{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,9]],"date-time":"2026-05-09T11:34:30Z","timestamp":1778326470058,"version":"3.51.4"},"reference-count":76,"publisher":"MDPI AG","issue":"3","license":[{"start":{"date-parts":[[2021,3,10]],"date-time":"2021-03-10T00:00:00Z","timestamp":1615334400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100000780","name":"European Union","doi-asserted-by":"publisher","award":["859853"],"award-info":[{"award-number":["859853"]}],"id":[{"id":"10.13039\/501100000780","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Genes"],"abstract":"<jats:p>DDX11\/ChlR1 is a super-family two iron\u2013sulfur cluster containing DNA helicase with roles in DNA replication and sister chromatid cohesion establishment, and general chromosome architecture. Bi-allelic mutations of the DDX11 gene cause a rare hereditary disease, named Warsaw breakage syndrome, characterized by a complex spectrum of clinical manifestations (pre- and post-natal growth defects, microcephaly, intellectual disability, heart anomalies and sister chromatid cohesion loss at cellular level) in accordance with the multifaceted, not yet fully understood, physiological functions of this DNA helicase. In the last few years, a possible role of DDX11 in the onset and progression of many cancers is emerging. Herein we summarize the results of recent studies, carried out either in tumoral cell lines or in xenograft cancer mouse models, suggesting that DDX11 may have an oncogenic role. The potential of DDX11 DNA helicase as a pharmacological target for novel anti-cancer therapeutic interventions, as inferred from these latest developments, is also discussed.<\/jats:p>","DOI":"10.3390\/genes12030395","type":"journal-article","created":{"date-parts":[[2021,3,10]],"date-time":"2021-03-10T13:27:20Z","timestamp":1615382840000},"page":"395","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":20,"title":["The Genome Stability Maintenance DNA Helicase DDX11 and Its Role in Cancer"],"prefix":"10.3390","volume":"12","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-9496-8941","authenticated-orcid":false,"given":"Mohammad","family":"Mahtab","sequence":"first","affiliation":[{"name":"Istituto di Biochimica e Biologia Cellulare\u2014CNR, Via P. Castellino, 111, 80131 Naples, Italy"},{"name":"Dipartimento di Scienze e Tecnologie Ambientali Biologiche e Farmaceutiche, Universit\u00e0 degli Studi della Campania Luigi Vanvitelli, Via Vivaldi, 43, 81100 Caserta, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5326-1085","authenticated-orcid":false,"given":"Ana","family":"Boavida","sequence":"additional","affiliation":[{"name":"Istituto di Biochimica e Biologia Cellulare\u2014CNR, Via P. Castellino, 111, 80131 Naples, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3403-5397","authenticated-orcid":false,"given":"Diana","family":"Santos","sequence":"additional","affiliation":[{"name":"Istituto di Biochimica e Biologia Cellulare\u2014CNR, Via P. Castellino, 111, 80131 Naples, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4591-7571","authenticated-orcid":false,"given":"Francesca M.","family":"Pisani","sequence":"additional","affiliation":[{"name":"Istituto di Biochimica e Biologia Cellulare\u2014CNR, Via P. Castellino, 111, 80131 Naples, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1968","published-online":{"date-parts":[[2021,3,10]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"542","DOI":"10.1038\/nrc3560","article-title":"DNA helicases involved in DNA repair and their roles in cancer","volume":"13","author":"Brosh","year":"2013","journal-title":"Nat. Rev. Cancer"},{"key":"ref_2","doi-asserted-by":"crossref","unstructured":"Brosh, R.M., and Matson, S.W. (2020). History of DNA Helicases. Genes, 11.","DOI":"10.3390\/genes11030255"},{"key":"ref_3","doi-asserted-by":"crossref","first-page":"102994","DOI":"10.1016\/j.dnarep.2020.102994","article-title":"DNA helicases and their roles in cancer","volume":"96","author":"Dhar","year":"2020","journal-title":"DNA Repair"},{"key":"ref_4","doi-asserted-by":"crossref","first-page":"1008","DOI":"10.1101\/gad.324517.119","article-title":"Transcription-mediated replication hindrance: A major driver of genome instability","volume":"33","author":"Aguilera","year":"2019","journal-title":"Genes Dev."},{"key":"ref_5","doi-asserted-by":"crossref","first-page":"425","DOI":"10.1146\/annurev-pathol-012414-040424","article-title":"DNA replication stress as a hallmark of cancer","volume":"10","author":"Macheret","year":"2015","journal-title":"Annu. Rev. Pathol."},{"key":"ref_6","doi-asserted-by":"crossref","first-page":"279","DOI":"10.1038\/s41586-018-0261-5","article-title":"High speed of fork progression induces DNA replication stress and genomic instability","volume":"559","author":"Moudry","year":"2018","journal-title":"Nature"},{"key":"ref_7","doi-asserted-by":"crossref","first-page":"4247","DOI":"10.1093\/nar\/gks039","article-title":"DNA helicase and helicase-nuclease enzymes with a conserved iron-sulfur cluster","volume":"40","author":"Wu","year":"2012","journal-title":"Nucleic Acids Res."},{"key":"ref_8","doi-asserted-by":"crossref","first-page":"2625","DOI":"10.1007\/s00018-014-1569-4","article-title":"Molecular functions and cellular roles of the ChlR1 (DDX11) helicase defective in the rare cohesinopathy Warsaw breakage syndrome","volume":"71","author":"Bharti","year":"2014","journal-title":"Cell. Mol. Life Sci."},{"key":"ref_9","doi-asserted-by":"crossref","unstructured":"Pisani, F.M., Napolitano, E., Napolitano, L.M.R., and Onesti, S. (2018). Molecular and Cellular Functions of the Warsaw Breakage Syndrome DNA Helicase DDX11. Genes, 9.","DOI":"10.3390\/genes9110564"},{"key":"ref_10","doi-asserted-by":"crossref","first-page":"239","DOI":"10.2147\/TACG.S186476","article-title":"Spotlight on Warsaw Breakage Syndrome","volume":"12","author":"Pisani","year":"2019","journal-title":"Appl. Clin. Genet."},{"key":"ref_11","doi-asserted-by":"crossref","first-page":"262","DOI":"10.1016\/j.ajhg.2010.01.008","article-title":"Warsaw breakage syndrome, a cohesinopathy associated with mutations in the XPD helicase family member DDX11\/ChlR1","volume":"86","author":"Chrzanowska","year":"2010","journal-title":"Am. J. Hum. Genet."},{"key":"ref_12","doi-asserted-by":"crossref","unstructured":"Cortone, G., Zheng, G., Pensieri, P., Chiappetta, V., Tat\u00e8, R., Malacaria, E., Pichierri, P., Yu, H., and Pisani, F.M. (2018). Interaction of the Warsaw breakage syndrome DNA helicase DDX11 with the replication fork-protection factor Timeless promotes sister chromatid cohesion. PLoS Genet., 14.","DOI":"10.1371\/journal.pgen.1007622"},{"key":"ref_13","doi-asserted-by":"crossref","first-page":"4347","DOI":"10.1002\/j.1460-2075.1990.tb07884.x","article-title":"The CHL 1 (CTF 1) gene product of Saccharomyces cerevisiae is important for chromosome transmission and normal cell cycle progression in G2\/M","volume":"9","author":"Gerring","year":"1990","journal-title":"EMBO J."},{"key":"ref_14","doi-asserted-by":"crossref","first-page":"917","DOI":"10.1093\/nar\/28.4.917","article-title":"Characterization of the enzymatic activity of hChlR1, a novel human DNA helicase","volume":"28","author":"Hirota","year":"2000","journal-title":"Nucleic Acids Res."},{"key":"ref_15","doi-asserted-by":"crossref","first-page":"20925","DOI":"10.1074\/jbc.M802696200","article-title":"Studies with the human cohesin establishment factor, ChlR1. Association of ChlR1 with Ctf18-RFC and Fen1","volume":"283","author":"Farina","year":"2008","journal-title":"J. Biol. Chem."},{"key":"ref_16","doi-asserted-by":"crossref","first-page":"1007","DOI":"10.1074\/jbc.M111.276022","article-title":"Biochemical characterization of Warsaw breakage syndrome helicase","volume":"287","author":"Wu","year":"2012","journal-title":"J. Biol. Chem."},{"key":"ref_17","doi-asserted-by":"crossref","first-page":"19188","DOI":"10.1074\/jbc.M112.352757","article-title":"DNA repair and replication fork helicases are differentially affected by alkyl phosphotriester lesion","volume":"287","author":"Suhasini","year":"2012","journal-title":"J. Biol. Chem."},{"key":"ref_18","doi-asserted-by":"crossref","first-page":"28217","DOI":"10.1074\/jbc.M113.496463","article-title":"Specialization among iron\u2013sulfur cluster helicases to resolve G-quadruplex DNA structures that threaten genomic stability","volume":"288","author":"Bharti","year":"2013","journal-title":"J. Biol. Chem."},{"key":"ref_19","doi-asserted-by":"crossref","first-page":"7505","DOI":"10.1074\/jbc.M809019200","article-title":"FANCJ uses its motor ATPase to destabilize protein-DNA complexes, unwind triplexes, and inhibit RAD51 strand exchange","volume":"284","author":"Sommers","year":"2009","journal-title":"J. Biol. Chem."},{"key":"ref_20","doi-asserted-by":"crossref","first-page":"279","DOI":"10.1038\/nrm.2017.3","article-title":"DNA G-quadruplexes in the human genome: Detection, functions and therapeutic potential","volume":"18","author":"Balasubramanian","year":"2017","journal-title":"Nat. Rev. Mol. Cell. Biol."},{"key":"ref_21","doi-asserted-by":"crossref","first-page":"832","DOI":"10.1038\/s41557-020-0506-4","article-title":"Single-molecule visualization of DNA G-quadruplex formation in live cells","volume":"12","author":"Ponjavic","year":"2020","journal-title":"Nat. Chem."},{"key":"ref_22","doi-asserted-by":"crossref","first-page":"162","DOI":"10.1038\/s41467-020-20414-7","article-title":"Visualising G-quadruplex DNA dynamics in live cells by fluorescence lifetime imaging microscopy","volume":"12","author":"Summers","year":"2021","journal-title":"Nat. Commun."},{"key":"ref_23","doi-asserted-by":"crossref","first-page":"459","DOI":"10.1038\/s41580-020-0236-x","article-title":"The regulation and functions of DNA and RNA G-quadruplexes","volume":"21","author":"Varshney","year":"2020","journal-title":"Nat. Rev. Mol. Cell Biol."},{"key":"ref_24","doi-asserted-by":"crossref","first-page":"1989","DOI":"10.1093\/nar\/gkw079","article-title":"G-quadruplexes and helicases","volume":"44","author":"Mendoza","year":"2016","journal-title":"Nucleic Acids Res."},{"key":"ref_25","doi-asserted-by":"crossref","unstructured":"Lerner, L.K., and Sale, J.E. (2019). Replication of G Quadruplex DNA. Genes, 10.","DOI":"10.3390\/genes10020095"},{"key":"ref_26","doi-asserted-by":"crossref","first-page":"5174","DOI":"10.1074\/jbc.M114.634923","article-title":"A distinct triplex DNA unwinding activity of ChlR1 helicase","volume":"290","author":"Guo","year":"2015","journal-title":"J. Biol. Chem."},{"key":"ref_27","doi-asserted-by":"crossref","first-page":"3024","DOI":"10.1074\/jbc.M006784200","article-title":"Unwinding of a DNA triple helix by the Werner and Bloom syndrome helicases","volume":"276","author":"Brosh","year":"2001","journal-title":"J. Biol. Chem."},{"key":"ref_28","doi-asserted-by":"crossref","first-page":"10345","DOI":"10.1093\/nar\/gkt804","article-title":"DHX9 helicase is involved in preventing genomic instability induced by alternatively structured DNA in human cells","volume":"41","author":"Jain","year":"2013","journal-title":"Nucleic Acids Res."},{"key":"ref_29","doi-asserted-by":"crossref","first-page":"5123","DOI":"10.1093\/nar\/gkn493","article-title":"The triple helix: 50 years later, the outcome","volume":"36","author":"Duca","year":"2008","journal-title":"Nucleic Acids Res."},{"key":"ref_30","doi-asserted-by":"crossref","first-page":"89","DOI":"10.1017\/S0033583502003773","article-title":"Triplex-forming oligonucleotides: Principles and applications","volume":"35","author":"Vasquez","year":"2002","journal-title":"Q. Rev. Biophys."},{"key":"ref_31","doi-asserted-by":"crossref","first-page":"185","DOI":"10.1007\/BF00292959","article-title":"Immunofluorescent staining of mammalian nuclei and chromosomes with a monoclonal antibody to triplex DNA","volume":"97","author":"Burkholder","year":"1988","journal-title":"Chromosoma"},{"key":"ref_32","doi-asserted-by":"crossref","first-page":"7019","DOI":"10.1016\/S0021-9258(17)37476-8","article-title":"Characterization of a new monoclonal antibody to triplex DNA and immunofluorescent staining of mammalian chromosomes","volume":"269","author":"Agazie","year":"1994","journal-title":"J. Biol. Chem."},{"key":"ref_33","doi-asserted-by":"crossref","first-page":"4287","DOI":"10.1038\/s41467-020-18066-8","article-title":"Warsaw Breakage Syndrome associated DDX11 helicase resolves G-quadruplex structures to support sister chromatid cohesion","volume":"11","author":"Faramarz","year":"2020","journal-title":"Nat. Commun."},{"key":"ref_34","doi-asserted-by":"crossref","first-page":"7653","DOI":"10.1158\/0008-5472.CAN-09-1304","article-title":"Anticancer activity of CX-3543: A direct inhibitor of rRNA biogenesis","volume":"69","author":"Drygin","year":"2009","journal-title":"Cancer Res."},{"key":"ref_35","doi-asserted-by":"crossref","first-page":"2098","DOI":"10.1021\/ja017308q","article-title":"Telomestatin, a potent telomerase inhibitor that interacts quite specifically with the human telomeric intramolecular g-quadruplex","volume":"124","author":"Kim","year":"2002","journal-title":"J. Am. Chem. Soc."},{"key":"ref_36","doi-asserted-by":"crossref","first-page":"4901","DOI":"10.1093\/hmg\/ddv213","article-title":"The Warsaw breakage syndrome-related protein DDX11 is required for ribosomal RNA synthesis and embryonic development","volume":"24","author":"Sun","year":"2015","journal-title":"Hum. Mol. Genet."},{"key":"ref_37","doi-asserted-by":"crossref","first-page":"6213","DOI":"10.1093\/nar\/gkw349","article-title":"G-rich telomeric and ribosomal DNA sequences from the fission yeast genome form stable G-quadruplex DNA structures in vitro and are unwound by the Pfh1 DNA helicase","volume":"44","author":"Wallgren","year":"2016","journal-title":"Nucleic Acids Res."},{"key":"ref_38","doi-asserted-by":"crossref","first-page":"3945","DOI":"10.4161\/cc.21989","article-title":"Local and global functions of Timeless and Tipin in replication fork protection","volume":"11","author":"Leman","year":"2012","journal-title":"Cell Cycle"},{"key":"ref_39","doi-asserted-by":"crossref","first-page":"705","DOI":"10.1093\/nar\/gkv1112","article-title":"Tim\/Timeless, a member of the replication fork protection complex, operates with the Warsaw breakage syndrome DNA helicase DDX11 in the same fork recovery pathway","volume":"44","author":"Bharti","year":"2016","journal-title":"Nucleic Acids Res."},{"key":"ref_40","doi-asserted-by":"crossref","first-page":"e104185","DOI":"10.15252\/embj.2019104185","article-title":"Timeless couples G-quadruplex detection with processing by DDX11 helicase during DNA replication","volume":"39","author":"Lerner","year":"2020","journal-title":"EMBO J."},{"key":"ref_41","doi-asserted-by":"crossref","first-page":"8412","DOI":"10.1073\/pnas.1803110115","article-title":"Warsaw breakage syndrome DDX11 helicase acts jointly with RAD17 in the repair of bulky lesions and replication through abasic sites","volume":"115","author":"Abe","year":"2018","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"ref_42","doi-asserted-by":"crossref","first-page":"371","DOI":"10.1016\/j.molcel.2016.05.036","article-title":"Ctf4 links DNA replication with sister chromatid cohesion establishment by recruiting the Chl1 helicase to the replisome","volume":"63","author":"Samora","year":"2016","journal-title":"Mol. Cell"},{"key":"ref_43","doi-asserted-by":"crossref","first-page":"2522","DOI":"10.1016\/j.yexcr.2011.08.006","article-title":"Mammalian ChlR1 has a role in heterochromatin organization","volume":"317","author":"Inoue","year":"2011","journal-title":"Exp. Cell Res."},{"key":"ref_44","doi-asserted-by":"crossref","first-page":"397","DOI":"10.1016\/j.molcel.2016.06.031","article-title":"A Long Noncoding RNA Regulates Sister Chromatid Cohesion","volume":"63","author":"Marchese","year":"2016","journal-title":"Mol. Cell"},{"key":"ref_45","doi-asserted-by":"crossref","first-page":"F55","DOI":"10.1016\/j.vaccine.2012.06.083","article-title":"The biology and life cycle of human papillomaviruses","volume":"30","author":"Doorbar","year":"2012","journal-title":"Vaccine"},{"key":"ref_46","doi-asserted-by":"crossref","first-page":"527","DOI":"10.1002\/path.4496","article-title":"Pathogenesis of human papillomavirus associated mucosal disease","volume":"235","author":"Groves","year":"2015","journal-title":"J. Pathol."},{"key":"ref_47","doi-asserted-by":"crossref","first-page":"979","DOI":"10.1016\/j.jmb.2003.10.009","article-title":"Comparison of the structure and DNA-binding properties of the E2 proteins from an oncogenic and a non-oncogenic human papillomavirus","volume":"334","author":"Dell","year":"2003","journal-title":"J. Mol. Biol."},{"key":"ref_48","doi-asserted-by":"crossref","first-page":"4857","DOI":"10.1242\/jcs.03262","article-title":"The DNA helicase ChlR1 is required for sister chromatid cohesion in mammalian cells","volume":"119","author":"Parish","year":"2006","journal-title":"J. Cell. Sci."},{"key":"ref_49","doi-asserted-by":"crossref","first-page":"e01853-16","DOI":"10.1128\/JVI.01853-16","article-title":"The Cellular DNA Helicase ChlR1 Regulates Chromatin and Nuclear Matrix Attachment of the Human Papillomavirus 16 E2 Protein and High-Copy-Number Viral Genome Establishment","volume":"91","author":"Harris","year":"2016","journal-title":"J. Virol."},{"key":"ref_50","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.virol.2011.03.015","article-title":"In vivo analysis of the cell cycle dependent association of the bovine papillomavirus E2 protein and ChlR1","volume":"414","author":"Feeney","year":"2011","journal-title":"Virology"},{"key":"ref_51","doi-asserted-by":"crossref","first-page":"5853","DOI":"10.1128\/JVI.02425-10","article-title":"The replisome pausing factor Timeless is required for episomal maintenance of latent Epstein-Barr virus","volume":"85","author":"Dheekollu","year":"2011","journal-title":"J. Virol."},{"key":"ref_52","doi-asserted-by":"crossref","first-page":"3699","DOI":"10.1128\/JVI.02211-12","article-title":"Timeless-dependent DNA replication-coupled recombination promotes Kaposi\u2019s Sarcoma-associated herpesvirus episome maintenance and terminal repeat stability","volume":"87","author":"Dheekollu","year":"2013","journal-title":"J. Virol."},{"key":"ref_53","doi-asserted-by":"crossref","first-page":"1450","DOI":"10.1056\/NEJMra1713263","article-title":"Hepatocellular Carcinoma","volume":"380","author":"Villanueva","year":"2019","journal-title":"N. Engl. J. Med."},{"key":"ref_54","doi-asserted-by":"crossref","first-page":"27","DOI":"10.1038\/s41419-020-2478-0","article-title":"E2F1 mediated DDX11 transcriptional activation promotes hepatocellular carcinoma progression through PI3K\/AKT\/mTOR pathway","volume":"11","author":"Yu","year":"2020","journal-title":"Cell Death Dis."},{"key":"ref_55","doi-asserted-by":"crossref","first-page":"59329","DOI":"10.3389\/fonc.2020.593293","article-title":"An E2F1\/DDX11\/EZH2 Positive Feedback Loop Promotes Cell Proliferation in Hepatocellular Carcinoma","volume":"10","author":"Su","year":"2021","journal-title":"Front. Oncol."},{"key":"ref_56","doi-asserted-by":"crossref","first-page":"5449","DOI":"10.1158\/0008-5472.CAN-20-2147","article-title":"EZH2-Targeted Therapies in Cancer: Hype or a Reality","volume":"80","author":"Eich","year":"2020","journal-title":"Cancer Res."},{"key":"ref_57","doi-asserted-by":"crossref","first-page":"877","DOI":"10.1038\/s41467-017-01029-x","article-title":"EZH2 enables germinal centre formation through epigenetic silencing of CDKN1A and an Rb-E2F1 feedback loop","volume":"8","author":"Rivas","year":"2017","journal-title":"Nat. Commun."},{"key":"ref_58","doi-asserted-by":"crossref","first-page":"vii320","DOI":"10.1093\/annonc\/mdq276","article-title":"Osteosarcoma","volume":"21","author":"Ritter","year":"2010","journal-title":"Ann. Oncol."},{"key":"ref_59","doi-asserted-by":"crossref","first-page":"117392","DOI":"10.1016\/j.lfs.2020.117392","article-title":"DDX11-AS1 contributes to osteosarcoma progression via stabilizing DDX11","volume":"254","author":"Zhang","year":"2020","journal-title":"Life Sci."},{"key":"ref_60","doi-asserted-by":"crossref","first-page":"2093","DOI":"10.1111\/cas.13642","article-title":"Emerging roles of long non-coding RNA in cancer","volume":"109","author":"Kawamura","year":"2018","journal-title":"Cancer Sci."},{"key":"ref_61","doi-asserted-by":"crossref","first-page":"145","DOI":"10.1146\/annurev-biochem-051410-092902","article-title":"Genome regulation by long noncoding RNAs","volume":"81","author":"Rinn","year":"2012","journal-title":"Annu. Rev. Biochem."},{"key":"ref_62","doi-asserted-by":"crossref","first-page":"1253","DOI":"10.1038\/nm.3981","article-title":"The emerging role of lncRNAs in cancer","volume":"21","author":"Huarte","year":"2015","journal-title":"Nat. Med."},{"key":"ref_63","doi-asserted-by":"crossref","first-page":"3965","DOI":"10.1158\/0008-5472.CAN-16-2634","article-title":"Long Noncoding RNA and Cancer: A New Paradigm","volume":"77","author":"Bhan","year":"2017","journal-title":"Cancer Res."},{"key":"ref_64","doi-asserted-by":"crossref","first-page":"44195","DOI":"10.18632\/oncotarget.17409","article-title":"DDX11-AS1 as potential therapy targets for human hepatocellular carcinoma","volume":"8","author":"Shi","year":"2017","journal-title":"Oncotarget"},{"key":"ref_65","doi-asserted-by":"crossref","first-page":"946","DOI":"10.1007\/s13577-020-00409-8","article-title":"LncRNA DDX11-AS1: A novel oncogene in human cancer","volume":"33","author":"Feng","year":"2020","journal-title":"Hum. Cell"},{"key":"ref_66","doi-asserted-by":"crossref","first-page":"549","DOI":"10.1007\/s12079-019-00522-w","article-title":"MiR-873-5p suppresses cell proliferation and epithelial-mesenchymal transition via directly targeting Jumonji domain-containing protein 8 through the NF-\u03baB pathway in colorectal cancer","volume":"13","author":"Wang","year":"2019","journal-title":"J. Cell Commun. Signal"},{"key":"ref_67","doi-asserted-by":"crossref","first-page":"344","DOI":"10.1038\/nature12986","article-title":"The multilayered complexity of ceRNA crosstalk and competition","volume":"505","author":"Tay","year":"2014","journal-title":"Nature"},{"key":"ref_68","doi-asserted-by":"crossref","first-page":"104","DOI":"10.1016\/j.lfs.2018.03.005","article-title":"MicroRNA-485-5p suppresses growth and metastasis in non-small cell lung cancer cells by targeting IGF2BP2","volume":"199","author":"Huang","year":"2018","journal-title":"Life Sci."},{"key":"ref_69","doi-asserted-by":"crossref","first-page":"1221","DOI":"10.1002\/jcb.27079","article-title":"Long noncoding RNA HOTAIR silencing inhibits invasion and proliferation of human colon cancer LoVo cells via regulating IGF2BP2","volume":"120","author":"Wu","year":"2019","journal-title":"J. Cell. Biochem."},{"key":"ref_70","doi-asserted-by":"crossref","first-page":"1727","DOI":"10.1016\/S0140-6736(10)62101-0","article-title":"Non-small-cell lung cancer","volume":"378","author":"Goldstraw","year":"2011","journal-title":"Lancet"},{"key":"ref_71","doi-asserted-by":"crossref","first-page":"4208","DOI":"10.7150\/jca.33457","article-title":"The Role of Upregulated DDX11 as a Potential Prognostic and Diagnostic Biomarker in Lung Adenocarcinoma","volume":"10","author":"Li","year":"2019","journal-title":"J. Cancer"},{"key":"ref_72","doi-asserted-by":"crossref","first-page":"261","DOI":"10.1016\/j.csbj.2020.12.007","article-title":"Lead DEAD\/H box helicase biomarkers with the therapeutic potential identified by integrated bioinformatic approaches in lung cancer","volume":"19","author":"Cui","year":"2020","journal-title":"Comput. Struct. Biotechnol. J."},{"key":"ref_73","doi-asserted-by":"crossref","first-page":"463","DOI":"10.1038\/nrclinonc.2017.43","article-title":"Targeted agents and immunotherapies: Optimizing outcomes in melanoma","volume":"14","author":"Luke","year":"2017","journal-title":"Nat. Rev. Clin. Oncol."},{"key":"ref_74","doi-asserted-by":"crossref","first-page":"82","DOI":"10.1186\/1476-4598-11-82","article-title":"The DEAD\/DEAH box helicase, DDX11, is essential for the survival of advanced melanomas","volume":"11","author":"Bhattacharya","year":"2012","journal-title":"Mol. Cancer"},{"key":"ref_75","doi-asserted-by":"crossref","first-page":"166","DOI":"10.1038\/nrc3891","article-title":"Therapeutic opportunities within the DNA damage response","volume":"15","author":"Pearl","year":"2015","journal-title":"Nat. Rev. Cancer"},{"key":"ref_76","doi-asserted-by":"crossref","first-page":"1546","DOI":"10.1126\/science.1235122","article-title":"Cancer genome landscapes","volume":"339","author":"Vogelstein","year":"2013","journal-title":"Science"}],"container-title":["Genes"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.mdpi.com\/2073-4425\/12\/3\/395\/pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,11]],"date-time":"2025-10-11T05:33:33Z","timestamp":1760160813000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.mdpi.com\/2073-4425\/12\/3\/395"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,3,10]]},"references-count":76,"journal-issue":{"issue":"3","published-online":{"date-parts":[[2021,3]]}},"alternative-id":["genes12030395"],"URL":"https:\/\/doi.org\/10.3390\/genes12030395","relation":{},"ISSN":["2073-4425"],"issn-type":[{"value":"2073-4425","type":"electronic"}],"subject":[],"published":{"date-parts":[[2021,3,10]]}}}