{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,5]],"date-time":"2026-06-05T00:17:38Z","timestamp":1780618658726,"version":"3.54.1"},"reference-count":31,"publisher":"MDPI AG","issue":"5","license":[{"start":{"date-parts":[[2021,5,18]],"date-time":"2021-05-18T00:00:00Z","timestamp":1621296000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Genes"],"abstract":"<jats:p>There are recent data suggesting an association between the R577X polymorphism (rs1815739) in the gene encoding \u03b1-actinin-3 (ACTN3) and the risk of musculoskeletal injuries. The purpose of this study was to analyze the association of rs1815739 with risk of, and recovery time from non-contact soft-tissue muscle injuries in professional soccer players. Forty-six (22 male and 24 female) players from a top-level professional soccer team were assessed during five consecutive seasons: the genotype distribution was: RR, 41.3%; RX, 47.8%; and XX, 10.9%. There was a trend towards a higher risk of muscle injury associated with the XX genotype (p = 0.092, with no injury-free XX player during the 5-year study period) and a significant genotype effect for the time needed to return to play (p = 0.044, with the highest value shown for the XX genotype, i.e., 36 \u00b1 26 days, vs. 20 \u00b1 10 and 17 \u00b1 12 days for RR and RX, respectively). In conclusion, the XX genotype might be associated not only with a higher risk of non-contact muscle injuries, but also of recovery time from these conditions. However, more research in larger cohorts is needed to confirm this preliminary hypothesis.<\/jats:p>","DOI":"10.3390\/genes12050769","type":"journal-article","created":{"date-parts":[[2021,5,18]],"date-time":"2021-05-18T12:17:16Z","timestamp":1621340236000},"page":"769","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":24,"title":["Alpha-Actinin-3 Deficiency Might Affect Recovery from Non-Contact Muscle Injuries: Preliminary Findings in a Top-Level Soccer Team"],"prefix":"10.3390","volume":"12","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-8060-3914","authenticated-orcid":false,"given":"Gil","family":"Rodas","sequence":"first","affiliation":[{"name":"Medical Department, Futbol Club Barcelona, Bar\u00e7a Innovation Hub, 08028 Barcelona, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"V\u00edctor","family":"Moreno-P\u00e9rez","sequence":"additional","affiliation":[{"name":"Center for Translational Research in Physiotherapy, Department of Pathology and Surgery, Miguel Hernandez University of Elche, 03202 Elche, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5785-984X","authenticated-orcid":false,"given":"Juan","family":"Del Coso","sequence":"additional","affiliation":[{"name":"Centre for Sport Studies, Rey Juan Carlos University, 28943 Fuenlabrada, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Daniel","family":"Florit","sequence":"additional","affiliation":[{"name":"Medical Department, Futbol Club Barcelona, Bar\u00e7a Innovation Hub, 08028 Barcelona, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lourdes","family":"Osaba","sequence":"additional","affiliation":[{"name":"Progenika Biopharma, A Grifols Company, 48160 Derio, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alejandro","family":"Lucia","sequence":"additional","affiliation":[{"name":"Faculty of Sport Sciences, Universidad Europea de Madrid, 28670 Villaviciosa de Od\u00f3n, Spain"},{"name":"Research Institute Imas12, Hospital 12 de Octubre, 28041 Madrid, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2021,5,18]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"501","DOI":"10.2165\/00007256-200535060-00004","article-title":"Physiology of soccer: An update","volume":"35","author":"Chamari","year":"2005","journal-title":"Sport. 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