{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,16]],"date-time":"2026-10-16T01:02:29Z","timestamp":1792112549869,"version":"4.4.0"},"reference-count":46,"publisher":"MDPI AG","issue":"6","license":[{"start":{"date-parts":[[2021,6,11]],"date-time":"2021-06-11T00:00:00Z","timestamp":1623369600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Genes"],"abstract":"<jats:p>Sj\u00f6gren\u2019s Syndrome (SS) is a chronic autoimmune inflammatory disease. It is considered a multifactorial pathology, in which underlying genetic predisposition, epigenetic mechanisms and environmental factors contribute to development. The epigenetic regulations represent a link between genetic predisposition and environmental factors. Recent studies suggested a regulatory role for non-coding RNAs in critical biological and disease processes. Among non-coding RNAs, microRNAs (miRNAs) and long non-coding RNAs (lncRNAs) play a critical role in the post-transcriptional mRNA expression, forming a complex network of gene expression regulation. This review aims to give an overview of the latest studies that have investigated the role of miRNAs and lncRNAs in the SS. We included papers that investigated the expression of non-coding RNAs on different tissues, in particular on peripheral blood mononuclear cells and salivary glands. However, regarding the involvement of non-coding RNAs genetic variability in SS susceptibility very few data are available. Further research could help to elucidate underlying pathogenic processes of SS and provide new opportunities for the development of targeted therapies.<\/jats:p>","DOI":"10.3390\/genes12060903","type":"journal-article","created":{"date-parts":[[2021,6,11]],"date-time":"2021-06-11T12:44:37Z","timestamp":1623415477000},"page":"903","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":19,"title":["Emerging Role of microRNAs and Long Non-Coding RNAs in Sj\u00f6gren\u2019s Syndrome"],"prefix":"10.3390","volume":"12","author":[{"given":"Giada","family":"De Benedittis","sequence":"first","affiliation":[{"name":"Department of Biomedicine & Prevention, Genetics Section, University of Rome Tor Vergata, 00133 Rome, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3995-7032","authenticated-orcid":false,"given":"Cinzia","family":"Ciccacci","sequence":"additional","affiliation":[{"name":"UniCamillus\u2013Saint Camillus International University of Health Sciences, 00131 Rome, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5350-7361","authenticated-orcid":false,"given":"Andrea","family":"Latini","sequence":"additional","affiliation":[{"name":"Department of Biomedicine & Prevention, Genetics Section, University of Rome Tor Vergata, 00133 Rome, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9639-0909","authenticated-orcid":false,"given":"Lucia","family":"Novelli","sequence":"additional","affiliation":[{"name":"UniCamillus\u2013Saint Camillus International University of Health Sciences, 00131 Rome, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7781-602X","authenticated-orcid":false,"given":"Giuseppe","family":"Novelli","sequence":"additional","affiliation":[{"name":"Department of Biomedicine & Prevention, Genetics Section, University of Rome Tor Vergata, 00133 Rome, Italy"},{"name":"IRCCS Neuromed, 86077 Pozzilli, Italy"},{"name":"Department of Pharmacology, School of Medicine, University of Nevada, Reno, NV 89557, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Paola","family":"Borgiani","sequence":"additional","affiliation":[{"name":"Department of Biomedicine & Prevention, Genetics Section, University of Rome Tor Vergata, 00133 Rome, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2021,6,11]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","unstructured":"Chivasso, C., Sarrand, J., Perret, J., Delporte, C., and Soyfoo, M.S. (2021). The Involvement of Innate and Adaptive Immunity in the Initiation and Perpetuation of Sj\u00f6gren\u2019s Syndrome. Int. J. Mol. Sci., 22.","DOI":"10.3390\/ijms22020658"},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"23","DOI":"10.1016\/j.coms.2013.09.005","article-title":"Salivary gland biopsy for Sj\u00f6gren\u2019s syndrome","volume":"26","author":"Delli","year":"2014","journal-title":"Oral. Maxillofac. Surg. Clin. N. Am."},{"key":"ref_3","first-page":"3","article-title":"One year in review 2019: Sj\u00f6gren\u2019s syndrome","volume":"37","author":"Cafaro","year":"2019","journal-title":"Clin. Exp. Rheumatol."},{"key":"ref_4","doi-asserted-by":"crossref","first-page":"665","DOI":"10.3899\/jrheum.180392","article-title":"Primary versus Secondary Sj\u00f6gren Syndrome: Is It Time To Reconsider These Terms?","volume":"46","author":"Mavragani","year":"2019","journal-title":"J. Rheumatol."},{"key":"ref_5","doi-asserted-by":"crossref","first-page":"35","DOI":"10.1002\/art.39859","article-title":"2016 American College of Rheumatology\/European League Against Rheumatism Classification Criteria for Primary Sj\u00f6gren\u2019s Syndrome: A Consensus and Data-Driven Methodology Involving Three International Patient Cohorts","volume":"69","author":"Shiboski","year":"2017","journal-title":"Arthritis Rheumatol."},{"key":"ref_6","first-page":"2085","article-title":"Genetics and epigenetics in primary Sj\u00f6gren\u2019s syndrome","volume":"60","author":"Rasmussen","year":"2019","journal-title":"Rheumatology"},{"key":"ref_7","doi-asserted-by":"crossref","first-page":"1284","DOI":"10.1038\/ng.2792","article-title":"Variants at multiple loci implicated in both innate and adaptive immune responses are associated with Sj\u00f6gren\u2019s syndrome","volume":"45","author":"Lessard","year":"2013","journal-title":"Nat. Genet."},{"key":"ref_8","doi-asserted-by":"crossref","first-page":"1361","DOI":"10.1038\/ng.2779","article-title":"A genome-wide association study in Han Chinese identifies a susceptibility locus for primary Sj\u00f6gren\u2019s syndrome at 7q11.23","volume":"45","author":"Li","year":"2013","journal-title":"Nat. Genet."},{"key":"ref_9","doi-asserted-by":"crossref","first-page":"515","DOI":"10.1002\/JLB.3MR0218-079R","article-title":"MicroRNA miR-223 as regulator of innate immunity","volume":"104","author":"Yuan","year":"2018","journal-title":"J. Leukoc. Biol."},{"key":"ref_10","doi-asserted-by":"crossref","first-page":"189","DOI":"10.1016\/j.jaut.2009.02.012","article-title":"MicroRNA in autoimmunity and autoimmune diseases","volume":"32","author":"Pauley","year":"2009","journal-title":"J. Autoimmun."},{"key":"ref_11","doi-asserted-by":"crossref","first-page":"818","DOI":"10.3389\/fcell.2020.00818","article-title":"MicroRNAs and Autoimmune-Mediated Eye Diseases","volume":"8","author":"Wei","year":"2020","journal-title":"Front. Cell Dev. Biol."},{"key":"ref_12","doi-asserted-by":"crossref","first-page":"e4","DOI":"10.4110\/in.2019.19.e4","article-title":"Potential Implications of Long Noncoding RNAs in Autoimmune Diseases","volume":"19","author":"Hur","year":"2019","journal-title":"Immune Netw."},{"key":"ref_13","first-page":"595","article-title":"Research progress on the interactions between long non-coding RNAs and microRNAs in human cancer (Review)","volume":"19","author":"Sun","year":"2019","journal-title":"Oncol. Lett."},{"key":"ref_14","doi-asserted-by":"crossref","first-page":"437301","DOI":"10.4061\/2011\/437301","article-title":"MiR-146a in Immunity and Disease","volume":"2011","author":"Rusca","year":"2011","journal-title":"Mol. Biol. Int."},{"key":"ref_15","doi-asserted-by":"crossref","first-page":"2029","DOI":"10.1002\/eji.201040757","article-title":"Altered miR-146a expression in Sj\u00f6gren\u2019s syndrome and its functional role in innate immunity","volume":"41","author":"Pauley","year":"2011","journal-title":"Eur. J. Immunol."},{"key":"ref_16","doi-asserted-by":"crossref","first-page":"165","DOI":"10.1016\/j.imlet.2011.09.006","article-title":"Increased microRNA-146a\/b, TRAF6 gene and decreased IRAK1 gene expressions in the peripheral mononuclear cells of patients with Sj\u00f6gren\u2019s syndrome","volume":"141","author":"Zilahi","year":"2012","journal-title":"Immunol. Lett."},{"key":"ref_17","doi-asserted-by":"crossref","first-page":"792","DOI":"10.1111\/jop.12187","article-title":"miR-146a and miR-155 expression in PBMCs from patients with Sj\u00f6gren\u2019s syndrome","volume":"43","author":"Shi","year":"2014","journal-title":"J. Oral Pathol. Med."},{"key":"ref_18","doi-asserted-by":"crossref","first-page":"2208","DOI":"10.3899\/jrheum.131154","article-title":"MicroRNA Profiling in Chinese Patients with Primary Sj\u00f6gren Syndrome Reveals Elevated miRNA-181a in Peripheral Blood Mononuclear Cells","volume":"41","author":"Peng","year":"2014","journal-title":"J. Rheumatol."},{"key":"ref_19","doi-asserted-by":"crossref","first-page":"133","DOI":"10.1136\/annrheumdis-2017-211417","article-title":"Deregulation of microRNA expression in purified T and B lymphocytes from patients with primary Sj\u00f6gren\u2019s syndrome","volume":"77","author":"Boudaoud","year":"2018","journal-title":"Ann. Rheum. Dis."},{"key":"ref_20","doi-asserted-by":"crossref","first-page":"604","DOI":"10.1016\/j.autrev.2010.05.006","article-title":"B-cell tolerance breakdown in Sj\u00f6gren\u2019s syndrome: Focus on BAFF","volume":"9","author":"Varin","year":"2010","journal-title":"Autoimmun. Rev."},{"key":"ref_21","doi-asserted-by":"crossref","first-page":"4","DOI":"10.1016\/j.clim.2017.04.003","article-title":"Innate immunity in Sj\u00f6gren\u2019s syndrome","volume":"182","author":"Kiripolsky","year":"2017","journal-title":"Clin. Immunol."},{"key":"ref_22","doi-asserted-by":"crossref","first-page":"1335","DOI":"10.3389\/fimmu.2019.01335","article-title":"MicroRNA-130a Contributes to Type-2 Classical DC-activation in Sj\u00f6gren\u2019s Syndrome by Targeting Mitogen- and Stress-Activated Protein Kinase-1","volume":"10","author":"Lopes","year":"2019","journal-title":"Front. Immunol."},{"key":"ref_23","doi-asserted-by":"crossref","first-page":"642","DOI":"10.4049\/jimmunol.169.2.642","article-title":"Cutting edge: IL-17D, a novel member of the IL-17 family, stimulates cytokine production and inhibits hemopoiesis","volume":"169","author":"Starnes","year":"2002","journal-title":"J. Immunol."},{"key":"ref_24","doi-asserted-by":"crossref","first-page":"67","DOI":"10.1007\/s11626-019-00409-5","article-title":"MiR-let-7d-3p regulates IL-17 expression through targeting AKT1\/mTOR signaling in CD4+ T cells","volume":"56","author":"Wang","year":"2020","journal-title":"In Vitro Cell Dev. Biol. Anim."},{"key":"ref_25","doi-asserted-by":"crossref","first-page":"888","DOI":"10.7326\/0003-4819-89-6-888","article-title":"Increased Risk of Lymphoma in Sicca Syndrome","volume":"89","author":"Kassan","year":"1978","journal-title":"Ann. Intern. Med."},{"key":"ref_26","first-page":"1200","article-title":"Low miR200b-5p levels in minor salivary glands: A novel molecular marker predicting lymphoma development in patients with Sj\u00f6gren\u2019s syndrome","volume":"77","author":"Kapsogeorgou","year":"2018","journal-title":"Ann. Rheum. Dis."},{"key":"ref_27","doi-asserted-by":"crossref","first-page":"526","DOI":"10.1016\/j.ebiom.2019.09.010","article-title":"Dual function of miR-1248 links interferon induction and calcium signaling defects in Sj\u00f6gren\u2019s syndrome","volume":"48","author":"Jang","year":"2019","journal-title":"EBioMedicine"},{"key":"ref_28","first-page":"49","article-title":"Differential expression of miR-17-92 cluster among varying histological stages of minor salivary gland in patients with primary Sj\u00f6gren\u2019s syndrome","volume":"37","author":"Yan","year":"2019","journal-title":"Clin. Exp. Rheumatol."},{"key":"ref_29","doi-asserted-by":"crossref","first-page":"e133497","DOI":"10.1172\/jci.insight.133497","article-title":"T cell exosome-derived miR-142-3p impairs glandular cell function in Sj\u00f6gren\u2019s syndrome","volume":"5","author":"Jang","year":"2020","journal-title":"JCI Insight"},{"key":"ref_30","doi-asserted-by":"crossref","first-page":"49","DOI":"10.1053\/sarh.2003.50019","article-title":"Apoptosis and Sj\u00f6gren syndrome","volume":"33","author":"Manganelli","year":"2003","journal-title":"Semin. Arthritis Rheum."},{"key":"ref_31","doi-asserted-by":"crossref","first-page":"1111","DOI":"10.1002\/cbf.3569","article-title":"Characterization of antiapoptotic microRNAs in primary Sj\u00f6gren\u2019s syndrome","volume":"38","author":"Yang","year":"2020","journal-title":"Cell Biochem. Funct."},{"key":"ref_32","doi-asserted-by":"crossref","first-page":"1044","DOI":"10.1111\/jop.13099","article-title":"Distinct microRNA expression profiles in saliva and salivary gland tissue differentiate patients with primary Sj\u00f6gren\u2019s syndrome from non-Sj\u00f6gren\u2019s sicca patients","volume":"49","author":"Locht","year":"2020","journal-title":"J. Oral Pathol. Med."},{"key":"ref_33","doi-asserted-by":"crossref","first-page":"4889","DOI":"10.1167\/iovs.19-27062","article-title":"Comparison of MicroRNA Expression in Tears of Normal Subjects and Sj\u00f6gren Syndrome Patients","volume":"60","author":"Kim","year":"2019","journal-title":"Investig. Ophthalmol. Vis. Sci."},{"key":"ref_34","doi-asserted-by":"crossref","first-page":"7484","DOI":"10.1038\/s41598-020-64422-5","article-title":"miR-744-5p contributes to ocular inflammation in patients with primary Sjogrens Syndrome","volume":"10","author":"Pilson","year":"2020","journal-title":"Sci. Rep."},{"key":"ref_35","doi-asserted-by":"crossref","first-page":"496","DOI":"10.3109\/08916934.2016.1167192","article-title":"Aberrant expression of long noncoding RNA TMEVPG1 in patients with primary immune thrombocytopenia","volume":"49","author":"Li","year":"2016","journal-title":"Autoimmunity"},{"key":"ref_36","doi-asserted-by":"crossref","first-page":"489","DOI":"10.1007\/s12026-015-8715-4","article-title":"Upregulation of long noncoding RNA TMEVPG1 enhances T helper type 1 cell response in patients with Sj\u00f6gren syndrome","volume":"64","author":"Wang","year":"2016","journal-title":"Immunol. Res."},{"key":"ref_37","doi-asserted-by":"crossref","first-page":"153","DOI":"10.1186\/s13075-020-02248-2","article-title":"Identification of novel genes associated with dysregulation of B cells in patients with primary Sj\u00f6gren\u2019s syndrome","volume":"22","author":"Inamo","year":"2020","journal-title":"Arthritis Res. Ther."},{"key":"ref_38","doi-asserted-by":"crossref","first-page":"133","DOI":"10.1038\/nrrheum.2018.1","article-title":"B cells in the pathogenesis of primary Sj\u00f6gren syndrome","volume":"14","author":"Nocturne","year":"2018","journal-title":"Nat. Rev. Rheumatol."},{"key":"ref_39","doi-asserted-by":"crossref","first-page":"106992","DOI":"10.1016\/j.intimp.2020.106992","article-title":"LncRNA Neat1 positively regulates MAPK signaling and is involved in the pathogenesis of Sj\u00f6gren\u2019s syndrome","volume":"88","author":"Ye","year":"2020","journal-title":"Int. Immunopharmacol."},{"key":"ref_40","doi-asserted-by":"crossref","first-page":"229","DOI":"10.1016\/j.jaut.2012.05.019","article-title":"The T cell in Sjogren\u2019s syndrome: Force majeure, not spectateur","volume":"39","author":"Singh","year":"2012","journal-title":"J. Autoimmun."},{"key":"ref_41","doi-asserted-by":"crossref","first-page":"102358","DOI":"10.1016\/j.jaut.2019.102358","article-title":"LncRNA PVT1 links Myc to glycolytic metabolism upon CD4+ T cell activation and Sj\u00f6gren\u2019s syndrome-like autoimmune response","volume":"107","author":"Singh","year":"2020","journal-title":"J. Autoimmun."},{"key":"ref_42","doi-asserted-by":"crossref","first-page":"19629","DOI":"10.1038\/s41598-020-76701-2","article-title":"LncRNA and mRNA expression profile of peripheral blood mononuclear cells in primary Sj\u00f6gren\u2019s syndrome patients","volume":"10","author":"Peng","year":"2020","journal-title":"Sci. Rep."},{"key":"ref_43","doi-asserted-by":"crossref","unstructured":"Dolcino, M., Tinazzi, E., Vitali, C., Del Papa, N., Puccetti, A., and Lunardi, C. (2019). Long Non-Coding RNAs Modulate Sj\u00f6gren\u2019s Syndrome Associated Gene Expression and Are Involved in the Pathogenesis of the Disease. J. Clin. Med., 8.","DOI":"10.3390\/jcm8091349"},{"key":"ref_44","doi-asserted-by":"crossref","first-page":"109","DOI":"10.1186\/s13075-016-1005-2","article-title":"Long non-coding RNA expression profile in minor salivary gland of primary Sj\u00f6gren\u2019s syndrome","volume":"18","author":"Shi","year":"2016","journal-title":"Arthritis Res. Ther."},{"key":"ref_45","doi-asserted-by":"crossref","first-page":"2447","DOI":"10.1007\/s10067-017-3833-0","article-title":"No association of single nucleotide polymorphisms within H19 and HOX transcript antisense RNA (HOTAIR) with genetic susceptibility to systemic lupus erythematosus, rheumatoid arthritis, and primary Sj\u00f6gren\u2019s syndrome in a Chinese Han population","volume":"36","author":"Huang","year":"2017","journal-title":"Clin. Rheumatol."},{"key":"ref_46","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1155\/2019\/7682827","article-title":"STAT4, TRAF3IP2, IL10, and HCP5 Polymorphisms in Sj\u00f6gren\u2019s Syndrome: Association with Disease Susceptibility and Clinical Aspects","volume":"2019","author":"Colafrancesco","year":"2019","journal-title":"J. Immunol. Res."}],"container-title":["Genes"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.mdpi.com\/2073-4425\/12\/6\/903\/pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,11]],"date-time":"2025-10-11T06:13:14Z","timestamp":1760163194000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.mdpi.com\/2073-4425\/12\/6\/903"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,6,11]]},"references-count":46,"journal-issue":{"issue":"6","published-online":{"date-parts":[[2021,6]]}},"alternative-id":["genes12060903"],"URL":"https:\/\/doi.org\/10.3390\/genes12060903","relation":{},"ISSN":["2073-4425"],"issn-type":[{"value":"2073-4425","type":"electronic"}],"subject":[],"published":{"date-parts":[[2021,6,11]]}}}