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This review presents the current knowledge on this multifactorial disorder, including phenotypic and anatomical characterization, epidemiology, proposed developmental mechanisms, existing animal models, and implicated genetic and environmental components.<\/jats:p>","DOI":"10.3390\/genes12081149","type":"journal-article","created":{"date-parts":[[2021,7,28]],"date-time":"2021-07-28T05:23:48Z","timestamp":1627449828000},"page":"1149","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":13,"title":["The Genomic Architecture of Bladder Exstrophy Epispadias Complex"],"prefix":"10.3390","volume":"12","author":[{"given":"Glenda M.","family":"Beaman","sequence":"first","affiliation":[{"name":"Division of Evolution and Genomic Sciences, Faculty of Biology, School of Biological Sciences, Medicine and Health, University of Manchester, Manchester M13 9PL, UK"},{"name":"Manchester Centre for Genomic Medicine, Manchester University NHS Foundation Trust, Manchester M13 9WL, UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Raimondo M.","family":"Cervellione","sequence":"additional","affiliation":[{"name":"Royal Manchester Children\u2019s Hospital, Manchester University NHS Foundation Trust, Manchester M13 9WL, UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"David","family":"Keene","sequence":"additional","affiliation":[{"name":"Royal Manchester Children\u2019s Hospital, Manchester University NHS Foundation Trust, Manchester M13 9WL, UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Heiko","family":"Reutter","sequence":"additional","affiliation":[{"name":"Department of Neonatology and Paediatric Intensive Care, University Hospital Erlangen, 91054 Erlangen, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"William G.","family":"Newman","sequence":"additional","affiliation":[{"name":"Division of Evolution and Genomic Sciences, Faculty of Biology, School of Biological Sciences, Medicine and Health, University of Manchester, Manchester M13 9PL, UK"},{"name":"Manchester Centre for Genomic Medicine, Manchester University NHS Foundation Trust, Manchester M13 9WL, UK"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2021,7,28]]},"reference":[{"key":"ref_1","unstructured":"Walsh, P.C., Wein, A.J., Vaughan, E.D., and Retik, A.B. 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