{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,12]],"date-time":"2025-10-12T02:11:13Z","timestamp":1760235073173,"version":"build-2065373602"},"reference-count":47,"publisher":"MDPI AG","issue":"8","license":[{"start":{"date-parts":[[2021,7,27]],"date-time":"2021-07-27T00:00:00Z","timestamp":1627344000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Genes"],"abstract":"<jats:p>Carriers of balanced constitutional reciprocal translocations usually present a normal phenotype, but often show reproductive disorders. For the first time in pigs, we analyzed the meiotic process of an autosome\u2013autosome translocation associated with azoospermia. Meiotic process analysis revealed the presence of unpaired autosomal segments with histone \u03b3H2AX accumulation sometimes associated with the XY body. Additionally, \u03b3H2AX signals were observed on apparently synapsed autosomes other than the SSC1 or SSC15, as previously observed in Ataxia with oculomotor apraxia type 2 patients or knock-out mice for the Senataxin gene. Gene expression showed a downregulation of genes selected on chromosomes 1 and 15, but no upregulation of SSCX genes. We hypothesized that the total meiotic arrest observed in this boar might be due to the silencing of crucial autosomal genes by the mechanism referred to as meiotic silencing of unsynapsed chromatin (MSUC).<\/jats:p>","DOI":"10.3390\/genes12081137","type":"journal-article","created":{"date-parts":[[2021,7,27]],"date-time":"2021-07-27T03:53:53Z","timestamp":1627358033000},"page":"1137","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Meiotic Silencing in Pigs: A Case Study in a Translocated Azoospermic Boar"],"prefix":"10.3390","volume":"12","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-7304-5555","authenticated-orcid":false,"given":"Nicolas","family":"Mary","sequence":"first","affiliation":[{"name":"GenPhySE, Universit\u00e9 de Toulouse, INRAE, ENVT, 31326 Castanet Tolosan, France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Anne","family":"Calgaro","sequence":"additional","affiliation":[{"name":"GenPhySE, Universit\u00e9 de Toulouse, INRAE, ENVT, 31326 Castanet Tolosan, France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Harmonie","family":"Barasc","sequence":"additional","affiliation":[{"name":"GenPhySE, Universit\u00e9 de Toulouse, INRAE, ENVT, 31326 Castanet Tolosan, France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Nathalie","family":"Bonnet","sequence":"additional","affiliation":[{"name":"GenPhySE, Universit\u00e9 de Toulouse, INRAE, ENVT, 31326 Castanet Tolosan, France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"St\u00e9phane","family":"Ferchaud","sequence":"additional","affiliation":[{"name":"GenESI, UE 1372 G\u00e9n\u00e9tique, Exp\u00e9rimentations et Syst\u00e8mes Innovants, 86480 Rouill\u00e9, France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Isabelle","family":"Raymond-Letron","sequence":"additional","affiliation":[{"name":"STROMA Lab, Universit\u00e9 de Toulouse, Inserm U1031, CNRS ERL 5311, EFS, ENVT, UPS, 31000 Toulouse, France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Alain","family":"Ducos","sequence":"additional","affiliation":[{"name":"GenPhySE, Universit\u00e9 de Toulouse, INRAE, ENVT, 31326 Castanet Tolosan, France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Alain","family":"Pinton","sequence":"additional","affiliation":[{"name":"GenPhySE, Universit\u00e9 de Toulouse, INRAE, ENVT, 31326 Castanet Tolosan, France"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1968","published-online":{"date-parts":[[2021,7,27]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"379","DOI":"10.1093\/humupd\/dmn017","article-title":"Cytogenetic Determinants of Male Fertility","volume":"14","author":"Martin","year":"2008","journal-title":"Hum. 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