{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,28]],"date-time":"2026-04-28T08:03:28Z","timestamp":1777363408989,"version":"3.51.4"},"reference-count":43,"publisher":"MDPI AG","issue":"6","license":[{"start":{"date-parts":[[2021,6,20]],"date-time":"2021-06-20T00:00:00Z","timestamp":1624147200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/100009633","name":"Eunice Kennedy Shriver National Institute of Child Health and Human Development","doi-asserted-by":"publisher","award":["1P50HD104224-01"],"award-info":[{"award-number":["1P50HD104224-01"]}],"id":[{"id":"10.13039\/100009633","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100005303","name":"Boston College","doi-asserted-by":"publisher","award":["Research Across Disciplines Grant"],"award-info":[{"award-number":["Research Across Disciplines Grant"]}],"id":[{"id":"10.13039\/100005303","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Genes"],"abstract":"<jats:p>Genetic testing is increasingly part of routine clinical care. However, testing decisions may be characterized by regret as findings also implicate blood relatives. It is not known if genetic testing decisions are affected by the way information is presented (i.e., framing effects). We employed a randomized factorial design to examine framing effects on hypothetical genetic testing scenarios (common, life-threatening disease and rare, life-altering disease). Participants (n = 1012) received one of six decision frames: choice, default (n = 2; opt-in, opt-out), or enhanced choice (n = 3, based on the Theory of Planned Behavior). We compared testing decision, satisfaction, regret, and decision cognitions across decision frames and between scenarios. Participants randomized to \u2018choice\u2019 were least likely to opt for genetic testing compared with default and enhanced choice frames (78% vs. 83\u201391%, p &lt; 0.05). Neither satisfaction nor regret differed across frames. Perceived autonomy (behavioral control) predicted satisfaction (B = 0.085, p &lt; 0.001) while lack of control predicted regret (B = 0.346, p &lt; 0.001). Opting for genetic testing did not differ between disease scenarios (p = 0.23). Results suggest framing can nudge individuals towards opting for genetic testing. These findings have important implications for individual self-determination in the genomic era. Similarities between scenarios with disparate disease trajectories point to possible modular approaches for web-based decisional support.<\/jats:p>","DOI":"10.3390\/genes12060941","type":"journal-article","created":{"date-parts":[[2021,6,20]],"date-time":"2021-06-20T22:00:02Z","timestamp":1624226402000},"page":"941","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":9,"title":["Framing Effects on Decision-Making for Diagnostic Genetic Testing: Results from a Randomized Trial"],"prefix":"10.3390","volume":"12","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-7023-6794","authenticated-orcid":false,"given":"Andrew A.","family":"Dwyer","sequence":"first","affiliation":[{"name":"William F. Connell School of Nursing, Boston College, Chestnut Hill, MA 02467, USA"},{"name":"Massachusetts General Hospital-Harvard Center for Reproductive Medicine, Massachusetts General Hospital, Boston, MA 02114, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hongjie","family":"Shen","sequence":"additional","affiliation":[{"name":"Department of Measurement, Evaluation, Statistics and Assessment, Lynch School of Education, Boston College, Chestnut Hill, MA 02467, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ziwei","family":"Zeng","sequence":"additional","affiliation":[{"name":"Department of Measurement, Evaluation, Statistics and Assessment, Lynch School of Education, Boston College, Chestnut Hill, MA 02467, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Matt","family":"Gregas","sequence":"additional","affiliation":[{"name":"Department of Research Services, Boston College, Chestnut Hill, MA 02467, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Min","family":"Zhao","sequence":"additional","affiliation":[{"name":"Carroll School of Management, Boston College, Chestnut Hill, MA 02467, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1968","published-online":{"date-parts":[[2021,6,20]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"1353","DOI":"10.1056\/NEJMra1711801","article-title":"Next-Generation Sequencing to Diagnose Suspected Genetic Disorders","volume":"379","author":"Adams","year":"2018","journal-title":"N. 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