{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,30]],"date-time":"2026-09-30T04:27:23Z","timestamp":1790742443618,"version":"4.1.0"},"reference-count":151,"publisher":"MDPI AG","issue":"12","license":[{"start":{"date-parts":[[2020,12,21]],"date-time":"2020-12-21T00:00:00Z","timestamp":1608508800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100003141","name":"Consejo Nacional de Ciencia y Tecnolog\u00eda","doi-asserted-by":"publisher","award":["SEP-243102 and 574025 scholarship"],"award-info":[{"award-number":["SEP-243102 and 574025 scholarship"]}],"id":[{"id":"10.13039\/501100003141","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100010292","name":"Fundaci\u00f3n Miguel Alem\u00e1n, A.C.","doi-asserted-by":"publisher","award":["Apoyo Investigaci\u00f3n M\u00e9dica 2018"],"award-info":[{"award-number":["Apoyo Investigaci\u00f3n M\u00e9dica 2018"]}],"id":[{"id":"10.13039\/501100010292","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100006087","name":"Direcci\u00f3n General de Asuntos del Personal Acad\u00e9mico, Universidad Nacional Aut\u00f3noma de M\u00e9xico","doi-asserted-by":"publisher","award":["PAPIIT IN205120"],"award-info":[{"award-number":["PAPIIT IN205120"]}],"id":[{"id":"10.13039\/501100006087","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100016928","name":"Instituto Nacional de Pediatr\u00eda","doi-asserted-by":"publisher","award":["Recursos Fiscales proyectos 41\/2014, 40\/2013"],"award-info":[{"award-number":["Recursos Fiscales proyectos 41\/2014, 40\/2013"]}],"id":[{"id":"10.13039\/100016928","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Genes"],"abstract":"<jats:p>Fanconi anemia (FA), a chromosomal instability syndrome, is caused by inherited pathogenic variants in any of 22 FANC genes, which cooperate in the FA\/BRCA pathway. This pathway regulates the repair of DNA interstrand crosslinks (ICLs) through homologous recombination. In FA proper repair of ICLs is impaired and accumulation of toxic DNA double strand breaks occurs. To repair this type of DNA damage, FA cells activate alternative error-prone DNA repair pathways, which may lead to the formation of gross structural chromosome aberrations of which radial figures are the hallmark of FA, and their segregation during cell division are the origin of subsequent aberrations such as translocations, dicentrics and acentric fragments. The deficiency in DNA repair has pleiotropic consequences in the phenotype of patients with FA, including developmental alterations, bone marrow failure and an extreme risk to develop cancer. The mechanisms leading to the physical abnormalities during embryonic development have not been clearly elucidated, however FA has features of premature aging with chronic inflammation mediated by pro-inflammatory cytokines, which results in tissue attrition, selection of malignant clones and cancer onset. Moreover, chromosomal instability and cell death are not exclusive of the somatic compartment, they also affect germinal cells, as evidenced by the infertility observed in patients with FA.<\/jats:p>","DOI":"10.3390\/genes11121528","type":"journal-article","created":{"date-parts":[[2020,12,21]],"date-time":"2020-12-21T20:42:01Z","timestamp":1608583321000},"page":"1528","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":50,"title":["Chromosome Instability in Fanconi Anemia: From Breaks to Phenotypic Consequences"],"prefix":"10.3390","volume":"11","author":[{"given":"Benilde","family":"Garc\u00eda-de-Teresa","sequence":"first","affiliation":[{"name":"Laboratorio de Citogen\u00e9tica, Instituto Nacional de Pediatr\u00eda, Ciudad de M\u00e9xico 04530, Mexico"},{"name":"Doctorado en Ciencias Biom\u00e9dicas, Universidad Nacional Aut\u00f3noma de M\u00e9xico, Ciudad de M\u00e9xico 04510, Mexico"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alfredo","family":"Rodr\u00edguez","sequence":"additional","affiliation":[{"name":"Laboratorio de Citogen\u00e9tica, Instituto Nacional de Pediatr\u00eda, Ciudad de M\u00e9xico 04530, Mexico"},{"name":"Instituto de Investigaciones Biom\u00e9dicas, Universidad Nacional Aut\u00f3noma de M\u00e9xico, Ciudad de M\u00e9xico 04510, Mexico"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sara","family":"Frias","sequence":"additional","affiliation":[{"name":"Laboratorio de Citogen\u00e9tica, Instituto Nacional de Pediatr\u00eda, Ciudad de M\u00e9xico 04530, Mexico"},{"name":"Instituto de Investigaciones Biom\u00e9dicas, Universidad Nacional Aut\u00f3noma de M\u00e9xico, Ciudad de M\u00e9xico 04510, Mexico"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2020,12,21]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"526","DOI":"10.1111\/bjh.14535","article-title":"The genomics of inherited bone marrow failure: From mechanism to the clinic","volume":"177","author":"Savage","year":"2017","journal-title":"Br. J. Haematol."},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"32","DOI":"10.1016\/j.gde.2015.07.002","article-title":"Fanconi anemia: A model disease for studies on human genetics and advanced therapeutics","volume":"33","author":"Bogliolo","year":"2015","journal-title":"Curr. Opin. Genet. Dev."},{"key":"ref_3","doi-asserted-by":"crossref","first-page":"R986","DOI":"10.1016\/j.cub.2017.07.043","article-title":"Fanconi anemia pathway","volume":"27","year":"2017","journal-title":"Curr. Biol."},{"key":"ref_4","doi-asserted-by":"crossref","first-page":"102806","DOI":"10.1016\/j.dnarep.2020.102806","article-title":"DNA-protein crosslink formation by endogenous aldehydes and AP sites","volume":"88","author":"Nakamura","year":"2020","journal-title":"DNA Repair"},{"key":"ref_5","doi-asserted-by":"crossref","first-page":"27","DOI":"10.1002\/cbic.200400287","article-title":"DNA interstrand crosslinks: Natural and drug-induced DNA adducts that induce unique cellular responses","volume":"6","year":"2005","journal-title":"ChemBioChem"},{"key":"ref_6","doi-asserted-by":"crossref","first-page":"1432","DOI":"10.1038\/nsmb.2173","article-title":"Formaldehyde catabolism is essential in cells deficient for the Fanconi anemia DNA-repair pathway","volume":"18","author":"Rosado","year":"2011","journal-title":"Nat. Struct. Mol. Biol."},{"key":"ref_7","doi-asserted-by":"crossref","first-page":"171","DOI":"10.1038\/nature25154","article-title":"Alcohol and endogenous aldehydes damage chromosomes and mutate stem cells","volume":"553","author":"Garaycoechea","year":"2018","journal-title":"Nature"},{"key":"ref_8","doi-asserted-by":"crossref","first-page":"100589","DOI":"10.1016\/j.blre.2019.100589","article-title":"Genotype-phenotype associations in Fanconi anemia: A literature review","volume":"37","author":"Giri","year":"2019","journal-title":"Blood Rev."},{"key":"ref_9","doi-asserted-by":"crossref","first-page":"337","DOI":"10.1038\/nrm.2016.48","article-title":"The Fanconi anaemia pathway: New players and new functions","volume":"17","author":"Ceccaldi","year":"2016","journal-title":"Nat. Rev. Mol. Cell Biol."},{"key":"ref_10","doi-asserted-by":"crossref","first-page":"458","DOI":"10.1038\/gim.2017.124","article-title":"Biallelic truncating FANCM mutations cause early-onset cancer but not Fanconi anemia","volume":"20","author":"Bogliolo","year":"2018","journal-title":"Genet. Med."},{"key":"ref_11","doi-asserted-by":"crossref","first-page":"242","DOI":"10.1038\/nsmb.2956","article-title":"DNA interstrand cross-link repair requires replication-fork convergence","volume":"22","author":"Zhang","year":"2015","journal-title":"Nat. Struct. Mol. Biol."},{"key":"ref_12","doi-asserted-by":"crossref","unstructured":"Renaudin, X., and Rosselli, F. (2020). The FANC\/BRCA Pathway Releases Replication Blockades by Eliminating DNA Interstrand Cross-Links. Genes, 11.","DOI":"10.3390\/genes11050585"},{"key":"ref_13","doi-asserted-by":"crossref","first-page":"313","DOI":"10.1016\/j.molcel.2008.10.014","article-title":"FANCM and FAAP24 Function in ATR-Mediated Checkpoint Signaling Independently of the Fanconi Anemia Core Complex","volume":"32","author":"Collis","year":"2008","journal-title":"Mol. Cell"},{"key":"ref_14","doi-asserted-by":"crossref","first-page":"5215","DOI":"10.1182\/blood-2007-09-113092","article-title":"Cell cycle-dependent chromatin loading of the Fanconi anemia core complex by FANCM\/FAAP24","volume":"111","author":"Kim","year":"2008","journal-title":"Blood"},{"key":"ref_15","doi-asserted-by":"crossref","first-page":"2","DOI":"10.3389\/fcell.2020.00002","article-title":"ATR-Mediated FANCI Phosphorylation Regulates Both Ubiquitination and Deubiquitination of FANCD2","volume":"8","author":"Tan","year":"2020","journal-title":"Front. Cell Dev. Biol."},{"key":"ref_16","doi-asserted-by":"crossref","first-page":"135","DOI":"10.1016\/j.dnarep.2014.03.018","article-title":"Mechanism and regulation of incisions during DNA interstrand cross-link repair","volume":"19","author":"Zhang","year":"2014","journal-title":"DNA Repair"},{"key":"ref_17","doi-asserted-by":"crossref","first-page":"1971","DOI":"10.15252\/embj.201490878","article-title":"Regulation of the Rev1\u2013pol \u03b6 complex during bypass of a DNA interstrand cross-link","volume":"34","author":"Budzowska","year":"2015","journal-title":"EMBO J."},{"key":"ref_18","doi-asserted-by":"crossref","first-page":"87","DOI":"10.1038\/s41556-019-0442-y","article-title":"TRIP13 regulates DNA repair pathway choice through REV7 conformational change","volume":"22","author":"Clairmont","year":"2020","journal-title":"Nat. Cell Biol."},{"key":"ref_19","doi-asserted-by":"crossref","unstructured":"Mar\u00edn, M., Ram\u00edrez, M.J., Carmona, M.A., Jia, N., Ogi, T., Bogliolo, M., and Surrall\u00e9s, J. (2019). Functional comparison of XPF missense mutations associated to multiple DNA repair disorders. Genes, 10.","DOI":"10.3390\/genes10010060"},{"key":"ref_20","doi-asserted-by":"crossref","unstructured":"Castella, M., Jacquemont, C., Thompson, E.L., Yeo, J.E., Cheung, R.S., Huang, J.W., Sobeck, A., Hendrickson, E.A., and Taniguchi, T. (2015). FANCI Regulates Recruitment of the FA Core Complex at Sites of DNA Damage Independently of FANCD2. PLoS Genet., 11.","DOI":"10.1371\/journal.pgen.1005563"},{"key":"ref_21","doi-asserted-by":"crossref","first-page":"457","DOI":"10.1146\/annurev-cancerbio-030617-050422","article-title":"The fanconi anemia pathway in cancer","volume":"3","author":"Niraj","year":"2019","journal-title":"Annu. Rev. Cancer Biol."},{"key":"ref_22","doi-asserted-by":"crossref","first-page":"187","DOI":"10.1007\/s00412-017-0658-1","article-title":"Main steps in DNA double-strand break repair: An introduction to homologous recombination and related processes","volume":"127","author":"Ranjha","year":"2018","journal-title":"Chromosoma"},{"key":"ref_23","doi-asserted-by":"crossref","unstructured":"Rageul, J., and Kim, H. (2020). Fanconi anemia and the underlying causes of genomic instability. Environ. Mol. Mutagen.","DOI":"10.1002\/em.22358"},{"key":"ref_24","doi-asserted-by":"crossref","first-page":"234","DOI":"10.1038\/s41586-019-1703-4","article-title":"Structure of the Fanconi anaemia monoubiquitin ligase complex","volume":"575","author":"Shakeel","year":"2019","journal-title":"Nature"},{"key":"ref_25","doi-asserted-by":"crossref","first-page":"10512","DOI":"10.1074\/jbc.TM117.000374","article-title":"Nonhomologous DNA end-joining for repair of DNA double-strand breaks","volume":"293","author":"Pannunzio","year":"2018","journal-title":"J. Biol. Chem."},{"key":"ref_26","doi-asserted-by":"crossref","first-page":"698","DOI":"10.1038\/s41580-019-0152-0","article-title":"DNA double-strand break repair-pathway choice in somatic mammalian cells","volume":"20","author":"Scully","year":"2019","journal-title":"Nat. Rev. Mol. Cell Biol."},{"key":"ref_27","doi-asserted-by":"crossref","first-page":"126","DOI":"10.1016\/j.gpb.2016.05.002","article-title":"DNA End Resection: Facts and Mechanisms","volume":"14","author":"Liu","year":"2016","journal-title":"Genom. Proteom. Bioinform."},{"key":"ref_28","doi-asserted-by":"crossref","first-page":"384","DOI":"10.1016\/j.molcel.2019.10.031","article-title":"HMCES Functions in the Alternative End-Joining Pathway of the DNA DSB Repair during Class Switch Recombination in B Cells","volume":"77","author":"Shukla","year":"2020","journal-title":"Mol. Cell"},{"key":"ref_29","doi-asserted-by":"crossref","first-page":"142","DOI":"10.1038\/ng.750","article-title":"Mutations of the SLX4 gene in Fanconi anemia","volume":"43","author":"Kim","year":"2011","journal-title":"Nat. Genet."},{"key":"ref_30","doi-asserted-by":"crossref","first-page":"937","DOI":"10.1038\/nrm1502","article-title":"Happy Hollidays: 40th Anniversary of the Holliday junction","volume":"5","author":"Liu","year":"2004","journal-title":"Nat. Rev. Mol. Cell Biol."},{"key":"ref_31","doi-asserted-by":"crossref","first-page":"329","DOI":"10.1016\/j.ymeth.2010.02.009","article-title":"Promotion and regulation of homologous recombination by DNA helicases","volume":"51","author":"Colavito","year":"2010","journal-title":"Methods"},{"key":"ref_32","doi-asserted-by":"crossref","first-page":"5343","DOI":"10.1074\/jbc.M808430200","article-title":"UAF1 is a subunit of multiple deubiquitinating enzyme complexes","volume":"284","author":"Cohn","year":"2009","journal-title":"J. Biol. Chem."},{"key":"ref_33","doi-asserted-by":"crossref","first-page":"166","DOI":"10.1016\/j.mrgentox.2015.07.001","article-title":"Alternative end-joining repair pathways are the ultimate backup for abrogated classical non-homologous end-joining and homologous recombination repair: Implications for the formation of chromosome translocations","volume":"793","author":"Iliakis","year":"2015","journal-title":"Mutat. Res. Genet. Toxicol. Environ. Mutagen."},{"key":"ref_34","doi-asserted-by":"crossref","first-page":"6170","DOI":"10.1093\/nar\/gkl840","article-title":"PARP-1 and Ku compete for repair of DNA double strand breaks by distinct NHEJ pathways","volume":"34","author":"Wang","year":"2006","journal-title":"Nucleic Acids Res."},{"key":"ref_35","doi-asserted-by":"crossref","first-page":"81","DOI":"10.1016\/j.mrfmmm.2017.07.002","article-title":"Microhomology-mediated end joining: Good, bad and ugly","volume":"809","author":"Seol","year":"2018","journal-title":"Mutat. Res. Fundam. Mol. Mech. Mutagen."},{"key":"ref_36","doi-asserted-by":"crossref","first-page":"495","DOI":"10.1038\/nrm.2017.48","article-title":"Non-homologous DNA end joining and alternative pathways to double-strand break repair","volume":"18","author":"Chang","year":"2017","journal-title":"Nat. Rev. Mol. Cell Biol."},{"key":"ref_37","doi-asserted-by":"crossref","first-page":"861","DOI":"10.1038\/nrc2248","article-title":"The impact of a negligent G2\/M checkpoint on genomic instability and cancer induction","volume":"7","author":"Jeggo","year":"2007","journal-title":"Nat. Rev. Cancer"},{"key":"ref_38","doi-asserted-by":"crossref","first-page":"460","DOI":"10.1038\/nature07955","article-title":"CtIP-BRCA1 modulates the choice of DNA double-strand-break repair pathway throughout the cell cycle","volume":"459","author":"Yun","year":"2009","journal-title":"Nature"},{"key":"ref_39","doi-asserted-by":"crossref","first-page":"50","DOI":"10.1038\/nature12318","article-title":"53BP1 is a reader of the DNA-damage-induced H2A Lys 15 ubiquitin mark","volume":"499","author":"Canny","year":"2013","journal-title":"Nature"},{"key":"ref_40","doi-asserted-by":"crossref","unstructured":"Arnoult, N., Correia, A., Ma, J., Merlo, A., Garcia-Gomez, S., Maric, M., Tognetti, M., Benner, C.W., Boulton, S.J., and Saghatelian, A. (2017). Regulation of DNA Repair pathway choice in S\/G2 by the NHEJ inhibitor CYREN Europe PMC Funders Group. Nature.","DOI":"10.1038\/nature24023"},{"key":"ref_41","doi-asserted-by":"crossref","first-page":"4","DOI":"10.1016\/j.mrfmmm.2009.01.013","article-title":"Fanconi anemia and its diagnosis","volume":"668","author":"Auerbach","year":"2009","journal-title":"Mutat. Res. Fundam. Mol. Mech. Mutagen."},{"key":"ref_42","doi-asserted-by":"crossref","first-page":"1400","DOI":"10.1101\/gad.14.11.1400","article-title":"Gross chromosomal rearrangements and genetic exchange between nonhomologous chromosomes following BRCA2 inactivation","volume":"14","author":"Yu","year":"2000","journal-title":"Genes Dev."},{"key":"ref_43","doi-asserted-by":"crossref","first-page":"168","DOI":"10.1038\/nrc.2017.116","article-title":"Fanconi anaemia and cancer: An intricate relationship","volume":"18","author":"Nalepa","year":"2018","journal-title":"Nat. Rev. Cancer"},{"key":"ref_44","doi-asserted-by":"crossref","unstructured":"Srinivasan, M., Fumasoni, M., Petela, N.J., Murray, A., and Nasmyth, K.A. (2020). Cohesion is established during dna replication utilising chromosome associated cohesin rings as well as those loaded de novo onto nascent dnas. Elife, 9.","DOI":"10.7554\/eLife.56611"},{"key":"ref_45","doi-asserted-by":"crossref","first-page":"535","DOI":"10.1016\/j.dnarep.2004.01.011","article-title":"Interstrand crosslink-induced radials form between non-homologous chromosomes, but are absent in sex chromosomes","volume":"3","author":"Newell","year":"2004","journal-title":"DNA Repair"},{"key":"ref_46","doi-asserted-by":"crossref","first-page":"174","DOI":"10.1159\/000138882","article-title":"Loss of homologous recombination or non-homologous end-joining leads to radial formation following DNA interstrand crosslink damage","volume":"121","author":"Hemphill","year":"2008","journal-title":"Cytogenet. Genome Res."},{"key":"ref_47","first-page":"1022","article-title":"Endogenous blockage and delay of the chromosome cycle despite normal recruitment and growth phase explain poor proliferation and frequent endomitosis in Fanconi anemia cells","volume":"37","author":"Kubbies","year":"1985","journal-title":"Am. J. Hum. Genet."},{"key":"ref_48","doi-asserted-by":"crossref","first-page":"913","DOI":"10.1007\/s00277-020-03954-2","article-title":"Mosaicism in Fanconi anemia: Concise review and evaluation of published cases with focus on clinical course of blood count normalization","volume":"99","author":"Nicoletti","year":"2020","journal-title":"Ann. Hematol."},{"key":"ref_49","first-page":"35","article-title":"DEB Test for Fanconi Anemia Detection in Patients with Atypical Phenotypes","volume":"124","author":"Esmer","year":"2003","journal-title":"Am. J. Med. Genet."},{"key":"ref_50","doi-asserted-by":"crossref","first-page":"297","DOI":"10.1038\/s41586-020-2842-3","article-title":"Equilibrium between nascent and parental MCM proteins protects replicating genomes","volume":"587","author":"Sedlackova","year":"2020","journal-title":"Nature"},{"key":"ref_51","doi-asserted-by":"crossref","first-page":"613","DOI":"10.1080\/15384101.2017.1288322","article-title":"Rescue from replication stress during mitosis","volume":"16","author":"Fragkos","year":"2017","journal-title":"Cell Cycle"},{"key":"ref_52","doi-asserted-by":"crossref","first-page":"2","DOI":"10.1038\/ncb2897","article-title":"Causes and consequences of replication stress","volume":"16","author":"Zeman","year":"2014","journal-title":"Nat. Cell Biol."},{"key":"ref_53","doi-asserted-by":"crossref","unstructured":"Primo, L.M.F., and Teixeira, L.K. (2020). DNA replication stress: Oncogenes in the spotlight. Genet. Mol. Biol., 43.","DOI":"10.1590\/1678-4685gmb-2019-0138"},{"key":"ref_54","doi-asserted-by":"crossref","first-page":"351","DOI":"10.1016\/j.molcel.2015.09.012","article-title":"The Fanconi Anemia Pathway Maintains Genome Stability by Coordinating Replication and Transcription","volume":"60","author":"Schwab","year":"2015","journal-title":"Mol. Cell"},{"key":"ref_55","doi-asserted-by":"crossref","first-page":"R158","DOI":"10.1093\/hmg\/ddaa087","article-title":"Emerging functions of Fanconi anemia genes in replication fork protection pathways","volume":"29","author":"Kolinjivadi","year":"2020","journal-title":"Hum. Mol. Genet."},{"key":"ref_56","doi-asserted-by":"crossref","unstructured":"Panday, A., Willis, N.A., Elango, R., Menghi, F., Duffey, E.E., Liu, E.T., and Scully, R. (2020). FANCM regulates repair pathway choice at stalled replication forks. bioRxiv.","DOI":"10.1101\/2020.10.29.357996"},{"key":"ref_57","doi-asserted-by":"crossref","first-page":"457","DOI":"10.1002\/em.21938","article-title":"Hydroxyurea induces chromosomal damage in G2 and enhances the clastogenic effect of mitomycin C in Fanconi anemia cells","volume":"56","author":"Molina","year":"2015","journal-title":"Environ. Mol. Mutagen."},{"key":"ref_58","doi-asserted-by":"crossref","unstructured":"Garc\u00eda-Rubio, M.L., P\u00e9rez-Calero, C., Barroso, S.I., Tumini, E., Herrera-Moyano, E., Rosado, I.V., and Aguilera, A. (2015). The Fanconi Anemia Pathway Protects Genome Integrity from R-loops. PLoS Genet., 11.","DOI":"10.1371\/journal.pgen.1005674"},{"key":"ref_59","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1038\/s41598-019-55537-5","article-title":"FANCM suppresses DNA replication stress at ALT telomeres by disrupting TERRA R-loops","volume":"9","author":"Pan","year":"2019","journal-title":"Sci. Rep."},{"key":"ref_60","doi-asserted-by":"crossref","first-page":"3834","DOI":"10.1172\/JCI43391","article-title":"Cytokinesis failure occurs in Fanconi anemia pathway-deficient murine and human bone marrow hematopoietic cells","volume":"120","author":"Vinciguerra","year":"2010","journal-title":"J. Clin. Investig."},{"key":"ref_61","doi-asserted-by":"crossref","first-page":"388","DOI":"10.1016\/j.molcel.2016.09.017","article-title":"FANCD2 Facilitates Replication through Common Fragile Sites","volume":"64","author":"Madireddy","year":"2016","journal-title":"Mol. Cell"},{"key":"ref_62","first-page":"307","article-title":"New aspects on chromosomal instability: Chromosomal break-points in Fanconi anemia patients co-localize on the molecular level with fragile sites","volume":"36","author":"Schoder","year":"2009","journal-title":"Int. J. Oncol."},{"key":"ref_63","doi-asserted-by":"crossref","unstructured":"Milletti, G., Strocchio, L., Pagliara, D., Girardi, K., Carta, R., Mastronuzzi, A., Locatelli, F., and Nazio, F. (2020). Canonical and noncanonical roles of fanconi anemia proteins: Implications in cancer predisposition. Cancers, 12.","DOI":"10.3390\/cancers12092684"},{"key":"ref_64","doi-asserted-by":"crossref","first-page":"411","DOI":"10.3389\/fgene.2019.00411","article-title":"WIP1 contributes to the adaptation of fanconi anemia cells to DNA damage as determined by the regulatory network of the fanconi anemia and checkpoint recovery pathways","volume":"10","author":"Torres","year":"2019","journal-title":"Front. Genet."},{"key":"ref_65","doi-asserted-by":"crossref","first-page":"238","DOI":"10.1016\/j.ceb.2007.02.009","article-title":"DNA damage checkpoints: From initiation to recovery or adaptation","volume":"19","author":"Bartek","year":"2007","journal-title":"Curr. Opin. Cell Biol."},{"key":"ref_66","doi-asserted-by":"crossref","first-page":"R1002","DOI":"10.1016\/j.cub.2015.08.051","article-title":"The Molecular Biology of Spindle Assembly Checkpoint Signaling Dynamics","volume":"25","author":"Musacchio","year":"2015","journal-title":"Curr. Biol."},{"key":"ref_67","doi-asserted-by":"crossref","first-page":"36","DOI":"10.1016\/j.stem.2012.05.013","article-title":"Bone marrow failure in fanconi anemia is triggered by an exacerbated p53\/p21 DNA damage response that impairs hematopoietic stem and progenitor cells","volume":"11","author":"Ceccaldi","year":"2012","journal-title":"Cell Stem Cell"},{"key":"ref_68","doi-asserted-by":"crossref","first-page":"208","DOI":"10.1006\/excr.2000.4994","article-title":"Arrest of S-phase progression is impaired in Fanconi anemia cells","volume":"260","author":"Rouillard","year":"2000","journal-title":"Exp. Cell Res."},{"key":"ref_69","doi-asserted-by":"crossref","first-page":"3943","DOI":"10.1038\/onc.2016.502","article-title":"Census and evaluation of p53 target genes","volume":"36","author":"Fischer","year":"2017","journal-title":"Oncogene"},{"key":"ref_70","doi-asserted-by":"crossref","unstructured":"Luo, Q., Beaver, J.M., Liu, Y., and Zhang, Z. (2017). Dynamics of p53: A master decider of cell fate. Genes, 8.","DOI":"10.3390\/genes8020066"},{"key":"ref_71","doi-asserted-by":"crossref","first-page":"277","DOI":"10.1016\/j.molcel.2008.03.016","article-title":"Recurrent Initiation: A Mechanism for Triggering p53 Pulses in Response to DNA Damage","volume":"30","author":"Batchelor","year":"2008","journal-title":"Mol. Cell"},{"key":"ref_72","doi-asserted-by":"crossref","first-page":"e3130","DOI":"10.1038\/cddis.2017.492","article-title":"P53 Dynamics Orchestrates With Binding Affinity To Target Genes for Cell Fate Decision","volume":"8","author":"Wu","year":"2017","journal-title":"Cell Death Dis."},{"key":"ref_73","first-page":"1","article-title":"Fanconi anemia cells with unrepaired DNA damage activate components of the checkpoint recovery process","volume":"12","author":"Torres","year":"2015","journal-title":"Theor. Biol. Med. Model."},{"key":"ref_74","doi-asserted-by":"crossref","first-page":"3739","DOI":"10.4161\/cc.21727","article-title":"A prototypical Fanconi anemia pathway in lower eukaryotes?","volume":"11","author":"McHugh","year":"2012","journal-title":"Cell Cycle"},{"key":"ref_75","doi-asserted-by":"crossref","first-page":"133","DOI":"10.1016\/j.mrfmmm.2009.03.015","article-title":"Mouse models of Fanconi anemia","volume":"668","author":"Parmar","year":"2009","journal-title":"Mutat. Res. Fundam. Mol. Mech. Mutagen."},{"key":"ref_76","first-page":"25","article-title":"Chemical teratogenesis in humans: Biochemical and molecular mechanisms","volume":"49","author":"Juchau","year":"1997","journal-title":"Prog. Drug Res."},{"key":"ref_77","doi-asserted-by":"crossref","first-page":"1185","DOI":"10.1002\/pd.5731","article-title":"Fetal alcohol spectrum disorders: Genetic and epigenetic mechanisms","volume":"40","year":"2020","journal-title":"Prenat. Diagn."},{"key":"ref_78","doi-asserted-by":"crossref","first-page":"28","DOI":"10.1016\/j.ymgme.2016.07.004","article-title":"Aldehyde dehydrogenase 2 in aplastic anemia, Fanconi anemia and hematopoietic stem cells","volume":"119","author":"Weinberg","year":"2016","journal-title":"Mol. Genet. Metab."},{"key":"ref_79","doi-asserted-by":"crossref","first-page":"3206","DOI":"10.1182\/blood-2013-06-507962","article-title":"Variant ALDH2 is associated with accelerated progression of bone marrow failure in Japanese Fanconi anemia patients","volume":"122","author":"Hira","year":"2013","journal-title":"Blood"},{"key":"ref_80","doi-asserted-by":"crossref","first-page":"457","DOI":"10.1111\/bjh.14243","article-title":"The phenotype and clinical course of Japanese Fanconi Anaemia infants is influenced by patient, but not maternal ALDH2 genotype","volume":"175","author":"Yabe","year":"2016","journal-title":"Br. J. Haematol."},{"key":"ref_81","doi-asserted-by":"crossref","first-page":"1116","DOI":"10.1542\/peds.91.6.1116","article-title":"The need for more accurate and timely diagnosis in Fanconi anemia: A report from the International Fanconi Anemia Registry","volume":"91","author":"Giampietro","year":"1993","journal-title":"Pediatrics"},{"key":"ref_82","doi-asserted-by":"crossref","first-page":"40","DOI":"10.1242\/dmm.009795","article-title":"Learning from a paradox: Recent insights into Fanconi anaemia through studying mouse models","volume":"6","author":"Bakker","year":"2013","journal-title":"DMM Dis. Model. Mech."},{"key":"ref_83","doi-asserted-by":"crossref","first-page":"3963","DOI":"10.1007\/s00018-018-2900-2","article-title":"Impact of DNA repair and stability defects on cortical development","volume":"75","author":"Bianchi","year":"2018","journal-title":"Cell. Mol. Life Sci."},{"key":"ref_84","doi-asserted-by":"crossref","unstructured":"Garc\u00eda-De Teresa, B., Hern\u00e1ndez-G\u00f3mez, M., and Fr\u00edas, S. (2017). DNA Damage as a Driver for Growth Delay: Chromosome Instability Syndromes with Intrauterine Growth Retardation. Biomed Res. Int., 2017.","DOI":"10.1155\/2017\/8193892"},{"key":"ref_85","doi-asserted-by":"crossref","first-page":"1052","DOI":"10.1016\/j.jhsa.2011.02.018","article-title":"Incidence of Fanconi anemia in children with congenital thumb anomalies referred for diepoxybutane testing","volume":"36","author":"Webb","year":"2011","journal-title":"J. Hand Surg. Am."},{"key":"ref_86","doi-asserted-by":"crossref","first-page":"101","DOI":"10.1016\/j.blre.2010.03.002","article-title":"Pathophysiology and Management of Inherited Bone Marrow Failure Syndromes","volume":"24","author":"Shimamura","year":"2010","journal-title":"Blood Rev."},{"key":"ref_87","doi-asserted-by":"crossref","first-page":"1083","DOI":"10.1016\/j.bjps.2012.02.015","article-title":"Fanconi\u2019s anaemia and unilateral thumb polydactyly\u2014Don\u2019t miss it","volume":"65","author":"Wilks","year":"2012","journal-title":"J. Plast. Reconstr. Aesthetic Surg."},{"key":"ref_88","doi-asserted-by":"crossref","first-page":"264","DOI":"10.2174\/1389202916666150528000412","article-title":"Role of Genetic Factors in the Pathogenesis of Radial Deficiencies in Humans","volume":"16","author":"Elmakky","year":"2015","journal-title":"Curr. Genom."},{"key":"ref_89","doi-asserted-by":"crossref","first-page":"1547","DOI":"10.1007\/s00467-018-3952-0","article-title":"Patterns and frequency of renal abnormalities in Fanconi anaemia: Implications for long-term management","volume":"33","author":"Sathyanarayana","year":"2018","journal-title":"Pediatr. Nephrol."},{"key":"ref_90","doi-asserted-by":"crossref","unstructured":"Ruggiero, J.L., Dodds, M., Freese, R., Polcari, I.C., Maguiness, S., Hook, K.P., and Boull, C. (2020). Cutaneous Findings in Fanconi Anemia. J. Am. Acad. Dermatol.","DOI":"10.1016\/j.jaad.2020.08.047"},{"key":"ref_91","doi-asserted-by":"crossref","first-page":"259","DOI":"10.1186\/s13023-019-1208-0","article-title":"Genetic and clinical characterization of 73 Pigmentary Mosaicism patients: Revealing the genetic basis of clinical manifestations","volume":"14","year":"2019","journal-title":"Orphanet J. Rare Dis."},{"key":"ref_92","first-page":"193","article-title":"Association of pigmentary anomalies with chromosomal and genetic mosaicism and chimerism","volume":"45","author":"Thomas","year":"1989","journal-title":"Am. J. Hum. Genet."},{"key":"ref_93","doi-asserted-by":"crossref","first-page":"30","DOI":"10.3324\/haematol.2017.178111","article-title":"Cancer in the national cancer institute inherited bone marrow failure syndrome cohort after fifteen years of follow-up","volume":"103","author":"Alter","year":"2018","journal-title":"Haematologica"},{"key":"ref_94","doi-asserted-by":"crossref","first-page":"1249","DOI":"10.1182\/blood-2002-07-2170","article-title":"A 20-year perspective on the International Fanconi Anemia Registry (IFAR)","volume":"101","author":"Kutler","year":"2003","journal-title":"Blood"},{"key":"ref_95","doi-asserted-by":"crossref","first-page":"4","DOI":"10.1186\/s13287-018-0882-5","article-title":"A small molecule p53 activator attenuates Fanconi anemia leukemic stem cell proliferation","volume":"9","author":"Du","year":"2018","journal-title":"Stem Cell Res. Ther."},{"key":"ref_96","doi-asserted-by":"crossref","first-page":"339","DOI":"10.1016\/j.stemcr.2017.12.006","article-title":"Cell-Cycle-Specific Function of p53 in Fanconi Anemia Hematopoietic Stem and Progenitor Cell Proliferation","volume":"10","author":"Li","year":"2018","journal-title":"Stem Cell Reports"},{"key":"ref_97","doi-asserted-by":"crossref","first-page":"949","DOI":"10.1387\/ijdb.120144jp","article-title":"The fate of granulosa cells following premature oocyte loss and the development of ovarian cancers","volume":"56","author":"Pitman","year":"2012","journal-title":"Int. J. Dev. Biol."},{"key":"ref_98","doi-asserted-by":"crossref","first-page":"51","DOI":"10.1093\/mutage\/gem042","article-title":"DNA repair deficiency and acetaldehyde-induced chromosomal alterations in CHO cells","volume":"23","author":"Mechilli","year":"2008","journal-title":"Mutagenesis"},{"key":"ref_99","first-page":"5","article-title":"The genetics of alcohol metabolism: Role of alcohol dehydrogenase and aldehyde dehydrogenase variants","volume":"30","author":"Edenberg","year":"2007","journal-title":"Alcohol Res. Health"},{"key":"ref_100","doi-asserted-by":"crossref","first-page":"571","DOI":"10.1038\/nature11368","article-title":"Genotoxic consequences of endogenous aldehydes on mouse haematopoietic stem cell function","volume":"489","author":"Garaycoechea","year":"2012","journal-title":"Nature"},{"key":"ref_101","doi-asserted-by":"crossref","first-page":"26","DOI":"10.1182\/blood-2013-09-427740","article-title":"Why does the bone marrow fail in Fanconi anemia?","volume":"123","author":"Garaycoechea","year":"2014","journal-title":"Blood"},{"key":"ref_102","doi-asserted-by":"crossref","first-page":"679","DOI":"10.1093\/hmg\/ddm340","article-title":"Loss of CHK1 function impedes DNA damage-induced FANCD2 monoubiquitination but normalizes the abnormal G2 arrest in Fanconi anemia","volume":"17","author":"Guervilly","year":"2008","journal-title":"Hum. Mol. Genet."},{"key":"ref_103","doi-asserted-by":"crossref","first-page":"1440","DOI":"10.1172\/JCI31245","article-title":"Fanconi anemia pathway-deficient tumor cells are hypersensitive to inhibition of ataxia telangiectasia mutated","volume":"117","author":"Kennedy","year":"2007","journal-title":"J. Clin. Investig."},{"key":"ref_104","doi-asserted-by":"crossref","first-page":"184","DOI":"10.1172\/JCI43836","article-title":"Spontaneous abrogation of the G2 DNA damage checkpoint has clinical benefits but promotes leukemogenesis in Fanconi anemia patients","volume":"121","author":"Ceccaldi","year":"2011","journal-title":"J. Clin. Investig."},{"key":"ref_105","doi-asserted-by":"crossref","first-page":"668","DOI":"10.1016\/j.stem.2016.03.002","article-title":"TGF-\u03b2 inhibition rescues hematopoietic stem cell defects and bone marrow failure in Fanconi anemia","volume":"18","author":"Zhang","year":"2016","journal-title":"Cell Stem Cell"},{"key":"ref_106","doi-asserted-by":"crossref","unstructured":"Rodr\u00edguez, A., Zhang, K., F\u00e4rkkil\u00e4, A., Filiatrault, J., Yang, C., Vel\u00e1zquez, M., Furutani, E., Goldman, D.C., Garc\u00eda de Teresa, B., and Garza-May\u00e9n, G. (2020). MYC Promotes Bone Marrow Stem Cell Dysfunction in Fanconi Anemia. Cell Stem Cell.","DOI":"10.1016\/j.stem.2020.09.004"},{"key":"ref_107","doi-asserted-by":"crossref","first-page":"214","DOI":"10.1016\/j.beha.2014.10.002","article-title":"Fanconi anemia and the development of leukemia","volume":"27","author":"Alter","year":"2014","journal-title":"Best Pract. Res. Clin. Haematol."},{"key":"ref_108","doi-asserted-by":"crossref","first-page":"92","DOI":"10.1309\/AJCP7W9VMJENZOVG","article-title":"Diagnosis of myelodysplastic syndrome among a cohort of 119 patients with fanconi anemia: Morphologic and cytogenetic characteristics","volume":"133","author":"Cioc","year":"2010","journal-title":"Am. J. Clin. Pathol."},{"key":"ref_109","doi-asserted-by":"crossref","first-page":"2072","DOI":"10.1182\/blood-2002-11-3597","article-title":"Cancer in Fanconi anemia","volume":"101","author":"Alter","year":"2003","journal-title":"Blood"},{"key":"ref_110","doi-asserted-by":"crossref","first-page":"2971","DOI":"10.1182\/blood-2016-01-583625","article-title":"How I treat MDS and AML in Fanconi anemia","volume":"127","author":"Soulier","year":"2016","journal-title":"Blood"},{"key":"ref_111","doi-asserted-by":"crossref","first-page":"425","DOI":"10.1002\/cncr.11046","article-title":"Cancer in Fanconi anemia, 1927\u20132001","volume":"97","author":"Alter","year":"2003","journal-title":"Cancer"},{"key":"ref_112","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/0165-4608(91)90002-C","article-title":"Leukemia and preleukemia in Fanconi anemia patients. A review of the literature and report of the International Fanconi Anemia Registry","volume":"51","author":"Auerbach","year":"1991","journal-title":"Cancer Genet. Cytogenet."},{"key":"ref_113","doi-asserted-by":"crossref","first-page":"384","DOI":"10.1111\/bjh.12634","article-title":"Haematopoietic cell transplantation for acute leukaemia and advanced myelodysplastic syndrome in Fanconi anaemia","volume":"164","author":"Mitchell","year":"2013","journal-title":"Br. J. Haematol."},{"key":"ref_114","doi-asserted-by":"crossref","first-page":"487","DOI":"10.2741\/s167","article-title":"The stem cell fitness landscape and pathways of molecular leukemogenesis","volume":"S3","author":"Bagby","year":"2011","journal-title":"Front. Biosci."},{"key":"ref_115","doi-asserted-by":"crossref","first-page":"822","DOI":"10.1182\/blood-2002-05-1498","article-title":"Cancer incidence in persons with Fanconi anemia","volume":"101","author":"Rosenberg","year":"2003","journal-title":"Blood"},{"key":"ref_116","doi-asserted-by":"crossref","first-page":"e161","DOI":"10.1182\/blood-2010-09-308726","article-title":"Myelodysplasia and leukemia of fanconi anemia are associated with a specific pattern of genomic abnormalities that includes cryptic RUNX1\/AML1 lesions","volume":"117","author":"Quentin","year":"2011","journal-title":"Blood"},{"key":"ref_117","doi-asserted-by":"crossref","unstructured":"Ye, C.J., Sharpe, Z., and Heng, H.H. (2020). Origins and consequences of chromosomal instability: From cellular adaptation to genome chaos-mediated system survival. Genes, 11.","DOI":"10.3390\/genes11101162"},{"key":"ref_118","doi-asserted-by":"crossref","first-page":"329","DOI":"10.1055\/s-0043-117046","article-title":"Mutational Spectrum of Fanconi Anemia Associated Myeloid Neoplasms","volume":"229","author":"Chao","year":"2017","journal-title":"Klin. Padiatr."},{"key":"ref_119","doi-asserted-by":"crossref","first-page":"1649","DOI":"10.1093\/jnci\/djn366","article-title":"Clinical and molecular characteristics of squamous cell carcinomas from Fanconi anemia patients","volume":"100","author":"Snijders","year":"2008","journal-title":"J. Natl. Cancer Inst."},{"key":"ref_120","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.canlet.2019.12.008","article-title":"Chromosome fragility in the buccal epithelium in patients with Fanconi anemia","volume":"472","author":"Loveless","year":"2020","journal-title":"Cancer Lett."},{"key":"ref_121","doi-asserted-by":"crossref","first-page":"403","DOI":"10.1002\/cncy.22249","article-title":"Diagnostic accuracy of brush biopsy\u2013based cytology for the early detection of oral cancer and precursors in Fanconi anemia","volume":"128","author":"Velleuer","year":"2020","journal-title":"Cancer Cytopathol."},{"key":"ref_122","doi-asserted-by":"crossref","first-page":"2139","DOI":"10.1038\/jid.2011.181","article-title":"Upregulation of fanconi anemia DNA repair genes in melanoma compared with non-melanoma skin cancer","volume":"131","author":"Kao","year":"2011","journal-title":"J. Investig. Dermatol."},{"key":"ref_123","doi-asserted-by":"crossref","first-page":"463","DOI":"10.1002\/pbc.25303","article-title":"Fanconi Anemia and Solid Malignancies in Childhood: A National Retrospective Study","volume":"62","author":"Malric","year":"2015","journal-title":"Pediatr. Blood Cancer"},{"key":"ref_124","doi-asserted-by":"crossref","first-page":"71","DOI":"10.1136\/jmedgenet-2013-101642","article-title":"Fanconi anaemia, BRCA2 mutations and childhood cancer: A developmental perspective from clinical and epidemiological observations with implications for genetic counselling","volume":"51","author":"Meyer","year":"2014","journal-title":"J. Med. Genet."},{"key":"ref_125","doi-asserted-by":"crossref","first-page":"606","DOI":"10.1126\/science.1073834","article-title":"Biallelic inactivation of BRCA2 in Fanconi anemia","volume":"297","author":"Howlett","year":"2002","journal-title":"Science"},{"key":"ref_126","doi-asserted-by":"crossref","first-page":"1608","DOI":"10.1210\/jc.2013-3559","article-title":"Anti-m\u00fcllerian hormone deficiency in females with Fanconi Anemia","volume":"99","author":"Sklavos","year":"2014","journal-title":"J. Clin. Endocrinol. Metab."},{"key":"ref_127","doi-asserted-by":"crossref","first-page":"1227","DOI":"10.1007\/s00439-019-02059-9","article-title":"Rare variants in FANCA induce premature ovarian insufficiency","volume":"138","author":"Yang","year":"2019","journal-title":"Hum. Genet."},{"key":"ref_128","doi-asserted-by":"crossref","first-page":"189","DOI":"10.1038\/s41436-018-0037-1","article-title":"From exome analysis in idiopathic azoospermia to the identification of a high-risk subgroup for occult Fanconi anemia","volume":"21","author":"Krausz","year":"2019","journal-title":"Genet. Med."},{"key":"ref_129","doi-asserted-by":"crossref","unstructured":"Fu, C., Begum, K., Jordan, P.W., He, Y., and Overbeek, P.A. (2016). Dearth and delayed maturation of testicular germ cells in Fanconi anemia E mutant male mice. PLoS ONE, 11.","DOI":"10.1371\/journal.pone.0159800"},{"key":"ref_130","doi-asserted-by":"crossref","unstructured":"Fu, C., Begum, K., and Overbeek, P.A. (2016). Primary ovarian insufficiency induced by fanconi anemia e mutation in a mouse model. PLoS ONE, 11.","DOI":"10.1371\/journal.pone.0144285"},{"key":"ref_131","doi-asserted-by":"crossref","first-page":"24617","DOI":"10.1074\/jbc.M114.566141","article-title":"Male fertility defect associated with disrupted BRCA1-PALB2 interaction in mice","volume":"289","author":"Simhadri","year":"2014","journal-title":"J. Biol. Chem."},{"key":"ref_132","doi-asserted-by":"crossref","first-page":"5234","DOI":"10.1093\/hmg\/ddv244","article-title":"FANCB is essential in the male germline and regulates H3K9 methylation on the sex chromosomes during meiosis","volume":"24","author":"Kato","year":"2015","journal-title":"Hum. Mol. Genet."},{"key":"ref_133","doi-asserted-by":"crossref","first-page":"199","DOI":"10.1016\/j.tig.2018.12.007","article-title":"The Fanconi Anemia Pathway and Fertility","volume":"35","author":"Tsui","year":"2019","journal-title":"Trends Genet."},{"key":"ref_134","doi-asserted-by":"crossref","first-page":"67","DOI":"10.1016\/j.arr.2016.05.005","article-title":"Fanconi Anemia: A DNA repair disorder characterized by accelerated decline of the hematopoietic stem cell compartment and other features of aging","volume":"33","author":"Brosh","year":"2017","journal-title":"Ageing Res. Rev."},{"key":"ref_135","doi-asserted-by":"crossref","first-page":"657","DOI":"10.1016\/j.hoc.2018.04.002","article-title":"Myelodysplastic Syndrome, Acute Myeloid Leukemia, and Cancer Surveillance in Fanconi Anemia","volume":"32","author":"Savage","year":"2018","journal-title":"Hematol. Oncol. Clin. North Am."},{"key":"ref_136","doi-asserted-by":"crossref","first-page":"2624","DOI":"10.1210\/jc.2007-0135","article-title":"Endocrine abnormalities in patients with fanconi anemia","volume":"92","author":"Giri","year":"2007","journal-title":"J. Clin. Endocrinol. Metab."},{"key":"ref_137","doi-asserted-by":"crossref","first-page":"1194","DOI":"10.1016\/j.cell.2013.05.039","article-title":"The hallmarks of aging","volume":"153","author":"Blasco","year":"2013","journal-title":"Cell"},{"key":"ref_138","doi-asserted-by":"crossref","first-page":"49","DOI":"10.3324\/haematol.2014.114389","article-title":"Telomere length in inherited bone marrow failure syndromes","volume":"100","author":"Alter","year":"2015","journal-title":"Haematologica"},{"key":"ref_139","doi-asserted-by":"crossref","first-page":"165","DOI":"10.1038\/onc.2012.583","article-title":"Evidence of mitochondrial dysfunction and impaired ROS detoxifying machinery in Fanconi Anemia cells","volume":"33","author":"Kumari","year":"2014","journal-title":"Oncogene"},{"key":"ref_140","first-page":"1","article-title":"Fanconi anemia proteins counteract the implementation of the oncogene-induced senescence program","volume":"9","author":"Evrard","year":"2019","journal-title":"Sci. Rep."},{"key":"ref_141","doi-asserted-by":"crossref","first-page":"826","DOI":"10.1038\/nri2873","article-title":"Sterile inflammation: Sensing and reacting to damage","volume":"10","author":"Chen","year":"2010","journal-title":"Nat. Rev. Immunol."},{"key":"ref_142","doi-asserted-by":"crossref","first-page":"611","DOI":"10.14336\/AD.2016.1230","article-title":"Cancer and aging\u2014The inflammatory connection","volume":"8","author":"Zinger","year":"2017","journal-title":"Aging Dis."},{"key":"ref_143","doi-asserted-by":"crossref","first-page":"95","DOI":"10.1038\/s41577-019-0215-7","article-title":"DAMP-sensing receptors in sterile inflammation and inflammatory diseases","volume":"20","author":"Gong","year":"2020","journal-title":"Nat. Rev. Immunol."},{"key":"ref_144","first-page":"51","article-title":"Main steps in DNA double-strand break repair: An introduction to homologous recombination and related processes","volume":"668","author":"Garaycoechea","year":"2018","journal-title":"Nature"},{"key":"ref_145","doi-asserted-by":"crossref","first-page":"2053","DOI":"10.1182\/blood-2003-01-0114","article-title":"TNF-\u03b1 and IFN-\u03b3 are overexpressed in the bone marrow of Fanconi anemia patients and TNF-\u03b1 suppresses erythropoiesis in vitro","volume":"102","author":"Dufour","year":"2003","journal-title":"Blood"},{"key":"ref_146","doi-asserted-by":"crossref","first-page":"1216","DOI":"10.1182\/blood.V83.5.1216.1216","article-title":"Abnormal lymphokine production: A novel feature of the genetic disease Fanconi anemia. II. In vitro and in vivo spontaneous overproduction of tumor necrosis factor \u03b1","volume":"83","author":"Rosselli","year":"1994","journal-title":"Blood"},{"key":"ref_147","doi-asserted-by":"crossref","first-page":"1572","DOI":"10.1242\/jcs.003152","article-title":"Inflammatory ROS promote and cooperate with the Fanconi anemia mutation for hematopoietic senescence","volume":"120","author":"Zhang","year":"2007","journal-title":"J. Cell Sci."},{"key":"ref_148","doi-asserted-by":"crossref","first-page":"700","DOI":"10.1016\/j.stem.2018.10.004","article-title":"PPM1D Mutations Drive Clonal Hematopoiesis in Response to Cytotoxic Chemotherapy","volume":"23","author":"Hsu","year":"2018","journal-title":"Cell Stem Cell"},{"key":"ref_149","doi-asserted-by":"crossref","first-page":"634","DOI":"10.1016\/j.stem.2018.10.003","article-title":"The Harmful Consequences of Increased Fitness in Hematopoietic Stem Cells","volume":"23","author":"McNerney","year":"2018","journal-title":"Cell Stem Cell"},{"key":"ref_150","doi-asserted-by":"crossref","first-page":"157","DOI":"10.1016\/j.stem.2018.01.011","article-title":"Clonal Hematopoiesis and Evolution to Hematopoietic Malignancies","volume":"22","author":"Bowman","year":"2018","journal-title":"Cell Stem Cell"},{"key":"ref_151","doi-asserted-by":"crossref","first-page":"4","DOI":"10.1053\/j.seminhematol.2016.11.002","article-title":"Molecular mechanisms underlying lineage bias in aging hematopoiesis","volume":"54","author":"Elias","year":"2017","journal-title":"Semin. Hematol."}],"container-title":["Genes"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.mdpi.com\/2073-4425\/11\/12\/1528\/pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,11]],"date-time":"2025-10-11T10:48:08Z","timestamp":1760179688000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.mdpi.com\/2073-4425\/11\/12\/1528"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020,12,21]]},"references-count":151,"journal-issue":{"issue":"12","published-online":{"date-parts":[[2020,12]]}},"alternative-id":["genes11121528"],"URL":"https:\/\/doi.org\/10.3390\/genes11121528","relation":{"has-preprint":[{"id-type":"doi","id":"10.20944\/preprints202011.0563.v1","asserted-by":"object"},{"id-type":"doi","id":"10.20944\/preprints202011.0563.v2","asserted-by":"object"}]},"ISSN":["2073-4425"],"issn-type":[{"value":"2073-4425","type":"electronic"}],"subject":[],"published":{"date-parts":[[2020,12,21]]}}}