{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,26]],"date-time":"2026-09-26T21:49:13Z","timestamp":1790459353510,"version":"4.1.0"},"reference-count":127,"publisher":"MDPI AG","issue":"3","license":[{"start":{"date-parts":[[2021,3,19]],"date-time":"2021-03-19T00:00:00Z","timestamp":1616112000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["No.31600662"],"award-info":[{"award-number":["No.31600662"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"name":"Haiyan Foundation from Harbin Medical University Cancer Hospital","award":["No.JJMS2020-02"],"award-info":[{"award-number":["No.JJMS2020-02"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Genes"],"abstract":"<jats:p>N6-methyladenosine (m6A) is one of the most prevalent epigenetic modifications of eukaryotic RNA. The m6A modification is a dynamic and reversible process, regulated by three kinds of regulator, including m6A methyltransferases, demethylases and m6A-binding proteins, and this modification plays a vital role in many diseases, especially in cancers. Accumulated evidence has proven that this modification has a significant effect on cellular biological functions and cancer progression; however, little is known about the effects of the m6A modification in non-small cell lung cancer (NSCLC). In this review, we summarized how various m6A regulators modulate m6A RNA metabolism and demonstrated the effect of m6A modification on the progression and cellular biological functions of NSCLC. We also discussed how m6A modification affects the treatment, drug resistance, diagnosis and prognosis of NSCLC patients.<\/jats:p>","DOI":"10.3390\/genes12030440","type":"journal-article","created":{"date-parts":[[2021,3,19]],"date-time":"2021-03-19T11:18:38Z","timestamp":1616152718000},"page":"440","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":21,"title":["The Important Role of N6-methyladenosine RNA Modification in Non-Small Cell Lung Cancer"],"prefix":"10.3390","volume":"12","author":[{"given":"Yue","family":"Cheng","sequence":"first","affiliation":[{"name":"Department of Clinical Laboratory, Harbin Medical University Cancer Hospital, 150 Haping Road, Harbin 150081, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Meiqi","family":"Wang","sequence":"additional","affiliation":[{"name":"Department of Clinical Laboratory, Harbin Medical University Cancer Hospital, 150 Haping Road, Harbin 150081, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Junliang","family":"Zhou","sequence":"additional","affiliation":[{"name":"Department of Clinical Laboratory, Harbin Medical University Cancer Hospital, 150 Haping Road, Harbin 150081, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Huanhuan","family":"Dong","sequence":"additional","affiliation":[{"name":"Department of Clinical Laboratory, Harbin Medical University Cancer Hospital, 150 Haping Road, Harbin 150081, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shuqing","family":"Wang","sequence":"additional","affiliation":[{"name":"Department of Clinical Laboratory, Harbin Medical University Cancer Hospital, 150 Haping Road, Harbin 150081, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7596-8011","authenticated-orcid":false,"given":"Hui","family":"Xu","sequence":"additional","affiliation":[{"name":"Department of Clinical Laboratory, Harbin Medical University Cancer Hospital, 150 Haping Road, Harbin 150081, China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2021,3,19]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"87","DOI":"10.3322\/caac.21262","article-title":"Global cancer statistics","volume":"65","author":"Torre","year":"2015","journal-title":"CA Cancer J. Clin."},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1007\/978-3-319-24223-1_1","article-title":"Lung Cancer Statistics","volume":"893","author":"Torre","year":"2016","journal-title":"Adv. Exp. Med. Biol."},{"key":"ref_3","doi-asserted-by":"crossref","first-page":"897","DOI":"10.1007\/s00408-020-00407-5","article-title":"Update 2020: Management of Non-Small Cell Lung Cancer","volume":"198","author":"Alexander","year":"2020","journal-title":"Lung"},{"key":"ref_4","doi-asserted-by":"crossref","first-page":"556","DOI":"10.1016\/j.jtho.2015.12.103","article-title":"Five-Year Survival in EGFR-Mutant Metastatic Lung Adenocarcinoma Treated with EGFR-TKIs","volume":"11","author":"Lin","year":"2016","journal-title":"J. Thorac. Oncol."},{"key":"ref_5","doi-asserted-by":"crossref","first-page":"1089","DOI":"10.1126\/science.1063443","article-title":"Epigenetic Reprogramming in Mammalian Development","volume":"293","author":"Reik","year":"2001","journal-title":"Science"},{"key":"ref_6","doi-asserted-by":"crossref","first-page":"1187","DOI":"10.1016\/j.cell.2017.05.045","article-title":"Dynamic RNA Modifications in Gene Expression Regulation","volume":"169","author":"Roundtree","year":"2017","journal-title":"Cell"},{"key":"ref_7","doi-asserted-by":"crossref","first-page":"3971","DOI":"10.1073\/pnas.71.10.3971","article-title":"Identification of Methylated Nucleosides in Messenger RNA from Novikoff Hepatoma Cells","volume":"71","author":"Desrosiers","year":"1974","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"ref_8","first-page":"1233","article-title":"Purification and cDNA cloning of the AdoMet-binding subunit of the human mRNA (N6-adenosine)-methyltransferase","volume":"3","author":"Bokar","year":"1997","journal-title":"RNA"},{"key":"ref_9","doi-asserted-by":"crossref","first-page":"1672","DOI":"10.1021\/bi00627a023","article-title":"Nucleotide sequences at the N6-methyladenosine sites of HeLa cell messenger ribonucleic acid","volume":"16","author":"Wei","year":"1977","journal-title":"Biochemistry"},{"key":"ref_10","doi-asserted-by":"crossref","first-page":"1635","DOI":"10.1016\/j.cell.2012.05.003","article-title":"Comprehensive Analysis of mRNA Methylation Reveals Enrichment in 3\u2032 UTRs and near Stop Codons","volume":"149","author":"Meyer","year":"2012","journal-title":"Cell"},{"key":"ref_11","doi-asserted-by":"crossref","first-page":"W548","DOI":"10.1093\/nar\/gkz479","article-title":"RNAmod: An integrated system for the annotation of mRNA modifications","volume":"47","author":"Liu","year":"2019","journal-title":"Nucleic Acids Res."},{"key":"ref_12","doi-asserted-by":"crossref","first-page":"6051","DOI":"10.1093\/nar\/gkx141","article-title":"N 6-methyladenosine alters RNA structure to regulate binding of a low-complexity protein","volume":"45","author":"Liu","year":"2017","journal-title":"Nucleic Acids Res."},{"key":"ref_13","doi-asserted-by":"crossref","first-page":"767","DOI":"10.1038\/nmeth.3453","article-title":"Single-nucleotide-resolution mapping of m6A and m6Am throughout the transcriptome","volume":"12","author":"Linder","year":"2015","journal-title":"Nat. Methods"},{"key":"ref_14","doi-asserted-by":"crossref","first-page":"692","DOI":"10.1038\/nmeth.3898","article-title":"m6A-LAIC-seq reveals the census and complexity of the m6A epitranscriptome","volume":"13","author":"Molinie","year":"2016","journal-title":"Nat. Methods"},{"key":"ref_15","doi-asserted-by":"crossref","first-page":"482","DOI":"10.1038\/nature14281","article-title":"N6-methyladenosine marks primary microRNAs for processing","volume":"519","author":"Lee","year":"2015","journal-title":"Nature"},{"key":"ref_16","doi-asserted-by":"crossref","first-page":"573","DOI":"10.1038\/nature21671","article-title":"RNA m(6)A methylation regulates the ultraviolet-induced DNA damage response","volume":"543","author":"Xiang","year":"2017","journal-title":"Nature"},{"key":"ref_17","doi-asserted-by":"crossref","first-page":"177","DOI":"10.1038\/cr.2014.3","article-title":"Mammalian WTAP is a regulatory subunit of the RNA N6-methyladenosine methyltransferase","volume":"24","author":"Ping","year":"2014","journal-title":"Cell Res."},{"key":"ref_18","doi-asserted-by":"crossref","first-page":"824","DOI":"10.1016\/j.cell.2017.05.003","article-title":"The U6 snRNA m 6 A Methyltransferase METTL16 Regulates SAM Synthetase Intron Retention","volume":"169","author":"Pendleton","year":"2017","journal-title":"Cell"},{"key":"ref_19","doi-asserted-by":"crossref","first-page":"7305","DOI":"10.1007\/s12035-019-1595-1","article-title":"RBM15 Modulates the Function of Chromatin Remodeling Factor BAF155 Through RNA Methylation in Developing Cortex","volume":"56","author":"Xie","year":"2019","journal-title":"Mol. Neurobiol."},{"key":"ref_20","doi-asserted-by":"crossref","first-page":"1403","DOI":"10.1038\/cr.2014.151","article-title":"FTO-dependent demethylation of N6-methyladenosine regulates mRNA splicing and is required for adipogenesis","volume":"24","author":"Zhao","year":"2014","journal-title":"Cell Res."},{"key":"ref_21","doi-asserted-by":"crossref","first-page":"E325","DOI":"10.1073\/pnas.1717794115","article-title":"ALKBH5-dependent m6A demethylation controls splicing and stability of long 3\u2032-UTR mRNAs in male germ cells","volume":"115","author":"Tang","year":"2018","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"ref_22","doi-asserted-by":"crossref","first-page":"949","DOI":"10.1083\/jcb.150.5.949","article-title":"The ER Repeat Protein Yt521-B Localizes to a Novel Subnuclear Compartment","volume":"150","author":"Nayler","year":"2000","journal-title":"J. Cell Biol."},{"key":"ref_23","doi-asserted-by":"crossref","first-page":"507","DOI":"10.1016\/j.molcel.2016.01.012","article-title":"Nuclear m 6 A Reader YTHDC1 Regulates mRNA Splicing","volume":"61","author":"Xiao","year":"2016","journal-title":"Mol. Cell"},{"key":"ref_24","doi-asserted-by":"crossref","unstructured":"Luxton, H.J., Simpson, B.S., Mills, I.G., Brindle, N.R., Ahmed, Z., Stavrinides, V., Heavey, S., Stamm, S., and Whitaker, H.C. (2019). The Oncogene Metadherin Interacts with the Known Splicing Proteins YTHDC1, Sam68 and T-STAR and Plays a Novel Role in Alternative mRNA Splicing. Cancers, 11.","DOI":"10.3390\/cancers11091233"},{"key":"ref_25","doi-asserted-by":"crossref","first-page":"1339","DOI":"10.1261\/rna.064238.117","article-title":"The m(6)A reader protein YTHDC2 interacts with the small ribosomal subunit and the 5-3 exoribonuclease XRN1","volume":"24","author":"Kretschmer","year":"2018","journal-title":"RNA"},{"key":"ref_26","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1038\/s41467-019-13317-9","article-title":"m6A in mRNA coding regions promotes translation via the RNA helicase-containing YTHDC","volume":"10","author":"Mao","year":"2019","journal-title":"Nat. Commun."},{"key":"ref_27","doi-asserted-by":"crossref","first-page":"1388","DOI":"10.1016\/j.cell.2015.05.014","article-title":"N6-methyladenosine Modulates Messenger RNA Translation Efficiency","volume":"161","author":"Wang","year":"2015","journal-title":"Cell"},{"key":"ref_28","doi-asserted-by":"crossref","first-page":"117","DOI":"10.1038\/nature12730","article-title":"N6-methyladenosine-dependent regulation of messenger RNA stability","volume":"505","author":"Wang","year":"2014","journal-title":"Nature"},{"key":"ref_29","doi-asserted-by":"crossref","first-page":"494","DOI":"10.1016\/j.molcel.2019.02.034","article-title":"Endoribonucleolytic Cleavage of m6A-Containing RNAs by RNase P\/MRP Complex","volume":"74","author":"Park","year":"2019","journal-title":"Mol. Cell"},{"key":"ref_30","doi-asserted-by":"crossref","first-page":"3752","DOI":"10.18632\/oncotarget.23365","article-title":"Downregulation of N6-methyladenosine binding YTHDF2 protein mediated by miR-493\u20133p suppresses prostate cancer by elevating N6-methyladenosine levels","volume":"9","author":"Li","year":"2017","journal-title":"Oncotarget"},{"key":"ref_31","doi-asserted-by":"crossref","first-page":"444","DOI":"10.1038\/cr.2017.10","article-title":"Cytoplasmic m6A reader YTHDF3 promotes mRNA translation","volume":"27","author":"Li","year":"2017","journal-title":"Cell Res."},{"key":"ref_32","doi-asserted-by":"crossref","first-page":"315","DOI":"10.1038\/cr.2017.15","article-title":"YTHDF3 facilitates translation and decay of N6-methyladenosine-modified RNA","volume":"27","author":"Shi","year":"2017","journal-title":"Cell Res."},{"key":"ref_33","doi-asserted-by":"crossref","first-page":"626","DOI":"10.1038\/cr.2017.31","article-title":"Extensive translation of circular RNAs driven by N6-methyladenosine","volume":"27","author":"Yang","year":"2017","journal-title":"Cell Res."},{"key":"ref_34","doi-asserted-by":"crossref","first-page":"104","DOI":"10.1261\/rna.1175909","article-title":"Control of c-myc mRNA stability by IGF2BP1-associated cytoplasmic RNPs","volume":"15","author":"Weidensdorfer","year":"2008","journal-title":"RNA"},{"key":"ref_35","doi-asserted-by":"crossref","first-page":"1243","DOI":"10.1016\/j.biopha.2018.07.052","article-title":"LncRNA THOR acts as a retinoblastoma promoter through enhancing the combination of c-myc mRNA and IGF2BP1 protein","volume":"106","author":"Shang","year":"2018","journal-title":"Biomed. Pharmacother."},{"key":"ref_36","doi-asserted-by":"crossref","first-page":"560","DOI":"10.1038\/nature14234","article-title":"N6-methyladenosine-dependent RNA structural switches regulate RNA\u2013protein interactions","volume":"518","author":"Liu","year":"2015","journal-title":"Nature"},{"key":"ref_37","doi-asserted-by":"crossref","first-page":"1643","DOI":"10.1126\/science.1218469","article-title":"hnRNP C Tetramer Measures RNA Length to Classify RNA Polymerase II Transcripts for Export","volume":"335","author":"McCloskey","year":"2012","journal-title":"Science"},{"key":"ref_38","doi-asserted-by":"crossref","first-page":"999","DOI":"10.1016\/j.cell.2015.10.012","article-title":"5\u2032 UTR m6A Promotes Cap-Independent Translation","volume":"163","author":"Meyer","year":"2015","journal-title":"Cell"},{"key":"ref_39","doi-asserted-by":"crossref","first-page":"306","DOI":"10.1016\/j.molcel.2016.05.041","article-title":"Structural Basis for Cooperative Function of Mettl3 and Mettl14 Methyltransferases","volume":"63","author":"Wang","year":"2016","journal-title":"Mol. Cell"},{"key":"ref_40","doi-asserted-by":"crossref","first-page":"575","DOI":"10.1038\/nature18298","article-title":"Structural basis of N6-adenosine methylation by the METTL3\u2013METTL14 complex","volume":"534","author":"Wang","year":"2016","journal-title":"Nature"},{"key":"ref_41","doi-asserted-by":"crossref","first-page":"93","DOI":"10.1038\/nchembio.1432","article-title":"A METTL3\u2013METTL14 complex mediates mammalian nuclear RNA N6-adenosine methylation","volume":"10","author":"Liu","year":"2014","journal-title":"Nat. Chem. Biol."},{"key":"ref_42","doi-asserted-by":"crossref","first-page":"369","DOI":"10.1038\/nature19342","article-title":"m6A RNA methylation promotes XIST-mediated transcriptional repression","volume":"537","author":"Patil","year":"2016","journal-title":"Nature."},{"key":"ref_43","doi-asserted-by":"crossref","first-page":"885","DOI":"10.1038\/nchembio.687","article-title":"N6-Methyladenosine in nuclear RNA is a major substrate of the obesity-associated FTO","volume":"7","author":"Jia","year":"2011","journal-title":"Nat. Chem. Biol."},{"key":"ref_44","doi-asserted-by":"crossref","first-page":"18","DOI":"10.1016\/j.molcel.2012.10.015","article-title":"ALKBH5 Is a Mammalian RNA Demethylase that Impacts RNA Metabolism and Mouse Fertility","volume":"49","author":"Zheng","year":"2013","journal-title":"Mol. Cell"},{"key":"ref_45","doi-asserted-by":"crossref","first-page":"srep42271","DOI":"10.1038\/srep42271","article-title":"AlkB homolog 3-mediated tRNA demethylation promotes protein synthesis in cancer cells","volume":"7","author":"Ueda","year":"2017","journal-title":"Sci. Rep."},{"key":"ref_46","doi-asserted-by":"crossref","first-page":"1916","DOI":"10.1016\/j.dnarep.2008.07.015","article-title":"AlkB demethylases flip out in different ways","volume":"7","author":"Sundheim","year":"2008","journal-title":"DNA Repair"},{"key":"ref_47","doi-asserted-by":"crossref","first-page":"201","DOI":"10.1016\/j.bbrc.2015.02.048","article-title":"mRNA m6A methylation downregulates adipogenesis in porcine adipocytes","volume":"459","author":"Wang","year":"2015","journal-title":"Biochem. Biophys. Res. Commun."},{"key":"ref_48","doi-asserted-by":"crossref","first-page":"973","DOI":"10.1016\/j.molcel.2018.08.011","article-title":"Differential m6A, m6Am, and m1A Demethylation Mediated by FTO in the Cell Nucleus and Cytoplasm","volume":"71","author":"Wei","year":"2018","journal-title":"Mol. Cell"},{"key":"ref_49","doi-asserted-by":"crossref","first-page":"2919","DOI":"10.1073\/pnas.1820574116","article-title":"Structural insights into FTO\u2019s catalytic mechanism for the demethylation of multiple RNA substrates","volume":"116","author":"Zhang","year":"2019","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"ref_50","doi-asserted-by":"crossref","first-page":"e31311","DOI":"10.7554\/eLife.31311","article-title":"YTHDC1 mediates nuclear export of N6-methyladenosine methylated mRNAs","volume":"6","author":"Roundtree","year":"2017","journal-title":"eLife"},{"key":"ref_51","doi-asserted-by":"crossref","first-page":"13834","DOI":"10.1073\/pnas.1412742111","article-title":"Molecular basis for the recognition of methylated adenines in RNA by the eukaryotic YTH domain","volume":"111","author":"Luo","year":"2014","journal-title":"Proc. Natl. Acad. Sci."},{"key":"ref_52","doi-asserted-by":"crossref","first-page":"14701","DOI":"10.1074\/jbc.M110.104711","article-title":"The YTH Domain Is a Novel RNA Binding Domain","volume":"285","author":"Zhang","year":"2010","journal-title":"J. Biol. Chem."},{"key":"ref_53","doi-asserted-by":"crossref","first-page":"13911","DOI":"10.1093\/nar\/gku1116","article-title":"Solution structure of the YTH domain in complex with N6-methyladenosine RNA: A reader of methylated RNA","volume":"42","author":"Theler","year":"2014","journal-title":"Nucleic Acids Res."},{"key":"ref_54","doi-asserted-by":"crossref","first-page":"355","DOI":"10.1007\/s12033-018-00149-z","article-title":"Understanding m6A Function Through Uncovering the Diversity Roles of YTH Domain-Containing Proteins","volume":"61","author":"Zhao","year":"2019","journal-title":"Mol. Biotechnol."},{"key":"ref_55","doi-asserted-by":"crossref","first-page":"1262","DOI":"10.1128\/MCB.19.2.1262","article-title":"A family of insulin-like growth factor II mRNA-binding proteins represses translation in late development","volume":"19","author":"Nielsen","year":"1999","journal-title":"Mol. Cell. Biol."},{"key":"ref_56","doi-asserted-by":"crossref","first-page":"2657","DOI":"10.1007\/s00018-012-1186-z","article-title":"Insulin-like growth factor 2 mRNA-binding proteins (IGF2BPs): Post-transcriptional drivers of cancer progression?","volume":"70","author":"Bell","year":"2013","journal-title":"Cell Mol. Life Sci."},{"key":"ref_57","doi-asserted-by":"crossref","first-page":"6285","DOI":"10.1093\/nar\/gky229","article-title":"IGF2BP1 enhances an aggressive tumor cell phenotype by impairing miRNA-directed downregulation of oncogenic factors","volume":"46","author":"Muller","year":"2018","journal-title":"Nucleic Acids Res."},{"key":"ref_58","first-page":"492","article-title":"The C proteins of HeLa 40S nuclear ribonucleoprotein particles exist as anisotropic tetramers of (C1) 3 C Mol","volume":"9","author":"Barnett","year":"1989","journal-title":"Cell. Biol."},{"key":"ref_59","first-page":"864","article-title":"The core proteins A2 and B1 exist as (A2)3B1 tetramers in 40S nuclear ribonucleoprotein particles","volume":"11","author":"Barnett","year":"1991","journal-title":"Mol. Cell. Biol."},{"key":"ref_60","doi-asserted-by":"crossref","first-page":"17","DOI":"10.1007\/BF00235189","article-title":"Reversible chemical cross-linking and ribonuclease digestion analysis of the organization of proteins in ribonucleoprotein particles","volume":"84","author":"Harris","year":"1988","journal-title":"Mol. Cell. Biochem."},{"key":"ref_61","doi-asserted-by":"crossref","first-page":"127","DOI":"10.1016\/0092-8674(77)90323-3","article-title":"Identification and characterization of the packaging proteins of core 40S hnRNP particles","volume":"11","author":"Beyer","year":"1977","journal-title":"Cell"},{"key":"ref_62","doi-asserted-by":"crossref","first-page":"909","DOI":"10.1038\/nsmb.1838","article-title":"iCLIP reveals the function of hnRNP particles in splicing at individual nucleotide resolution","volume":"17","author":"Zarnack","year":"2010","journal-title":"Nat. Struct. Mol. Biol."},{"key":"ref_63","doi-asserted-by":"crossref","first-page":"14536","DOI":"10.1021\/ja507690d","article-title":"Structural and Mechanistic Insights into Poly(uridine) Tract Recognition by the hnRNP C RNA Recognition Motif","volume":"136","author":"Damberger","year":"2014","journal-title":"J. Am. Chem. Soc."},{"key":"ref_64","doi-asserted-by":"crossref","first-page":"96","DOI":"10.1038\/nature18954","article-title":"eIF3d is an mRNA cap-binding protein that is required for specialized translation initiation","volume":"536","author":"Lee","year":"2016","journal-title":"Nature"},{"key":"ref_65","first-page":"612","article-title":"Eukaryotic translation initiation factor 3 subunit G promotes human colorectal cancer","volume":"11","author":"Yang","year":"2019","journal-title":"Am. J. Transl. Res."},{"key":"ref_66","doi-asserted-by":"crossref","first-page":"556","DOI":"10.1038\/s41586-018-0538-8","article-title":"mRNA circularization by METTL3\u2013eIF3h enhances translation and promotes oncogenesis","volume":"561","author":"Choe","year":"2018","journal-title":"Nature"},{"key":"ref_67","doi-asserted-by":"crossref","first-page":"499","DOI":"10.1261\/rna.064063.117","article-title":"Interactions, localization, and phosphorylation of the m6A generating METTL3\u2013METTL14\u2013WTAP complex","volume":"24","author":"Weichmann","year":"2018","journal-title":"RNA"},{"key":"ref_68","doi-asserted-by":"crossref","first-page":"1582","DOI":"10.1016\/j.cell.2020.05.012","article-title":"A Unified Model for the Function of YTHDF Proteins in Regulating m6A-Modified mRNA","volume":"181","author":"Zaccara","year":"2020","journal-title":"Cell"},{"key":"ref_69","doi-asserted-by":"crossref","first-page":"4357","DOI":"10.18632\/aging.202397","article-title":"The hepatic microenvironment promotes lung adenocarcinoma cell proliferation, metastasis, and epithelial\u2013mesenchymal transition via METTL3-mediated N6-methyladenosine modification of YAP","volume":"13","author":"Ni","year":"2021","journal-title":"Aging"},{"key":"ref_70","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1186\/s13045-019-0830-6","article-title":"m6A mRNA methylation initiated by METTL3 directly promotes YAP translation and increases YAP activity by regulating the MALAT1-miR-1914\u20133p-YAP axis to induce NSCLC drug resistance and metastasis","volume":"12","author":"Jin","year":"2019","journal-title":"J. Hematol. Oncol."},{"key":"ref_71","first-page":"4263","article-title":"Simvastatin is beneficial to lung cancer progression by inducing METTL3-induced m6A modification on EZH2 mRNA","volume":"24","author":"Chen","year":"2020","journal-title":"Eur. Rev. Med. Pharmacol. Sci."},{"key":"ref_72","doi-asserted-by":"crossref","first-page":"150","DOI":"10.1016\/j.bbrc.2020.01.042","article-title":"The m6A methyltransferase METTL3 contributes to Transforming Growth Factor-beta-induced epithelial-mesenchymal transition of lung cancer cells through the regulation of JUNB","volume":"524","author":"Terashima","year":"2020","journal-title":"Biochem. Biophys. Res. Commun."},{"key":"ref_73","doi-asserted-by":"crossref","first-page":"284","DOI":"10.1111\/jcmm.15997","article-title":"G protein-coupled oestrogen receptor promotes cell growth of non-small cell lung cancer cells via YAP1\/QKI\/circNOTCH1\/m6A methylated NOTCH1 signalling","volume":"25","author":"Shen","year":"2020","journal-title":"J. Cell. Mol. Med."},{"key":"ref_74","doi-asserted-by":"crossref","first-page":"153284","DOI":"10.1016\/j.prp.2020.153284","article-title":"KIAA1429 promotes the progression of lung adenocarcinoma by regulating the m6A level of MUC3A","volume":"217","author":"Zhao","year":"2021","journal-title":"Pathol. Res. Pract."},{"key":"ref_75","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1186\/s12943-020-01161-1","article-title":"m6A demethylase ALKBH5 inhibits tumor growth and metastasis by reducing YTHDFs-mediated YAP expression and inhibiting miR-107\/LATS2\u2013mediated YAP activity in NSCLC","volume":"19","author":"Jin","year":"2020","journal-title":"Mol. Cancer"},{"key":"ref_76","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1038\/s41389-018-0054-6","article-title":"Deregulation of UBE2C-mediated autophagy repression aggravates NSCLC progression","volume":"7","author":"Guo","year":"2018","journal-title":"Oncogenesis"},{"key":"ref_77","doi-asserted-by":"crossref","first-page":"499","DOI":"10.1016\/j.bbrc.2019.10.145","article-title":"ALKBH5-m(6)A-FOXM1 signaling axis promotes proliferation and invasion of lung adenocarcinoma cells under intermittent hypoxia","volume":"521","author":"Chao","year":"2020","journal-title":"Biochem. Biophys. Res. Commun."},{"key":"ref_78","doi-asserted-by":"crossref","first-page":"144348","DOI":"10.1016\/j.gene.2020.144348","article-title":"N6-methyladenosine ALKBH5 promotes non-small cell lung cancer progress by regulating TIMP3 stability","volume":"731","author":"Zhu","year":"2020","journal-title":"Gene"},{"key":"ref_79","doi-asserted-by":"crossref","first-page":"479","DOI":"10.1016\/j.bbrc.2019.03.093","article-title":"The m6A demethylase FTO promotes the growth of lung cancer cells by regulating the m6A level of USP7 mRNA","volume":"512","author":"Li","year":"2019","journal-title":"Biochem. Biophys. Res. Commun."},{"key":"ref_80","doi-asserted-by":"crossref","first-page":"456","DOI":"10.1016\/j.bbrc.2018.05.175","article-title":"m 6 A demethylase FTO facilitates tumor progression in lung squamous cell carcinoma by regulating MZF1 expression","volume":"502","author":"Liu","year":"2018","journal-title":"Biochem. Biophys. Res. Commun."},{"key":"ref_81","doi-asserted-by":"crossref","first-page":"541","DOI":"10.1093\/carcin\/bgz152","article-title":"YTH domain family 2 promotes lung cancer cell growth by facilitating 6-phosphogluconate dehydrogenase mRNA translation","volume":"41","author":"Sheng","year":"2020","journal-title":"Carcinogenesis"},{"key":"ref_82","doi-asserted-by":"crossref","first-page":"101801","DOI":"10.1016\/j.redox.2020.101801","article-title":"The m6A reader YTHDC2 inhibits lung adenocarcinoma tumorigenesis by suppressing SLC7A11-dependent antioxidant function","volume":"38","author":"Ma","year":"2021","journal-title":"Redox Biol."},{"key":"ref_83","doi-asserted-by":"crossref","first-page":"2649","DOI":"10.1002\/jcp.30023","article-title":"m(6) A transferase METTL3-induced lncRNA ABHD11-AS1 promotes the Warburg effect of non-small-cell lung cancer","volume":"236","author":"Xue","year":"2020","journal-title":"J. Cell. Physiol."},{"key":"ref_84","first-page":"1","article-title":"N6-methyladenosine induced miR-143\u20133p promotes the brain metastasis of lung cancer via regulation of VASHMol","volume":"18","author":"Wang","year":"2019","journal-title":"Cancer"},{"key":"ref_85","doi-asserted-by":"crossref","first-page":"1333","DOI":"10.3892\/ijo.2020.5142","article-title":"Long noncoding RNA FEZF1AS1 facilitates nonsmall cell lung cancer progression via the ITGA11\/miR516b5p axis","volume":"57","author":"Song","year":"2020","journal-title":"Int. J. Oncol."},{"key":"ref_86","doi-asserted-by":"crossref","unstructured":"Sardo, F.L., Strano, S., and Blandino, G. (2018). YAP and TAZ in Lung Cancer: Oncogenic Role and Clinical Targeting. Cancers, 10.","DOI":"10.3390\/cancers10050137"},{"key":"ref_87","doi-asserted-by":"crossref","first-page":"155","DOI":"10.1016\/j.gde.2004.02.001","article-title":"The functions of E(Z)\/EZH2-mediated methylation of lysine 27 in histone H3","volume":"14","author":"Cao","year":"2004","journal-title":"Curr. Opin. Genet. Dev."},{"key":"ref_88","doi-asserted-by":"crossref","first-page":"2514","DOI":"10.1093\/nar\/gkw126","article-title":"Synergistic action of master transcription factors controls epithelial-to-mesenchymal transition","volume":"44","author":"Chang","year":"2016","journal-title":"Nucleic Acids Res."},{"key":"ref_89","doi-asserted-by":"crossref","first-page":"85","DOI":"10.1038\/nrc2981","article-title":"Regulation of cancer cell metabolism","volume":"11","author":"Cairns","year":"2011","journal-title":"Nat. Rev. Cancer"},{"key":"ref_90","doi-asserted-by":"crossref","first-page":"1484","DOI":"10.1038\/ncb3255","article-title":"6-Phosphogluconate dehydrogenase links oxidative PPP, lipogenesis and tumour growth by inhibiting LKB1\u2013AMPK signalling","volume":"17","author":"Lin","year":"2015","journal-title":"Nat. Cell Biol."},{"key":"ref_91","doi-asserted-by":"crossref","first-page":"50017","DOI":"10.18632\/oncotarget.10312","article-title":"Increased expression of MUC3A is associated with poor prognosis in localized clear-cell renal cell carcinoma","volume":"7","author":"Niu","year":"2016","journal-title":"Oncotarget"},{"key":"ref_92","doi-asserted-by":"crossref","first-page":"333","DOI":"10.1016\/j.bbrc.2010.05.124","article-title":"Promoter hypomethylation contributes to the expression of MUC3A in cancer cells","volume":"397","author":"Kitamoto","year":"2010","journal-title":"Biochem. Biophys. Res. Commun."},{"key":"ref_93","doi-asserted-by":"crossref","first-page":"2217","DOI":"10.1016\/j.ejca.2004.07.006","article-title":"The ubiquitin-mediated protein degradation pathway in cancer: Therapeutic implications","volume":"40","author":"Burger","year":"2004","journal-title":"Eur. J. Cancer"},{"key":"ref_94","doi-asserted-by":"crossref","first-page":"702","DOI":"10.1158\/1940-6207.CAPR-09-0084","article-title":"Identification of Gene Signatures and Molecular Markers for Human Lung Cancer Prognosis using an In vitro Lung Carcinogenesis System","volume":"2","author":"Kadara","year":"2009","journal-title":"Cancer Prev. Res."},{"key":"ref_95","first-page":"3200","article-title":"circTP63 functions as a ceRNA to promote lung squamous cell carcinoma progression by upregulating FOXM Nat","volume":"10","author":"Cheng","year":"2019","journal-title":"Commun."},{"key":"ref_96","doi-asserted-by":"crossref","first-page":"4736","DOI":"10.1158\/0008-5472.CAN-07-6612","article-title":"Tissue Inhibitor of Metalloproteinase 3 Suppresses Tumor Angiogenesis in Matrix Metalloproteinase 2\u2013Down-regulated Lung Cancer","volume":"68","author":"Chetty","year":"2008","journal-title":"Cancer Res."},{"key":"ref_97","doi-asserted-by":"crossref","first-page":"827","DOI":"10.1161\/01.RES.0000070112.80711.3D","article-title":"Matrix metalloproteinases and tissue inhibitors of metalloproteinases: Structure, function, and biochemistry","volume":"92","author":"Visse","year":"2003","journal-title":"Circ. Res."},{"key":"ref_98","doi-asserted-by":"crossref","first-page":"61","DOI":"10.1007\/s12013-011-9185-5","article-title":"The Multifaceted Roles of USP7: New Therapeutic Opportunities","volume":"60","author":"Nicholson","year":"2011","journal-title":"Cell Biophys."},{"key":"ref_99","doi-asserted-by":"crossref","first-page":"209","DOI":"10.1016\/j.biocel.2016.08.025","article-title":"USP7 promotes cell proliferation through the stabilization of Ki-67 protein in non-small cell lung cancer cells","volume":"79","author":"Zhang","year":"2016","journal-title":"Int. J. Biochem. Cell Biol."},{"key":"ref_100","doi-asserted-by":"crossref","first-page":"1641","DOI":"10.1038\/onc.2014.118","article-title":"The MZF1\/c-MYC axis mediates lung adenocarcinoma progression caused by wild-type lkb1 loss","volume":"34","author":"Tsai","year":"2014","journal-title":"Oncogene"},{"key":"ref_101","doi-asserted-by":"crossref","first-page":"10829","DOI":"10.2147\/OTT.S248492","article-title":"Dihydroartemisinin Inhibits the Proliferation, Colony Formation and Induces Ferroptosis of Lung Cancer Cells by Inhibiting PRIM2\/SLC7A11 Axis","volume":"13","author":"Yuan","year":"2020","journal-title":"OncoTargets Ther."},{"key":"ref_102","doi-asserted-by":"crossref","first-page":"216","DOI":"10.1080\/15384101.2017.1395534","article-title":"Notch1 regulates tongue cancer cells proliferation, apoptosis and invasion","volume":"17","author":"Gan","year":"2017","journal-title":"Cell Cycle"},{"key":"ref_103","doi-asserted-by":"crossref","unstructured":"Liu, J., Liu, S., Deng, X., Rao, J., Huang, K., Xu, G., and Wang, X. (2019). MicroRNA-582\u20135p suppresses non-small cell lung cancer cells growth and invasion via downregulating NOTCH1. PLoS ONE, 14.","DOI":"10.1371\/journal.pone.0217652"},{"key":"ref_104","first-page":"1853","article-title":"Long non-coding RNA MALAT1 regulates proliferation, apoptosis, migration and invasion via miR-374b-5p\/SRSF7 axis in non-small cell lung cancer","volume":"24","author":"Song","year":"2020","journal-title":"Eur. Rev. Med. Pharmacol. Sci"},{"key":"ref_105","doi-asserted-by":"crossref","first-page":"7074","DOI":"10.1002\/cam4.2586","article-title":"lncRNA ABHD11-AS1, regulated by the EGFR pathway, contributes to the ovarian cancer tumorigenesis by epigenetically suppressing TIMP2","volume":"8","author":"Zeng","year":"2019","journal-title":"Cancer Med."},{"key":"ref_106","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1038\/s41419-019-1850-4","article-title":"Long noncoding RNA ABHD11-AS1 functions as a competing endogenous RNA to regulate papillary thyroid cancer progression by miR-199a-5p\/SLC1A5 axis","volume":"10","author":"Zhuang","year":"2019","journal-title":"Cell Death Dis."},{"key":"ref_107","doi-asserted-by":"crossref","first-page":"12070","DOI":"10.1002\/jcp.27877","article-title":"Long noncoding RNA ABHD11-AS1 promote cells proliferation and invasion of colorectal cancer via regulating the miR-1254-WNT11 pathway","volume":"234","author":"He","year":"2019","journal-title":"J. Cell. Physiol."},{"key":"ref_108","doi-asserted-by":"crossref","first-page":"980","DOI":"10.1016\/j.bbrc.2016.04.002","article-title":"MicroRNA-376c suppresses non-small-cell lung cancer cell growth and invasion by targeting LRH-1-mediated Wnt signaling pathway","volume":"473","author":"Jiang","year":"2016","journal-title":"Biochem. Biophys. Res. Commun."},{"key":"ref_109","doi-asserted-by":"crossref","unstructured":"Zhou, J., Xiao, D., Qiu, T., Li, J., and Liu, Z. (2020). Loading MicroRNA-376c in Extracellular Vesicles Inhibits Properties of Non-Small Cell Lung Cancer Cells by Targeting YTHDF1. Technol. Cancer Res. Treat., 19.","DOI":"10.1177\/1533033820977525"},{"key":"ref_110","doi-asserted-by":"crossref","first-page":"1479","DOI":"10.1016\/j.ymthe.2020.03.010","article-title":"Integrative Analysis of NSCLC Identifies LINC01234 as an Oncogenic lncRNA that Interacts with HNRNPA2B1 and Regulates miR-106b Biogenesis","volume":"28","author":"Chen","year":"2020","journal-title":"Mol. Ther."},{"key":"ref_111","doi-asserted-by":"crossref","first-page":"295","DOI":"10.1038\/s41467-020-20527-z","article-title":"circNDUFB2 inhibits non-small cell lung cancer progression via destabilizing IGF2BPs and activating anti-tumor immunity","volume":"12","author":"Li","year":"2021","journal-title":"Nat. Commun."},{"key":"ref_112","doi-asserted-by":"crossref","unstructured":"Mu, X., Zhao, Q., Chen, W., Zhao, Y., Yan, Q., Peng, R., Zhu, J., Yang, C., Lan, K., and Gu, X. (2021). IL-37 Confers Anti-Tumor Activity by Regulation of m6A Methylation. Front. Oncol., 10.","DOI":"10.3389\/fonc.2020.526866"},{"key":"ref_113","doi-asserted-by":"crossref","unstructured":"Xiao, P., Liu, Y.K., Han, W., Hu, Y., Zhang, B.Y., and Liu, W.L. (2021). Exosomal Delivery of FTO Confers Gefitinib Resistance to Recipient Cells through ABCC10 Regulation in an m6A-dependent Manner. Mol. Cancer Res.","DOI":"10.1158\/1541-7786.MCR-20-0541"},{"key":"ref_114","doi-asserted-by":"crossref","first-page":"1167","DOI":"10.2147\/CMAR.S171517","article-title":"Rhein shows potent efficacy against non-small-cell lung cancer through inhibiting the STAT3 pathway","volume":"11","author":"Yang","year":"2019","journal-title":"Cancer Manag. Res."},{"key":"ref_115","doi-asserted-by":"crossref","first-page":"373","DOI":"10.1093\/nar\/gku1276","article-title":"Meclofenamic acid selectively inhibits FTO demethylation of m6A over ALKBH","volume":"43","author":"Huang","year":"2015","journal-title":"Nucleic Acids Res."},{"key":"ref_116","doi-asserted-by":"crossref","first-page":"677","DOI":"10.1016\/j.ccell.2019.03.006","article-title":"Small-Molecule Targeting of Oncogenic FTO Demethylase in Acute Myeloid Leukemia","volume":"35","author":"Huang","year":"2019","journal-title":"Cancer Cell"},{"key":"ref_117","first-page":"227","article-title":"Dissecting the m6A methylation affection on afatinib resistance in non-small cell lung cancer","volume":"20","author":"Meng","year":"2020","journal-title":"Pharm. J."},{"key":"ref_118","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1038\/s41467-019-12801-6","article-title":"YTHDF1 links hypoxia adaptation and non-small cell lung cancer progression","volume":"10","author":"Shi","year":"2019","journal-title":"Nat. Commun."},{"key":"ref_119","doi-asserted-by":"crossref","first-page":"1785","DOI":"10.7150\/ijbs.39046","article-title":"Diagnostic, progressive and prognostic performance of m6A methylation RNA regulators in lung adenocarcinoma","volume":"16","author":"Zhuang","year":"2020","journal-title":"Int. J. Biol. Sci."},{"key":"ref_120","doi-asserted-by":"crossref","first-page":"316","DOI":"10.1089\/dna.2020.6136","article-title":"Prognostic Impact of IGF2BP3 Expression in Patients with Surgically Resected Lung Adenocarcinoma","volume":"40","author":"Guo","year":"2021","journal-title":"DNA Cell Biol."},{"key":"ref_121","doi-asserted-by":"crossref","first-page":"1378","DOI":"10.1021\/acs.analchem.5b03962","article-title":"Determination of DNA and RNA Methylation in Circulating Tumor Cells by Mass Spectrometry","volume":"88","author":"Huang","year":"2016","journal-title":"Anal. Chem."},{"key":"ref_122","doi-asserted-by":"crossref","first-page":"246","DOI":"10.3390\/genes9050246","article-title":"tRNA-Derived Small RNA: A Novel Regulatory Small Non-Coding RNA","volume":"9","author":"Li","year":"2018","journal-title":"Genes"},{"key":"ref_123","doi-asserted-by":"crossref","first-page":"625","DOI":"10.1007\/s10549-020-05581-x","article-title":"Anti-HER2 antibody therapy using gene-transduced adipocytes for HER2-positive breast cancer","volume":"180","author":"Masuda","year":"2020","journal-title":"Breast Cancer Res. Treat."},{"key":"ref_124","doi-asserted-by":"crossref","unstructured":"Toulany, M. (2019). Targeting DNA Double-Strand Break Repair Pathways to Improve Radiotherapy Response. Genes, 10.","DOI":"10.3390\/genes10010025"},{"key":"ref_125","doi-asserted-by":"crossref","first-page":"6043","DOI":"10.1002\/jcp.29531","article-title":"Contributions and prognostic values of m 6 A RNA methylation regulators in non-small-cell lung cancer","volume":"235","author":"Liu","year":"2020","journal-title":"J. Cell. Physiol."},{"key":"ref_126","first-page":"2514230","article-title":"Deciphering N6-Methyladenosine-Related Genes Signature to Predict Survival in Lung Adenocarcinoma","volume":"2020","author":"Zhu","year":"2020","journal-title":"BioMed Res. Int."},{"key":"ref_127","doi-asserted-by":"crossref","first-page":"582","DOI":"10.1016\/j.bbrc.2016.11.077","article-title":"MiR-33a suppresses proliferation of NSCLC cells via targeting METTL3 mRNA","volume":"482","author":"Du","year":"2017","journal-title":"Biochem. Biophys. Res. Commun."}],"container-title":["Genes"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.mdpi.com\/2073-4425\/12\/3\/440\/pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,11]],"date-time":"2025-10-11T05:38:13Z","timestamp":1760161093000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.mdpi.com\/2073-4425\/12\/3\/440"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,3,19]]},"references-count":127,"journal-issue":{"issue":"3","published-online":{"date-parts":[[2021,3]]}},"alternative-id":["genes12030440"],"URL":"https:\/\/doi.org\/10.3390\/genes12030440","relation":{},"ISSN":["2073-4425"],"issn-type":[{"value":"2073-4425","type":"electronic"}],"subject":[],"published":{"date-parts":[[2021,3,19]]}}}