{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,12]],"date-time":"2025-10-12T01:58:40Z","timestamp":1760234320684,"version":"build-2065373602"},"reference-count":24,"publisher":"MDPI AG","issue":"5","license":[{"start":{"date-parts":[[2021,4,29]],"date-time":"2021-04-29T00:00:00Z","timestamp":1619654400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"Chang Gung Memorial Hospital","award":["CMRPG3H0313 and CMRPG3J127"],"award-info":[{"award-number":["CMRPG3H0313 and CMRPG3J127"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Genes"],"abstract":"<jats:p>Parkinson\u2019s disease (PD) is a neurodegenerative disease with the pathological hallmark of Lewy bodies and Lewy neurites composed of \u03b1-synuclein. The SNP rs591323 is one of the risk loci located near the FGF20 gene that has been implicated in PD. The variation of FGF20 in the 3\u2032 untranslated region was shown to increase \u03b1-synuclein expression. We examined the association of rs591323 with the risk of PD in a Taiwanese population and conducted a meta-analysis, including our study and two other studies from China, to further confirm the role of this SNP in Taiwanese\/Chinese populations. A total of 586 patients with PD and 586 health controls (HCs) were included in our study. We found that the minor allele (A) and the AA + GA genotype under the dominant model are significantly less frequent in PD than in controls. The meta-analysis consisted of 1950 patients with PD and 2073 healthy controls from three studies. There was significant association between rs591323 and the risk of PD in the additive (Z = \u22123.96; p &lt; 0.0001) and the dominant models (Z = \u22124.01; p &lt; 0.0001). Our study results and the meta-analysis support the possible protective role of the rs591323 A allele in PD in Taiwanese\/Chinese populations.<\/jats:p>","DOI":"10.3390\/genes12050674","type":"journal-article","created":{"date-parts":[[2021,4,30]],"date-time":"2021-04-30T05:10:55Z","timestamp":1619759455000},"page":"674","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["Fibroblast Growth Factor 20 Gene Polymorphism in Parkinson\u2019s Disease in Asian Population: A Meta-Analysis"],"prefix":"10.3390","volume":"12","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-0768-0059","authenticated-orcid":false,"given":"Han-Lin","family":"Chiang","sequence":"first","affiliation":[{"name":"Department of Neurology, Neurological Institute, Taipei Veterans General Hospital, Taipei 112, Taiwan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yih-Ru","family":"Wu","sequence":"additional","affiliation":[{"name":"Chang Gung Memorial Hospital Linkou Medical Center and College of Medicine, Department of Neurology, Chang Gung University, Taoyuan 333, Taiwan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1115-2205","authenticated-orcid":false,"given":"Yi-Chun","family":"Chen","sequence":"additional","affiliation":[{"name":"Chang Gung Memorial Hospital Linkou Medical Center and College of Medicine, Department of Neurology, Chang Gung University, Taoyuan 333, Taiwan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hon-Chung","family":"Fung","sequence":"additional","affiliation":[{"name":"Fu Jen Faculty of Theology of St. Robert Bellarmine, Fu Jen University Clinic, Taipei 242, Taiwan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0769-0353","authenticated-orcid":false,"given":"Chiung-Mei","family":"Chen","sequence":"additional","affiliation":[{"name":"Chang Gung Memorial Hospital Linkou Medical Center and College of Medicine, Department of Neurology, Chang Gung University, Taoyuan 333, Taiwan"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1968","published-online":{"date-parts":[[2021,4,29]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"896","DOI":"10.1016\/S0140-6736(14)61393-3","article-title":"Parkinson\u2019s disease","volume":"386","author":"Kalia","year":"2015","journal-title":"Lancet"},{"key":"ref_2","doi-asserted-by":"crossref","unstructured":"Emamzadeh, F.N., and Surguchov, A. 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