{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,12]],"date-time":"2025-10-12T01:46:56Z","timestamp":1760233616774,"version":"build-2065373602"},"reference-count":37,"publisher":"MDPI AG","issue":"2","license":[{"start":{"date-parts":[[2021,2,3]],"date-time":"2021-02-03T00:00:00Z","timestamp":1612310400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100003243","name":"Ministerstvo Zdravotnictv\u00ed Cesk\u00e9 Republiky","doi-asserted-by":"publisher","award":["Conceptual development of research organization (FNBr, 65269705)."],"award-info":[{"award-number":["Conceptual development of research organization (FNBr, 65269705)."]}],"id":[{"id":"10.13039\/501100003243","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Genes"],"abstract":"<jats:p>Spindle cell hemangioma is a benign vascular tumor typically occurring in the dermis or subcutis of distal extremities as red\u2013brown lesions that can grow in both size and number over time. They can be very painful and potentially disabling. A family history of cancer or previous history may be relevant and must be taken into consideration. Juxtaglomerular cell tumor (reninoma) is an extremely rare cause of secondary hypertension diagnosed mostly among adolescents and young adults. Excessive renin secretion results in secondary hyperaldosteronism. Subsequent hypokalemia and metabolic alkalosis, together with high blood pressure, are clues for clinical diagnosis. Histological examination of the excised tumor leads to a definitive diagnosis. Reninoma is found in subcapsular localization, in most cases as a solitary mass, in imaging studies of kidneys. Exceptionally, it can be located in another part of a kidney. Both spindle cell hemangioma and reninoma are extremely rare tumors in children and adolescents. Herein, the authors present a case report of a patient with hereditary BRCA1 interacting protein C-terminal helicase 1 (BRIP1) mutation, spindle cell hemangioma, and secondary hypertension caused by atypically localized reninoma.<\/jats:p>","DOI":"10.3390\/genes12020220","type":"journal-article","created":{"date-parts":[[2021,2,3]],"date-time":"2021-02-03T11:54:31Z","timestamp":1612353271000},"page":"220","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["Spindle Cell Hemangioma and Atypically Localized Juxtaglomerular Cell Tumor in a Patient with Hereditary BRIP1 Mutation: A Case Report"],"prefix":"10.3390","volume":"12","author":[{"given":"Jan","family":"Papez","sequence":"first","affiliation":[{"name":"Department of Pediatrics, University Hospital Brno, 613 00 Brno, Czech Republic"},{"name":"Faculty of Medicine, Masaryk University, Brno, 625 00 Brno, Czech Republic"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jiri","family":"Starha","sequence":"additional","affiliation":[{"name":"Department of Pediatrics, University Hospital Brno, 613 00 Brno, Czech Republic"},{"name":"Faculty of Medicine, Masaryk University, Brno, 625 00 Brno, Czech Republic"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Pavel","family":"Zerhau","sequence":"additional","affiliation":[{"name":"Faculty of Medicine, Masaryk University, Brno, 625 00 Brno, Czech Republic"},{"name":"Department of Pediatric Surgery, Orthopedics and Traumatology, University Hospital Brno, 613 00 Brno, Czech Republic"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Denisa","family":"Pavlovska","sequence":"additional","affiliation":[{"name":"Faculty of Medicine, Masaryk University, Brno, 625 00 Brno, Czech Republic"},{"name":"Department of Pediatric Radiology, University Hospital Brno, 613 00 Brno, Czech Republic"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Marta","family":"Jezova","sequence":"additional","affiliation":[{"name":"Faculty of Medicine, Masaryk University, Brno, 625 00 Brno, Czech Republic"},{"name":"Department of Pathology, University Hospital Brno, 613 00 Brno, Czech Republic"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tomas","family":"Jurencak","sequence":"additional","affiliation":[{"name":"Department of Pediatrics, University Hospital Brno, 613 00 Brno, Czech Republic"},{"name":"Faculty of Medicine, Masaryk University, Brno, 625 00 Brno, Czech Republic"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Katerina","family":"Slaba","sequence":"additional","affiliation":[{"name":"Department of Pediatrics, University Hospital Brno, 613 00 Brno, Czech Republic"},{"name":"Faculty of Medicine, Masaryk University, Brno, 625 00 Brno, Czech Republic"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Martin","family":"Sterba","sequence":"additional","affiliation":[{"name":"Department of Pediatrics, University Hospital Brno, 613 00 Brno, Czech Republic"},{"name":"Faculty of Medicine, Masaryk University, Brno, 625 00 Brno, Czech Republic"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Arpad","family":"Kerekes","sequence":"additional","affiliation":[{"name":"Faculty of Medicine, Masaryk University, Brno, 625 00 Brno, Czech Republic"},{"name":"Department of Pediatric Oncology, University Hospital Brno, 613 00 Brno, Czech Republic"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tomas","family":"Merta","sequence":"additional","affiliation":[{"name":"Faculty of Medicine, Masaryk University, Brno, 625 00 Brno, Czech Republic"},{"name":"Department of Pediatric Oncology, University Hospital Brno, 613 00 Brno, Czech Republic"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Terezia","family":"Haluskova","sequence":"additional","affiliation":[{"name":"Faculty of Medicine, Masaryk University, Brno, 625 00 Brno, Czech Republic"},{"name":"Department of Pediatric Oncology, University Hospital Brno, 613 00 Brno, Czech Republic"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hana","family":"Palova","sequence":"additional","affiliation":[{"name":"Central European Institute of Technology, 625 00 Brno, Czech Republic"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ondrej","family":"Slaby","sequence":"additional","affiliation":[{"name":"Central European Institute of Technology, 625 00 Brno, Czech Republic"},{"name":"Department of Biology, Faculty of Medicine, Masaryk University, 602 00 Brno, Czech Republic"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jaroslav","family":"Sterba","sequence":"additional","affiliation":[{"name":"Faculty of Medicine, Masaryk University, Brno, 625 00 Brno, Czech Republic"},{"name":"Department of Pediatric Oncology, University Hospital Brno, 613 00 Brno, Czech Republic"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4094-2364","authenticated-orcid":false,"given":"Petr","family":"Jabandziev","sequence":"additional","affiliation":[{"name":"Department of Pediatrics, University Hospital Brno, 613 00 Brno, Czech Republic"},{"name":"Faculty of Medicine, Masaryk University, Brno, 625 00 Brno, Czech Republic"},{"name":"Central European Institute of Technology, 625 00 Brno, Czech Republic"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1968","published-online":{"date-parts":[[2021,2,3]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"29","DOI":"10.1053\/j.semdp.2012.01.003","article-title":"Hemangioendothelioma","volume":"30","author":"Requena","year":"2013","journal-title":"Semin. 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