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ASD is a complex disorder with known environmental and genetic contributors; however, ASD etiology is far from being clear. In the past decades, many efforts have been put into developing new models to study ASD, both in vitro and in vivo. These models have a lot of potential to help to validate some of the previously associated risk factors to the development of the disorder, and to test new potential therapies that help to alleviate ASD symptoms. The present review is focused on the recent advances towards the generation of models for the study of ASD, which would be a useful tool to decipher the bases of the disorder, as well as to conduct drug screenings that hopefully lead to the identification of useful compounds to help patients deal with the symptoms of ASD.<\/jats:p>","DOI":"10.3390\/genes11111376","type":"journal-article","created":{"date-parts":[[2020,11,20]],"date-time":"2020-11-20T09:46:18Z","timestamp":1605865578000},"page":"1376","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":28,"title":["Experimental Models to Study Autism Spectrum Disorders: hiPSCs, Rodents and Zebrafish"],"prefix":"10.3390","volume":"11","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-1622-3068","authenticated-orcid":false,"given":"Alba","family":"Pensado-L\u00f3pez","sequence":"first","affiliation":[{"name":"Department of Zoology, Genetics and Physical Anthropology, Universidade de Santiago de Compostela, Campus de Lugo, 27002 Lugo, Spain"},{"name":"Genomic Medicine Group, Center for Research in Molecular Medicine and Chronic Diseases (CiMUS), Universidade de Santiago de Compostela, 15706 Santiago de Compostela, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2363-2815","authenticated-orcid":false,"given":"Sara","family":"Veiga-R\u00faa","sequence":"additional","affiliation":[{"name":"Department of Zoology, Genetics and Physical Anthropology, Universidade de Santiago de Compostela, Campus de Lugo, 27002 Lugo, Spain"},{"name":"Genomic Medicine Group, Center for Research in Molecular Medicine and Chronic Diseases (CiMUS), Universidade de Santiago de Compostela, 15706 Santiago de Compostela, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1085-8986","authenticated-orcid":false,"given":"\u00c1ngel","family":"Carracedo","sequence":"additional","affiliation":[{"name":"Genomic Medicine Group, Center for Research in Molecular Medicine and Chronic Diseases (CiMUS), Universidade de Santiago de Compostela, 15706 Santiago de Compostela, Spain"},{"name":"Centro de Investigaci\u00f3n Biom\u00e9dica en Red de Enfermedades Raras (CIBERER), CIMUS, Universidade de Santiago de Compostela, 15706 Santiago de Compostela, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Catarina","family":"Allegue","sequence":"additional","affiliation":[{"name":"Genomic Medicine Group, Center for Research in Molecular Medicine and Chronic Diseases (CiMUS), Universidade de Santiago de Compostela, 15706 Santiago de Compostela, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7927-5303","authenticated-orcid":false,"given":"Laura","family":"S\u00e1nchez","sequence":"additional","affiliation":[{"name":"Department of Zoology, Genetics and Physical Anthropology, Universidade de Santiago de Compostela, Campus de Lugo, 27002 Lugo, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2020,11,20]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","unstructured":"American Psychiatric Association (2013). Diagnostic and Statistical Manual of Mental Disorders (DSM-5), American Psychiatric Publishing. [5th ed.].","DOI":"10.1176\/appi.books.9780890425596"},{"key":"ref_2","unstructured":"IHME, Global Burden of Disease (2020, March 20). Prevalence of Autistic Spectrum Disorder. Available online: https:\/\/ourworldindata.org\/grapher\/prevalence-of-autistic-spectrum."},{"key":"ref_3","doi-asserted-by":"crossref","first-page":"81","DOI":"10.1146\/annurev-publhealth-031816-044318","article-title":"The changing epidemiology of Autism Spectrum Disorders","volume":"38","author":"Lyall","year":"2017","journal-title":"Annu. Rev. Public Health"},{"key":"ref_4","unstructured":"Global Burden of Disease Collaborative Network (2020, March 20). Global Burden of Disease Study 2016 (GBD 2016) Results. Available online: http:\/\/ghdx.healthdata.org\/gbd-results-tool."},{"key":"ref_5","doi-asserted-by":"crossref","first-page":"1","DOI":"10.15585\/mmwr.ss6513a1","article-title":"Prevalence and characteristics of Autism Spectrum Disorder among children aged 8 years\u2014Autism and developmental disabilities monitoring network, 11 sites, United States, 2012","volume":"65","author":"Christensen","year":"2018","journal-title":"MMWR Surveill. Summ."},{"key":"ref_6","unstructured":"R Core Team (2020). R: A Language and Environment for Statistical Computing, R Foundation for Statistical Computing."},{"key":"ref_7","doi-asserted-by":"crossref","unstructured":"Mitchell, K.J. (2015). The Genetics of Neurodevelopmental Disorders, John Wiley & Sons, Inc.. [1st ed.].","DOI":"10.1002\/9781118524947"},{"key":"ref_8","doi-asserted-by":"crossref","first-page":"155","DOI":"10.1016\/j.reprotox.2015.05.007","article-title":"Prenatal factors associated with Autism Spectrum Disorder (ASD)","volume":"56","author":"Ornoy","year":"2015","journal-title":"Reprod. Toxicol."},{"key":"ref_9","doi-asserted-by":"crossref","first-page":"102","DOI":"10.1016\/j.mehy.2009.07.052","article-title":"Environmental risk factors for autism: Do they help cause de novo genetic mutations that contribute to the disorder?","volume":"74","author":"Kinney","year":"2010","journal-title":"Med. Hypotheses"},{"key":"ref_10","doi-asserted-by":"crossref","first-page":"13","DOI":"10.1186\/s13229-017-0121-4","article-title":"Environmental risk factors for autism: An evidence-based review of systematic reviews and meta-analyses","volume":"8","author":"Modabbernia","year":"2017","journal-title":"Mol. Autism"},{"key":"ref_11","doi-asserted-by":"crossref","first-page":"943","DOI":"10.1038\/35103559","article-title":"Genetics of austim: Complex aetiology for a heterogeneous disorder","volume":"2","author":"Folstein","year":"2001","journal-title":"Nat. Rev. Genet."},{"key":"ref_12","doi-asserted-by":"crossref","first-page":"907","DOI":"10.1001\/archpediatrics.2009.98","article-title":"Characteristics and concordance of Autism Spectrum Disorders among 277 twin pairs","volume":"163","author":"Rosenberg","year":"2009","journal-title":"Arch. Pediatr. Adolesc. Med."},{"key":"ref_13","doi-asserted-by":"crossref","first-page":"409","DOI":"10.1016\/j.tics.2011.07.003","article-title":"Genetics of autism spectrum disorders","volume":"15","author":"Geschwind","year":"2011","journal-title":"Trends Cogn. Sci."},{"key":"ref_14","doi-asserted-by":"crossref","first-page":"125","DOI":"10.3389\/fpsyt.2017.00125","article-title":"Editorial: Autism spectrum disorders: Developmental trajectories, neurobiological basis, treatment update","volume":"8","author":"Canitano","year":"2017","journal-title":"Front Psychiatry"},{"key":"ref_15","first-page":"94","article-title":"Involvement of synaptic genes in the pathogenesis of Autism Spectrum Disorders: The case of synapsins","volume":"2","author":"Corradi","year":"2014","journal-title":"Front. Pediatr."},{"key":"ref_16","doi-asserted-by":"crossref","first-page":"216","DOI":"10.1038\/nature13908","article-title":"The contribution of de novo coding mutations to Autism Spectrum Disorder","volume":"515","author":"Iossifov","year":"2014","journal-title":"Nature"},{"key":"ref_17","doi-asserted-by":"crossref","first-page":"685","DOI":"10.1126\/science.aav8130","article-title":"Single-cell genomics identifies cell type\u2013specific molecular changes in autism","volume":"364","author":"Velmeshev","year":"2019","journal-title":"Science"},{"key":"ref_18","doi-asserted-by":"crossref","first-page":"445","DOI":"10.1111\/dmcn.13717","article-title":"Progress in the genetics of Autism Spectrum Disorder","volume":"60","author":"Scherer","year":"2018","journal-title":"Dev. Med. Child. Neurol."},{"key":"ref_19","doi-asserted-by":"crossref","first-page":"406","DOI":"10.3389\/fgene.2018.00406","article-title":"De novo mutations (DNMs) in autism spectrum disorder (ASD): Pathway and network analysis","volume":"9","author":"Carracedo","year":"2018","journal-title":"Front. Genet."},{"key":"ref_20","doi-asserted-by":"crossref","first-page":"36","DOI":"10.1186\/2040-2392-4-36","article-title":"SFARI Gene 2.0: A community-driven knowledgebase for the autism spectrum disorders (ASDs)","volume":"4","author":"Abrahams","year":"2013","journal-title":"Mol. Autism"},{"key":"ref_21","unstructured":"(2019, May 16). SFARI Gene. Available online: https:\/\/gene.sfari.org\/."},{"key":"ref_22","doi-asserted-by":"crossref","first-page":"466","DOI":"10.1016\/j.jaac.2017.03.013","article-title":"What is the male-to-female ratio in Autism Spectrum Disorder? A systematic review and meta-analysis","volume":"56","author":"Loomes","year":"2017","journal-title":"J. Am. Acad. Child Adolesc. Psychiatry"},{"key":"ref_23","doi-asserted-by":"crossref","first-page":"e329","DOI":"10.1038\/tp.2013.108","article-title":"Neurodevelopmental disorders: Mechanisms and boundary definitions from genomes, interactomes and proteomes","volume":"3","author":"Mullin","year":"2013","journal-title":"Transl. Psychiatry"},{"key":"ref_24","first-page":"18","article-title":"Treatment of Autism Spectrum Disorder in children and adolescents","volume":"46","author":"DeFilippis","year":"2016","journal-title":"Psychopharmacol. Bull."},{"key":"ref_25","doi-asserted-by":"crossref","first-page":"303","DOI":"10.1007\/s40265-013-0021-7","article-title":"Pharmacotherapy for the core symptoms in autistic disorder: Current status of the research","volume":"73","author":"Farmer","year":"2013","journal-title":"Drugs"},{"key":"ref_26","doi-asserted-by":"crossref","first-page":"1156","DOI":"10.1073\/pnas.93.3.1156","article-title":"Hybrid restriction enzymes: Zinc finger fusions to Fok I cleavage domain","volume":"93","author":"Kim","year":"1996","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"ref_27","doi-asserted-by":"crossref","first-page":"757","DOI":"10.1534\/genetics.110.120717","article-title":"Targeting DNA double-strand breaks with TAL effector nucleases","volume":"186","author":"Christian","year":"2010","journal-title":"Genetics"},{"key":"ref_28","doi-asserted-by":"crossref","first-page":"e00471","DOI":"10.7554\/eLife.00471","article-title":"RNA-programmed genome editing in human cells","volume":"2","author":"Jinek","year":"2013","journal-title":"Elife"},{"key":"ref_29","doi-asserted-by":"crossref","first-page":"1258096","DOI":"10.1126\/science.1258096","article-title":"Genome Editing. The new frontier of genome engineering with CRISPR-Cas9","volume":"346","author":"Doudna","year":"2014","journal-title":"Science"},{"key":"ref_30","doi-asserted-by":"crossref","first-page":"1262","DOI":"10.1016\/j.cell.2014.05.010","article-title":"Development and applications of CRISPR-Cas9 for genome engineering","volume":"157","author":"Hsu","year":"2014","journal-title":"Cell"},{"key":"ref_31","doi-asserted-by":"crossref","first-page":"811","DOI":"10.1016\/j.tim.2016.06.005","article-title":"On the origin of CRISPR-Cas technology: From prokaryotes to mammals","volume":"24","author":"Mojica","year":"2016","journal-title":"Trends Microbiol."},{"key":"ref_32","doi-asserted-by":"crossref","first-page":"11","DOI":"10.1038\/nsmb.1710","article-title":"DNA resection in eukaryotes: Deciding how to fix the break","volume":"17","author":"Huertas","year":"2010","journal-title":"Nat. Struct. Mol. Biol."},{"key":"ref_33","doi-asserted-by":"crossref","first-page":"773","DOI":"10.1534\/genetics.111.131433","article-title":"Genome engineering with zinc-finger nucleases","volume":"188","author":"Carroll","year":"2011","journal-title":"Genetics"},{"key":"ref_34","doi-asserted-by":"crossref","first-page":"451","DOI":"10.1534\/genetics.110.117002","article-title":"Targeted genome modification in mice using zinc-finger nucleases","volume":"186","author":"Carbery","year":"2010","journal-title":"Genetics"},{"key":"ref_35","doi-asserted-by":"crossref","first-page":"851","DOI":"10.1038\/nbt.1562","article-title":"Efficient targeting of expressed and silent genes in human ESCs and iPSCs using zinc-finger nucleases","volume":"27","author":"Hockemeyer","year":"2009","journal-title":"Nat. Biotechnol."},{"key":"ref_36","doi-asserted-by":"crossref","first-page":"725","DOI":"10.1016\/j.neuron.2015.12.039","article-title":"Estrogens suppress a behavioral phenotype in zebrafish mutants of the autism risk gene, CNTNAP2","volume":"89","author":"Hoffman","year":"2016","journal-title":"Neuron"},{"key":"ref_37","doi-asserted-by":"crossref","first-page":"460","DOI":"10.1093\/bfgp\/eln043","article-title":"Emerging gene knockout technology in zebrafish: Zinc-finger nucleases","volume":"7","author":"Amacher","year":"2008","journal-title":"Br. Funct Genom. Proteom."},{"key":"ref_38","doi-asserted-by":"crossref","first-page":"49","DOI":"10.1038\/nrm3486","article-title":"TALENs: A widely applicable technology for targeted genome editing","volume":"14","author":"Joung","year":"2013","journal-title":"Nat. Rev. Mol. Cell Biol."},{"key":"ref_39","doi-asserted-by":"crossref","first-page":"29","DOI":"10.1016\/j.cell.2015.12.035","article-title":"Biology and applications of CRISPR systems: Harnessing nature\u2019s toolbox for genome engineering","volume":"164","author":"Wright","year":"2016","journal-title":"Cell"},{"key":"ref_40","doi-asserted-by":"crossref","first-page":"280","DOI":"10.1038\/nature24049","article-title":"RNA targeting with CRISPR\u2013Cas13","volume":"550","author":"Abudayyeh","year":"2017","journal-title":"Nature"},{"key":"ref_41","doi-asserted-by":"crossref","first-page":"665","DOI":"10.1016\/j.cell.2018.02.033","article-title":"Transcriptome engineering with RNA-Targeting Type VI-D CRISPR effectors","volume":"173","author":"Konermann","year":"2018","journal-title":"Cell"},{"key":"ref_42","doi-asserted-by":"crossref","first-page":"57","DOI":"10.1038\/nature26155","article-title":"Evolved Cas9 variants with broad PAM compatibility and high DNA specificity","volume":"556","author":"Hu","year":"2018","journal-title":"Nature"},{"key":"ref_43","doi-asserted-by":"crossref","first-page":"84","DOI":"10.1126\/science.aad5227","article-title":"Rationally engineered Cas9 nucleases with improved specificity","volume":"351","author":"Slaymaker","year":"2016","journal-title":"Science"},{"key":"ref_44","doi-asserted-by":"crossref","first-page":"1173","DOI":"10.1016\/j.cell.2013.02.022","article-title":"Repurposing CRISPR as an RNA-guided platform for sequence-specific control of gene expression","volume":"152","author":"Qi","year":"2013","journal-title":"Cell"},{"key":"ref_45","doi-asserted-by":"crossref","first-page":"973","DOI":"10.1038\/nmeth.2600","article-title":"RNA-guided gene activation by CRISPR-Cas9-based transcription factors","volume":"10","author":"Kocak","year":"2013","journal-title":"Nat. Methods"},{"key":"ref_46","doi-asserted-by":"crossref","first-page":"464","DOI":"10.1038\/nature24644","article-title":"Programmable base editing of A\u2022T to G\u2022C in genomic DNA without DNA cleavage","volume":"551","author":"Gaudelli","year":"2017","journal-title":"Nature"},{"key":"ref_47","doi-asserted-by":"crossref","first-page":"149","DOI":"10.1038\/s41586-019-1711-4","article-title":"Search-and-replace genome editing without double-strand breaks or donor DNA","volume":"576","author":"Anzalone","year":"2019","journal-title":"Nature"},{"key":"ref_48","doi-asserted-by":"crossref","first-page":"12","DOI":"10.1016\/j.stem.2014.06.011","article-title":"Whole-Genome Sequencing analysis reveals high specificity of CRISPR\/Cas9 and TALEN-based genome editing in human iPSCs","volume":"15","author":"Smith","year":"2014","journal-title":"Cell Stem Cell"},{"key":"ref_49","doi-asserted-by":"crossref","first-page":"132","DOI":"10.1101\/gr.162339.113","article-title":"Analysis of off-target effects of CRISPR\/Cas-derived RNA-guided endonucleases and nickases","volume":"24","author":"Cho","year":"2014","journal-title":"Genome Res."},{"key":"ref_50","doi-asserted-by":"crossref","first-page":"741","DOI":"10.1038\/nmeth.2532","article-title":"Heritable genome editing in C. elegans via a CRISPR-Cas9 system","volume":"10","author":"Friedland","year":"2013","journal-title":"Nat. Methods"},{"key":"ref_51","doi-asserted-by":"crossref","first-page":"220","DOI":"10.1016\/j.celrep.2013.06.020","article-title":"Highly efficient targeted mutagenesis of Drosophila with the CRISPR\/Cas9 System","volume":"4","author":"Bassett","year":"2013","journal-title":"Cell Rep."},{"key":"ref_52","doi-asserted-by":"crossref","first-page":"227","DOI":"10.1038\/nbt.2501","article-title":"Efficient genome editing in zebrafish using a CRISPR-Cas system","volume":"31","author":"Hwang","year":"2013","journal-title":"Nat. Biotechnol."},{"key":"ref_53","doi-asserted-by":"crossref","first-page":"681","DOI":"10.1038\/nbt.2661","article-title":"Heritable gene targeting in the mouse and rat using a CRISPR-Cas system","volume":"31","author":"Li","year":"2013","journal-title":"Nat. Biotechnol."},{"key":"ref_54","doi-asserted-by":"crossref","first-page":"326","DOI":"10.1038\/s41586-019-1278-0","article-title":"Atypical behaviour and connectivity in SHANK3-mutant macaques","volume":"570","author":"Zhou","year":"2019","journal-title":"Nature"},{"key":"ref_55","doi-asserted-by":"crossref","first-page":"36","DOI":"10.1126\/science.aab1028","article-title":"Biotechnology. A prudent path forward for genomic engineering and germline gene modification","volume":"348","author":"Baltimore","year":"2015","journal-title":"Science"},{"key":"ref_56","doi-asserted-by":"crossref","first-page":"e294","DOI":"10.1038\/tp.2013.71","article-title":"Differentiation from human pluripotent stem cells of cortical neurons of the superficial layers amenable to psychiatric disease modeling and high-throughput drug screening","volume":"3","author":"Boissart","year":"2013","journal-title":"Transl. Psychiatry"},{"key":"ref_57","doi-asserted-by":"crossref","first-page":"115","DOI":"10.1038\/nrd.2016.245","article-title":"Induced pluripotent stem cell technology: A decade of progress","volume":"16","author":"Shi","year":"2017","journal-title":"Nat. Rev. Drug Discov."},{"key":"ref_58","doi-asserted-by":"crossref","first-page":"663","DOI":"10.1016\/j.cell.2006.07.024","article-title":"Induction of pluripotent stem cells from mouse embryonic and adult fibroblast cultures by defined factors","volume":"126","author":"Takahashi","year":"2006","journal-title":"Cell"},{"key":"ref_59","doi-asserted-by":"crossref","first-page":"363","DOI":"10.2217\/fnl.11.14","article-title":"Modeling neurological diseases using patient-derived induced pluripotent stem cells","volume":"6","author":"Juopperi","year":"2011","journal-title":"Future Neurol."},{"key":"ref_60","doi-asserted-by":"crossref","first-page":"1239","DOI":"10.1038\/mp.2012.20","article-title":"Modeling psychiatric disorders at the cellular and network levels","volume":"17","author":"Brennand","year":"2012","journal-title":"Mol. Psychiatry"},{"key":"ref_61","doi-asserted-by":"crossref","first-page":"139","DOI":"10.1016\/j.biopsych.2019.07.014","article-title":"Synaptic dysfunction in human neurons with autism-associated deletions in PTCHD1-AS","volume":"87","author":"Ross","year":"2020","journal-title":"Biol. Psychiatry"},{"key":"ref_62","doi-asserted-by":"crossref","unstructured":"Rontani, P., Perche, O., Greetham, L., Jullien, N., Gepner, B., F\u00e9ron, F., Nivet, E., and Erard-Garcia, M. (2020). Impaired expression of the COSMOC\/MOCOS gene unit in ASD patient stem cells. Mol. Psychiatry.","DOI":"10.1038\/s41380-020-0728-2"},{"key":"ref_63","doi-asserted-by":"crossref","first-page":"33","DOI":"10.1186\/s13229-020-00333-6","article-title":"Modeling neuronal consequences of autism-associated gene regulatory variants with human induced pluripotent stem cells","volume":"11","author":"Ross","year":"2020","journal-title":"Mol. Autism"},{"key":"ref_64","doi-asserted-by":"crossref","first-page":"e1179","DOI":"10.1038\/tp.2017.144","article-title":"Altered neurite morphology and cholinergic function of induced pluripotent stem cell-derived neurons from a patient with Kleefstra Syndrome and autism","volume":"7","author":"Nagy","year":"2017","journal-title":"Transl. Psychiatry"},{"key":"ref_65","doi-asserted-by":"crossref","first-page":"178","DOI":"10.1038\/mp.2015.128","article-title":"Altered neuronal network and rescue in a human MECP2 duplication model","volume":"21","author":"Nageshappa","year":"2016","journal-title":"Mol. Psychiatry"},{"key":"ref_66","doi-asserted-by":"crossref","first-page":"52","DOI":"10.1186\/s13229-019-0303-3","article-title":"Increased Ca2+ signaling in NRXN1\u03b1 +\/- neurons derived from ASD induced pluripotent stem cells","volume":"10","author":"Avazzadeh","year":"2019","journal-title":"Mol. Autism"},{"key":"ref_67","doi-asserted-by":"crossref","first-page":"556","DOI":"10.1038\/s41593-019-0365-8","article-title":"SHANK2 mutations associated with autism spectrum disorder cause hyperconnectivity of human neurons","volume":"22","author":"Zaslavsky","year":"2019","journal-title":"Nat. Neurosci."},{"key":"ref_68","doi-asserted-by":"crossref","first-page":"94","DOI":"10.1038\/s41598-018-36993-x","article-title":"Altered spinogenesis in iPSC-derived cortical neurons from patients with autism carrying de novo SHANK3 mutations","volume":"9","author":"Gouder","year":"2019","journal-title":"Sci. Rep."},{"key":"ref_69","doi-asserted-by":"crossref","first-page":"293","DOI":"10.1016\/j.ebiom.2016.05.032","article-title":"Human pluripotent stem cell-derived cortical neurons for high throughput medication screening in autism: A proof of concept study in SHANK3 haploinsufficiency syndrome","volume":"9","author":"Darville","year":"2016","journal-title":"EBioMedicine"},{"key":"ref_70","doi-asserted-by":"crossref","first-page":"1053","DOI":"10.1016\/j.celrep.2016.09.054","article-title":"Impaired mitochondrial dynamics and mitophagy in neuronal models of tuberous sclerosis complex","volume":"17","author":"Saffari","year":"2016","journal-title":"Cell Rep."},{"key":"ref_71","doi-asserted-by":"crossref","first-page":"9294","DOI":"10.1523\/JNEUROSCI.0642-19.2019","article-title":"Biallelic mutations in TSC2 lead to abnormalities associated with cortical tubers in human iPSC-derived neurons","volume":"39","author":"Winden","year":"2019","journal-title":"J. Neurosci."},{"key":"ref_72","doi-asserted-by":"crossref","first-page":"129","DOI":"10.1038\/s41398-018-0177-8","article-title":"Single-cell trajectory analysis of human homogenous neurons carrying a rare RELN variant","volume":"8","author":"Arioka","year":"2018","journal-title":"Transl. Psychiatry"},{"key":"ref_73","doi-asserted-by":"crossref","first-page":"1211","DOI":"10.1016\/j.stemcr.2018.10.003","article-title":"Complete disruption of autism-susceptibility genes by gene editing predominantly reduces functional connectivity of isogenic human neurons","volume":"11","author":"Deneault","year":"2018","journal-title":"Stem Cell Rep."},{"key":"ref_74","doi-asserted-by":"crossref","first-page":"e40092","DOI":"10.7554\/eLife.40092","article-title":"CNTN5\u2212\/+ or EHMT2\u2212\/+ human iPSC-derived neurons from individuals with autism develop hyperactive neuronal networks","volume":"8","author":"Deneault","year":"2019","journal-title":"Elife"},{"key":"ref_75","doi-asserted-by":"crossref","first-page":"59","DOI":"10.1038\/ejhg.2015.69","article-title":"Collybistin binds and inhibits mTORC1 signaling: A potential novel mechanism contributing to intellectual disability and autism","volume":"24","author":"Machado","year":"2016","journal-title":"Eur. J. Hum. Genet."},{"key":"ref_76","doi-asserted-by":"crossref","first-page":"1657","DOI":"10.1038\/nm.2576","article-title":"Using iPSC-derived neurons to uncover cellular phenotypes associated with Timothy Syndrome","volume":"17","author":"Portmann","year":"2011","journal-title":"Nat. Med."},{"key":"ref_77","doi-asserted-by":"crossref","first-page":"75","DOI":"10.1186\/s13073-014-0075-5","article-title":"Alteration in basal and depolarization induced transcriptional network in iPSC derived neurons from Timothy Syndrome","volume":"6","author":"Tian","year":"2014","journal-title":"Genome Med."},{"key":"ref_78","doi-asserted-by":"crossref","first-page":"811","DOI":"10.1093\/brain\/awaa028","article-title":"Gene replacement ameliorates deficits in mouse and human models of cyclin-dependent kinase-like 5 disorder","volume":"143","author":"Gao","year":"2020","journal-title":"Brain"},{"key":"ref_79","doi-asserted-by":"crossref","first-page":"55","DOI":"10.1186\/s13229-015-0048-6","article-title":"CRISPR\/Cas9-mediated heterozygous knockout of the autism gene CHD8 and characterization of its transcriptional networks in neurodevelopment","volume":"6","author":"Wang","year":"2015","journal-title":"Mol. Autism"},{"key":"ref_80","first-page":"582","article-title":"Molecular analyses of neurogenic defects in a human pluripotent stem cell model of Fragile X Syndrome","volume":"140","author":"Boland","year":"2017","journal-title":"Brain"},{"key":"ref_81","doi-asserted-by":"crossref","first-page":"1777","DOI":"10.1089\/scd.2014.0030","article-title":"iPSC-derived forebrain neurons from FXS individuals show defects in initial neurite outgrowth","volume":"23","author":"Doers","year":"2014","journal-title":"Stem Cells Dev."},{"key":"ref_82","doi-asserted-by":"crossref","unstructured":"Sheridan, S.D., Theriault, K.M., Reis, S.A., Zhou, F., Madison, J.M., Daheron, L., Loring, J.F., and Haggarty, S.J. (2011). Epigenetic characterization of the FMR1 gene and aberrant neurodevelopment in human induced pluripotent stem cell models of Fragile X Syndrome. PLoS ONE, 6.","DOI":"10.1371\/journal.pone.0026203"},{"key":"ref_83","doi-asserted-by":"crossref","first-page":"23","DOI":"10.3389\/fnana.2019.00023","article-title":"Uncovering the functional link between SHANK3 deletions and deficiency in neurodevelopment using iPSC-derived human neurons","volume":"13","author":"Huang","year":"2019","journal-title":"Front. Neuroanat."},{"key":"ref_84","doi-asserted-by":"crossref","first-page":"267","DOI":"10.1038\/nature12618","article-title":"SHANK3 and IGF1 restore synaptic deficits in neurons from 22q13 deletion syndrome patients","volume":"503","author":"Shcheglovitov","year":"2013","journal-title":"Nature"},{"key":"ref_85","doi-asserted-by":"crossref","first-page":"1350","DOI":"10.1038\/mp.2014.141","article-title":"Modeling non-syndromic autism and the impact of TRPC6 disruption in human neurons","volume":"20","author":"Acab","year":"2015","journal-title":"Mol. Psychiatry"},{"key":"ref_86","doi-asserted-by":"crossref","first-page":"11","DOI":"10.1186\/s13229-017-0124-1","article-title":"CRISPR\/Cas9-mediated heterozygous knockout of the autism gene CHD8 and characterization of its transcriptional networks in cerebral organoids derived from iPS cells","volume":"8","author":"Wang","year":"2017","journal-title":"Mol. Autism"},{"key":"ref_87","doi-asserted-by":"crossref","first-page":"111469","DOI":"10.1016\/j.yexcr.2019.06.014","article-title":"Single cell analysis of autism patient with bi-allelic NRXN1-alpha deletion reveals skewed fate choice in neural progenitors and impaired neuronal functionality","volume":"383","author":"Lam","year":"2019","journal-title":"Exp. Cell Res."},{"key":"ref_88","doi-asserted-by":"crossref","unstructured":"Zeng, L., Zhang, P., Shi, L., Yamamoto, V., Lu, W., and Wang, K. (2013). Functional impacts of NRXN1 knockdown on neurodevelopment in stem cell models. PLoS ONE, 8.","DOI":"10.1371\/journal.pone.0059685"},{"key":"ref_89","doi-asserted-by":"crossref","first-page":"1372","DOI":"10.1002\/humu.23584","article-title":"Rare RELN variants affect Reelin-DAB1 signal transduction in Autism Spectrum Disorder","volume":"39","author":"Magdalon","year":"2018","journal-title":"Hum. Mutat."},{"key":"ref_90","doi-asserted-by":"crossref","unstructured":"Chen, J., Lin, M., Hrabovsky, A., Pedrosa, E., Dean, J., Jain, S., Zheng, D., and Lachman, H.M. (2015). ZNF804A transcriptional networks in differentiating neurons derived from induced pluripotent stem cells of human origin. PLoS ONE, 10.","DOI":"10.1371\/journal.pone.0124597"},{"key":"ref_91","doi-asserted-by":"crossref","first-page":"735","DOI":"10.1038\/mp.2017.185","article-title":"Stem cell-derived neurons from autistic individuals with SHANK3 mutation show morphogenetic abnormalities during early development","volume":"23","author":"Kathuria","year":"2018","journal-title":"Mol. Psychiatry"},{"key":"ref_92","doi-asserted-by":"crossref","first-page":"2167","DOI":"10.1038\/s41380-018-0018-4","article-title":"Purkinje cells derived from TSC patients display hypoexcitability and synaptic deficits associated with reduced FMRP levels and reversed by rapamycin","volume":"23","author":"Sundberg","year":"2018","journal-title":"Mol. Psychiatry"},{"key":"ref_93","doi-asserted-by":"crossref","first-page":"490","DOI":"10.1038\/nrn2851","article-title":"Behavioural phenotyping assays for mouse models of autism","volume":"11","author":"Silverman","year":"2010","journal-title":"Nat. Rev. Neurosci."},{"key":"ref_94","doi-asserted-by":"crossref","first-page":"34R","DOI":"10.1203\/PDR.0b013e318212b80f","article-title":"Modeling autistic features in animals","volume":"69","author":"Patterson","year":"2011","journal-title":"Pediatr. Res."},{"key":"ref_95","doi-asserted-by":"crossref","first-page":"79","DOI":"10.3389\/fncir.2013.00079","article-title":"Toward developmental models of psychiatric disorders in zebrafish","volume":"7","author":"Norton","year":"2013","journal-title":"Front. Neural Circuits"},{"key":"ref_96","doi-asserted-by":"crossref","first-page":"294","DOI":"10.3389\/fnmol.2018.00294","article-title":"Zebrafish models of neurodevelopmental disorders: Past, present, and future","volume":"11","author":"Sakai","year":"2018","journal-title":"Front. Mol. Neurosci."},{"key":"ref_97","doi-asserted-by":"crossref","first-page":"1079","DOI":"10.1242\/dmm.026120","article-title":"Rodent models in neuroscience research: Is it a rat race?","volume":"9","author":"Ellenbroek","year":"2016","journal-title":"Dis. Model. Mech."},{"key":"ref_98","doi-asserted-by":"crossref","first-page":"5","DOI":"10.1016\/j.bbr.2013.05.047","article-title":"Behavioural methods used in rodent models of Autism Spectrum Disorders: Current standards and new developments","volume":"251","author":"Scattoni","year":"2013","journal-title":"Behav. Brain Res."},{"key":"ref_99","doi-asserted-by":"crossref","first-page":"207","DOI":"10.1016\/j.expneurol.2017.02.004","article-title":"Zebrafish models of Autism Spectrum Disorder","volume":"299","author":"Meshalkina","year":"2018","journal-title":"Exp. Neurol."},{"key":"ref_100","doi-asserted-by":"crossref","first-page":"25","DOI":"10.1016\/j.bbr.2012.07.021","article-title":"The BTBR T+tf\/J mouse model for Autism Spectrum Disorders\u2013in search of biomarkers","volume":"251","author":"Meyza","year":"2013","journal-title":"Behav. Brain Res."},{"key":"ref_101","doi-asserted-by":"crossref","first-page":"1467","DOI":"10.1038\/mp.2015.208","article-title":"Sexual divergence in microtubule function: The novel intranasal microtubule targeting SKIP normalizes axonal transport and enhances memory","volume":"21","author":"Amram","year":"2016","journal-title":"Mol. Psychiatry"},{"key":"ref_102","doi-asserted-by":"crossref","first-page":"2","DOI":"10.1038\/s41398-018-0357-6","article-title":"The autism\/neuroprotection-linked ADNP\/NAP regulate the excitatory glutamatergic synapse","volume":"9","author":"Sragovich","year":"2019","journal-title":"Transl. Psychiatry"},{"key":"ref_103","doi-asserted-by":"crossref","first-page":"438","DOI":"10.1124\/jpet.107.129551","article-title":"Activity-dependent neuroprotective protein snippet NAP reduces tau hyperphosphorylation and enhances learning in a novel transgenic mouse model","volume":"323","author":"Pinhasov","year":"2007","journal-title":"J. Pharmacol. Exp. Ther."},{"key":"ref_104","doi-asserted-by":"crossref","first-page":"e25730","DOI":"10.7554\/eLife.25730","article-title":"Arid1b haploinsufficient mice reveal neuropsychiatric phenotypes and reversible causes of growth impairment","volume":"6","author":"Celen","year":"2017","journal-title":"Elife"},{"key":"ref_105","doi-asserted-by":"crossref","unstructured":"Shibutani, M., Horii, T., Shoji, H., Morita, S., Kimura, M., Terawaki, N., Miyakawa, T., Hatada, I., Shibutani, M., and Horii, T. (2017). Arid1b Haploinsufficiency Causes Abnormal Brain Gene Expression and Autism-Related Behaviors in Mice. Int. J. Mol. Sci., 18.","DOI":"10.3390\/ijms18091872"},{"key":"ref_106","doi-asserted-by":"crossref","first-page":"121","DOI":"10.1095\/biolreprod.115.131516","article-title":"The histone methyltransferase gene Absent, Small, or Homeotic Discs-1 Like is required for normal hox gene expression and fertility in mice","volume":"93","author":"Brinkmeier","year":"2015","journal-title":"Biol. Reprod."},{"key":"ref_107","doi-asserted-by":"crossref","first-page":"470","DOI":"10.1016\/j.immuni.2013.08.016","article-title":"Histone Methyltransferase Ash1l Suppresses Interleukin-6 Production and Inflammatory Autoimmune Diseases by Inducing the Ubiquitin-Editing Enzyme A20","volume":"39","author":"Xia","year":"2013","journal-title":"Immunity"},{"key":"ref_108","doi-asserted-by":"crossref","first-page":"26597","DOI":"10.1038\/srep26597","article-title":"Histone methyltransferase Ash1L mediates activity-dependent repression of neurexin-1\u03b1","volume":"6","author":"Zhu","year":"2016","journal-title":"Sci. Rep."},{"key":"ref_109","doi-asserted-by":"crossref","first-page":"1180","DOI":"10.1016\/j.neuron.2018.09.049","article-title":"Chd2 Is Necessary for Neural Circuit Development and Long-Term Memory","volume":"100","author":"Kim","year":"2018","journal-title":"Neuron"},{"key":"ref_110","doi-asserted-by":"crossref","first-page":"1053","DOI":"10.1038\/onc.2008.440","article-title":"Role of chromodomain helicase DNA-binding protein 2 in DNA damage response signaling and tumorigenesis","volume":"28","author":"Nagarajan","year":"2009","journal-title":"Oncogene"},{"key":"ref_111","doi-asserted-by":"crossref","first-page":"1477","DOI":"10.1038\/nn.4400","article-title":"Chd8 mediates cortical neurogenesis via transcriptional regulation of cell cycle and Wnt signaling","volume":"19","author":"Durak","year":"2016","journal-title":"Nat. Neurosci."},{"key":"ref_112","doi-asserted-by":"crossref","first-page":"1062","DOI":"10.1038\/nn.4592","article-title":"Germline Chd8 haploinsufficiency alters brain development in mouse","volume":"20","author":"Gompers","year":"2017","journal-title":"Nat. Neurosci."},{"key":"ref_113","doi-asserted-by":"crossref","first-page":"1218","DOI":"10.1038\/s41593-018-0208-z","article-title":"Sexually dimorphic behavior, neuronal activity, and gene expression in Chd8-mutant mice","volume":"21","author":"Jung","year":"2018","journal-title":"Nat. Neurosci."},{"key":"ref_114","doi-asserted-by":"crossref","first-page":"675","DOI":"10.1038\/nature19357","article-title":"CHD8 haploinsufficiency results in autistic-like phenotypes in mice","volume":"537","author":"Katayama","year":"2016","journal-title":"Nature"},{"key":"ref_115","doi-asserted-by":"crossref","first-page":"172","DOI":"10.1038\/ncb1831","article-title":"CHD8 suppresses p53-mediated apoptosis through histone H1 recruitment during early embryogenesis","volume":"11","author":"Nishiyama","year":"2009","journal-title":"Nat. Cell Biol."},{"key":"ref_116","doi-asserted-by":"crossref","first-page":"335","DOI":"10.1016\/j.celrep.2017.03.052","article-title":"Chd8 Mutation Leads to Autistic-like Behaviors and Impaired Striatal Circuits","volume":"19","author":"Platt","year":"2017","journal-title":"Cell Rep."},{"key":"ref_117","doi-asserted-by":"crossref","first-page":"2192","DOI":"10.1093\/cercor\/bhy058","article-title":"Altered neocortical gene expression, brain overgrowth and functional over-connectivity in chd8 haploinsufficient mice","volume":"28","author":"Suetterlin","year":"2018","journal-title":"Cereb. Cortex"},{"key":"ref_118","doi-asserted-by":"crossref","first-page":"753","DOI":"10.1016\/j.devcel.2018.05.022","article-title":"Dual Requirement of CHD8 for Chromatin Landscape Establishment and Histone Methyltransferase Recruitment to Promote CNS Myelination and Repair","volume":"45","author":"Zhao","year":"2018","journal-title":"Dev. Cell"},{"key":"ref_119","doi-asserted-by":"crossref","first-page":"527","DOI":"10.1038\/ng.3808","article-title":"Disruption of the ATXN1\u2013CIC complex causes a spectrum of neurobehavioral phenotypes in mice and humans","volume":"49","author":"Lu","year":"2017","journal-title":"Nat. Genet."},{"key":"ref_120","doi-asserted-by":"crossref","first-page":"2480","DOI":"10.1523\/JNEUROSCI.5225-09.2010","article-title":"Organization of myelinated axons by Caspr and Caspr2 requires the cytoskeletal adapter protein 4.1B","volume":"30","author":"Horresh","year":"2010","journal-title":"J. Neurosci."},{"key":"ref_121","doi-asserted-by":"crossref","first-page":"235","DOI":"10.1016\/j.cell.2011.08.040","article-title":"Absence of CNTNAP2 leads to epilepsy, neuronal migration abnormalities, and core autism-related deficits","volume":"147","author":"Abrahams","year":"2011","journal-title":"Cell"},{"key":"ref_122","first-page":"ra8","article-title":"Exogenous and evoked oxytocin restores social behavior in the Cntnap2 mouse model of autism","volume":"7","author":"Lu","year":"2015","journal-title":"Sci. Transl. Med."},{"key":"ref_123","doi-asserted-by":"crossref","first-page":"1149","DOI":"10.1083\/jcb.200305018","article-title":"Juxtaparanodal clustering of Shaker-like K+ channels in myelinated axons depends on Caspr2 and TAG-1","volume":"162","author":"Poliak","year":"2003","journal-title":"J. Cell Biol."},{"key":"ref_124","doi-asserted-by":"crossref","first-page":"1383","DOI":"10.1073\/pnas.1619312114","article-title":"Sex-specific gene\u2013environment interactions underlying ASD-like behaviors","volume":"114","author":"Schaafsma","year":"2017","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"ref_125","doi-asserted-by":"crossref","first-page":"eaah6733","DOI":"10.1126\/scitranslmed.aah6733","article-title":"Modulation of prefrontal cortex excitation\/inhibition balance rescues social behavior in CNTNAP2 -deficient mice","volume":"9","author":"Selimbeyoglu","year":"2017","journal-title":"Sci. Transl. Med."},{"key":"ref_126","doi-asserted-by":"crossref","first-page":"8505","DOI":"10.1523\/JNEUROSCI.18-20-08505.1998","article-title":"Mice lacking the \u03b23 subunit of the GABA(A) receptor have the epilepsy phenotype and many of the behavioral characteristics of Angelman syndrome","volume":"18","author":"DeLorey","year":"1998","journal-title":"J. Neurosci."},{"key":"ref_127","doi-asserted-by":"crossref","first-page":"36","DOI":"10.1016\/j.bbr.2010.06.032","article-title":"Somatosensory and sensorimotor consequences associated with the heterozygous disruption of the autism candidate gene, Gabrb3","volume":"216","author":"DeLorey","year":"2011","journal-title":"Behav. Brain Res."},{"key":"ref_128","doi-asserted-by":"crossref","first-page":"221","DOI":"10.1038\/cr.2017.135","article-title":"Endothelial cell-derived GABA signaling modulates neuronal migration and postnatal behavior","volume":"28","author":"Li","year":"2018","journal-title":"Cell Res."},{"key":"ref_129","doi-asserted-by":"crossref","first-page":"150","DOI":"10.1016\/j.devbrainres.2005.03.014","article-title":"GABAA receptor \u03b23 subunit gene-deficient heterozygous mice show parent-of-origin and gender-related differences in \u03b23 subunit levels, EEG, and behavior","volume":"157","author":"Liljelund","year":"2005","journal-title":"Dev. Brain Res."},{"key":"ref_130","doi-asserted-by":"crossref","first-page":"299","DOI":"10.1016\/j.cell.2016.05.033","article-title":"Peripheral Mechanosensory Neuron Dysfunction Underlies Tactile and Behavioral Deficits in Mouse Models of ASDs","volume":"166","author":"Orefice","year":"2016","journal-title":"Cell"},{"key":"ref_131","doi-asserted-by":"crossref","first-page":"8595","DOI":"10.1038\/s41598-018-26814-6","article-title":"Intermittent fasting uncovers and rescues cognitive phenotypes in PTEN neuronal haploinsufficient mice","volume":"8","author":"Andreotti","year":"2018","journal-title":"Sci. Rep."},{"key":"ref_132","doi-asserted-by":"crossref","first-page":"145","DOI":"10.1111\/gbb.12192","article-title":"Decreased aggression and increased repetitive behavior in Pten haploinsufficient mice","volume":"14","author":"Page","year":"2015","journal-title":"Genes Brain Behav."},{"key":"ref_133","doi-asserted-by":"crossref","first-page":"1457","DOI":"10.1038\/npp.2015.339","article-title":"Autistic-like traits and cerebellar dysfunction in purkinje cell PTEN knock-out mice","volume":"41","author":"Cupolillo","year":"2016","journal-title":"Neuropsychopharmacology"},{"key":"ref_134","doi-asserted-by":"crossref","first-page":"377","DOI":"10.1016\/j.neuron.2006.03.023","article-title":"Pten Regulates Neuronal Arborization and Social Interaction in Mice","volume":"50","author":"Kwon","year":"2006","journal-title":"Neuron"},{"key":"ref_135","doi-asserted-by":"crossref","first-page":"944","DOI":"10.1016\/j.celrep.2015.04.019","article-title":"The Parvalbumin\/Somatostatin Ratio Is Increased in Pten Mutant Mice and by Human PTEN ASD Alleles","volume":"11","author":"Vogt","year":"2015","journal-title":"Cell Rep."},{"key":"ref_136","doi-asserted-by":"crossref","first-page":"943","DOI":"10.1523\/JNEUROSCI.3144-14.2015","article-title":"Hyperactivity of Newborn Pten Knock-out Neurons Results from Increased Excitatory Synaptic Drive","volume":"35","author":"Williams","year":"2015","journal-title":"J. Neurosci."},{"key":"ref_137","doi-asserted-by":"crossref","first-page":"1773","DOI":"10.1523\/JNEUROSCI.5685-08.2009","article-title":"Pharmacological inhibition of mTORCl suppresses anatomical, cellular, and behavioral abnormalities in neural-specific PTEN knock-out mice","volume":"29","author":"Zhou","year":"2009","journal-title":"J. Neurosci."},{"key":"ref_138","doi-asserted-by":"crossref","first-page":"27","DOI":"10.1042\/AN20120060","article-title":"Decreased reelin expression and organophosphate pesticide exposure alters mouse behaviour and brain morphology","volume":"5","author":"Mullen","year":"2013","journal-title":"ASN Neuro"},{"key":"ref_139","doi-asserted-by":"crossref","first-page":"337","DOI":"10.1007\/s00381-013-2195-4","article-title":"Cloacal exstrophy with extensive Chiari II malformation: Case report and review of the literature","volume":"30","author":"Nyarenchi","year":"2014","journal-title":"Child\u2019s Nerv. Syst."},{"key":"ref_140","doi-asserted-by":"crossref","first-page":"929","DOI":"10.1016\/S0896-6273(01)00436-6","article-title":"The Reelin Pathway Modulates the Structure and Function of Retinal Synaptic Circuitry","volume":"31","author":"Rice","year":"2001","journal-title":"Neuron"},{"key":"ref_141","doi-asserted-by":"crossref","first-page":"655","DOI":"10.1016\/j.nbd.2010.11.016","article-title":"Neuronal voltage-gated ion channels are genetic modifiers of generalized epilepsy with febrile seizures plus","volume":"41","author":"Hawkins","year":"2011","journal-title":"Neurobiol. Dis."},{"key":"ref_142","doi-asserted-by":"crossref","first-page":"2878","DOI":"10.1016\/S0006-3495(00)76829-9","article-title":"Neuronal death and perinatal lethality in voltage-gated sodium channel \u03b1(II)-deficient mice","volume":"78","author":"Caprini","year":"2000","journal-title":"Biophys. J."},{"key":"ref_143","doi-asserted-by":"crossref","first-page":"15","DOI":"10.1186\/s13229-019-0265-5","article-title":"Scn2a haploinsufficient mice display a spectrum of phenotypes affecting anxiety, sociability, memory flexibility and ampakine CX516 rescues their hyperactivity","volume":"10","author":"Tatsukawa","year":"2019","journal-title":"Mol. Autism"},{"key":"ref_144","doi-asserted-by":"crossref","first-page":"534","DOI":"10.1016\/j.biopsych.2018.09.025","article-title":"Early Correction of N-Methyl-D-Aspartate Receptor Function Improves Autistic-like Social Behaviors in Adult Shank2\u2212\/\u2212 Mice","volume":"85","author":"Chung","year":"2019","journal-title":"Biol. Psychiatry"},{"key":"ref_145","doi-asserted-by":"crossref","first-page":"12129","DOI":"10.1523\/JNEUROSCI.1849-16.2016","article-title":"Cerebellar Shank2 Regulates Excitatory Synapse Density, Motor Coordination, and Specific Repetitive and Anxiety-Like Behaviors","volume":"36","author":"Ha","year":"2016","journal-title":"J. Neurosci."},{"key":"ref_146","doi-asserted-by":"crossref","first-page":"7168","DOI":"10.1038\/ncomms8168","article-title":"Trans-synaptic zinc mobilization improves social interaction in two mouse models of autism through NMDAR activation","volume":"6","author":"Lee","year":"2015","journal-title":"Nat. Commun."},{"key":"ref_147","doi-asserted-by":"crossref","first-page":"104","DOI":"10.1016\/j.neuropharm.2016.08.016","article-title":"Enhancing inhibitory synaptic function reverses spatial memory deficits in Shank2 mutant mice","volume":"112","author":"Lim","year":"2017","journal-title":"Neuropharmacology"},{"key":"ref_148","doi-asserted-by":"crossref","first-page":"261","DOI":"10.1038\/nature11208","article-title":"Autistic-like social behaviour in Shank2-mutant mice improved by restoring NMDA receptor function","volume":"486","author":"Won","year":"2012","journal-title":"Nature"},{"key":"ref_149","doi-asserted-by":"crossref","first-page":"1329","DOI":"10.1038\/s41380-018-0025-5","article-title":"Altered TAOK2 activity causes autism-related neurodevelopmental and cognitive abnormalities through RhoA signaling","volume":"24","author":"Richter","year":"2019","journal-title":"Mol. Psychiatry"},{"key":"ref_150","doi-asserted-by":"crossref","first-page":"831","DOI":"10.1016\/j.neuron.2018.09.027","article-title":"Neonatal Tbr1 Dosage Controls Cortical Layer 6 Connectivity","volume":"100","author":"Qi","year":"2018","journal-title":"Neuron"},{"key":"ref_151","doi-asserted-by":"crossref","first-page":"353","DOI":"10.1016\/S0896-6273(01)00211-2","article-title":"Tbr1 regulates differentiation of the preplate and layer 6","volume":"29","author":"Hevner","year":"2001","journal-title":"Neuron"},{"key":"ref_152","doi-asserted-by":"crossref","first-page":"5","DOI":"10.1186\/s13229-019-0257-5","article-title":"Haploinsufficiency of autism causative gene Tbr1 impairs olfactory discrimination and neuronal activation of the olfactory system in mice","volume":"10","author":"Huang","year":"2019","journal-title":"Mol. Autism"},{"key":"ref_153","doi-asserted-by":"crossref","first-page":"240","DOI":"10.1038\/nn.3626","article-title":"Tbr1 haploinsufficiency impairs amygdalar axonal projections and results in cognitive abnormality","volume":"17","author":"Huang","year":"2014","journal-title":"Nat. Neurosci."},{"key":"ref_154","doi-asserted-by":"crossref","first-page":"1773","DOI":"10.1038\/mp.2017.173","article-title":"A Upf3b-mutant mouse model with behavioral and neurogenesis defects","volume":"23","author":"Huang","year":"2018","journal-title":"Mol. Psychiatry"},{"key":"ref_155","doi-asserted-by":"crossref","unstructured":"Zigler, J.S., Hodgkinson, C.A., Wright, M., Klise, A., Sundin, O., Broman, K.W., Hejtmancik, F., Huang, H., Patek, B., and Sergeev, Y. (2016). A Spontaneous missense mutation in branched chain keto acid dehydrogenase kinase in the rat affects both the central and peripheral nervous systems. PLoS ONE, 11.","DOI":"10.1371\/journal.pone.0160447"},{"key":"ref_156","doi-asserted-by":"crossref","first-page":"dmm034116","DOI":"10.1242\/dmm.034116","article-title":"Cacna1c haploinsufficiency leads to pro-social 50-kHz ultrasonic communication deficits in rats","volume":"11","author":"Kisko","year":"2018","journal-title":"Dis. Model. Mech."},{"key":"ref_157","doi-asserted-by":"crossref","first-page":"109849","DOI":"10.1016\/j.pnpbp.2019.109849","article-title":"Sex-dependent effects of Cacna1c haploinsufficiency on behavioral inhibition evoked by conspecific alarm signals in rats","volume":"99","author":"Willadsen","year":"2020","journal-title":"Prog. Neuro-Psychopharmacol. Biol. Psychiatry"},{"key":"ref_158","doi-asserted-by":"crossref","first-page":"8588","DOI":"10.1523\/JNEUROSCI.0759-18.2018","article-title":"Altered auditory processing, filtering, and reactivity in the Cntnap2 knock-out rat model for neurodevelopmental disorders","volume":"38","author":"Scott","year":"2018","journal-title":"J. Neurosci."},{"key":"ref_159","doi-asserted-by":"crossref","unstructured":"Thomas, A.M., Schwartz, M.D., Saxe, M.D., and Kilduff, T.S. (2017). Cntnap2 knockout rats and mice exhibit epileptiform activity and abnormal sleep\u2013wake physiology. Sleep, 40.","DOI":"10.1093\/sleep\/zsw026"},{"key":"ref_160","doi-asserted-by":"crossref","first-page":"3455","DOI":"10.1038\/s41467-019-11119-7","article-title":"Cyfip1 haploinsufficient rats show white matter changes, myelin thinning, abnormal oligodendrocytes and behavioural inflexibility","volume":"10","author":"Silva","year":"2019","journal-title":"Nat. Commun."},{"key":"ref_161","doi-asserted-by":"crossref","unstructured":"Asiminas, A., Jackson, A.D., Louros, S.R., Till, S.M., Spano, T., Dando, O., Bear, M.F., Chattarji, S., Hardingham, G.E., and Osterweil, E.K. (2019). Sustained correction of associative learning deficits after brief, early treatment in a rat model of Fragile X Syndrome. Sci. Transl. Med., 11.","DOI":"10.1126\/scitranslmed.aao0498"},{"key":"ref_162","doi-asserted-by":"crossref","first-page":"103","DOI":"10.1037\/a0035988","article-title":"Fmr1 and Nlgn3 knockout rats: Novel tools for investigating autism spectrum disorders","volume":"128","author":"Hamilton","year":"2014","journal-title":"Behav. Neurosci."},{"key":"ref_163","doi-asserted-by":"crossref","first-page":"285","DOI":"10.1016\/j.neuroscience.2015.06.061","article-title":"Abnormal neuronal morphology and neurochemistry in the auditory brainstem of Fmr1 knockout rats","volume":"303","author":"Ruby","year":"2015","journal-title":"Neuroscience"},{"key":"ref_164","doi-asserted-by":"crossref","first-page":"26","DOI":"10.1016\/j.nbd.2015.08.019","article-title":"Degraded neural and behavioral processing of speech sounds in a rat model of Rett syndrome","volume":"83","author":"Engineer","year":"2015","journal-title":"Neurobiol. Dis."},{"key":"ref_165","doi-asserted-by":"crossref","first-page":"23","DOI":"10.1186\/s11689-016-9156-7","article-title":"Characterization of Rett Syndrome-like phenotypes in Mecp2-knockout rats","volume":"8","author":"Wu","year":"2016","journal-title":"J. Neurodev. Disord."},{"key":"ref_166","doi-asserted-by":"crossref","unstructured":"Kohl, C., Riccio, O., Grosse, J., Zanoletti, O., Fournier, C., Schmidt, M.V., and Sandi, C. (2013). Hippocampal neuroligin-2 overexpression leads to reduced aggression and inhibited novelty reactivity in rats. PLoS ONE, 8.","DOI":"10.1371\/journal.pone.0056871"},{"key":"ref_167","doi-asserted-by":"crossref","unstructured":"Thomas, A.M., Schwartz, M.D., Saxe, M.D., and Kilduff, T.S. (2017). Sleep\/wake physiology and quantitative electroencephalogram analysis of the Neuroligin-3 knockout rat model of Autism Spectrum Disorder. Sleep, 40.","DOI":"10.1093\/sleep\/zsx138"},{"key":"ref_168","doi-asserted-by":"crossref","first-page":"74","DOI":"10.1037\/bne0000024","article-title":"Phenotypic characterization of nonsocial behavioral impairment in neurexin 1\u03b1 knockout rats","volume":"129","author":"Esclassan","year":"2015","journal-title":"Behav. Neurosci."},{"key":"ref_169","doi-asserted-by":"crossref","first-page":"83","DOI":"10.1016\/j.pscychresns.2018.12.007","article-title":"Convergent microstructural brain changes across genetic models of Autism Spectrum Disorder\u2014A pilot study","volume":"283","author":"Rowley","year":"2019","journal-title":"Psychiatry Res. Neuroimaging"},{"key":"ref_170","doi-asserted-by":"crossref","first-page":"1558","DOI":"10.1111\/epi.12750","article-title":"Methylphenidate improves learning impairments and hyperthermia-induced seizures caused by an Scn1a mutation","volume":"55","author":"Ohmori","year":"2014","journal-title":"Epilepsia"},{"key":"ref_171","doi-asserted-by":"crossref","first-page":"107","DOI":"10.3389\/fnmol.2018.00107","article-title":"Hyperactivity and hypermotivation associated with increased striatal mGluR1 signaling in a Shank2 rat model of autism","volume":"11","author":"Modi","year":"2018","journal-title":"Front. Mol. Neurosci."},{"key":"ref_172","doi-asserted-by":"crossref","first-page":"e18904","DOI":"10.7554\/eLife.18904","article-title":"Oxytocin improves behavioral and electrophysiological deficits in a novel Shank3-deficient rat","volume":"6","author":"Kay","year":"2017","journal-title":"Elife"},{"key":"ref_173","doi-asserted-by":"crossref","first-page":"e1220468","DOI":"10.1080\/21675511.2016.1220468","article-title":"Neurodevelopmental models of transcription factor 4 deficiency converge on a common ion channel as a potential therapeutic target for Pitt Hopkins Syndrome","volume":"4","author":"Rannals","year":"2016","journal-title":"Rare Dis."},{"key":"ref_174","doi-asserted-by":"crossref","first-page":"305","DOI":"10.1007\/s12017-015-8359-5","article-title":"Restoration of normal cerebral oxygen consumption with rapamycin treatment in a rat model of autism\u2013tuberous sclerosis","volume":"17","author":"Chi","year":"2015","journal-title":"NeuroMol. Med."},{"key":"ref_175","doi-asserted-by":"crossref","first-page":"407","DOI":"10.1111\/j.1471-4159.2005.03538.x","article-title":"Enhanced episodic-like memory and kindling epilepsy in a rat model of tuberous sclerosis","volume":"96","author":"Waltereit","year":"2006","journal-title":"J. Neurochem."},{"key":"ref_176","doi-asserted-by":"crossref","first-page":"397","DOI":"10.1002\/aur.2267","article-title":"Generation of a novel rat model of Angelman Syndrome with a complete Ube3a gene deletion","volume":"13","author":"Dodge","year":"2020","journal-title":"Autism Res."},{"key":"ref_177","doi-asserted-by":"crossref","first-page":"110778","DOI":"10.1016\/j.mce.2020.110778","article-title":"Zebrafish as a model for studying ovarian development: Recent advances from targeted gene knockout studies","volume":"507","author":"Li","year":"2020","journal-title":"Mol. Cell. Endocrinol."},{"key":"ref_178","doi-asserted-by":"crossref","first-page":"99","DOI":"10.1101\/gr.9.2.99","article-title":"Zebrafish: A new model for human disease","volume":"9","author":"Zon","year":"1999","journal-title":"Genome Res."},{"key":"ref_179","doi-asserted-by":"crossref","first-page":"413","DOI":"10.1038\/nmeth.2434","article-title":"Whole-brain functional imaging at cellular resolution using light-sheet microscopy","volume":"10","author":"Ahrens","year":"2013","journal-title":"Nat. Methods"},{"key":"ref_180","doi-asserted-by":"crossref","first-page":"135","DOI":"10.1007\/BF00043269","article-title":"Inland fishes of India and adjacent countries","volume":"4","author":"Rainboth","year":"1994","journal-title":"Rev. Fish Biol. Fish."},{"key":"ref_181","doi-asserted-by":"crossref","first-page":"e05635","DOI":"10.7554\/eLife.05635","article-title":"The natural history of model organisms: Advancing biology through a deeper understanding of zebrafish ecology and evolution","volume":"2015","author":"Parichy","year":"2015","journal-title":"Elife"},{"key":"ref_182","unstructured":"Westerfield, M. (2020, September 19). The Zebrafish Book: A Guide for the Laboratory Use of Zebrafish. Available online: https:\/\/zfin.org\/zf_info\/zfbook\/zfbk.html."},{"key":"ref_183","doi-asserted-by":"crossref","first-page":"378","DOI":"10.1038\/laban.1345","article-title":"Adult zebrafish in CNS disease modeling: A tank that\u2019s half-full, not half-empty, and still filling","volume":"46","author":"Meshalkina","year":"2017","journal-title":"Lab Anim"},{"key":"ref_184","doi-asserted-by":"crossref","first-page":"9","DOI":"10.1016\/S0145-305X(03)00103-4","article-title":"Development and maturation of the immune system in zebrafish, Danio rerio: A gene expression profiling, in situ hybridization and immunological study","volume":"28","author":"Lam","year":"2004","journal-title":"Dev. Comp. Immunol."},{"key":"ref_185","doi-asserted-by":"crossref","first-page":"956","DOI":"10.1038\/35103567","article-title":"The art and design of genetic screens: Zebrafish","volume":"2","author":"Patton","year":"2001","journal-title":"Nat. Rev. Genet."},{"key":"ref_186","doi-asserted-by":"crossref","first-page":"252","DOI":"10.1016\/S0959-437X(00)00074-5","article-title":"Zebrafish: A model system for the study of human disease","volume":"10","author":"Dooley","year":"2000","journal-title":"Curr. Opin. Genet. Dev."},{"key":"ref_187","doi-asserted-by":"crossref","first-page":"7368","DOI":"10.1523\/JNEUROSCI.5746-12.2013","article-title":"Modeling transformations of neurodevelopmental sequences across mammalian species","volume":"33","author":"Workman","year":"2013","journal-title":"J. Neurosci."},{"key":"ref_188","doi-asserted-by":"crossref","first-page":"1109","DOI":"10.1126\/science.274.5290.1109","article-title":"Patterning the vertebrate neuraxis","volume":"274","author":"Lumsden","year":"1996","journal-title":"Science"},{"key":"ref_189","doi-asserted-by":"crossref","first-page":"253","DOI":"10.1002\/aja.1002030302","article-title":"Stages of embryonic development of the zebrafish","volume":"203","author":"Kimmel","year":"1995","journal-title":"Dev. Dyn."},{"key":"ref_190","doi-asserted-by":"crossref","first-page":"715","DOI":"10.1517\/17460440902988464","article-title":"Using zebrafish to assess the impact of drugs on neural development and function","volume":"4","author":"Guo","year":"2009","journal-title":"Expert Opin. Drug Discov."},{"key":"ref_191","doi-asserted-by":"crossref","first-page":"156","DOI":"10.1016\/j.brainres.2004.02.073","article-title":"The adult central nervous cholinergic system of a neurogenetic model animal, the zebrafish Danio rerio","volume":"1011","author":"Mueller","year":"2004","journal-title":"Brain Res."},{"key":"ref_192","doi-asserted-by":"crossref","first-page":"30","DOI":"10.1159\/000229011","article-title":"An evolutionary interpretation of teleostean forebrain anatomy","volume":"74","author":"Mueller","year":"2009","journal-title":"Brain Behav. Evol."},{"key":"ref_193","doi-asserted-by":"crossref","first-page":"95","DOI":"10.1016\/j.brainres.2010.12.089","article-title":"The dorsal pallium in zebrafish, Danio rerio (Cyprinidae, Teleostei)","volume":"1381","author":"Mueller","year":"2011","journal-title":"Brain Res."},{"key":"ref_194","doi-asserted-by":"crossref","unstructured":"Kozol, R.A. (2018). Prenatal neuropathologies in autism spectrum disorder and intellectual disability: The gestation of a comprehensive Zebrafish model. J. Dev. Biol., 6.","DOI":"10.3390\/jdb6040029"},{"key":"ref_195","doi-asserted-by":"crossref","first-page":"406","DOI":"10.1016\/j.ydbio.2009.04.013","article-title":"Anatomy of zebrafish cerebellum and screen for mutations affecting its development","volume":"330","author":"Bae","year":"2009","journal-title":"Dev. Biol."},{"key":"ref_196","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.ydbio.2010.03.024","article-title":"Proneural gene-linked neurogenesis in zebrafish cerebellum","volume":"343","author":"Kani","year":"2010","journal-title":"Dev. Biol."},{"key":"ref_197","doi-asserted-by":"crossref","first-page":"950","DOI":"10.1007\/s12311-013-0490-y","article-title":"Defining the role of cerebellar purkinje cells in autism spectrum disorders","volume":"12","author":"Sudarov","year":"2013","journal-title":"Cerebellum"},{"key":"ref_198","doi-asserted-by":"crossref","first-page":"183","DOI":"10.1016\/j.ijdevneu.2004.09.006","article-title":"Neuroanatomic observations of the brain in autism: A review and future directions","volume":"23","author":"Bauman","year":"2005","journal-title":"Int. J. Dev. Neurosci."},{"key":"ref_199","doi-asserted-by":"crossref","first-page":"110","DOI":"10.3389\/fnhum.2014.00110","article-title":"In vivo detection of reduced purkinje cell fibers with diffusion MRI tractography in children with autistic spectrum disorders","volume":"8","author":"Jeong","year":"2014","journal-title":"Front. Hum. Neurosci."},{"key":"ref_200","doi-asserted-by":"crossref","first-page":"608","DOI":"10.1016\/j.ntt.2011.07.007","article-title":"Zebrafish neurotransmitter systems as potential pharmacological and toxicological targets","volume":"33","author":"Rico","year":"2011","journal-title":"Neurotoxicol. Teratol."},{"key":"ref_201","doi-asserted-by":"crossref","first-page":"744","DOI":"10.1016\/j.ajhg.2018.02.021","article-title":"Dual Molecular Effects of Dominant RORA Mutations Cause Two Variants of Syndromic Intellectual Disability with Either Autism or Cerebellar Ataxia","volume":"102","author":"Guissart","year":"2018","journal-title":"Am. J. Hum. Genet."},{"key":"ref_202","doi-asserted-by":"crossref","first-page":"498","DOI":"10.1038\/nature12111","article-title":"The zebrafish reference genome sequence and its relationship to the human genome","volume":"496","author":"Howe","year":"2013","journal-title":"Nature"},{"key":"ref_203","doi-asserted-by":"crossref","first-page":"107","DOI":"10.1515\/rns.2011.012","article-title":"The role of dopaminergic signalling during larval zebrafish brain development: A tool for investigating the developmental basis of neuropsychiatric disorders","volume":"22","author":"Souza","year":"2011","journal-title":"Rev. Neurosci."},{"key":"ref_204","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1002\/jnr.20516","article-title":"Oligodendrocyte development and myelination in GFP-transgenic zebrafish","volume":"81","author":"Yoshida","year":"2005","journal-title":"J. Neurosci. Res."},{"key":"ref_205","doi-asserted-by":"crossref","first-page":"1411","DOI":"10.1016\/j.cell.2017.10.021","article-title":"Ancestral Circuits for the Coordinated Modulation of Brain State","volume":"171","author":"Andalman","year":"2017","journal-title":"Cell"},{"key":"ref_206","doi-asserted-by":"crossref","first-page":"26","DOI":"10.1111\/dgd.12094","article-title":"Genome editing using artificial site-specific nucleases in zebrafish","volume":"56","author":"Hisano","year":"2014","journal-title":"Dev. Growth Differ."},{"key":"ref_207","doi-asserted-by":"crossref","first-page":"216","DOI":"10.1038\/79951","article-title":"Effective targeted gene \u201cknockdown\u201d in zebrafish","volume":"26","author":"Nasevicius","year":"2000","journal-title":"Nat. Genet."},{"key":"ref_208","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1007\/978-1-4939-6817-6_1","article-title":"Invention and early history of morpholinos: From pipe dream to practical products","volume":"Volume 1565","author":"Summerton","year":"2017","journal-title":"Methods in Molecular Biology"},{"key":"ref_209","doi-asserted-by":"crossref","first-page":"69","DOI":"10.1089\/zeb.2008.0555","article-title":"A primer for morpholino use in zebrafish","volume":"6","author":"Bill","year":"2009","journal-title":"Zebrafish"},{"key":"ref_210","doi-asserted-by":"crossref","first-page":"1735","DOI":"10.1242\/dev.001115","article-title":"Controlling morpholino experiments: Don\u2019t stop making antisense","volume":"135","author":"Eisen","year":"2008","journal-title":"Development"},{"key":"ref_211","doi-asserted-by":"crossref","unstructured":"Stainier, D.Y.R., Raz, E., Lawson, N.D., Ekker, S.C., Burdine, R.D., Eisen, J.S., Ingham, P.W., Schulte-Merker, S., Yelon, D., and Weinstein, B.M. (2017). Guidelines for morpholino use in zebrafish. PLoS Genet., 13.","DOI":"10.1371\/journal.pgen.1007000"},{"key":"ref_212","doi-asserted-by":"crossref","first-page":"2700","DOI":"10.1101\/gr.1725103","article-title":"Efficient target-selected mutagenesis in zebrafish","volume":"13","author":"Wienholds","year":"2003","journal-title":"Genome Res."},{"key":"ref_213","doi-asserted-by":"crossref","unstructured":"Kuroyanagi, M., Katayama, T., Imai, T., Yamamoto, Y., Shin-ichi, C., Yoshiura, Y., Ushijima, T., Matsushita, T., Fujita, M., and Nozawa, A. (2013). New approach for fish breeding by chemical mutagenesis: Establishment of TILLING method in fugu (Takifugu rubripes) with ENU mutagenesis. BMC Genomics, 14.","DOI":"10.1186\/1471-2164-14-786"},{"key":"ref_214","doi-asserted-by":"crossref","first-page":"702","DOI":"10.1038\/nbt1409","article-title":"Heritable targeted gene disruption in zebrafish using designed zinc-finger nucleases","volume":"26","author":"Doyon","year":"2008","journal-title":"Nat. Biotechnol."},{"key":"ref_215","doi-asserted-by":"crossref","first-page":"699","DOI":"10.1038\/nbt.1939","article-title":"Heritable gene targeting in zebrafish using customized TALENs","volume":"29","author":"Huang","year":"2011","journal-title":"Nat. Biotechnol."},{"key":"ref_216","doi-asserted-by":"crossref","first-page":"982","DOI":"10.1038\/nmeth.3543","article-title":"CRISPRscan: Designing highly efficient sgRNAs for CRISPR-Cas9 targeting in vivo","volume":"12","author":"Vejnar","year":"2015","journal-title":"Nat. Methods"},{"key":"ref_217","first-page":"856","article-title":"Optimized CRISPR-Cas9 system for genome editing in zebrafish","volume":"2016","author":"Vejnar","year":"2016","journal-title":"Cold Spring Harb. Protoc."},{"key":"ref_218","doi-asserted-by":"crossref","first-page":"478","DOI":"10.1016\/j.cell.2019.01.048","article-title":"Phenotypic Landscape of Schizophrenia-Associated Genes Defines Candidates and Their Shared Functions","volume":"177","author":"Thyme","year":"2019","journal-title":"Cell"},{"key":"ref_219","doi-asserted-by":"crossref","first-page":"1012","DOI":"10.1002\/humu.23990","article-title":"De Novo ARID1B mutations cause growth delay associated with aberrant Wnt\/\u03b2\u2013catenin signaling","volume":"41","author":"Liu","year":"2020","journal-title":"Hum. Mutat."},{"key":"ref_220","doi-asserted-by":"crossref","first-page":"1163","DOI":"10.1007\/s00439-015-1594-x","article-title":"Copy number variants in patients with intellectual disability affect the regulation of ARX transcription factor gene","volume":"134","author":"Ishibashi","year":"2015","journal-title":"Hum. Genet."},{"key":"ref_221","doi-asserted-by":"crossref","unstructured":"Oksenberg, N., Stevison, L., Wall, J.D., and Ahituv, N. (2013). Function and regulation of AUTS2, a gene implicated in autism and human evolution. PLoS Genet., 9.","DOI":"10.1371\/journal.pgen.1003221"},{"key":"ref_222","doi-asserted-by":"crossref","first-page":"1638","DOI":"10.1172\/JCI66903","article-title":"Calcium influx through L-type CaV1.2 Ca2+ channels regulates mandibular development","volume":"123","author":"Ramachandran","year":"2013","journal-title":"J. Clin. Investig."},{"key":"ref_223","doi-asserted-by":"crossref","unstructured":"Patowary, A., Won, S.Y., Oh, S.J., Nesbitt, R.R., Archer, M., Nickerson, D., Raskind, W.H., Bernier, R., Lee, J.E., and Brkanac, Z. (2019). Family-based exome sequencing and case-control analysis implicate CEP41 as an ASD gene. Transl. Psychiatry, 9.","DOI":"10.1038\/s41398-018-0343-z"},{"key":"ref_224","doi-asserted-by":"crossref","first-page":"967","DOI":"10.1016\/j.ajhg.2013.09.017","article-title":"De novo loss-of-function mutations in CHD2 cause a fever-sensitive myoclonic epileptic encephalopathy sharing features with dravet syndrome","volume":"93","author":"Suls","year":"2013","journal-title":"Am. J. Hum. Genet."},{"key":"ref_225","doi-asserted-by":"crossref","first-page":"263","DOI":"10.1016\/j.cell.2014.06.017","article-title":"Disruptive CHD8 mutations define a subtype of autism early in development","volume":"158","author":"Bernier","year":"2014","journal-title":"Cell"},{"key":"ref_226","doi-asserted-by":"crossref","first-page":"E4468","DOI":"10.1073\/pnas.1405266111","article-title":"CHD8 regulates neurodevelopmental pathways associated with autism spectrum disorder in neural progenitors","volume":"111","author":"Sugathan","year":"2014","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"ref_227","doi-asserted-by":"crossref","first-page":"51","DOI":"10.1038\/nature14186","article-title":"Loss of \u03b4-catenin function in severe autism","volume":"520","author":"Turner","year":"2015","journal-title":"Nature"},{"key":"ref_228","doi-asserted-by":"crossref","unstructured":"Kim, O.H., Cho, H.J., Han, E., Hong, T.I., Ariyasiri, K., Choi, J.H., Hwang, K.S., Jeong, Y.M., Yang, S.Y., and Yu, K. (2017). Zebrafish knockout of Down syndrome gene, DYRK1A, shows social impairments relevant to autism. Mol. Autism, 8.","DOI":"10.1186\/s13229-017-0168-2"},{"key":"ref_229","doi-asserted-by":"crossref","first-page":"152","DOI":"10.1007\/s10519-020-09995-7","article-title":"Hyperactivity, memory defects, and craniofacial abnormalities in zebrafish fmr1 mutant larvae","volume":"50","author":"Hu","year":"2020","journal-title":"Behav. Genet."},{"key":"ref_230","doi-asserted-by":"crossref","first-page":"40","DOI":"10.1016\/j.pnpbp.2014.03.007","article-title":"Anxiety, hyperactivity and stereotypy in a zebrafish model of Fragile X Syndrome and Autism Spectrum Disorder","volume":"55","author":"Kim","year":"2014","journal-title":"Prog. Neuro-Psychopharmacol. Biol. Psychiatry"},{"key":"ref_231","doi-asserted-by":"crossref","first-page":"438","DOI":"10.1089\/zeb.2017.1446","article-title":"Fragile X mental retardation-1 knockout zebrafish shows precocious development in social behavior","volume":"14","author":"Wu","year":"2017","journal-title":"Zebrafish"},{"key":"ref_232","doi-asserted-by":"crossref","first-page":"34325","DOI":"10.1038\/srep34325","article-title":"Gain-of-function defects of astrocytic Kir4.1 channels in children with Autism Spectrum Disorders and epilepsy","volume":"6","author":"Sicca","year":"2016","journal-title":"Sci. Rep."},{"key":"ref_233","doi-asserted-by":"crossref","first-page":"3585","DOI":"10.1172\/JCI80102","article-title":"RAP1-mediated MEK\/ERK pathway defects in Kabuki syndrome","volume":"125","author":"Tsai","year":"2015","journal-title":"J. Clin. Investig."},{"key":"ref_234","doi-asserted-by":"crossref","first-page":"4443","DOI":"10.1093\/hmg\/ddv180","article-title":"Kabuki syndrome genes KMT2D and KDM6A: Functional analyses demonstrate critical roles in craniofacial, heart and brain development","volume":"24","author":"Neitzel","year":"2015","journal-title":"Hum. Mol. Genet."},{"key":"ref_235","doi-asserted-by":"crossref","unstructured":"Leong, W.Y., Lim, Z.H., Korzh, V., Pietri, T., and Goh, E.L.K. (2015). Methyl-CpG binding protein 2 (Mecp2) regulates sensory function through Sema5b and Robo2. Front. Cell. Neurosci., 9.","DOI":"10.3389\/fncel.2015.00481"},{"key":"ref_236","doi-asserted-by":"crossref","first-page":"118","DOI":"10.3389\/fncir.2013.00118","article-title":"The first mecp2-null zebrafish model shows altered motor behaviors","volume":"7","author":"Pietri","year":"2013","journal-title":"Front. Neural Circuits"},{"key":"ref_237","first-page":"1439","article-title":"Mecp2 regulates tnfa during zebrafish embryonic development and acute inflammation","volume":"10","author":"Svoboda","year":"2017","journal-title":"DMM Dis. Model. Mech."},{"key":"ref_238","doi-asserted-by":"crossref","first-page":"78","DOI":"10.1016\/j.ydbio.2009.08.024","article-title":"The autism susceptibility gene met regulates zebrafish cerebellar development and facial motor neuron migration","volume":"335","author":"Elsen","year":"2009","journal-title":"Dev. Biol."},{"key":"ref_239","doi-asserted-by":"crossref","unstructured":"Blanchet, P., Bebin, M., Bruet, S., Cooper, G.M., Thompson, M.L., Duban-Bedu, B., Gerard, B., Piton, A., Suckno, S., and Deshpande, C. (2017). MYT1L mutations cause intellectual disability and variable obesity by dysregulating gene expression and development of the neuroendocrine hypothalamus. PLoS Genet., 13.","DOI":"10.1371\/journal.pgen.1006957"},{"key":"ref_240","doi-asserted-by":"crossref","first-page":"16","DOI":"10.1016\/j.cub.2014.10.071","article-title":"Neurobeachin is required postsynaptically for electrical and chemical synapse formation","volume":"25","author":"Miller","year":"2015","journal-title":"Curr. Biol."},{"key":"ref_241","doi-asserted-by":"crossref","first-page":"850","DOI":"10.1016\/j.cell.2019.07.015","article-title":"Inherited and de novo genetic risk for autism impacts shared networks","volume":"178","author":"Ruzzo","year":"2019","journal-title":"Cell"},{"key":"ref_242","doi-asserted-by":"crossref","first-page":"e12834","DOI":"10.1111\/jne.12834","article-title":"Oxytocin receptor signalling modulates novelty recognition but not social preference in zebrafish","volume":"32","author":"Ribeiro","year":"2020","journal-title":"J. Neuroendocrinol."},{"key":"ref_243","doi-asserted-by":"crossref","first-page":"214","DOI":"10.3389\/fnbeh.2019.00214","article-title":"Reelin signaling controls the preference for social novelty in zebrafish","volume":"13","author":"Vecchia","year":"2019","journal-title":"Front. Behav. Neurosci."},{"key":"ref_244","doi-asserted-by":"crossref","first-page":"1891","DOI":"10.1002\/dvdy.21196","article-title":"REREa\/Atrophin-2 interacts with histone deacetylase and Fgf8 signaling to regulate multiple processes of zebrafish development","volume":"236","author":"Plaster","year":"2007","journal-title":"Dev. Dyn."},{"key":"ref_245","doi-asserted-by":"crossref","first-page":"4006","DOI":"10.1093\/hmg\/ddv138","article-title":"Two knockdown models of the autism genes SYNGAP1 and SHANK3 in zebrafish produce similar behavioral phenotypes associated with embryonic disruptions of brain morphogenesis","volume":"24","author":"Kozol","year":"2015","journal-title":"Hum. Mol. Genet."},{"key":"ref_246","doi-asserted-by":"crossref","unstructured":"Liu, C.X., Li, C.Y., Hu, C.C., Wang, Y., Lin, J., Jiang, Y.H., Li, Q., and Xu, X. (2018). CRISPR\/Cas9-induced shank3b mutant zebrafish display autism-like behaviors. Mol. Autism, 9.","DOI":"10.1186\/s13229-018-0204-x"},{"key":"ref_247","doi-asserted-by":"crossref","first-page":"2479","DOI":"10.1242\/dev.00465","article-title":"N-cadherin mediates retinal lamination, maintenance of forebrain compartments and patterning of retinal neurites","volume":"130","author":"Masai","year":"2003","journal-title":"Development"},{"key":"ref_248","doi-asserted-by":"crossref","first-page":"2955","DOI":"10.1242\/dev.01861","article-title":"A GFP-based genetic screen reveals mutations that disrupt the architecture of the zebrafish retinotectal projection","volume":"132","author":"Xiao","year":"2005","journal-title":"Development"},{"key":"ref_249","doi-asserted-by":"crossref","first-page":"2539","DOI":"10.1002\/dvdy.22742","article-title":"Transgenic zebrafish expressing green fluorescent protein in dopaminergic neurons of the ventral diencephalon","volume":"240","author":"Xi","year":"2011","journal-title":"Dev. Dyn."},{"key":"ref_250","doi-asserted-by":"crossref","first-page":"774","DOI":"10.1016\/j.neuron.2017.04.034","article-title":"Linking Neurons to Network Function and Behavior by Two-Photon Holographic Optogenetics and Volumetric Imaging","volume":"94","author":"Donovan","year":"2017","journal-title":"Neuron"},{"key":"ref_251","doi-asserted-by":"crossref","first-page":"5827","DOI":"10.1523\/JNEUROSCI.5342-03.2004","article-title":"Engrailed-1 expression marks a primitive class of inhibitory spinal interneuron","volume":"24","author":"Higashijima","year":"2004","journal-title":"J. Neurosci."},{"key":"ref_252","doi-asserted-by":"crossref","first-page":"735","DOI":"10.1016\/j.ydbio.2007.01.023","article-title":"FoxH1 negatively modulates flk1 gene expression and vascular formation in zebrafish","volume":"304","author":"Choi","year":"2007","journal-title":"Dev. Biol."},{"key":"ref_253","doi-asserted-by":"crossref","first-page":"3927","DOI":"10.1242\/dev.099531","article-title":"Transgenic tools to characterize neuronal properties of discrete populations of zebrafish neurons","volume":"140","author":"Satou","year":"2013","journal-title":"Development"},{"key":"ref_254","doi-asserted-by":"crossref","first-page":"1007","DOI":"10.1016\/j.modgep.2006.04.006","article-title":"GFAP transgenic zebrafish","volume":"6","author":"Bernardos","year":"2006","journal-title":"Gene Expr. Patterns"},{"key":"ref_255","doi-asserted-by":"crossref","first-page":"71","DOI":"10.1038\/nature05588","article-title":"A topographic map of recruitment in spinal cord","volume":"446","author":"McLean","year":"2007","journal-title":"Nature"},{"key":"ref_256","doi-asserted-by":"crossref","first-page":"206","DOI":"10.1523\/JNEUROSCI.20-01-00206.2000","article-title":"Visualization of cranial motor neurons in live transgenic zebrafish expressing green fluorescent protein under the control of the Islet-1 promoter\/enhancer","volume":"20","author":"Higashijima","year":"2000","journal-title":"J. Neurosci."},{"key":"ref_257","doi-asserted-by":"crossref","unstructured":"Heffer, A., Marquart, G.D., Aquilina-Beck, A., Saleem, N., Burgess, H.A., and Dawid, I.B. (2017). Generation and characterization of Kctd15 mutations in zebrafish. PLoS ONE, 12.","DOI":"10.1371\/journal.pone.0189162"},{"key":"ref_258","doi-asserted-by":"crossref","unstructured":"Spir\u00f3, Z., Koh, A., Tay, S., See, K., and Winkler, C. (2016). Transcriptional enhancement of Smn levels in motoneurons is crucial for proper axon morphology in zebrafish. Sci. Rep., 6.","DOI":"10.1038\/srep27470"},{"key":"ref_259","doi-asserted-by":"crossref","first-page":"2110","DOI":"10.1523\/JNEUROSCI.5230-07.2008","article-title":"Vesicular glutamate transporter 3 is required for synaptic transmission in zebrafish hair cells","volume":"28","author":"Obholzer","year":"2008","journal-title":"J. Neurosci."},{"key":"ref_260","doi-asserted-by":"crossref","first-page":"211","DOI":"10.1016\/S0925-4773(02)00413-6","article-title":"Multiple regulatory elements with spatially and temporally distinct activities control neurogenin1 expression in primary neurons of the zebrafish embryo","volume":"120","author":"Blader","year":"2003","journal-title":"Mech. Dev."},{"key":"ref_261","doi-asserted-by":"crossref","first-page":"7","DOI":"10.1023\/B:MICS.0000006847.09037.3a","article-title":"Neural cell fate analysis in zebrafish using olig2 BAC transgenics","volume":"25","author":"Shin","year":"2003","journal-title":"Methods Cell Sci."},{"key":"ref_262","doi-asserted-by":"crossref","first-page":"158","DOI":"10.1002\/cne.21887","article-title":"Axonal projections originating from raphe serotonergic neurons in the developing and adult Zebrafish, Danio Rerio, using transgenics to visualize Raphe-specific pet1 expression","volume":"512","author":"Lillesaar","year":"2009","journal-title":"J. Comp. Neurol."},{"key":"ref_263","doi-asserted-by":"crossref","first-page":"1823","DOI":"10.1523\/JNEUROSCI.2579-15.2016","article-title":"QRFP and its receptors regulate locomotor activity and sleep in zebrafish","volume":"36","author":"Chen","year":"2016","journal-title":"J. Neurosci."},{"key":"ref_264","doi-asserted-by":"crossref","first-page":"3977","DOI":"10.1242\/dev.01943","article-title":"Hedgehog signaling is required for cranial neural crest morphogenesis and chondrogenesis at the midline in the zebrafish skull","volume":"132","author":"Wada","year":"2005","journal-title":"Development"},{"key":"ref_265","doi-asserted-by":"crossref","first-page":"90","DOI":"10.1016\/S0014-5793(03)00977-3","article-title":"Fluorescence visualization of ultraviolet-sensitive cone photoreceptor development in living zebrafish","volume":"553","author":"Takechi","year":"2003","journal-title":"FEBS Lett."},{"key":"ref_266","doi-asserted-by":"crossref","first-page":"84","DOI":"10.1016\/j.ydbio.2007.11.012","article-title":"Visualization of monoaminergic neurons and neurotoxicity of MPTP in live transgenic zebrafish","volume":"314","author":"Wen","year":"2008","journal-title":"Dev. Biol."},{"key":"ref_267","doi-asserted-by":"crossref","first-page":"95","DOI":"10.1016\/j.isci.2019.04.007","article-title":"Cereblon Control of Zebrafish Brain Size by Regulation of Neural Stem Cell Proliferation","volume":"15","author":"Ando","year":"2019","journal-title":"iScience"},{"key":"ref_268","doi-asserted-by":"crossref","unstructured":"Liu, T., Shi, Y., Chan, M.T.V., Peng, G., Zhang, Q., Sun, X., Zhu, Z., Xie, Y., Sham, K.W.Y., and Li, J. (2018). Developmental protein kinase C hyper-activation results in microcephaly and behavioral abnormalities in zebrafish. Transl. Psychiatry, 8.","DOI":"10.1038\/s41398-018-0285-5"},{"key":"ref_269","doi-asserted-by":"crossref","first-page":"936","DOI":"10.1038\/mp.2015.139","article-title":"Genetic and functional analyses demonstrate a role for abnormal glycinergic signaling in autism","volume":"21","author":"Pilorge","year":"2016","journal-title":"Mol. Psychiatry"},{"key":"ref_270","doi-asserted-by":"crossref","first-page":"797","DOI":"10.1111\/bph.14124","article-title":"Embryonic exposure to valproic acid affects the histaminergic system and the social behaviour of adult zebrafish (Danio rerio)","volume":"175","author":"Baronio","year":"2018","journal-title":"Br. J. Pharmacol."},{"key":"ref_271","doi-asserted-by":"crossref","unstructured":"James, D.M., Kozol, R.A., Kajiwara, Y., Wahl, A.L., Storrs, E.C., Buxbaum, J.D., Klein, M., Moshiree, B., and Dallman, J.E. (2019). Intestinal dysmotility in a zebrafish (Danio rerio) shank3a;shank3b mutant model of autism. Mol. Autism, 10.","DOI":"10.1186\/s13229-018-0250-4"},{"key":"ref_272","doi-asserted-by":"crossref","unstructured":"Lee, S., Chun, H.S., Lee, J., Park, H.J., Kim, K.T., Kim, C.H., Yoon, S., and Kim, W.K. (2018). Plausibility of the zebrafish embryos\/larvae as an alternative animal model for autism: A comparison study of transcriptome changes. PLoS ONE, 13.","DOI":"10.1371\/journal.pone.0203543"},{"key":"ref_273","doi-asserted-by":"crossref","unstructured":"Campbell, P.D., and Granato, M. (2020). Zebrafish as a tool to study schizophrenia-associated copy number variants. DMM Dis. Model. Mech., 13.","DOI":"10.1242\/dmm.043877"},{"key":"ref_274","doi-asserted-by":"crossref","first-page":"77","DOI":"10.1016\/j.jphysparis.2003.10.009","article-title":"Steps during the development of the zebrafish locomotor network","volume":"97","author":"Brustein","year":"2003","journal-title":"J. Physiol. Paris"},{"key":"ref_275","doi-asserted-by":"crossref","first-page":"170","DOI":"10.1101\/lm.025668.112","article-title":"Ontogeny of classical and operant learning behaviors in zebrafish","volume":"19","author":"Valente","year":"2012","journal-title":"Learn. Mem."},{"key":"ref_276","doi-asserted-by":"crossref","first-page":"1357","DOI":"10.1016\/j.cub.2018.03.025","article-title":"A Forward Genetic Screen in Zebrafish Identifies the G-Protein-Coupled Receptor CaSR as a Modulator of Sensorimotor Decision Making","volume":"28","author":"Jain","year":"2018","journal-title":"Curr. Biol."},{"key":"ref_277","doi-asserted-by":"crossref","first-page":"21347","DOI":"10.1073\/pnas.0911632106","article-title":"The transmembrane inner ear (Tmie) protein is essential for normal hearing and balance in the zebrafish","volume":"106","author":"Gleason","year":"2009","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"ref_278","doi-asserted-by":"crossref","first-page":"148","DOI":"10.1152\/jn.00839.2011","article-title":"Touch responsiveness in zebrafish requires voltage-gated calcium channel 2.1b","volume":"108","author":"Low","year":"2012","journal-title":"J. Neurophysiol."},{"key":"ref_279","doi-asserted-by":"crossref","first-page":"538","DOI":"10.1016\/j.cub.2012.01.061","article-title":"Chondroitin fragments are odorants that trigger fear behavior in fish","volume":"22","author":"Mathuru","year":"2012","journal-title":"Curr. Biol."},{"key":"ref_280","doi-asserted-by":"crossref","first-page":"168","DOI":"10.1016\/j.bbr.2007.10.031","article-title":"Alarm substance induced behavioral responses in zebrafish (Danio rerio)","volume":"188","author":"Speedie","year":"2008","journal-title":"Behav. Brain Res."},{"key":"ref_281","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.bbr.2013.03.013","article-title":"Maturation of shoaling in two zebrafish strains: A behavioral and neurochemical analysis","volume":"247","author":"Mahabir","year":"2013","journal-title":"Behav. Brain Res."},{"key":"ref_282","doi-asserted-by":"crossref","first-page":"185","DOI":"10.1089\/zeb.2013.0969","article-title":"Induction of social behavior in zebrafish: Live versus computer animated fish as stimuli","volume":"11","author":"Qin","year":"2014","journal-title":"Zebrafish"},{"key":"ref_283","doi-asserted-by":"crossref","first-page":"36","DOI":"10.1016\/j.pneurobio.2014.03.001","article-title":"Zebrafish models of human motor neuron diseases: Advantages and limitations","volume":"118","author":"Babin","year":"2014","journal-title":"Prog. Neurobiol."},{"key":"ref_284","doi-asserted-by":"crossref","first-page":"95","DOI":"10.1021\/acs.chemrestox.9b00335","article-title":"Use of Zebrafish in Drug Discovery Toxicology","volume":"33","author":"Cassar","year":"2020","journal-title":"Chem. Res. Toxicol."},{"key":"ref_285","doi-asserted-by":"crossref","first-page":"56","DOI":"10.1016\/j.vascn.2018.11.006","article-title":"Larval zebrafish model for studying the effects of valproic acid on neurodevelopment: An approach towards modeling autism","volume":"95","author":"Dwivedi","year":"2019","journal-title":"J. Pharmacol. Toxicol. Methods"},{"key":"ref_286","doi-asserted-by":"crossref","first-page":"459","DOI":"10.1093\/genetics\/154.1.459","article-title":"The probability of duplicate gene preservation by subfunctionalization","volume":"154","author":"Lynch","year":"2000","journal-title":"Genetics"},{"key":"ref_287","doi-asserted-by":"crossref","first-page":"3953","DOI":"10.1007\/s00018-019-03193-3","article-title":"Direct reprogramming into interneurons: Potential for brain repair","volume":"76","author":"Pereira","year":"2019","journal-title":"Cell. Mol. Life Sci."},{"key":"ref_288","doi-asserted-by":"crossref","first-page":"927","DOI":"10.1038\/s41591-018-0049-z","article-title":"CRISPR\u2013Cas9 genome editing induces a p53-mediated DNA damage response","volume":"24","author":"Haapaniemi","year":"2018","journal-title":"Nat. Med."},{"key":"ref_289","doi-asserted-by":"crossref","first-page":"939","DOI":"10.1038\/s41591-018-0050-6","article-title":"p53 inhibits CRISPR\u2013Cas9 engineering in human pluripotent stem cells","volume":"24","author":"Ihry","year":"2018","journal-title":"Nat. Med."},{"key":"ref_290","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1186\/s13010-019-0085-4","article-title":"Joining forces: The need to combine science and ethics to address problems of validity and translation in neuropsychiatry research using animal models","volume":"15","author":"Meijboom","year":"2020","journal-title":"Philos. Ethics Humanit. Med."},{"key":"ref_291","doi-asserted-by":"crossref","first-page":"420","DOI":"10.1017\/S0963180115000080","article-title":"Necessary conditions for morally responsible animal research","volume":"24","author":"DeGrazia","year":"2015","journal-title":"Cambridge Q. Healthc. Ethics"},{"key":"ref_292","doi-asserted-by":"crossref","first-page":"273","DOI":"10.1093\/biostatistics\/kxx069","article-title":"Estimation of clinical trial success rates and related parameters","volume":"20","author":"Wong","year":"2019","journal-title":"Biostatistics"},{"key":"ref_293","doi-asserted-by":"crossref","first-page":"681","DOI":"10.1007\/s11095-016-2069-z","article-title":"Alternative animal and non-animal models for drug discovery and development: Bonus or burden?","volume":"34","author":"Freires","year":"2017","journal-title":"Pharm. Res."},{"key":"ref_294","doi-asserted-by":"crossref","first-page":"17","DOI":"10.1007\/7854_2014_329","article-title":"The use of animal models in behavioural neuroscience research","volume":"19","author":"Bovenkerk","year":"2015","journal-title":"Curr. Top. Behav. Neurosci."},{"key":"ref_295","doi-asserted-by":"crossref","unstructured":"Kilkenny, C., Browne, W.J., Cuthill, I.C., Emerson, M., and Altman, D.G. (2010). Improving bioscience research reporting: The ARRIVE guidelines for reporting animal research. PLoS Biol., 8.","DOI":"10.1371\/journal.pbio.1000412"},{"key":"ref_296","doi-asserted-by":"crossref","first-page":"135","DOI":"10.1177\/0023677217724823","article-title":"PREPARE: Guidelines for planning animal research and testing","volume":"52","author":"Smith","year":"2018","journal-title":"Lab. Anim."}],"container-title":["Genes"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.mdpi.com\/2073-4425\/11\/11\/1376\/pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,11]],"date-time":"2025-10-11T10:35:04Z","timestamp":1760178904000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.mdpi.com\/2073-4425\/11\/11\/1376"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020,11,20]]},"references-count":296,"journal-issue":{"issue":"11","published-online":{"date-parts":[[2020,11]]}},"alternative-id":["genes11111376"],"URL":"https:\/\/doi.org\/10.3390\/genes11111376","relation":{},"ISSN":["2073-4425"],"issn-type":[{"value":"2073-4425","type":"electronic"}],"subject":[],"published":{"date-parts":[[2020,11,20]]}}}