{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,13]],"date-time":"2026-05-13T08:48:33Z","timestamp":1778662113646,"version":"3.51.4"},"reference-count":49,"publisher":"MDPI AG","issue":"6","license":[{"start":{"date-parts":[[2021,6,18]],"date-time":"2021-06-18T00:00:00Z","timestamp":1623974400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"The Ministry of Science and Technology of Taiwan","award":["MOST-108-2313-B-005-039-MY3"],"award-info":[{"award-number":["MOST-108-2313-B-005-039-MY3"]}]},{"name":"The Kaohsiung Armed Forces General Hospital Gangshan Branch, Taiwan","award":["KAFGHGB-107-01"],"award-info":[{"award-number":["KAFGHGB-107-01"]}]},{"name":"The Ministry of Education of Taiwan","award":["MOE-110-S-0023-A"],"award-info":[{"award-number":["MOE-110-S-0023-A"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Genes"],"abstract":"<jats:p>Osteoporosis is a rising health threat in the increasingly aging world population. It is a common skeletal disease strongly linked to genetic predisposition. We aim to identify the effects of the anti-inflammatory TGF-\u03b21- and IL-10-specific single-nucleotide polymorphism (SNP) combination on the risk for osteoporosis. We investigated and analyzed the relationships between three TGF-\u03b21 SNPs (\u2212509C\/T, +869 T\/C and +29T\/C), one IL-10 SNP (+1927A\/C) and the level of bone mineral density (BMD), as well as the risk of osteoporosis in Taiwanese osteoporotic patients. A total of 217 subjects were recruited, including 88 osteoporotic patients and 129 healthy controls, for SNPs, BMD and clinical characteristics statistical analyses. Females with TGF-\u03b21 SNP (\u2212509 C\/C) and IL-10 SNP (+1927 C\/C) genotypes showed a great benefit for femoral neck T-scores. However, the combination of TGF-\u03b21 SNP (\u2212509 T\/T) and IL-10 SNP (+1927 A\/A) genotypes in all subjects showed a significant decrease in total hip BMD T-scores. The TGF-\u03b21 SNP (\u2212509 C\/T) genotype in all subjects and TGF-\u03b21 SNP (\u2212509 T\/T) and IL-10 SNP (+1927 A\/C) genotypes in males showed positive effects on body height. The combination of the many SNPs in the anti-inflammatory TGF-\u03b21 and IL-10 genes may be cooperatively involved in the development of osteoporosis. Our data suggested that the specific SNP combination of TGF-\u03b21 (\u2212509) and IL-10 (+1927) may act as a predictive factor for postmenopausal osteoporosis in Taiwanese women.<\/jats:p>","DOI":"10.3390\/genes12060930","type":"journal-article","created":{"date-parts":[[2021,6,18]],"date-time":"2021-06-18T11:19:20Z","timestamp":1624015160000},"page":"930","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":14,"title":["Association of TGF-\u03b21 and IL-10 Gene Polymorphisms with Osteoporosis in a Study of Taiwanese Osteoporotic Patients"],"prefix":"10.3390","volume":"12","author":[{"given":"Min-Yu","family":"Tu","sequence":"first","affiliation":[{"name":"Department of Life Sciences and Ph.D. Program in Translational Medicine, National Chung Hsing University, Taichung 402, Taiwan"},{"name":"Department of Health Business Administration, Meiho University, Pingtung 912, Taiwan"},{"name":"Institute of Biomedical Science and Technology, National Sun Yat-Sen University, Kaohsiung 804, Taiwan"},{"name":"Kaohsiung Armed Forces General Hospital Gangshan Branch, Kaohsiung 820, Taiwan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kuei-Yang","family":"Han","sequence":"additional","affiliation":[{"name":"Department of Family Medicine, Jen-Ai Hospital, Dali Branch, Taichung 402, Taiwan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ying-Wei","family":"Lan","sequence":"additional","affiliation":[{"name":"Department of Life Sciences and Ph.D. Program in Translational Medicine, National Chung Hsing University, Taichung 402, Taiwan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ku-Yi","family":"Chang","sequence":"additional","affiliation":[{"name":"Department of Orthopedic Surgery, Jen-Ai Hospital, Dali Branch, Taichung 402, Taiwan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Cheng-Wei","family":"Lai","sequence":"additional","affiliation":[{"name":"Department of Life Sciences and Ph.D. Program in Translational Medicine, National Chung Hsing University, Taichung 402, Taiwan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3137-3833","authenticated-orcid":false,"given":"Theresa","family":"Staniczek","sequence":"additional","affiliation":[{"name":"Department of Life Sciences and Ph.D. Program in Translational Medicine, National Chung Hsing University, Taichung 402, Taiwan"},{"name":"Department of Dermatology, Venereology and Allergology, University Medical Center and Medical Faculty Mannheim, and Center of Excellence in Dermatology, Heidelberg University, Mannheim 69117, Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7524-3010","authenticated-orcid":false,"given":"Chung-Yu","family":"Lai","sequence":"additional","affiliation":[{"name":"Graduate Institute of Aerospace and Undersea Medicine, National Defense Medical Center, Taipei 114, Taiwan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0974-0673","authenticated-orcid":false,"given":"Kowit-Yu","family":"Chong","sequence":"additional","affiliation":[{"name":"Department of Medical Biotechnology and Laboratory Science and Graduate Institute of Biomedical Sciences, Division of Biotechnology, College of Medicine, Chang Gung University, Taoyuan 333, Taiwan"},{"name":"Hyperbaric Oxygen Medical Research Lab, Bone and Joint Research Center, Department of Laboratory Medicine, Chang Gung Memorial Hospital, Linkou, Taoyuan 333, Taiwan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2461-9150","authenticated-orcid":false,"given":"Chuan-Mu","family":"Chen","sequence":"additional","affiliation":[{"name":"Department of Life Sciences and Ph.D. Program in Translational Medicine, National Chung Hsing University, Taichung 402, Taiwan"},{"name":"The iEGG and Animal Biotechnology Center and the Rong Hsing Research Center for Translational Medicine, National Chung Hsing University, Taichung 402, Taiwan"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1968","published-online":{"date-parts":[[2021,6,18]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"46","DOI":"10.5152\/eurjrheum.2016.048","article-title":"An overview and management of osteoporosis","volume":"4","year":"2017","journal-title":"Eur. 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