":"Nemazee","year":"2000","journal-title":"Annu. 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