{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,10]],"date-time":"2026-09-10T08:57:41Z","timestamp":1789030661583,"version":"build-2803163510"},"reference-count":159,"publisher":"MDPI AG","issue":"7","license":[{"start":{"date-parts":[[2021,6,25]],"date-time":"2021-06-25T00:00:00Z","timestamp":1624579200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Genes"],"abstract":"<jats:p>Preeclampsia (PE) and Intrauterine Growth Restriction (IUGR) are two pregnancy-specific placental disorders with high maternal, fetal, and neonatal morbidity and mortality rates worldwide. The identification biomarkers involved in the dysregulation of PE and IUGR are fundamental for developing new strategies for early detection and management of these pregnancy pathologies. Several studies have demonstrated the importance of long non-coding RNAs (lncRNAs) as essential regulators of many biological processes in cells and tissues, and the placenta is not an exception. In this review, we summarize the importance of lncRNAs in the regulation of trophoblasts during the development of PE and IUGR, and other placental disorders.<\/jats:p>","DOI":"10.3390\/genes12070970","type":"journal-article","created":{"date-parts":[[2021,6,25]],"date-time":"2021-06-25T04:46:57Z","timestamp":1624596417000},"page":"970","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":28,"title":["The Role of Long Non-Coding RNAs in Trophoblast Regulation in Preeclampsia and Intrauterine Growth Restriction"],"prefix":"10.3390","volume":"12","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-2078-380X","authenticated-orcid":false,"given":"Lara J.","family":"Monteiro","sequence":"first","affiliation":[{"name":"Faculty of Medicine, Universidad de los Andes, Santiago 7620001, Chile"},{"name":"Laboratory of Reproductive Biology, Center for Biomedical Research and Innovation (CIIB), Universidad de los Andes, Santiago 7620001, Chile"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5300-1208","authenticated-orcid":false,"given":"Reyna","family":"Pe\u00f1ailillo","sequence":"additional","affiliation":[{"name":"Laboratory of Reproductive Biology, Center for Biomedical Research and Innovation (CIIB), Universidad de los Andes, Santiago 7620001, Chile"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5991-9930","authenticated-orcid":false,"given":"Mario","family":"S\u00e1nchez","sequence":"additional","affiliation":[{"name":"Molecular Biology and Bioinformatics Lab, Program in Molecular Biology and Bioinformatics, Center for Biomedical Research and Innovation (CIIB), Universidad de los Andes, Santiago 7620001, Chile"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Stephanie","family":"Acu\u00f1a-Gallardo","sequence":"additional","affiliation":[{"name":"Faculty of Medicine, Universidad de los Andes, Santiago 7620001, Chile"},{"name":"Laboratory of Reproductive Biology, Center for Biomedical Research and Innovation (CIIB), Universidad de los Andes, Santiago 7620001, Chile"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Max","family":"M\u00f6nckeberg","sequence":"additional","affiliation":[{"name":"Faculty of Medicine, Universidad de los Andes, Santiago 7620001, Chile"},{"name":"Laboratory of Reproductive Biology, Center for Biomedical Research and Innovation (CIIB), Universidad de los Andes, Santiago 7620001, Chile"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Judith","family":"Ong","sequence":"additional","affiliation":[{"name":"Yong Loo Lin School of Medicine, National University of Singapore, Singapore 119228, Singapore"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mahesh","family":"Choolani","sequence":"additional","affiliation":[{"name":"Yong Loo Lin School of Medicine, National University of Singapore, Singapore 119228, Singapore"},{"name":"Department of Obstetrics and Gynaecology, National University Hospital, Singapore 119228, Singapore"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sebasti\u00e1n E.","family":"Illanes","sequence":"additional","affiliation":[{"name":"Faculty of Medicine, Universidad de los Andes, Santiago 7620001, Chile"},{"name":"Laboratory of Reproductive Biology, Center for Biomedical Research and Innovation (CIIB), Universidad de los Andes, Santiago 7620001, Chile"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2342-6480","authenticated-orcid":false,"given":"Gino","family":"Nardocci","sequence":"additional","affiliation":[{"name":"Faculty of Medicine, Universidad de los Andes, Santiago 7620001, Chile"},{"name":"Molecular Biology and Bioinformatics Lab, Program in Molecular Biology and Bioinformatics, Center for Biomedical Research and Innovation (CIIB), Universidad de los Andes, Santiago 7620001, Chile"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2021,6,25]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"141","DOI":"10.1210\/er.2005-0011","article-title":"Endocrine Regulation of Human Fetal Growth: The Role of the Mother, Placenta, and Fetus","volume":"27","author":"Murphy","year":"2006","journal-title":"Endocr. 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