{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,6]],"date-time":"2026-07-06T19:28:26Z","timestamp":1783366106991,"version":"3.54.6"},"reference-count":89,"publisher":"MDPI AG","issue":"2","license":[{"start":{"date-parts":[[2021,1,27]],"date-time":"2021-01-27T00:00:00Z","timestamp":1611705600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"NATIONAL COUNCIL OF SCIENTIFIC AND TECHNOLOGICAL DEVELOPMENT (CNPq)","award":["476146\/2013"],"award-info":[{"award-number":["476146\/2013"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Genes"],"abstract":"<jats:p>Hernia is one of the most common defects in pigs. The most prevalent are the scrotal (SH), inguinal (IH) and umbilical (UH) hernias. We compared the inguinal ring transcriptome of normal and SH-affected pigs with the umbilical ring transcriptome of normal and UH-affected pigs to discover genes and pathways involved with the development of both types of hernia. A total of 13,307 transcripts was expressed in the inguinal and 13,302 in the umbilical ring tissues with 94.91% of them present in both tissues. From those, 35 genes were differentially expressed in both groups, participating in 108 biological processes. A total of 67 polymorphisms was identified in the inguinal ring and 76 in the umbilical ring tissue, of which 11 and 14 were novel, respectively. A single nucleotide polymorphism (SNP) with deleterious function was identified in the integrin \u03b1 M (ITGAM) gene. The microtubule associated protein 1 light chain 3 \u03b3 (MAP1LC3C), vitrin (VIT), aggrecan (ACAN), alkaline ceramidase 2 (ACER2), potassium calcium-activated channel subfamily M \u03b1 1 (KCNMA1) and synaptopodin 2 (SYNPO2) genes are highlighted as candidates to trigger both types of hernia. We generated the first comparative study of the pig umbilical and inguinal ring transcriptomes, contributing to the understanding of the genetic mechanism involved with these two types of hernia in pigs and probably in other mammals.<\/jats:p>","DOI":"10.3390\/genes12020166","type":"journal-article","created":{"date-parts":[[2021,1,26]],"date-time":"2021-01-26T23:01:28Z","timestamp":1611702088000},"page":"166","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":12,"title":["Genes and SNPs Involved with Scrotal and Umbilical Hernia in Pigs"],"prefix":"10.3390","volume":"12","author":[{"given":"Ariene Fernanda Grando","family":"Rodrigues","sequence":"first","affiliation":[{"name":"Programa de P\u00f3s-Gradua\u00e7\u00e3o em Zootecnia, Departamento de Zootecnia, Centro de Educa\u00e7\u00e3o Superior do Oeste (CEO), Universidade do Estado de Santa Catarina, UDESC, 89815-630 Chapec\u00f3, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0626-8879","authenticated-orcid":false,"given":"Adriana M\u00e9rcia Guaratini","family":"Ibelli","sequence":"additional","affiliation":[{"name":"Embrapa Su\u00ednos e Aves, Distrito de Tamandu\u00e1, 89715-899 Conc\u00f3rdia, Brazil"},{"name":"Programa de P\u00f3s-Gradua\u00e7\u00e3o em Ci\u00eancias Veterin\u00e1rias, Departamento de Ci\u00eancias Veterin\u00e1rias, Universidade Estadual do Centro-Oeste, 85015-430 Guarapuava, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0644-3684","authenticated-orcid":false,"given":"Jane de Oliveira","family":"Peixoto","sequence":"additional","affiliation":[{"name":"Embrapa Su\u00ednos e Aves, Distrito de Tamandu\u00e1, 89715-899 Conc\u00f3rdia, Brazil"},{"name":"Programa de P\u00f3s-Gradua\u00e7\u00e3o em Ci\u00eancias Veterin\u00e1rias, Departamento de Ci\u00eancias Veterin\u00e1rias, Universidade Estadual do Centro-Oeste, 85015-430 Guarapuava, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maur\u00edcio Eg\u00eddio","family":"Cant\u00e3o","sequence":"additional","affiliation":[{"name":"Embrapa Su\u00ednos e Aves, Distrito de Tamandu\u00e1, 89715-899 Conc\u00f3rdia, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7317-2004","authenticated-orcid":false,"given":"Haniel Cedraz de","family":"Oliveira","sequence":"additional","affiliation":[{"name":"Animal Science Department, Universidade Federal de Vi\u00e7osa, 36570-900 Vi\u00e7osa, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6821-1523","authenticated-orcid":false,"given":"Igor Ricardo","family":"Savoldi","sequence":"additional","affiliation":[{"name":"Programa de P\u00f3s-Gradua\u00e7\u00e3o em Zootecnia, Departamento de Zootecnia, Centro de Educa\u00e7\u00e3o Superior do Oeste (CEO), Universidade do Estado de Santa Catarina, UDESC, 89815-630 Chapec\u00f3, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2452-9633","authenticated-orcid":false,"given":"Mayla Regina","family":"Souza","sequence":"additional","affiliation":[{"name":"Programa de P\u00f3s-Gradua\u00e7\u00e3o em Zootecnia, Departamento de Zootecnia, Centro de Educa\u00e7\u00e3o Superior do Oeste (CEO), Universidade do Estado de Santa Catarina, UDESC, 89815-630 Chapec\u00f3, Brazil"},{"name":"Programa de P\u00f3s-Gradua\u00e7\u00e3o em Zootecnia, Departamento de Zootecnia, Universidade Federal do Rio Grande do Sul, UFRGS, 91540-000 Porto Alegre, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marcos Ant\u00f4nio Zanella","family":"Mores","sequence":"additional","affiliation":[{"name":"Embrapa Su\u00ednos e Aves, Distrito de Tamandu\u00e1, 89715-899 Conc\u00f3rdia, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Luis Orlando Duitama","family":"Carre\u00f1o","sequence":"additional","affiliation":[{"name":"BRF SA, 82305-100 Curitiba, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2645-4735","authenticated-orcid":false,"given":"M\u00f4nica Corr\u00eaa","family":"Ledur","sequence":"additional","affiliation":[{"name":"Programa de P\u00f3s-Gradua\u00e7\u00e3o em Zootecnia, Departamento de Zootecnia, Centro de Educa\u00e7\u00e3o Superior do Oeste (CEO), Universidade do Estado de Santa Catarina, UDESC, 89815-630 Chapec\u00f3, Brazil"},{"name":"Embrapa Su\u00ednos e Aves, Distrito de Tamandu\u00e1, 89715-899 Conc\u00f3rdia, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2021,1,27]]},"reference":[{"key":"ref_1","first-page":"211","article-title":"Fatores que influenciam o desenvolvimento dos leit\u00f5es na recria e termina\u00e7\u00e3o","volume":"37","author":"Heck","year":"2009","journal-title":"Acta Sci. 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