{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,22]],"date-time":"2026-07-22T20:55:39Z","timestamp":1784753739598,"version":"3.55.0"},"reference-count":12,"publisher":"MDPI AG","issue":"1","license":[{"start":{"date-parts":[[2021,1,19]],"date-time":"2021-01-19T00:00:00Z","timestamp":1611014400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Genes"],"abstract":"<jats:p>Advances in embryo and reproductive genetics have influenced clinical approaches to overcome infertility. Since the 1990s, many attempts have been made to decipher the genetic causes of infertility and to understand the role of chromosome aneuploidies in embryo potential. At the embryo stage, preimplantation genetic testing for chromosomal abnormalities and genetic disorders has offered many couples the opportunity to have healthy offspring. Recently, the application of new technologies has resulted in more comprehensive and accurate diagnoses of chromosomal abnormalities and genetic conditions to improve clinical outcome. In this Special Issue, we include a collection of reviews and original articles covering many aspects of embryo diagnosis, genome editing, and maternal\u2013embryo cross-communication during the implantation process.<\/jats:p>","DOI":"10.3390\/genes12010118","type":"journal-article","created":{"date-parts":[[2021,1,19]],"date-time":"2021-01-19T11:39:55Z","timestamp":1611056395000},"page":"118","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":7,"title":["Embryo Genetics"],"prefix":"10.3390","volume":"12","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-1522-6152","authenticated-orcid":false,"given":"Carmen","family":"Rubio","sequence":"first","affiliation":[{"name":"EmbryoGenetics Department, Igenomix, 46980 Valencia, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Carlos","family":"Sim\u00f3n","sequence":"additional","affiliation":[{"name":"Professor of Obstetrics &amp; Gynecology, Valencia University, 46010 Valencia, Spain"},{"name":"Senior Lecturer PT, BIDMC Harvard University, Boston, MA 02215, USA"},{"name":"Adjunct Clinical Professor, Department of Ob\/Gyn, Baylor College of Medicine, Houston, TX 77030, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2021,1,19]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","unstructured":"Mascarenhas, M., Flaxman, S., Boerma, T., Vanderpoel, S., and Stevens, G. (2012). National, Regional, and Global Trends in Infertility Prevalence Since 1990: A Systematic Analysis of 277 Health Surveys. PLoS Med., 9.","DOI":"10.1371\/journal.pmed.1001356"},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"768","DOI":"10.1038\/344768a0","article-title":"Pregnancies from biopsied human preimplantation embryos sexed by Y-specific DNA amplification","volume":"344","author":"Handyside","year":"1990","journal-title":"Nature"},{"key":"ref_3","doi-asserted-by":"crossref","unstructured":"Garc\u00eda-Herrero, S., Sim\u00f3n, B., and Garc\u00eda-Planells, J. (2020). The reproductive journey in the genomic era: From preconception to childhood. Genes, submitted.","DOI":"10.3390\/genes11121521"},{"key":"ref_4","doi-asserted-by":"crossref","unstructured":"De Rycke, M., and Berckmoes, V. (2020). Preimplantation Genetic Testing for Monogenic Disorders. Genes, 11.","DOI":"10.3390\/genes11080871"},{"key":"ref_5","doi-asserted-by":"crossref","unstructured":"Mir Pardo, P., Mart\u00ednez-Conejero, J., Mart\u00edn, J., Sim\u00f3n, C., and Cervero, A. (2020). Combined Preimplantation Genetic Testing for Autosomal Dominant Polycystic Kidney Disease: Consequences for Embryos Available for Transfer. Genes, 11.","DOI":"10.3390\/genes11060692"},{"key":"ref_6","doi-asserted-by":"crossref","unstructured":"Treff, N., Eccles, J., Marin, D., Messick, E., Lello, L., Gerber, J., Xu, J., and Tellier, L. (2020). Preimplantation Genetic Testing for Polygenic Disease Relative Risk Reduction: Evaluation of Genomic Index Performance in 11,883 Adult Sibling Pairs. Genes, 11.","DOI":"10.3390\/genes11060648"},{"key":"ref_7","doi-asserted-by":"crossref","unstructured":"Viotti, M. (2020). Preimplantation Genetic Testing for Chromosomal Abnormalities: Aneuploidy, Mosaicism, and Structural Rearrangements. Genes, 11.","DOI":"10.3390\/genes11060602"},{"key":"ref_8","doi-asserted-by":"crossref","unstructured":"Garc\u00eda-Pascual, C., Navarro-S\u00e1nchez, L., Navarro, R., Mart\u00ednez, L., Jim\u00e9nez, J., Rodrigo, L., Sim\u00f3n, C., and Rubio, C. (2020). Optimized NGS Approach for Detection of Aneuploidies and Mosaicism in PGT-A and Imbalances in PGT-SR. Genes, 11.","DOI":"10.3390\/genes11070724"},{"key":"ref_9","doi-asserted-by":"crossref","unstructured":"Rodrigo, L., Clemente-C\u00edscar, M., Campos-Galindo, I., Peinado, V., Sim\u00f3n, C., and Rubio, C. (2020). Characteristics of the IVF Cycle that Contribute to the Incidence of Mosaicism. Genes, 11.","DOI":"10.3390\/genes11101151"},{"key":"ref_10","doi-asserted-by":"crossref","unstructured":"Simon, B., Bolumar, D., Amadoz, A., Jimenez-Almaz\u00e1n, J., Valbuena, D., Vilella, F., and Moreno, I. (2020). Identification and Characterization of Extracellular Vesicles and Its DNA Cargo Secreted During Murine Embryo Development. Genes, 11.","DOI":"10.3390\/genes11020203"},{"key":"ref_11","doi-asserted-by":"crossref","unstructured":"Reddy, P., Vilella, F., Izpisua Belmonte, J., and Sim\u00f3n, C. (2020). Use of Customizable Nucleases for Gene Editing and Other Novel Applications. Genes, 11.","DOI":"10.3390\/genes11090976"},{"key":"ref_12","doi-asserted-by":"crossref","unstructured":"Idelevich, A., and Vilella, F. (2020). Mother and Embryo Cross-Communication. 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