{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,26]],"date-time":"2026-02-26T23:23:58Z","timestamp":1772148238343,"version":"3.50.1"},"reference-count":45,"publisher":"MDPI AG","issue":"4","license":[{"start":{"date-parts":[[2021,4,16]],"date-time":"2021-04-16T00:00:00Z","timestamp":1618531200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Genes"],"abstract":"<jats:p>It is known that genetic factors determine odontogenesis; furthermore, studies have revealed that various genes in humans can regulate the development of different types and generations of teeth. In this study it has been assumed that tooth impaction\u2014at least to some extent\u2014also depends on the presence of specific genetic markers, especially allelic variants of the MSX1 gene. The primary objective of the study was to evaluate the suitability of selected molecular markers located within the MSX1 gene for the determination of the risk of tooth impaction in particular patients. The study participants were divided into two groups: (1) the study group\u2014at least one secondary tooth was impacted in the jaws; (2) the control group\u2014no impacted tooth in the jaws. Real-Time PCR and TaqMan probes were used to detect selected polymorphisms in the analyzed genes. Two single nucleotide polymorphisms of MSX1 were analyzed. After the two subgroups of patients were distinguished in the study group based on the number of impacted teeth, statistically significant differences in the frequency of genotypes described for rs12532 in the MSX1 gene were found.<\/jats:p>","DOI":"10.3390\/genes12040577","type":"journal-article","created":{"date-parts":[[2021,4,16]],"date-time":"2021-04-16T10:20:11Z","timestamp":1618568411000},"page":"577","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":13,"title":["Association of Polymorphic and Haplotype Variants of the MSX1 Gene and the Impacted Teeth Phenomenon"],"prefix":"10.3390","volume":"12","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-3900-4901","authenticated-orcid":false,"given":"Grzegorz","family":"Trybek","sequence":"first","affiliation":[{"name":"Department of Oral Surgery, Pomeranian Medical University in Szczecin, Powsta\u0144c\u00f3w Wielkopolskich 72\/18, 70-111 Szczecin, Poland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7727-6388","authenticated-orcid":false,"given":"Aleksandra","family":"Jaro\u0144","sequence":"additional","affiliation":[{"name":"Department of Oral Surgery, Pomeranian Medical University in Szczecin, Powsta\u0144c\u00f3w Wielkopolskich 72\/18, 70-111 Szczecin, Poland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2633-520X","authenticated-orcid":false,"given":"Anna","family":"Grzywacz","sequence":"additional","affiliation":[{"name":"Independent Laboratory of Health Promotion, Pomeranian Medical University in Szczecin, 70-204 Szczecin, Poland"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1968","published-online":{"date-parts":[[2021,4,16]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"382","DOI":"10.1002\/dvg.20634","article-title":"Ectoderm, endoderm, and the evolution of heterodont dentitions","volume":"48","author":"Ohazama","year":"2010","journal-title":"Genesis"},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"795","DOI":"10.1038\/nature07304","article-title":"Dual epithelial origin of vertebrate oral teeth","volume":"455","author":"Soukup","year":"2008","journal-title":"Nature"},{"key":"ref_3","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1007\/978-0-387-46954-6_1","article-title":"Neural crest cells and the community of plan for craniofacial development: Historical debates and current perspectives","volume":"589","author":"Noden","year":"2006","journal-title":"Adv. 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