{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,17]],"date-time":"2026-09-17T00:53:24Z","timestamp":1789606404798,"version":"build-2803163510"},"reference-count":134,"publisher":"MDPI AG","issue":"11","license":[{"start":{"date-parts":[[2020,11,18]],"date-time":"2020-11-18T00:00:00Z","timestamp":1605657600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"National Council for Scientific and Technological Development -Brazil  (CNPq)","award":["430756\/2018-6"],"award-info":[{"award-number":["430756\/2018-6"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Genes"],"abstract":"<jats:p>Thyroid cancer is the most frequent endocrine malignancy with the majority of cases derived from thyroid follicular cells and caused by sporadic mutations. However, when at least two or more first degree relatives present thyroid cancer, it is classified as familial non-medullary thyroid cancer (FNMTC) that may comprise 3\u20139% of all thyroid cancer. In this context, 5% of FNMTC are related to hereditary syndromes such as Cowden and Werner Syndromes, displaying specific genetic predisposition factors. On the other hand, the other 95% of cases are classified as non-syndromic FNMTC. Over the last 20 years, several candidate genes emerged in different studies of families worldwide. Nevertheless, the identification of a prevalent polymorphism or germinative mutation has not progressed in FNMTC. In this work, an overview of genetic alteration related to syndromic and non-syndromic FNMTC is presented.<\/jats:p>","DOI":"10.3390\/genes11111364","type":"journal-article","created":{"date-parts":[[2020,11,18]],"date-time":"2020-11-18T07:41:00Z","timestamp":1605685260000},"page":"1364","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":19,"title":["Genetic Mutations and Variants in the Susceptibility of Familial Non-Medullary Thyroid Cancer"],"prefix":"10.3390","volume":"11","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-6852-4300","authenticated-orcid":false,"given":"Fab\u00edola Yukiko","family":"Miasaki","sequence":"first","affiliation":[{"name":"Department of Endocrinology and Metabolism (SEMPR), Hospital de Cl\u00ednicas, Federal University of Paran\u00e1, Curitiba 80030-110, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Cesar Seigi","family":"Fuziwara","sequence":"additional","affiliation":[{"name":"Department of Cell and Developmental Biology, Institute of Biomedical Sciences, University of S\u00e3o Paulo, S\u00e3o Paulo 05508-000, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gisah Amaral de","family":"Carvalho","sequence":"additional","affiliation":[{"name":"Department of Endocrinology and Metabolism (SEMPR), Hospital de Cl\u00ednicas, Federal University of Paran\u00e1, Curitiba 80030-110, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8403-4459","authenticated-orcid":false,"given":"Edna Teruko","family":"Kimura","sequence":"additional","affiliation":[{"name":"Department of Cell and Developmental Biology, Institute of Biomedical Sciences, University of S\u00e3o Paulo, S\u00e3o Paulo 05508-000, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2020,11,18]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","unstructured":"Hincza, K., Kowalik, A., and Kowalska, A. (2019). Current Knowledge of Germline Genetic Risk Factors for the Development of Non-Medullary Thyroid Cancer. Genes, 10.","DOI":"10.3390\/genes10070482"},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"70","DOI":"10.1111\/his.13373","article-title":"Hereditary and familial thyroid tumours","volume":"72","author":"Guilmette","year":"2017","journal-title":"Histopathology"},{"key":"ref_3","first-page":"427","article-title":"Carcinoma of the thyroid: Papillary adenocarcinoma occurring in twins and a case of H\u00fcrthle cell carcinoma; tumor conference","volume":"54","author":"Firminger","year":"1953","journal-title":"J. Kans. Med. Soc."},{"key":"ref_4","doi-asserted-by":"crossref","first-page":"924","DOI":"10.1007\/s00268-006-0847-1","article-title":"An evidence-based approach to familial nonmedullary thyroid cancer: Screening, clinical management, and follow-up","volume":"31","author":"Sippel","year":"2007","journal-title":"World J. Surg."},{"key":"ref_5","doi-asserted-by":"crossref","first-page":"1049","DOI":"10.1089\/thy.2013.0079","article-title":"Familial nonmedullary thyroid carcinoma","volume":"23","author":"Mazeh","year":"2013","journal-title":"Thyroid"},{"key":"ref_6","doi-asserted-by":"crossref","first-page":"1743","DOI":"10.1086\/302164","article-title":"A gene predisposing to familial thyroid tumors with cell oxyphilia maps to chromosome 19p13.2","volume":"63","author":"Canzian","year":"1998","journal-title":"Am. J. Hum. Genet."},{"key":"ref_7","doi-asserted-by":"crossref","first-page":"1123","DOI":"10.1086\/301610","article-title":"Familial nontoxic multinodular thyroid goiter locus maps to chromosome 14q but does not account for familial nonmedullary thyroid cancer","volume":"61","author":"Bignell","year":"1997","journal-title":"Am. J. Hum. Genet."},{"key":"ref_8","first-page":"1758","article-title":"Papillary thyroid carcinoma associated with papillary renal neoplasia: Genetic linkage analysis of a distinct heritable tumor syndrome","volume":"85","author":"Malchoff","year":"2000","journal-title":"J. Clin. Endocrinol. Metab."},{"key":"ref_9","doi-asserted-by":"crossref","first-page":"440","DOI":"10.1086\/321979","article-title":"Localization of a susceptibility gene for familial nonmedullary thyroid carcinoma to chromosome 2q21","volume":"69","author":"McKay","year":"2001","journal-title":"Am. J. Hum. Genet."},{"key":"ref_10","doi-asserted-by":"crossref","first-page":"4426","DOI":"10.1210\/jc.2008-0449","article-title":"Mapping a new familial thyroid epithelial neoplasia susceptibility locus to chromosome 8p23.1-p22 by high-density single-nucleotide polymorphism genome-wide linkage analysis","volume":"93","author":"Cavaco","year":"2008","journal-title":"J. Clin. Endocrinol. Metab."},{"key":"ref_11","doi-asserted-by":"crossref","first-page":"946","DOI":"10.1089\/thy.2018.0736","article-title":"Identification of Rare Variants Predisposing to Thyroid Cancer","volume":"29","author":"Wang","year":"2019","journal-title":"Thyroid"},{"key":"ref_12","doi-asserted-by":"crossref","first-page":"164","DOI":"10.3803\/EnM.2018.33.2.164","article-title":"Genetic Polymorphism Predisposing to Differentiated Thyroid Cancer: A Review of Major Findings of the Genome-Wide Association Studies","volume":"33","author":"Saenko","year":"2018","journal-title":"Endocrinol. Metab."},{"key":"ref_13","doi-asserted-by":"crossref","first-page":"533","DOI":"10.1038\/s41568-020-0265-y","article-title":"Tumour predisposition and cancer syndromes as models to study gene-environment interactions","volume":"20","author":"Carbone","year":"2020","journal-title":"Nat. Rev. Cancer"},{"key":"ref_14","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1089\/thy.2015.0020","article-title":"2015 American Thyroid Association Management Guidelines for Adult Patients with Thyroid Nodules and Differentiated Thyroid Cancer: The American Thyroid Association Guidelines Task Force on Thyroid Nodules and Differentiated Thyroid Cancer","volume":"26","author":"Haugen","year":"2016","journal-title":"Thyroid"},{"key":"ref_15","doi-asserted-by":"crossref","first-page":"105","DOI":"10.1111\/cge.12710","article-title":"Health risks for ataxia-telangiectasia mutated heterozygotes: A systematic review, meta-analysis and evidence-based guideline","volume":"90","author":"Roeleveld","year":"2016","journal-title":"Clin. Genet."},{"key":"ref_16","doi-asserted-by":"crossref","first-page":"288","DOI":"10.1002\/ijc.1329","article-title":"Cancer risk in heterozygotes for ataxia-telangiectasia","volume":"93","author":"Janin","year":"2001","journal-title":"Int. J. Cancer"},{"key":"ref_17","doi-asserted-by":"crossref","first-page":"156","DOI":"10.1055\/a-0753-4943","article-title":"Carney Complex","volume":"127","author":"Kamilaris","year":"2019","journal-title":"Exp. Clin. Endocrinol. Diabetes"},{"key":"ref_18","doi-asserted-by":"crossref","first-page":"83","DOI":"10.2147\/TACG.S41947","article-title":"Genetic basis of Cowden syndrome and its implications for clinical practice and risk management","volume":"9","author":"Gammon","year":"2016","journal-title":"Appl. Clin. Genet."},{"key":"ref_19","doi-asserted-by":"crossref","first-page":"103","DOI":"10.1146\/annurev-med-052218-125823","article-title":"The Clinical Spectrum of PTEN Mutations","volume":"71","author":"Yehia","year":"2020","journal-title":"Annu. Rev. Med."},{"key":"ref_20","doi-asserted-by":"crossref","first-page":"68","DOI":"10.1001\/jama.2010.1910","article-title":"DICER1 Mutations in Familial Multinodular Goiter With and Without Ovarian Sertoli-Leydig Cell Tumors","volume":"305","author":"Frio","year":"2011","journal-title":"JAMA"},{"key":"ref_21","doi-asserted-by":"crossref","first-page":"965","DOI":"10.1126\/science.1174334","article-title":"DICER1 Mutations in Familial Pleuropulmonary Blastoma","volume":"325","author":"Hill","year":"2009","journal-title":"Science"},{"key":"ref_22","doi-asserted-by":"crossref","first-page":"886","DOI":"10.1007\/s00268-004-7475-4","article-title":"Cribriform-morular variant of papillary thyroid carcinoma: Clue to early detection of familial adenomatous polyposis-associated colon cancer","volume":"28","author":"Tomoda","year":"2004","journal-title":"World J. Surg."},{"key":"ref_23","doi-asserted-by":"crossref","first-page":"380","DOI":"10.1089\/thy.2019.0561","article-title":"Thyroid Carcinomas That Occur in Familial Adenomatous Polyposis Patients Recurrently Harbor Somatic Variants in APC, BRAF, and KTM2D","volume":"30","author":"Nieminen","year":"2020","journal-title":"Thyroid"},{"key":"ref_24","doi-asserted-by":"crossref","first-page":"1400","DOI":"10.1001\/jamaoncol.2016.6389","article-title":"Frequency of Thyroid Carcinoma in Brazilian TP53 p.R337H Carriers with Li Fraumeni Syndrome","volume":"3","author":"Formiga","year":"2017","journal-title":"JAMA Oncol."},{"key":"ref_25","doi-asserted-by":"crossref","first-page":"105","DOI":"10.1016\/j.arr.2016.03.002","article-title":"Werner syndrome: Clinical features, pathogenesis and potential therapeutic interventions","volume":"33","author":"Oshima","year":"2017","journal-title":"Ageing Res. Rev."},{"key":"ref_26","doi-asserted-by":"crossref","unstructured":"Pereda, C.M., Lesueur, F., Pertesi, M., Robinot, N., Lence-Anta, J.J., Turcios, S., Velasco, M., Chappe, M., Infante, I., and Bustillo, M. (2015). Common variants at the 9q22.33, 14q13.3 and ATM loci, and risk of differentiated thyroid cancer in the Cuban population. BMC Genet., 16.","DOI":"10.1186\/s12863-015-0180-5"},{"key":"ref_27","doi-asserted-by":"crossref","unstructured":"Maillard, S., Damiola, F., Clero, E., Pertesi, M., Robinot, N., Rach\u00e9di, F., Boissin, J.-L., Sebbag, J., Shan, L., and Bost-Bezeaud, F. (2015). Common variants at 9q22.33, 14q13.3, and ATM loci, and risk of differentiated thyroid cancer in the French Polynesian population. PLoS ONE, 10.","DOI":"10.1371\/journal.pone.0123700"},{"key":"ref_28","doi-asserted-by":"crossref","first-page":"42","DOI":"10.1016\/j.ajhg.2010.11.013","article-title":"A clinical scoring system for selection of patients for PTEN mutation testing is proposed on the basis of a prospective study of 3042 probands","volume":"88","author":"Tan","year":"2011","journal-title":"Am. J. Hum. Genet."},{"key":"ref_29","doi-asserted-by":"crossref","first-page":"e76","DOI":"10.1158\/1078-0432.CCR-17-0629","article-title":"PTEN, DICER1, FH, and Their Associated Tumor Susceptibility Syndromes: Clinical Features, Genetics, and Surveillance Recommendations in Childhood","volume":"23","author":"Schultz","year":"2017","journal-title":"Clin. Cancer Res."},{"key":"ref_30","doi-asserted-by":"crossref","first-page":"171","DOI":"10.1530\/ERC-15-0359","article-title":"Germline PARP4 mutations in patients with primary thyroid and breast cancers","volume":"23","author":"Ikeda","year":"2016","journal-title":"Endocr. Relat. Cancer"},{"key":"ref_31","doi-asserted-by":"crossref","unstructured":"Yehia, L., Ni, Y., Sesock, K., Niazi, F., Fletcher, B., Chen, H.J.L., LaFramboise, T., and Eng, C. (2018). Unexpected cancer-predisposition gene variants in Cowden syndrome and Bannayan-Riley-Ruvalcaba syndrome patients without underlying germline PTEN mutations. PLoS Genet., 14.","DOI":"10.1371\/journal.pgen.1007352"},{"key":"ref_32","doi-asserted-by":"crossref","first-page":"E1316","DOI":"10.1210\/jc.2014-1225","article-title":"Germline alterations in RASAL1 in Cowden syndrome patients presenting with follicular thyroid cancer and in individuals with apparently sporadic epithelial thyroid cancer","volume":"99","author":"Ngeow","year":"2014","journal-title":"J. Clin. Endocrinol. Metab."},{"key":"ref_33","doi-asserted-by":"crossref","first-page":"2869","DOI":"10.1007\/s11033-018-4321-6","article-title":"Regulation and modulation of PTEN activity","volume":"45","author":"Naderali","year":"2018","journal-title":"Mol. Biol. Rep."},{"key":"ref_34","doi-asserted-by":"crossref","first-page":"13976","DOI":"10.1073\/pnas.1422504112","article-title":"Discovery and functional characterization of a neomorphic PTEN mutation","volume":"112","author":"Costa","year":"2015","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"ref_35","doi-asserted-by":"crossref","first-page":"24","DOI":"10.3389\/fonc.2015.00024","article-title":"PTEN: Multiple Functions in Human Malignant Tumors","volume":"5","author":"Milella","year":"2015","journal-title":"Front. Oncol."},{"key":"ref_36","first-page":"6105","article-title":"Overexpression and overactivation of Akt in thyroid carcinoma","volume":"61","author":"Ringel","year":"2001","journal-title":"Cancer Res."},{"key":"ref_37","doi-asserted-by":"crossref","first-page":"184","DOI":"10.1038\/nrc3431","article-title":"Molecular pathogenesis and mechanisms of thyroid cancer","volume":"13","author":"Xing","year":"2013","journal-title":"Nat. Rev. Cancer"},{"key":"ref_38","doi-asserted-by":"crossref","first-page":"1617","DOI":"10.1093\/jnci\/djt249","article-title":"Identification of RASAL1 as a major tumor suppressor gene in thyroid cancer","volume":"105","author":"Liu","year":"2013","journal-title":"J. Natl. Cancer Inst."},{"key":"ref_39","doi-asserted-by":"crossref","first-page":"R21","DOI":"10.1530\/JOE-18-0446","article-title":"Germline and mosaic mutations causing pituitary tumours: Genetic and molecular aspects","volume":"240","author":"Pepe","year":"2019","journal-title":"J. Endocrinol."},{"key":"ref_40","doi-asserted-by":"crossref","first-page":"8811","DOI":"10.1158\/0008-5472.CAN-04-3620","article-title":"Down-regulation of regulatory subunit type 1A of protein kinase A leads to endocrine and other tumors","volume":"64","author":"Griffin","year":"2004","journal-title":"Cancer Res."},{"key":"ref_41","doi-asserted-by":"crossref","first-page":"182","DOI":"10.1002\/gcc.10112","article-title":"Regulatory subunit type I-\u03b1 of protein kinase A (PRKAR1A): A tumor-suppressor gene for sporadic thyroid cancer","volume":"35","author":"Sandrini","year":"2002","journal-title":"Genes Chromosomes Cancer"},{"key":"ref_42","doi-asserted-by":"crossref","first-page":"435","DOI":"10.1530\/ERC-11-0306","article-title":"Thyroid-specific ablation of the Carney complex gene, PRKAR1A, results in hyperthyroidism and follicular thyroid cancer","volume":"19","author":"Pringle","year":"2012","journal-title":"Endocrine-Related Cancer"},{"key":"ref_43","doi-asserted-by":"crossref","first-page":"769","DOI":"10.3389\/fendo.2019.00769","article-title":"PKA Activates AMPK Through LKB1 Signaling in Follicular Thyroid Cancer","volume":"10","author":"Kari","year":"2019","journal-title":"Front. Endocrinol."},{"key":"ref_44","first-page":"239","article-title":"Excess of rare cancers in Werner syndrome (adult progeria)","volume":"5","author":"Goto","year":"1996","journal-title":"Cancer Epidemiol. Biomarkers Prev."},{"key":"ref_45","doi-asserted-by":"crossref","first-page":"369","DOI":"10.1007\/s00439-008-0562-0","article-title":"The clinical characteristics of Werner syndrome: Molecular and biochemical diagnosis","volume":"124","author":"Muftuoglu","year":"2008","journal-title":"Hum. Genet."},{"key":"ref_46","doi-asserted-by":"crossref","first-page":"13785","DOI":"10.1038\/ncomms13785","article-title":"WRN regulates pathway choice between classical and alternative non-homologous end joining","volume":"7","author":"Shamanna","year":"2016","journal-title":"Nat. Commun."},{"key":"ref_47","doi-asserted-by":"crossref","first-page":"1345","DOI":"10.1002\/(SICI)1097-0142(19990315)85:6<1345::AID-CNCR18>3.0.CO;2-#","article-title":"Unusual features of thyroid carcinomas in Japanese patients with Werner syndrome and possible genotype-phenotype relations to cell type and race","volume":"85","author":"Ishikawa","year":"1999","journal-title":"Cancer"},{"key":"ref_48","doi-asserted-by":"crossref","first-page":"775","DOI":"10.1007\/s00268-005-0368-3","article-title":"Mutational analysis of the APC gene in cribriform-morula variant of papillary thyroid carcinoma","volume":"30","author":"Uchino","year":"2006","journal-title":"World J. Surg."},{"key":"ref_49","doi-asserted-by":"crossref","unstructured":"De Herreros, A.G., and Du\u00f1ach, M. (2019). Intracellular Signals Activated by Canonical Wnt Ligands Independent of GSK3 Inhibition and \u03b2-Catenin Stabilization. Cells, 8.","DOI":"10.3390\/cells8101148"},{"key":"ref_50","doi-asserted-by":"crossref","first-page":"32","DOI":"10.1016\/j.mrfmmm.2009.09.004","article-title":"Genotype to phenotype: Analyzing the effects of inherited mutations in colorectal cancer families","volume":"693","author":"Heinen","year":"2010","journal-title":"Mutat. Res."},{"key":"ref_51","doi-asserted-by":"crossref","first-page":"1184","DOI":"10.1089\/thy.2013.0589","article-title":"Familial adenomatous polyposis-associated, cribriform morular variant of papillary thyroid carcinoma harboring a K-RAS mutation: Case presentation and review of molecular mechanisms","volume":"24","author":"Giannelli","year":"2014","journal-title":"Thyroid"},{"key":"ref_52","doi-asserted-by":"crossref","first-page":"372","DOI":"10.1111\/j.1349-7006.1999.tb00757.x","article-title":"Somatic mutation of the APC gene in thyroid carcinoma associated with familial adenomatous polyposis","volume":"90","author":"Iwama","year":"1999","journal-title":"Jpn. J. Cancer Res."},{"key":"ref_53","doi-asserted-by":"crossref","first-page":"1825","DOI":"10.1016\/S0002-9440(10)64821-3","article-title":"Molecular Evidence for Multicentric Development of Thyroid Carcinomas in Patients with Familial Adenomatous Polyposis","volume":"157","author":"Miyaki","year":"2000","journal-title":"Am. J. Pathol."},{"key":"ref_54","doi-asserted-by":"crossref","first-page":"223","DOI":"10.1038\/ajg.2014.435","article-title":"ACG clinical guideline: Genetic testing and management of hereditary gastrointestinal cancer syndromes","volume":"110","author":"Syngal","year":"2015","journal-title":"Am. J. Gastroenterol."},{"key":"ref_55","doi-asserted-by":"crossref","first-page":"e107","DOI":"10.1158\/1078-0432.CCR-17-0790","article-title":"Cancer Screening Recommendations and Clinical Management of Inherited Gastrointestinal Cancer Syndromes in Childhood","volume":"23","author":"Achatz","year":"2017","journal-title":"Clin. Cancer Res."},{"key":"ref_56","doi-asserted-by":"crossref","first-page":"3057","DOI":"10.1200\/JCO.2007.14.6613","article-title":"Risk of cancer by ATM missense mutations in the general population","volume":"26","author":"Dombernowsky","year":"2008","journal-title":"J. Clin. Oncol."},{"key":"ref_57","doi-asserted-by":"crossref","first-page":"154","DOI":"10.1016\/j.yexcr.2014.09.002","article-title":"ATM: Expanding roles as a chief guardian of genome stability","volume":"329","author":"Shiloh","year":"2014","journal-title":"Exp. Cell Res."},{"key":"ref_58","doi-asserted-by":"crossref","first-page":"26","DOI":"10.1016\/j.semcancer.2015.12.005","article-title":"Systemic DNA damage responses in aging and diseases","volume":"37\u201338","author":"Ribezzo","year":"2016","journal-title":"Semin. Cancer Biol."},{"key":"ref_59","doi-asserted-by":"crossref","first-page":"491","DOI":"10.1677\/ERC-08-0336","article-title":"Polymorphisms of DNA damage response genes in radiation-related and sporadic papillary thyroid carcinoma","volume":"16","author":"Akulevich","year":"2009","journal-title":"Endocr. Relat. Cancer"},{"key":"ref_60","doi-asserted-by":"crossref","first-page":"1913","DOI":"10.1210\/jc.2011-3299","article-title":"Functional variations in the ATM gene and susceptibility to differentiated thyroid carcinoma","volume":"97","author":"Xu","year":"2012","journal-title":"J. Clin. Endocrinol. Metab."},{"key":"ref_61","doi-asserted-by":"crossref","unstructured":"Gu, Y., Shi, J., Qiu, S., Qiao, Y., Zhang, X., Cheng, Y., and Liu, Y. (2018). Association between ATM rs1801516 polymorphism and cancer susceptibility: A meta-analysis involving 12,879 cases and 18,054 controls. BMC Cancer, 18.","DOI":"10.1186\/s12885-018-4941-1"},{"key":"ref_62","doi-asserted-by":"crossref","first-page":"70","DOI":"10.1002\/em.21898","article-title":"Single nucleotide polymorphisms of ataxia telangiectasia mutated and the risk of papillary thyroid carcinoma","volume":"56","author":"Song","year":"2015","journal-title":"Environ. Mol. Mutagen."},{"key":"ref_63","doi-asserted-by":"crossref","first-page":"516","DOI":"10.1002\/gcc.22162","article-title":"Variants in the ATM-CHEK2-BRCA1 axis determine genetic predisposition and clinical presentation of papillary thyroid carcinoma","volume":"53","author":"Czajka","year":"2014","journal-title":"Genes Chromosomes Cancer"},{"key":"ref_64","doi-asserted-by":"crossref","first-page":"2216","DOI":"10.1210\/jc.2017-02599","article-title":"Benign Thyroid Diseases and Risk of Thyroid Cancer: A Nationwide Cohort Study","volume":"103","author":"Kitahara","year":"2018","journal-title":"J. Clin. Endocrinol. Metab."},{"key":"ref_65","doi-asserted-by":"crossref","first-page":"571","DOI":"10.1016\/j.jamcollsurg.2012.12.022","article-title":"Cancer after Thyroidectomy: A Multi-Institutional Experience with 1,523 Patients","volume":"216","author":"Smith","year":"2013","journal-title":"J. Am. Coll. Surg."},{"key":"ref_66","doi-asserted-by":"crossref","first-page":"1614","DOI":"10.1210\/jc.2016-2954","article-title":"Quantification of Thyroid Cancer and Multinodular Goiter Risk in the DICER1 Syndrome: A Family-Based Cohort Study","volume":"102","author":"Khan","year":"2017","journal-title":"J. Clin. Endocrinol. Metab."},{"key":"ref_67","doi-asserted-by":"crossref","first-page":"321","DOI":"10.1038\/nrc3932","article-title":"MicroRNA biogenesis pathways in cancer","volume":"15","author":"Lin","year":"2015","journal-title":"Nat. Rev. Cancer"},{"key":"ref_68","doi-asserted-by":"crossref","first-page":"1785","DOI":"10.18632\/oncotarget.26639","article-title":"DICER1 somatic mutations strongly impair miRNA processing even in benign thyroid lesions","volume":"10","author":"Poma","year":"2019","journal-title":"Oncotarget"},{"key":"ref_69","doi-asserted-by":"crossref","first-page":"44","DOI":"10.1016\/j.mce.2016.12.017","article-title":"MicroRNAs in thyroid development, function and tumorigenesis","volume":"456","author":"Fuziwara","year":"2017","journal-title":"Mol. Cell. Endocrinol."},{"key":"ref_70","doi-asserted-by":"crossref","unstructured":"Rodriguez, W., Jin, L., Janssens, V., Pierreux, C., Hick, A.-C., Urizar, E., and Costagliola, S. (2012). Deletion of the RNaseIII Enzyme Dicer in Thyroid Follicular Cells Causes Hypothyroidism with Signs of Neoplastic Alterations. PLoS ONE, 7.","DOI":"10.1371\/journal.pone.0029929"},{"key":"ref_71","doi-asserted-by":"crossref","unstructured":"Frezzetti, D., Reale, C., Cal\u00ec, G., Nitsch, L., Fagman, H., Nilsson, O., Scarf\u00f2, M., De Vita, G., and Di Lauro, R. (2011). The microRNA-Processing Enzyme Dicer Is Essential for Thyroid Function. PLoS ONE, 6.","DOI":"10.1371\/journal.pone.0027648"},{"key":"ref_72","doi-asserted-by":"crossref","first-page":"2251","DOI":"10.1158\/1078-0432.CCR-17-3089","article-title":"DICER1 and Associated Conditions: Identification of At-risk Individuals and Recommended Surveillance Strategies","volume":"24","author":"Schultz","year":"2018","journal-title":"Clin. Cancer Res."},{"key":"ref_73","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1210\/jc.2015-2169","article-title":"DICER1Mutations and Differentiated Thyroid Carcinoma: Evidence of a Direct Association","volume":"101","author":"Rutter","year":"2016","journal-title":"J. Clin. Endocrinol. Metab."},{"key":"ref_74","doi-asserted-by":"crossref","first-page":"401","DOI":"10.1158\/2159-8290.CD-12-0095","article-title":"The cBio Cancer Genomics Portal: An Open Platform for Exploring Multidimensional Cancer Genomics Data: Figure 1","volume":"2","author":"Cerami","year":"2012","journal-title":"Cancer Discov."},{"key":"ref_75","doi-asserted-by":"crossref","first-page":"pl1","DOI":"10.1126\/scisignal.2004088","article-title":"Integrative Analysis of Complex Cancer Genomics and Clinical Profiles Using the cBioPortal","volume":"6","author":"Gao","year":"2013","journal-title":"Sci. Signal."},{"key":"ref_76","unstructured":"(2020, August 16). cBioPortal for Cancer Genomics. Available online: https:\/\/www.cbioportal.org."},{"key":"ref_77","unstructured":"Cancer Genome Atlas Research Network (2014). Integrated genomic characterization of papillary thyroid carcinoma. Cell, 159, 676\u2013690."},{"key":"ref_78","doi-asserted-by":"crossref","first-page":"1052","DOI":"10.1172\/JCI85271","article-title":"Genomic and transcriptomic hallmarks of poorly differentiated and anaplastic thyroid cancers","volume":"126","author":"Landa","year":"2016","journal-title":"J. Clin. Investig."},{"key":"ref_79","doi-asserted-by":"crossref","first-page":"1264","DOI":"10.1038\/s41379-020-0458-7","article-title":"Poorly differentiated thyroid carcinoma of childhood and adolescence: A distinct entity characterized by DICER1 mutations","volume":"33","author":"Chernock","year":"2020","journal-title":"Mod. Pathol."},{"key":"ref_80","doi-asserted-by":"crossref","first-page":"2009","DOI":"10.1210\/jc.2017-02698","article-title":"DICER1 Mutations Are Frequent in Adolescent-Onset Papillary Thyroid Carcinoma","volume":"103","author":"Wasserman","year":"2018","journal-title":"J. Clin. Endocrinol. Metab."},{"key":"ref_81","doi-asserted-by":"crossref","unstructured":"Canberk, S., Ferreira, J.C., Pereira, L., Bat\u0131sta, R., Vieira, A.F., Soares, P., Sim\u00f5es, M.S., and M\u00e1ximo, V. (2020). Analyzing the Role of DICER1 Germline Variations in Papillary Thyroid Carcinoma. Eur. Thyroid J., 1\u20138.","DOI":"10.1159\/000509183"},{"key":"ref_82","doi-asserted-by":"crossref","first-page":"1479","DOI":"10.1172\/JCI130206","article-title":"DGCR8 microprocessor defect characterizes familial multinodular goiter with schwannomatosis","volume":"130","author":"Rivera","year":"2020","journal-title":"J. Clin. Investig."},{"key":"ref_83","doi-asserted-by":"crossref","first-page":"1062","DOI":"10.1016\/j.cell.2017.08.028","article-title":"Putting p53 in Context","volume":"170","author":"Kastenhuber","year":"2017","journal-title":"Cell"},{"key":"ref_84","doi-asserted-by":"crossref","first-page":"1600","DOI":"10.1093\/jnci\/86.21.1600","article-title":"Systematic Population-Based Assessment of Cancer Risk in First-Degree Relatives of Cancer Probands","volume":"86","author":"Goldgar","year":"1994","journal-title":"J. Natl. Cancer Inst."},{"key":"ref_85","doi-asserted-by":"crossref","first-page":"5747","DOI":"10.1210\/jc.2005-0935","article-title":"Familial Risks for Nonmedullary Thyroid Cancer","volume":"90","author":"Hemminki","year":"2005","journal-title":"J. Clin. Endocrinol. Metab."},{"key":"ref_86","doi-asserted-by":"crossref","first-page":"141","DOI":"10.1159\/000345674","article-title":"Clinical Behavior and Genetics of Nonsyndromic, Familial Nonmedullary Thyroid Cancer","volume":"41","author":"Bauer","year":"2013","journal-title":"Front. Horm. Res."},{"key":"ref_87","doi-asserted-by":"crossref","first-page":"1075","DOI":"10.1677\/ERC-08-0080","article-title":"Familial non-medullary thyroid carcinoma displays the features of clinical anticipation suggestive of a distinct biological entity","volume":"15","author":"Capezzone","year":"2008","journal-title":"Endocr. Relat. Cancer"},{"key":"ref_88","doi-asserted-by":"crossref","first-page":"E973","DOI":"10.1210\/jc.2012-3823","article-title":"SRGAP1 Is a Candidate Gene for Papillary Thyroid Carcinoma Susceptibility","volume":"98","author":"He","year":"2013","journal-title":"J. Clin. Endocrinol. Metab."},{"key":"ref_89","doi-asserted-by":"crossref","first-page":"1073","DOI":"10.1016\/j.surg.2009.09.012","article-title":"Distinct loci on chromosome 1q21 and 6q22 predispose to familial nonmedullary thyroid cancer: A SNP array-based linkage analysis of 38 families","volume":"146","author":"Suh","year":"2009","journal-title":"Surgery"},{"key":"ref_90","doi-asserted-by":"crossref","first-page":"625","DOI":"10.1158\/0008-5472.CAN-08-1071","article-title":"A Susceptibility Locus for Papillary Thyroid Carcinoma on Chromosome 8q24","volume":"69","author":"He","year":"2009","journal-title":"Cancer Res."},{"key":"ref_91","doi-asserted-by":"crossref","unstructured":"He, H., Li, W., Wu, D., Nagy, R., Liyanarachchi, S., Akagi, K., Jendrzejewski, J., Jiao, H., Hoag, K., and Wen, B. (2013). Ultra-Rare Mutation in Long-Range Enhancer Predisposes to Thyroid Carcinoma with High Penetrance. PLoS ONE, 8.","DOI":"10.1371\/annotation\/1cd4e899-2184-497b-b659-de1722b6d402"},{"key":"ref_92","doi-asserted-by":"crossref","first-page":"162","DOI":"10.1093\/jnci\/djn471","article-title":"A Germline Mutation (A339V) in Thyroid Transcription Factor-1 (TITF-1\/NKX2.1) in Patients with Multinodular Goiter and Papillary Thyroid Carcinoma","volume":"101","author":"Ngan","year":"2009","journal-title":"J. Natl. Cancer Inst."},{"key":"ref_93","doi-asserted-by":"crossref","first-page":"407","DOI":"10.1136\/jmg.2003.017350","article-title":"Evidence for interaction between the TCO and NMTC1 loci in familial non-medullary thyroid cancer","volume":"41","author":"McKay","year":"2004","journal-title":"J. Med. Genet."},{"key":"ref_94","doi-asserted-by":"crossref","first-page":"514","DOI":"10.1089\/thy.2014.0257","article-title":"RAGE Mediates the Pro-Migratory Response of Extracellular S100A4 in Human Thyroid Cancer Cells","volume":"25","author":"Medapati","year":"2015","journal-title":"Thyroid"},{"key":"ref_95","doi-asserted-by":"crossref","first-page":"345","DOI":"10.1210\/jcem.82.2.3789","article-title":"Two Families with an Autosomal Dominant Inheritance Pattern for Papillary Carcinoma of the Thyroid","volume":"82","author":"Burgess","year":"1997","journal-title":"J. Clin. Endocrinol. Metab."},{"key":"ref_96","doi-asserted-by":"crossref","first-page":"475","DOI":"10.1677\/erc.1.01138","article-title":"A new form of familial multi-nodular goitre with progression to differentiated thyroid cancer","volume":"13","author":"Bakhsh","year":"2006","journal-title":"Endocr.-Relat. Cancer"},{"key":"ref_97","doi-asserted-by":"crossref","first-page":"583","DOI":"10.1023\/A:1008907227706","article-title":"A pooled analysis of case\u2014Control studies of thyroid cancer. IV. Benign thyroid diseases","volume":"10","author":"Franceschi","year":"1999","journal-title":"Cancer Causes Control."},{"key":"ref_98","doi-asserted-by":"crossref","first-page":"460","DOI":"10.1038\/ng.339","article-title":"Common variants on 9q22.33 and 14q13.3 predispose to thyroid cancer in European populations","volume":"41","author":"Gudmundsson","year":"2009","journal-title":"Nat. Genet."},{"key":"ref_99","doi-asserted-by":"crossref","first-page":"319","DOI":"10.1038\/ng.1046","article-title":"Discovery of common variants associated with low TSH levels and thyroid cancer risk","volume":"44","author":"Gudmundsson","year":"2012","journal-title":"Nat. Genet."},{"key":"ref_100","doi-asserted-by":"crossref","first-page":"2516","DOI":"10.1093\/hmg\/ddq123","article-title":"The FOXE1 locus is a major genetic determinant for radiation-related thyroid carcinoma in Chernobyl","volume":"19","author":"Takahashi","year":"2010","journal-title":"Hum. Mol. Genet."},{"key":"ref_101","doi-asserted-by":"crossref","first-page":"E1674","DOI":"10.1210\/jc.2013-1941","article-title":"Genome-Wide Association Study on Differentiated Thyroid Cancer","volume":"98","author":"Chen","year":"2013","journal-title":"J. Clin. Endocrinol. Metab."},{"key":"ref_102","doi-asserted-by":"crossref","first-page":"15966","DOI":"10.1038\/ncomms15966","article-title":"Genome-wide association and expression quantitative trait loci studies identify multiple susceptibility loci for thyroid cancer","volume":"8","author":"Son","year":"2017","journal-title":"Nat. Commun."},{"key":"ref_103","doi-asserted-by":"crossref","first-page":"14517","DOI":"10.1038\/ncomms14517","article-title":"A genome-wide association study yields five novel thyroid cancer risk loci","volume":"8","author":"Gudmundsson","year":"2017","journal-title":"Nat. Commun."},{"key":"ref_104","doi-asserted-by":"crossref","first-page":"224","DOI":"10.1089\/thy.2015.0541","article-title":"Genotype Analyses in the Japanese and Belarusian Populations Reveal Independent Effects of rs965513 and rs1867277 but Do Not Support the Role of FOXE1 Polyalanine Tract Length in Conferring Risk for Papillary Thyroid Carcinoma","volume":"27","author":"Nikitski","year":"2017","journal-title":"Thyroid"},{"key":"ref_105","doi-asserted-by":"crossref","unstructured":"Landa, I., Ruiz-Llorente, S., Montero-Conde, C., Inglada-P\u00e9rez, L., Schiavi, F., Leskel\u00e4, S., Pita, G., Milne, R., Maravall, J., and Ramos, I. (2009). The Variant rs1867277 in FOXE1 Gene Confers Thyroid Cancer Susceptibility through the Recruitment of USF1\/USF2 Transcription Factors. PLoS Genet., 5.","DOI":"10.1371\/journal.pgen.1000637"},{"key":"ref_106","doi-asserted-by":"crossref","first-page":"2182","DOI":"10.1210\/en.2015-2066","article-title":"Targeted Foxe1 Overexpression in Mouse Thyroid Causes the Development of Multinodular Goiter But Does Not Promote Carcinogenesis","volume":"157","author":"Nikitski","year":"2016","journal-title":"Endocrinology"},{"key":"ref_107","doi-asserted-by":"crossref","first-page":"474","DOI":"10.1073\/pnas.1619917114","article-title":"MYH9 binds to lncRNA genePTCSC2and regulates FOXE1 in the 9q22 thyroid cancer risk locus","volume":"114","author":"Wang","year":"2017","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"ref_108","doi-asserted-by":"crossref","first-page":"158","DOI":"10.1136\/jmedgenet-2011-100586","article-title":"Thyroid cancer susceptibility polymorphisms: Confirmation of loci on chromosomes 9q22 and 14q13, validation of a recessive 8q24 locus and failure to replicate a locus on 5q24","volume":"49","author":"Jones","year":"2012","journal-title":"J. Med. Genet."},{"key":"ref_109","doi-asserted-by":"crossref","first-page":"8646","DOI":"10.1073\/pnas.1205654109","article-title":"The polymorphism rs944289 predisposes to papillary thyroid carcinoma through a large intergenic noncoding RNA gene of tumor suppressor type","volume":"109","author":"Jendrzejewski","year":"2012","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"ref_110","doi-asserted-by":"crossref","first-page":"1662","DOI":"10.1038\/s41598-017-01957-0","article-title":"Identification of Long Noncoding RNAs Deregulated in Papillary Thyroid Cancer and Correlated with BRAFV600E Mutation by Bioinformatics Integrative Analysis","volume":"7","author":"Goedert","year":"2017","journal-title":"Sci. Rep."},{"key":"ref_111","doi-asserted-by":"crossref","first-page":"E1370","DOI":"10.1210\/jc.2015-2247","article-title":"PTCSC3 Is Involved in Papillary Thyroid Carcinoma Development by Modulating S100A4 Gene Expression","volume":"100","author":"Jendrzejewski","year":"2015","journal-title":"J. Clin. Endocrinol. Metab."},{"key":"ref_112","doi-asserted-by":"crossref","first-page":"4","DOI":"10.1186\/1756-6614-3-4","article-title":"Lack of germline A339V mutation in thyroid transcription factor-1 (TITF-1\/NKX2.1) gene in familial papillary thyroid cancer","volume":"3","author":"Cantara","year":"2010","journal-title":"Thyroid Res."},{"key":"ref_113","doi-asserted-by":"crossref","first-page":"1369","DOI":"10.1210\/jc.2017-01798","article-title":"The Role of NRG1 in the Predisposition to Papillary Thyroid Carcinoma","volume":"103","author":"He","year":"2018","journal-title":"J. Clin. Endocrinol. Metab."},{"key":"ref_114","doi-asserted-by":"crossref","unstructured":"Coe, E.A., Tan, J.Y., Shapiro, M., Louphrasitthiphol, P., Bassett, A.R., Marques, A.C., Goding, C.R., and Vance, K.W. (2019). The MITF-SOX10 regulated long non-coding RNA DIRC3 is a melanoma tumour suppressor. PLoS Genet., 15.","DOI":"10.1101\/591065"},{"key":"ref_115","doi-asserted-by":"crossref","first-page":"1111","DOI":"10.1158\/1078-0432.CCR-15-1746","article-title":"Association between GWAS-Derived rs966423 Genetic Variant and Overall Mortality in Patients with Differentiated Thyroid Cancer","volume":"22","author":"Stachlewska","year":"2016","journal-title":"Clin. Cancer Res."},{"key":"ref_116","doi-asserted-by":"crossref","unstructured":"Hi\u0144cza, K., Kowalik, A., Pa\u0142yga, I., Walczyk, A., G\u0105sior-Perczak, D., Mikina, E., Trybek, T., Szymonek, M., Gadawska-Juszczyk, K., and Zajkowska, K. (2020). Does the TT Variant of the rs966423 Polymorphism in DIRC3 Affect the Stage and Clinical Course of Papillary Thyroid Cancer?. Cancers, 12.","DOI":"10.3390\/cancers12020423"},{"key":"ref_117","doi-asserted-by":"crossref","first-page":"5997","DOI":"10.1073\/pnas.1919976117","article-title":"Assessing thyroid cancer risk using polygenic risk scores","volume":"117","author":"Liyanarachchi","year":"2020","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"ref_118","doi-asserted-by":"crossref","first-page":"3950","DOI":"10.1210\/jc.2008-0372","article-title":"Short Telomeres, Telomerase Reverse Transcriptase Gene Amplification, and Increased Telomerase Activity in the Blood of Familial Papillary Thyroid Cancer Patients","volume":"93","author":"Capezzone","year":"2008","journal-title":"J. Clin. Endocrinol. Metab."},{"key":"ref_119","doi-asserted-by":"crossref","first-page":"301","DOI":"10.1089\/thy.2012.0270","article-title":"Telomere Length Is Shorter in Affected Members of Families with Familial Nonmedullary Thyroid Cancer","volume":"23","author":"He","year":"2013","journal-title":"Thyroid"},{"key":"ref_120","doi-asserted-by":"crossref","first-page":"363","DOI":"10.1089\/thy.2011.0109","article-title":"Lack of Mutations of the Telomerase RNA Component in Familial Papillary Thyroid Cancer with Short Telomeres","volume":"22","author":"Cantara","year":"2012","journal-title":"Thyroid"},{"key":"ref_121","doi-asserted-by":"crossref","first-page":"204","DOI":"10.1089\/thy.2019.0156","article-title":"A Truncating Germline Mutation of TINF2 in Individuals with Thyroid Cancer or Melanoma Results in Longer Telomeres","volume":"30","author":"He","year":"2020","journal-title":"Thyroid"},{"key":"ref_122","doi-asserted-by":"crossref","unstructured":"Srivastava, A., Miao, B., Skopelitou, D., Kumar, V., Kumar, A., Paramasivam, N., Bonora, E., Hemminki, K., Foersti, A., and Bandapalli, O.R. (2020). A Germline Mutation in the POT1 Gene Is a Candidate for Familial Non-Medullary Thyroid Cancer. Cancers, 12.","DOI":"10.1101\/2020.03.23.004663"},{"key":"ref_123","doi-asserted-by":"crossref","first-page":"561","DOI":"10.1007\/s10689-017-9984-y","article-title":"A new POT1 germline mutation\u2014expanding the spectrum of POT1-associated cancers","volume":"16","author":"Wilson","year":"2017","journal-title":"Fam. Cancer"},{"key":"ref_124","doi-asserted-by":"crossref","unstructured":"Richard, M.A., Lupo, P.J., Morton, L.M., Yasui, Y.A., Sapkota, Y.A., Arnold, M.A., Aubert, G., Neglia, J.P., Turcotte, L.M., and Leisenring, W.M. (2020). Genetic variation in POT1 and risk of thyroid subsequent malignant neoplasm: A report from the Childhood Cancer Survivor Study. PLoS ONE, 15.","DOI":"10.1371\/journal.pone.0228887"},{"key":"ref_125","doi-asserted-by":"crossref","first-page":"6475","DOI":"10.18632\/oncotarget.14129","article-title":"Variants in microRNA genes in familial papillary thyroid carcinoma","volume":"8","author":"Tomsic","year":"2017","journal-title":"Oncotarget"},{"key":"ref_126","doi-asserted-by":"crossref","first-page":"10566","DOI":"10.1038\/srep10566","article-title":"A germline mutation in SRRM2, a splicing factor gene, is implicated in papillary thyroid carcinoma predisposition","volume":"5","author":"Tomsic","year":"2015","journal-title":"Sci. Rep."},{"key":"ref_127","doi-asserted-by":"crossref","unstructured":"Orois, A., Gara, S.K., Mora, M., Halperin, I., Mart\u00ednez, S., Alfayate, R., Kebebew, E., and Oriola, J. (2019). NOP53 as A Candidate Modifier Locus for Familial Non-Medullary Thyroid Cancer. Genes, 10.","DOI":"10.3390\/genes10110899"},{"key":"ref_128","doi-asserted-by":"crossref","first-page":"448","DOI":"10.1056\/NEJMoa1502449","article-title":"Germline HABP2 Mutation Causing Familial Nonmedullary Thyroid Cancer","volume":"373","author":"Gara","year":"2015","journal-title":"N. Engl. J. Med."},{"key":"ref_129","first-page":"2086","article-title":"HABP2 Mutation and Nonmedullary Thyroid Cancer","volume":"373","author":"Tomsic","year":"2015","journal-title":"N. Engl. J. Med."},{"key":"ref_130","doi-asserted-by":"crossref","unstructured":"Tomsic, J., Fultz, R., Liyanarachchi, S., He, H., Senter, L., and De La Chapelle, A. (2016). HABP2 G534E Variant in Papillary Thyroid Carcinoma. PLoS ONE, 11.","DOI":"10.1371\/journal.pone.0146315"},{"key":"ref_131","doi-asserted-by":"crossref","first-page":"58304","DOI":"10.18632\/oncotarget.16870","article-title":"The p.G534E variant of HABP2 is not associated with sporadic papillary thyroid carcinoma in a Polish population","volume":"8","author":"Kowalik","year":"2017","journal-title":"Oncotarget"},{"key":"ref_132","doi-asserted-by":"crossref","first-page":"e1015","DOI":"10.1002\/mgg3.1015","article-title":"Identification of susceptibility gene mutations associated with the pathogenesis of familial nonmedullary thyroid cancer","volume":"7","author":"Zhu","year":"2019","journal-title":"Mol. Genet. Genom. Med."},{"key":"ref_133","doi-asserted-by":"crossref","first-page":"14","DOI":"10.1007\/s12022-020-09607-4","article-title":"Germline Mutations in Familial Papillary Thyroid Cancer","volume":"31","author":"Sarquis","year":"2020","journal-title":"Endocr. Pathol."},{"key":"ref_134","first-page":"548","article-title":"CHEK2mutations and the risk of papillary thyroid cancer","volume":"137","author":"Cybulski","year":"2015","journal-title":"Int. J. Cancer"}],"container-title":["Genes"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.mdpi.com\/2073-4425\/11\/11\/1364\/pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,11]],"date-time":"2025-10-11T10:33:49Z","timestamp":1760178829000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.mdpi.com\/2073-4425\/11\/11\/1364"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020,11,18]]},"references-count":134,"journal-issue":{"issue":"11","published-online":{"date-parts":[[2020,11]]}},"alternative-id":["genes11111364"],"URL":"https:\/\/doi.org\/10.3390\/genes11111364","relation":{},"ISSN":["2073-4425"],"issn-type":[{"value":"2073-4425","type":"electronic"}],"subject":[],"published":{"date-parts":[[2020,11,18]]}}}